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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
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Cites
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943 · cited 3×
“FRPkd into the BamHI sites of pUHD10-3 (Gossen and Bujard, 1992),”
BackgroundMethodInfluentialLessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
Transcriptional Activation by Tetracyclines in Mammalian Cells
Gossen, M., Freundlieb, S., Bender, G., Müller, G., Hillen, W., & Bujard, H. (1995) · Science · doi:10.1126/science.7792603 · Cited by 2,488 · cited 4×
“1neo (encoding the rtTA transcriptional activator; Gossen et al., 1995) into GM847 fibroblasts, and clones displaying highly regulated expression of FLAG-tagged ATRwt and ATRkd were isolated (Figure 1A).”
BackgroundMethodInfluentialPaulovich, A. G., & Hartwell, L. H. (1995) · Cell · doi:10.1016/0092-8674(95)90481-6 · Cited by 588
Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways
Sanchez, Y., Desany, B. A., Jones, W. J., Liu, Q., Wang, B., & Elledge, S. J. (1996) · Science · doi:10.1126/science.271.5247.357 · Cited by 585 · cited 12×
“ATRkd overexpression sensitizes cells to several DNA-damaging agents To determine whether ATR kinase activity is important for survival after DNA damage, we performed clonogenic survival assays on GM847 fibroblasts, GM847/ATRwt( ) and GM847/ATRkd( /–) cells after exposure to IR, MMS cis-platinum and UV (Figure 2A–”
BackgroundInfluentialMorrow, D. M., Tagle, D. A., Shiloh, Y., Collins, F. S., & Hieter, P. (1995) · Cell · doi:10.1016/0092-8674(95)90480-8 · Cited by 370
Siede, W., Allen, J. B., Elledge, S. J., & Friedberg, E. C. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.19.5841-5843.1996 · Cited by 50
Research works printed but not linked: 47
- Allen JB, Zhou Z, Siede W, Friedberg EC and Elledge SJ (1994) The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage‐induced transcription in yeast. Genes Dev, 8, 2401‐2415. · DOI · Paper page
- Anderson HJ and Roberge M (1992) DNA topoisomerase II: a review of its involvement in chromosome structure, DNA replication, transcription and mitosis. Cell Biol Int Rep, 16, 717‐724. · doi:10.1016/s0309-1651(05)80016-5
- Arlett CF, Green MH, Priestley A, Harcourt SA and Mayne LV (1988) Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma‐irradiation survival of skin derived fibroblasts from normal individuals and from ataxia‐telangiectasia patients and heterozygotes. Int J Radiat Biol, 54, 911‐928. · DOI
- Bentley NJ, Holtzman DA, Flaggs G, Keegan KS, DeMaggio A, Ford JC, Hoekstra MF and Carr AM (1996) The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J, 15, 6641‐6651. · DOI · Paper page
- Brown EJ and Schreiber SL (1996) A signaling pathway to translational control. Cell, 86, 517‐520. · DOI · Paper page
- Brown EJ, Beal PA, Keith CT, Chen J, Shin TB and Schreiber SL (1995) Control of p70 S6 kinase by kinase activity of FRAP in vivo. Nature, 377, 441‐446. · DOI · Paper page
- Carr AM (1997) Control of cell cycle arrest by the Mec1Sc/Rad3Sp DNA structure checkpoint pathway. Curr Opin Genet Dev, 7, 93‐98. · DOI
- Cimprich KA, Shin TB, Keith CT and Schreiber SL (1996) cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci USA, 93, 2850‐2855. · DOI · Paper page
- Clipstone NA and Crabtree GR (1992) Identification of calcineurin as a key signalling enzyme in T‐lymphocyte activation. Nature, 357, 695‐697. · DOI · Paper page
- Dasso M and Newport JW (1990) Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus. Cell, 61, 811‐823. · DOI · Paper page
- Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science, 274, 1664‐1672. · DOI · Paper page
- Enoch T and Nurse P (1990) Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell, 60, 665‐673. · DOI · Paper page
- Enoch T, Carr AM and Nurse P (1992) Fission yeast genes involved in coupling mitosis to completion of DNA replication. Genes Dev, 6, 2035‐2046. · DOI · Paper page
- Greenwell PW, Kronmal SL, Porter SE, Gassenhuber J, Obermaier B and Petes TD (1995) TEL1, a gene involved in controlling telomere length in S.cerevisiae, is homologous to the human Ataxia telangiectasia gene. Cell, 82, 823‐829. · DOI · Paper page
- Hall MN (1996) The TOR signalling pathway and growth control in yeast. Biochem Soc Trans, 24, 234‐239. · DOI
- Hari KL, Santerre A, Sekelsky JJ, McKim KS, Boyd JB and Hawley RS (1995) The mei‐41 gene of D.melanogaster is a structural and functional homolog of the human Ataxia telangiectasia gene. Cell, 82, 815‐821. · DOI · Paper page
- Hartwell LH and Kastan MB (1994) Cell cycle control and cancer. Science, 266, 1821‐1828. · DOI · Paper page
- Hawley RS and Friend SH (1996) Strange bedfellows in even stranger places: the role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53. Genes Dev, 10, 2383‐2388. · DOI
- Hoekstra MF (1997) Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family. Curr Opin Genet Dev, 7, 170‐175. · DOI · Paper page
- Jackson SP (1996a) DNA damage detection by DNA dependent protein kinase and related enzymes. Cancer Surv, 28, 261‐279.
