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Signaling from Ras to Rac and beyond: not just a matter of GEFs

Scita, Giorgio, Tenca, Pierluigi, Frittoli, Emanuela, Tocchetti, Arianna, Innocenti, Metello, Giardina, Giuseppina, Di Fiore, Pier Paolo·2000·The EMBO Journal

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  1. Bagrodia S, Taylor SJ, Jordon KA, Van Aelst L and Cerione RA (1998) A novel regulator of p21‐activated kinases. J Biol Chem, 273, 23633–23636. · DOI
  2. Barbacid M (1990) ras oncogenes: their role in neoplasia. Eur J Clin Invest, 20, 225–235. · DOI
  3. Bellanger JM, Lazaro JB, Diriong S, Fernandez A, Lamb N and Debant A (1998) The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo. Oncogene, 16, 147–152. · DOI
  4. Boriack‐Sjodin PA, Margarit SM, Bar‐Sagi D and Kuriyan J (1998) The structural basis of the activation of Ras by Sos. Nature, 394, 337–343. · DOI · Paper page
  5. Carpenter CL and Cantley LC (1996) Phosphoinositide kinases. Curr Opin Cell Biol, 8, 153–158. · DOI
  6. Cerione RA and Zheng Y (1996) The Dbl family of oncogenes. Curr Opin Cell Biol, 8, 216–222. · DOI · Paper page
  7. Chant J and Stowers L (1995) GTPase cascades choreographing cellular behavior: movement, morphogenesis and more. Cell, 81, 1–4. · DOI
  8. Chuang TH, Xu X, Knaus UG, Hart MJ and Bokoch GM (1993) GDP dissociation inhibitor prevents intrinsic and GTPase activating protein‐stimulated GTP hydrolysis by the Rac GTP‐binding protein. J Biol Chem, 268, 775–778. · DOI
  9. Debant A, Serra‐Pages C, Seipel K, O'Brien S, Tang M, Park SH and Streuli M (1996) The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain and has separate rac‐specific and rho‐specific guanine nucleotide exchange factor domains. Proc Natl Acad Sci USA, 93, 5466–5471. · DOI
  10. Downward J (1994) The GRB2/Sem‐5 adaptor protein. FEBS Lett, 338, 113–117. · DOI
  11. Fan WT, Koch CA, de Hoog CL, Fam NP and Moran MF (1998) The exchange factor Ras‐GRF2 activates Ras‐dependent and Rac‐dependent mitogen‐activated protein kinase pathways. Curr Biol, 8, 935–938. · DOI
  12. Fukumoto Y, Kaibuchi K, Hori Y, Fujioka H, Araki S, Ueda T, Kikuchi A and Takai Y (1990) Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21‐like small GTP‐binding proteins. Oncogene, 5, 1321–1328.
  13. Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A and Collard JG (1994) Identification of an invasion‐inducing gene, Tiam‐1, that encodes a protein with homology to GDP–GTP exchangers for Rho‐like proteins. Cell, 77, 537–549. · DOI
  14. Hall A (1998) Rho GTPases and the actin cytoskeleton. Science, 279, 509–514. · DOI
  15. Han J et al. (1998) Role of substrates and products of PI 3‐kinase in regulating activation of Rac‐related guanosine triphosphatases by Vav. Science, 279, 558–560. · DOI
  16. Hart MJ, Maru Y, Leonard D, Witte ON, Evans T and Cerione RA (1992) A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras‐like protein CDC42Hs. Science, 258, 812–815. · DOI · Paper page
  17. Hawkins PT et al. (1995) PDGF stimulates an increase in GTP‐Rac via activation of phosphoinositide 3‐kinase. Curr Biol, 5, 393–403. · DOI
  18. Hirao M, Sato N, Kondo T, Yonemura S, Monden M, Sasaki T, Takai Y and Tsukita S (1996) Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho‐dependent signaling pathway. J Cell Biol, 135, 37–51. · DOI
  19. Innocenti M, Zippel R, Brambilla R and Sturani E (1999) CDC25 (Mm)/Ras‐GRF1 regulates both Ras and Rac signaling pathways. FEBS Lett, 460, 357–362. · DOI
  20. Jalink K, van Corven EJ, Hengeveld T, Morii N, Narumiya S and Moolenaar WH (1994) Inhibition of lysophosphatidate‐ and thrombin‐induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP‐binding protein Rho. J Cell Biol, 126, 801–810. · DOI
  21. Kiyono M, Satoh T and Kaziro Y (1999) G protein β γ subunit‐dependent Rac‐guanine nucleotide exchange activity of Ras‐GRF1/CDC25 (Mm). Proc Natl Acad Sci USA, 96, 4826–4831. · DOI
  22. Kotani K et al. (1994) Involvement of phosphoinositide 3‐kinase in insulin‐ or IGF‐1‐induced membrane ruffling. EMBO J, 13, 2313–2321. · DOI
  23. Kozma R, Ahmed S, Best A and Lim L (1995) The Ras‐related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol Cell Biol, 15, 1942–1952. · DOI
  24. Kozma R, Sarner S, Ahmed S and Lim L (1997) Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1 and acetylcholine and collapse induced by RhoA and lysophosphatidic acid. Mol Cell Biol, 17, 1201–1211. · DOI
  25. Leberer E, Thomas DY and Whiteway M (1997) Pheromone signalling and polarized morphogenesis in yeast. Curr Opin Genet Dev, 7, 59–66. · DOI
  26. Leeuw T, Fourest‐Lieuvin A, Wu C, Chenevert J, Clark K, Whiteway M, Thomas DY and Leberer E (1995) Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin. Science, 270, 1210–1213. · DOI
