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The Golgi apparatus is an inositol 1,4,5‐trisphosphate‐sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum
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In the past few years, intracellular organelles, such as the endoplasmic reticulum, the nucleus and the mitochondria, have emerged as key determinants in the generation and transduction of Ca2+ signals of high spatio-temporal complexity. Little is known about the Golgi apparatus, despite the fact that Ca2+ within its lumen controls essential processes, such as protein processing and sorting. We report the direct monitoring of the [Ca2+] in the Golgi lumen ([Ca2+]Golgi) of living HeLa cells, using a specifically targeted Ca2+-sensitive photoprotein. With this probe, we show that, in resting cells, [Ca2+]Golgi is approximately 0.3 mM and that Ca2+ accumulation by the Golgi has properties distinct from those of the endoplasmic reticulum (as inferred by the sensitivity to specific inhibitors). Upon stimulation with histamine, an agonist coupled to the generation of inositol 1,4,5-trisphosphate (IP3), a large, rapid decrease in [Ca2+]Golgi is observed. The Golgi apparatus can thus be regarded as a bona fide IP3-sensitive intracellular Ca2+ store, a notion with major implications for the control of organelle function, as well as for the generation of local cytosolic Ca2+ signals.
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“The Golgi apparatus is an established calcium store (31), and its role in sorting and processing secretory and membrane proteins is highly sensitive to changes in calcium concentration within the lumen.”
From SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis (2008) · cites this paper as [31]
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Cites
Thastrup, M., Cullen, P. J., Drøbak, B. K., Hanley, M. R., & Dawson, A. P. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.7.2466 · Cited by 3,272
Molecular and cellular physiology of intracellular calcium stores
Pozzan, T., Rizzuto, R., Pompeo Volpe, D., & Meldolesi, J. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.3.595 · Cited by 1,113
Self-citationField, J. M., Nikawa, J., Broek, D., MACDONALD, B. S., Rodgers, L., Wilson, I. A., Lerner, R. A., & Wigler, M. H. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.5.2159 · Cited by 949
Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin
Rizzuto, R., Simpson, A. W. M., Brini, M., & Pozzan, T. (1992) · Nature · doi:10.1038/358325a0 · Cited by 931
Self-citationCaroni, P., & Carafoli, E. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69600-6 · Cited by 474
Antebi, A., & Fink, G. R. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.6.633 · Cited by 443
Cunningham, K. W., & Fink, G. R. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.3.351 · Cited by 432
Transfected Aequorin in the Measurement of Cytosolic Ca2+ Concentration ([Ca2+]c)
Brini, M., Marsault, R., Bastianutto, C., Álvarez, J., Pozzan, T., & Rizzuto, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.9896 · Cited by 363
Self-citationField, J. M., Nikawa, J., Broek, D., MACDONALD, B. S., Rodgers, L., Wilson, I. A., Lerner, R. A., & Wigler, M. H. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.5.2159-2165.1988 · Cited by 330
Cloning and sequence analysis of cDNA for the luminescent protein aequorin.
Inouye, S., Noguchi, M., Sakaki, Y., Takagi, Y., Miyata, T., Iwanaga, S., Miyata, T., & Tsuji, F. I. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.10.3154 · Cited by 326
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Mitochondria as sensors and regulators of calcium signalling
Rizzuto, R., De Stefani, D., Raffaello, A., & Mammucari, C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3412 · Cited by 1,781
Self-citationMicrodomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences
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Measurement of Intracellular Calcium
Takahashi, A., Camacho, P., Lechleiter, J. D., & Herman, B. A. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1089 · Cited by 767
Pinton, P., Ferrari, D., Rapizzi, E., Virgilio, F. D., Pozzan, T., & Rizzuto, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2690 · Cited by 605
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Tinel, H., Cancela, J., Mogami, H., Gerasimenko, J. V., Gerasimenko, O. V., Tepikin, A. V., & Petersen, O. H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.4999 · Cited by 365
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Rudd, J. J., & Franklin‐Tong, V. E. (2001) · New Phytologist · doi:10.1046/j.1469-8137.2001.00173.x · Cited by 288
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Arnaudeau, S., Kelley, W. L., Walsh, J. V., & Demaurex, N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103274200 · Cited by 274
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Patel, S., & Docampo, R. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.02.003 · Cited by 237