- Jackson SP (1996b) The recognition of DNA damage. Curr Opin Genet Dev, 6, 19‐25. · DOI
- Jimenez G, Yucel J, Rowley R and Subramani S (1992) The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair. Proc Natl Acad Sci USA, 89, 4952‐4956. · DOI
- Kastan MB (1996) Signalling to p53: where does it all start?. BioEssays, 18, 617‐619. · DOI
- Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res, 22, 3104‐3112. · DOI · Paper page
- Keegan KS et al. (1996) The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev, 10, 2423‐2437. · DOI · Paper page
- Keith CT and Schreiber SL (1995) PIK‐related kinases: DNA repair, recombination, and cell cycle checkpoints. Science, 270, 50‐51. · DOI · Paper page
- Kumagai A and Dunphy WG (1995) Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors. Mol Biol Cell, 6, 199‐213. · DOI
- Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell, 88, 323‐331. · DOI · Paper page
- Lew DJ and Kornbluth S (1996) Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. Curr Opin Cell Biol, 8, 795‐804. · DOI · Paper page
- Linke SP, Clarkin KC, KiLeonardo A, Tsou A and Wahl GM (1996) A reversible, p53‐dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev, 10, 934‐947. · DOI · Paper page
- Lydall D and Weinert T (1996) From DNA damage to cell cycle arrest and suicide: a budding yeast perspective. Curr Opin Genet Dev, 6, 4‐11. · DOI
- Meyn MS (1995) Ataxia‐telangiectasia and cellular responses to DNA damage. Cancer Res, 55, 5991‐6001.
- Nevins JR (1994) Cell cycle targets of the DNA tumor viruses. Curr Opin Genet Dev, 4, 130‐134. · DOI
- Painter RB and Young BR (1980) Radiosensitivity in ataxia‐telangiectasia: a new explanation. Proc Natl Acad Sci USA, 77, 7315‐7317. · DOI · Paper page
- Paules RS et al. (1995) Defective G2 checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res, 55, 1763‐1773.
- Paulovich AG, Toczyski DP and Hartwell LH (1997) When checkpoints fail. Cell, 88, 315‐321. · DOI · Paper page
- Perlmutter RM and Alberola IJ (1996) The use of dominant‐negative mutations to elucidate signal transduction pathways in lymphocytes. Curr Opin Immunol, 8, 285‐290. · DOI
- Prickett KS, Amberg DC and Hopp TP (1989) A calcium‐dependent antibody for identification and purification of recombinant proteins. Biotechniques, 7, 580‐589.
- Rudner AD and Murray AW (1996) The spindle assembly checkpoint. Curr Opin Cell Biol, 8, 773‐780. · DOI · Paper page
- Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, Collins FS, Shiloh Y and Rotman G (1995) The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum Mol Genet, 4, 2025‐2032. · DOI · Paper page
- Schmidt A, Kunz J and Hall MN (1996) TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci USA, 93, 13780‐13785. · DOI · Paper page
- Seaton BL, Yucel J, Sunnerhagen P and Subramani S (1992) Isolation and characterization of the Schizosaccharomyces pombe rad3 gene, involved in the DNA damage and DNA synthesis checkpoints. Gene, 119, 83‐89. · DOI
- Stewart E and Enoch T (1996) S‐phase and DNA‐damage checkpoints: a tale of two yeasts. Curr Opin Cell Biol, 8, 781‐787. · DOI
- Stewart E, Chapman CR, Al KF, Carr AM and Enoch T (1997) rqh1+, a fission yeast gene related to the Bloom‘s and Werner's syndrome genes, is required for reversible S‐phase arrest. EMBO J, 16, 2682‐2692. · DOI · Paper page
- Weaver DT (1995) What to do at an end: DNA double‐strand‐break repair. Trends Genet, 11, 388‐392. · DOI
- Weinert TA, Kiser GL and Hartwell LH (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev, 8, 652‐665. · DOI · Paper page
- Zheng XF, Florentino D, Chen J, Crabtree GR and Schreiber SL (1995) TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell, 82, 121‐130. · DOI · Paper page
Cited by
The DNA damage response: putting checkpoints in perspective
Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213
A DNA damage checkpoint response in telomere-initiated senescence
Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,917
DNA double-strand breaks: signaling, repair and the cancer connection
Khanna, K. K., & Jackson, S. P. (2001) · Nature Genetics · doi:10.1038/85798 · Cited by 2,455
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042
Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966
Metadata
- Authors
- Cliby, W. A.
- Venue
- The EMBO Journal
- Published
- 1998-01-01
- Volume
- 17
- Issue
- 1
- Pages
- 159-169
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W2133318290
- Cited by
- 536
- References
- 8
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
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- Cliby, W. A. (1998). Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. The EMBO Journal. https://doi.org/10.1093/emboj/17.1.159
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