Aut2p and Aut7p, two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole

Open access

Lang, T.·1998·The EMBO Journal

DOI 10.1093/emboj/17.13.3597

Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/emboj/17.13.3597

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
Scherz‐Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L., & Elazar, Z. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601623 · Cited by 2,101
Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells
Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y., & Yoshimori, T. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.657 · Cited by 1,361
Molecular dissection of autophagy: two ubiquitin-like systems
Ohsumi, Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056522 · Cited by 1,240
Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast
Kirisako, T., Baba, M., Ishihara, N., Miyazawa, K., Ohsumi, M., Yoshimori, T., Noda, T., & Ohsumi, Y. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.435 · Cited by 881
“Lang et al. (1998) stated the accumulation of double membrane structure in aut7/apg8 mutant.”
BackgroundMethodResultInfluential
Methods for Monitoring Autophagy from Yeast to Human
Klionsky, D. J., Cuervo, A. M., & Seglen, P. O. (2007) · Autophagy · doi:10.4161/auto.3678 · Cited by 656
Atg8: an autophagy-related ubiquitin-like protein family.
Shpilka, T., Weidberg, H., Pietrokovski, S., & Elazar, Z. (2011) · Genome biology · doi:10.1186/gb-2011-12-7-226 · Cited by 543
“autophagic factors The first link between Atg8 proteins and autophagy was established in Saccharomyces cerevisiae, where the single Atg8 protein was identified as an autophagy and cytoplasm-to-vacuole targeting essential factor [54-56].”
Background
Autophagy: Basic Principles and Relevance to Disease
Kundu, M., & Thompson, C. B. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.2.010506.091842 · Cited by 523
A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation
Munafó, D. B., & Colombo, M. I. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.20.3619 · Cited by 516
Mitophagy in Yeast Occurs through a Selective Mechanism
Kanki, T., & Klionsky, D. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802403200 · Cited by 335
LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy
von Muhlinen, N., Akutsu, M., Ravenhill, B. J., Foeglein, Á., Bloor, S., Rutherford, T. J., Freund, S. M. V., Komander, D., & Randow, F. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.024 · Cited by 332
Post-translational Modifications of Three Members of the Human MAP1LC3 Family and Detection of a Novel Type of Modification for MAP1LC3B
He, H., Dang, Y., Dai, F., Guo, Z., Wu, J., She, X., Pei, Y., Chen, Y., Ling, W., Wu, C., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303800200 · Cited by 273
The Itinerary of a Vesicle Component, Aut7p/Cvt5p, Terminates in the Yeast Vacuole via the Autophagy/Cvt Pathways
Huang, W.-P., Scott, S. V., Kim, J., & Klionsky, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5845 · Cited by 241
KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses
Stavoe, A. K. H., Kargbo-Hill, S. E., Hall, D. H., & Colón-Ramos, D. A. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.06.012 · Cited by 211
In Vivo and in Vitro Reconstitution of Atg8 Conjugation Essential for Autophagy
Ichimura, Y., Imamura, Y., Emoto, K., Umeda, M., Noda, T., & Ohsumi, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405860200 · Cited by 193
Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana
Williams, R. A., Tetley, L., Mottram, J. C., & Coombs, G. H. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05274.x · Cited by 140
Association of increased autophagic inclusions labeled for β-galactosidase with fibroblastic aging
Gerland, L.-M., Peyrol, S., Lallemand, C., Branche, R., Magaud, J.-P., & Ffrench, M. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00132-3 · Cited by 130
Antiproliferative activity of fucoidan was associated with the induction of apoptosis and autophagy in AGS human gastric cancer cells
Park, H. S., Kim, G., Nam, T., Deuk Kim, N., & Hyun Choi, Y. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2011.02099.x · Cited by 116
Cloning, Expression Patterns, and Chromosome Localization of Three Human and Two Mouse Homologues of GABAA Receptor-Associated Protein
Xin, Y., Yu, L., Chen, Z., Zheng, L., Fu, Q., Jiang, J., Zhang, P., Gong, R., & Zhao, S. (2001) · Genomics · doi:10.1006/geno.2001.6555 · Cited by 113
Aup1-mediated regulation of Rtg3 during mitophagy
Journo, D., Mor, A., & Abeliovich, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.048140 · Cited by 90
Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs
Szalai, P., Hagen, L. K., Sætre, F., Luhr, M., Sponheim, M., Øverbye, A., Mills, I. G., Seglen, P. O., & Engedal, N. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.02.003 · Cited by 82
Atg8 regulates vacuolar membrane dynamics in a lipidation-independent manner in Pichia pastoris
Tamura, N., Oku, M., & Sakai, Y. (2010) · Journal of Cell Science · doi:10.1242/jcs.070045 · Cited by 68
Autophagy in the epithelial cells of murine seminal vesicle in vitro
Kovács, A. L., Réz, G., Pálfia, Z., & Kovács, J. (2000) · Cell and Tissue Research · doi:10.1007/s004410000275 · Cited by 53

Authors: Lang, T.
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 1998-07-01
Volume: 17
Issue: 13
Pages: 3597-3607
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1093/emboj/17.13.3597
OpenAlex: W2091975733
Cited by: 254
References: 0
FWCI: 15.76
Type: journal article
Language: en
Open access: green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review