Aup1-mediated regulation of Rtg3 during mitophagy
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Mitophagy is an autophagic process that degrades mitochondria by an intracellular engulfment that leads to their delivery into the lumen of the cell's hydrolytic compartment, such as the lysosome in animal cells or the vacuole in yeast. It is hypothesized that such processes serve a quality control function to prevent or slow the accumulation of malfunctioning mitochondria, which are thought in turn to underlie central aspects of the aging process in eukaryotic organisms. We recently identified a conserved mitochondrial protein phosphatase homolog, Aup1, which is required for efficient stationary phase mitophagy in yeast. In the present report, we demonstrate that the retrograde signaling pathway (RTG) is defective in aup1Delta mutants. In agreement with a role for Aup1 in the regulation of the RTG pathway, we find that deletion of RTG3, a transcription factor that mediates the RTG response, causes a defect in stationary phase mitophagy and that deletion of AUP1 leads to changes in Rtg3 phosphorylation patterns under these conditions. In addition, we find that mitophagic conditions lead to induction of RTG pathway target genes in an Aup1-dependent fashion. Thus, our results suggest that the function of Aup1 in mitophagy could be explained through its regulation of Rtg3-dependent transcription.
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In S. cerevisiae, the mitochondrial type 2C protein phosphatase encoded by PTC6 (AUP1) is involved in mitophagy, and it is also a retrograde target in C. albicans.
“Involvement in mitophagy was also demonstrated in S. cerevisiae for the mitochondrial type 2C protein phosphatase encoded by PTC6 (AUP1) (Tal et al. 2007; Journo et al. 2009), which is also a retrograde target in C. albicans.”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Journo et al. 2009
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- Authors
- Journo, D., Mor, A., & Abeliovich, H.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Abeliovich, Hagai
- ORCID
- Abeliovich, Hagai
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 284
- Issue
- 51
- Pages
- 35885-35895
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC2791017
- OpenAlex
- W2006985224
- Cited by
- 90
- References
- 60
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 6 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 11 · 2013: 9 · 2012: 10
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- mitophagy, transcriptional regulation, mitochondrial quality control, aging, Saccharomyces cerevisiae
- MeSH terms
- Autophagy, Mitochondria, Phosphoprotein Phosphatases, Phosphorylation, Saccharomyces cerevisiae, Transcription, Genetic, Signal Transduction, Gene Deletion, Saccharomyces cerevisiae Proteins, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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