Cited by 435Calcium signaling and nucleotide metabolismIon Channels and ReceptorsCellular transport and secretion

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The Golgi apparatus is an inositol 1,4,5‐trisphosphate‐sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum

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Pinton, Paolo, Pozzan, Tullio, Rizzuto, Rosario·1998·The EMBO Journal

DOI 10.1093/emboj/17.18.5298PMC PMC1170857

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Abstract

In the past few years, intracellular organelles, such as the endoplasmic reticulum, the nucleus and the mitochondria, have emerged as key determinants in the generation and transduction of Ca2+ signals of high spatio-temporal complexity. Little is known about the Golgi apparatus, despite the fact that Ca2+ within its lumen controls essential processes, such as protein processing and sorting. We report the direct monitoring of the [Ca2+] in the Golgi lumen ([Ca2+]Golgi) of living HeLa cells, using a specifically targeted Ca2+-sensitive photoprotein. With this probe, we show that, in resting cells, [Ca2+]Golgi is approximately 0.3 mM and that Ca2+ accumulation by the Golgi has properties distinct from those of the endoplasmic reticulum (as inferred by the sensitivity to specific inhibitors). Upon stimulation with histamine, an agonist coupled to the generation of inositol 1,4,5-trisphosphate (IP3), a large, rapid decrease in [Ca2+]Golgi is observed. The Golgi apparatus can thus be regarded as a bona fide IP3-sensitive intracellular Ca2+ store, a notion with major implications for the control of organelle function, as well as for the generation of local cytosolic Ca2+ signals.

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Authors: Pinton, P., Pozzan, T., & Rizzuto, R.
Affiliations: University of Padua (IT)
Corresponding author: Rizzuto, Rosario
ORCID: Pinton, Paolo
Pozzan, Tullio
Rizzuto, Rosario
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 1998-09-15
Volume: 17
Issue: 18
Pages: 5298-5308
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1093/emboj/17.18.5298
PMC: PMC1170857
OpenAlex: W2111698016
Cited by: 435
References: 41
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 6 · 2018: 9 · 2017: 11 · 2016: 17 · 2015: 10 · 2014: 18 · 2013: 15 · 2012: 19
FWCI: 10.59
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: The EMBO Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Padua Research Archive (University of Padova) (submittedVersion)
Funders: Harvard University
European Commission
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: Golgi apparatus, inositol 1,4,5-trisphosphate, intracellular calcium stores, endoplasmic reticulum, calcium signaling, histamine stimulation, HeLa cells
MeSH terms: Calcium-Transporting ATPases, Aequorin, Biological Transport, Calcium Chloride, Calcium-Binding Proteins, Endoplasmic Reticulum, Enzyme Inhibitors, Golgi Apparatus, HeLa Cells, Humans, Hydroquinones, Recombinant Fusion Proteins, Ribonucleoproteins, Sialyltransferases, Strontium, Vanadates, Inositol 1,4,5-Trisphosphate, Guanosine 5'-O-(3-Thiotriphosphate), Thapsigargin, Calcium Signaling, Calreticulin

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The Golgi apparatus is an inositol 1,4,5‐trisphosphate‐sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum

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