Ho, H., & Suárez, S. S. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.011320 · Cited by 237
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Tong, B. C., Wu, A. J., Li, M., & Cheung, K. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.07.018 · Cited by 243
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Missiaen, L., Robberecht, W., Bosch, L. V. D., Callewaert, G., Parys, J. B., Wuytack, F., Raeymaekers, L., Nilius, B., Eggermont, J., & SMEDT, H. D. (2000) · Cell Calcium · doi:10.1054/ceca.2000.0131 · Cited by 229
Gerasimenko, J. V., Maruyama, Y., Yano, K., Dolman, N. J., Tepikin, A. V., Petersen, O. H., & Gerasimenko, O. V. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200306134 · Cited by 223
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Mitchell, K. J., Pinton, P., Váradi, A., Tacchetti, C., Ainscow, E., Pozzan, T., Rizzuto, R., & Rutter, G. A. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103145 · Cited by 199
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Camello, C., Lomax, R. B., Petersen, O. H., & Tepikin, A. V. (2002) · Cell Calcium · doi:10.1016/s0143416002001926 · Cited by 192
Danese, A., Patergnani, S., Bonora, M., Wieckowski, M. R., Previati, M., Giorgi, C., & Pinton, P. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.01.003 · Cited by 192
Self-citationThe versatility of inositol phosphates as cellular signals
Shears, S. B. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s0005-2760(98)00131-3 · Cited by 184
Biagioli, M., Pifferi, S., Ragghianti, M., Bucci, S., Rizzuto, R., & Pinton, P. (2007) · Cell Calcium · doi:10.1016/j.ceca.2007.05.003 · Cited by 183
Self-citationVermassen, E., Parys, J. B., & Mauger, J. (2004) · Biology of the Cell · doi:10.1016/j.biolcel.2003.11.004 · Cited by 185
Mitchell, K. J., Lai, F. A., & Rutter, G. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210257200 · Cited by 175
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Small heat-shock proteins protect from heat-stroke-associated neurodegeneration
Kourtis, N., Nikoletopoulou, V., & Tavernarakis, N. (2012) · Nature · doi:10.1038/nature11417 · Cited by 173
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Self-citationCalcium signalling: a historical account, recent developments and future perspectives
Brini, M., & Carafoli, E. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000698 · Cited by 169
Bonora, M., Giorgi, C., Bononi, A., Marchi, S., Patergnani, S., Rimessi, A., Rizzuto, R., & Pinton, P. (2013) · Nature Protocols · doi:10.1038/nprot.2013.127 · Cited by 166
Self-citationGinger, R. S., Askew, S. E., Ogborne, R. M., Wilson, S., Ferdinando, D., Dadd, T., Smith, A. M., Kazi, S., Szerencsei, R. T., Winkfein, R. J., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707521200 · Cited by 158
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Johnson, J. M., Nicot, C., Fullen, J., Ciminale, V., Casareto, L., Mulloy, J. C., Jacobson, S., & Franchini, G. (2001) · Journal of Virology · doi:10.1128/jvi.75.13.6086-6094.2001 · Cited by 137
Haynes, L. P., Tepikin, A. V., & Burgoyne, R. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309617200 · Cited by 135
Strayle, J., Pozzan, T., & Rudolph, H. K. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4733 · Cited by 133
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Marino, M., Stoilova, T., Giorgi, C., Bachi, A., Cattaneo, A., Auricchio, A., Pinton, P., & Zito, E. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu602 · Cited by 126
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Marchi, S., Rimessi, A., Giorgi, C., Baldini, C., Ferroni, L., Rizzuto, R., & Pinton, P. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.153 · Cited by 120
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Metadata
- Authors
- Pinton, P., Pozzan, T., & Rizzuto, R.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Rizzuto, Rosario
- Venue
- The EMBO Journal
- Published
- 1998-09-15
- Volume
- 17
- Issue
- 18
- Pages
- 5298-5308
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC1170857
- OpenAlex
- W2111698016
- Cited by
- 435
- References
- 41
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 6 · 2018: 9 · 2017: 11 · 2016: 17 · 2015: 10 · 2014: 18 · 2013: 15 · 2012: 19
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Harvard University
- European Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- Golgi apparatus, inositol 1,4,5-trisphosphate, intracellular calcium stores, endoplasmic reticulum, calcium signaling, histamine stimulation, HeLa cells
- MeSH terms
- Calcium-Transporting ATPases, Aequorin, Biological Transport, Calcium Chloride, Calcium-Binding Proteins, Endoplasmic Reticulum, Enzyme Inhibitors, Golgi Apparatus, HeLa Cells, Humans, Hydroquinones, Recombinant Fusion Proteins, Ribonucleoproteins, Sialyltransferases, Strontium, Vanadates, Inositol 1,4,5-Trisphosphate, Guanosine 5'-O-(3-Thiotriphosphate), Thapsigargin, Calcium Signaling, Calreticulin
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