The role of mHealth for improving medication adherence in patients with cardiovascular disease: a systematic review
Open accessAbstract
Cardiovascular disease is a leading cause of morbidity and mortality worldwide, and a key barrier to improved outcomes is medication non-adherence. The aim of this study is to review the role of mobile health (mHealth) tools for improving medication adherence in patients with cardiovascular disease. We performed a systematic search for randomized controlled trials that primarily investigated mHealth tools for improving adherence to cardiovascular disease medications in patients with hypertension, coronary artery disease, heart failure, peripheral arterial disease, and stroke. We extracted and reviewed data on the types of mHealth tools used, preferences of patients and healthcare providers, the effect of the mHealth interventions on medication adherence, and the limitations of trials. We identified 10 completed trials matching our selection criteria, mostly with <100 participants, and ranging in duration from 1 to 18 months. mHealth tools included text messages, Bluetooth-enabled electronic pill boxes, online messaging platforms, and interactive voice calls. Patients and healthcare providers generally preferred mHealth to other interventions. All 10 studies reported that mHealth interventions improved medication adherence, though the magnitude of benefit was not consistently large and in one study was not greater than a telehealth comparator. Limitations of trials included small sample sizes, short duration of follow-up, self-reported outcomes, and insufficient assessment of unintended harms and financial implications. Current evidence suggests that mHealth tools can improve medication adherence in patients with cardiovascular diseases. However, high-quality clinical trials of sufficient size and duration are needed to move the field forward and justify use in routine care.
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Previous systematic reviews reported that digital health interventions improve medication adherence and other health outcomes.
“The effectiveness of digital health interventions on adherence to medication was reported in previous systematic reviews with an improvement in medication adherence and other health outcomes.59,61,62”
From Effectiveness of digital health interventions on blood pressure control, lifestyle behaviours and adherence to medication in patients with hypertension in low-income and middle-income countries: a systematic review and meta-analysis of randomised controlled trials (2024) · cites this paper as [61]
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Self-citation
- Authors
- Gandapur, Y., Kianoush, S., Kelli, H. M., Misra, S., Urrea, B., Blaha, M. J., Graham, G., Marvel, F. A., & Martin, S. S.
- Affiliations
- MedStar Union Memorial Hospital (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of Connecticut (US)
- Corresponding author
- Gandapur, Yousuf
- ORCID
- Venue
- European Heart Journal - Quality of Care and Clinical Outcomes
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-04-12
- Volume
- 2
- Issue
- 4
- Pages
- 237-244
- ISSN
- 2058-1742 (ISSN-L)
- 2058-5225
- PMC
- PMC5862021
- OpenAlex
- W2342277966
- Cited by
- 202
- References
- 38
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 28 · 2023: 29 · 2022: 29 · 2021: 29 · 2020: 23 · 2019: 17 · 2018: 9 · 2017: 10 · 2016: 1
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- European Heart Journal - Quality of Care and Clinical Outcomes (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Health Sciences › Health Professions › Health Information Management › Health, Technology, Consumer Behavior
- Keywords
- mobile health, medication adherence, cardiovascular disease, hypertension, coronary artery disease, heart failure, peripheral arterial disease, stroke, text messaging, telemedicine, patient preferences, healthcare provider preferences
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Coronary Artery Disease, Female, Heart Failure, Humans, Hypertension, Male, Middle Aged, Randomized Controlled Trials as Topic, Drug Monitoring, Reminder Systems, Outcome Assessment, Health Care, Telemedicine, Stroke, Cell Phone, Peripheral Arterial Disease, Text Messaging
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