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The Golgi apparatus is an inositol 1,4,5‐trisphosphate‐sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum
Open accessAbstract
In the past few years, intracellular organelles, such as the endoplasmic reticulum, the nucleus and the mitochondria, have emerged as key determinants in the generation and transduction of Ca2+ signals of high spatio-temporal complexity. Little is known about the Golgi apparatus, despite the fact that Ca2+ within its lumen controls essential processes, such as protein processing and sorting. We report the direct monitoring of the [Ca2+] in the Golgi lumen ([Ca2+]Golgi) of living HeLa cells, using a specifically targeted Ca2+-sensitive photoprotein. With this probe, we show that, in resting cells, [Ca2+]Golgi is approximately 0.3 mM and that Ca2+ accumulation by the Golgi has properties distinct from those of the endoplasmic reticulum (as inferred by the sensitivity to specific inhibitors). Upon stimulation with histamine, an agonist coupled to the generation of inositol 1,4,5-trisphosphate (IP3), a large, rapid decrease in [Ca2+]Golgi is observed. The Golgi apparatus can thus be regarded as a bona fide IP3-sensitive intracellular Ca2+ store, a notion with major implications for the control of organelle function, as well as for the generation of local cytosolic Ca2+ signals.
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“The Golgi apparatus is an established calcium store (31), and its role in sorting and processing secretory and membrane proteins is highly sensitive to changes in calcium concentration within the lumen.”
From SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis (2008) · cites this paper as [31]
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Metadata
- Authors
- Pinton, P., Pozzan, T., & Rizzuto, R.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Rizzuto, Rosario
- Venue
- The EMBO Journal
- Published
- 1998-09-15
- Volume
- 17
- Issue
- 18
- Pages
- 5298-5308
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC1170857
- OpenAlex
- W2111698016
- Cited by
- 435
- References
- 41
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 6 · 2018: 9 · 2017: 11 · 2016: 17 · 2015: 10 · 2014: 18 · 2013: 15 · 2012: 19
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Harvard University
- European Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- Golgi apparatus, inositol 1,4,5-trisphosphate, intracellular calcium stores, endoplasmic reticulum, calcium signaling, histamine stimulation, HeLa cells
- MeSH terms
- Calcium-Transporting ATPases, Aequorin, Biological Transport, Calcium Chloride, Calcium-Binding Proteins, Endoplasmic Reticulum, Enzyme Inhibitors, Golgi Apparatus, HeLa Cells, Humans, Hydroquinones, Recombinant Fusion Proteins, Ribonucleoproteins, Sialyltransferases, Strontium, Vanadates, Inositol 1,4,5-Trisphosphate, Guanosine 5'-O-(3-Thiotriphosphate), Thapsigargin, Calcium Signaling, Calreticulin
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