  27. Leeuwen FN, Kain HE, Kammen RA, Michiels F, Kranenburg OW and Collard JG (1997) The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho. J Cell Biol, 139, 797–807. · DOI
  28. Manser E, Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, Tan I, Leung T and Lim L (1998) PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol Cell, 1, 183–192. · DOI
  29. Margolis B and Skolnik EY (1994) Activation of Ras by receptor tyrosine kinases. J Am Soc Nephrol, 5, 1288–1299. · DOI
  30. Marshall M (1995) Interactions between Ras and Raf: key regulatory proteins in cellular transformation. Mol Reprod Dev, 42, 493–499. · DOI
  31. McCormick F (1994) Activators and effectors of ras p21 proteins. Curr Opin Genet Dev, 4, 71–76. · DOI
  32. McGlade J, Brunkhorst B, Anderson D, Mbamalu G, Settleman J, Dedhar S, Rozakis‐Adcock M, Chen LB and Pawson T (1993) The N‐terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J, 12, 3073–3081. · DOI
  33. Medema RH, de Laat WL, Martin GA, McCormick F and Bos JL (1992) GTPase‐activating protein SH2–SH3 domains induce gene expression in a Ras‐dependent fashion. Mol Cell Biol, 12, 3425–3430. · DOI
  34. Nimnual AS, Yatsula BA and Bar‐Sagi D (1998) Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science, 279, 560–563. · DOI
  35. Nobes CD and Hall A (1995) Rho, rac and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell, 81, 53–62. · DOI
  36. Nobes CD, Hawkins P, Stephens L and Hall A (1995) Activation of the small GTP‐binding proteins rho and rac by growth factor receptors. J Cell Sci, 108, 225–233. · DOI
  37. Obermeier A, Ahmed S, Manser E, Yen SC, Hall C and Lim L (1998) PAK promotes morphological changes by acting upstream of Rac. EMBO J, 17, 4328–4339. · DOI
  38. Provenzano C, Gallo R, Carbone R, Di Fiore PP, Falcone G, Castellani L and Alema S (1998) Eps8, a tyrosine kinase substrate, is recruited to the cell cortex and dynamic F‐actin upon cytoskeleton remodeling. Exp Cell Res, 242, 186–200. · DOI
  39. Qiu RG, Abo A, McCormick F and Symons M (1997) Cdc42 regulates anchorage‐independent growth and is necessary for Ras transformation. Mol Cell Biol, 17, 3449–3458. · DOI
  40. Ridley AJ, Self AJ, Kasmi F, Paterson HF, Hall A, Marshall CJ and Ellis C (1993) rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo. EMBO J, 12, 5151–5160. · DOI · Paper page
  41. Rodriguez‐Viciana P, Marte BM, Warne PH and Downward J (1996) Phosphatidylinositol 3′ kinase: one of the effectors of Ras. Philos Trans R Soc Lond B Biol Sci, 351, 225–231. · DOI
  42. Rodriguez‐Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A and Downward J (1997) Role of phosphoinositide 3‐OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell, 89, 457–467. · DOI
  43. Sander EE, ten Klooster JP, van Delft S, van der Kammen RA and Collard JG (1999) Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J Cell Biol, 147, 1009–1022. · DOI
  44. Schmidt A, Kunz J and Hall MN (1996) TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci USA, 93, 13780–13785. · DOI
  45. Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegard M, Betsholtz C and Di Fiore PP (1999) EPS8 and E3B1 transduce signals from Ras to Rac. Nature, 401, 290–293. · DOI
  46. Settleman J, Narasimhan V, Foster LC and Weinberg RA (1992) Molecular cloning of cDNAs encoding the GAP‐associated protein p190: implications for a signaling pathway from ras to the nucleus. Cell, 69, 539–549. · DOI
  47. Soisson SM, Nimnual AS, Uy M, Bar‐Sagi D and Kuriyan J (1998) Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell, 95, 259–268. · DOI
  48. Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S and Takai Y (1997) Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein. J Biol Chem, 272, 23371–23375. · DOI
  49. Takahashi K, Sasaki T, Mammoto A, Hotta I, Takaishi K, Imamura H, Nakano K, Kodama A and Takai Y (1998) Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl. Oncogene, 16, 3279–3284. · DOI
  50. Takai Y, Sasaki T, Tanaka K and Nakanishi H (1995) Rho as a regulator of the cytoskeleton. Trends Biochem Sci, 20, 227–231. · DOI
  51. Tolias KF and Cantley LC (1999) Pathways for phosphoinositide synthesis. Chem Phys Lipids, 98, 69–77. · DOI
  52. Tsukita S, Oishi K, Sato N, Sagara J and Kawai A (1994) ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin‐based cytoskeletons. J Cell Biol, 126, 391–401. · DOI
  53. Ueda T, Kikuchi A, Ohga N, Yamamoto J and Takai Y (1990) Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21‐like GTP‐binding protein. J Biol Chem, 265, 9373–9380. · DOI · Paper page
  54. Van Aelst L and D'Souza‐Schorey C (1997) Rho GTPases and signaling networks. Genes Dev, 11, 2295–2322. · DOI
  55. Wennstrom S, Hawkins P, Cooke F, Hara K, Yonezawa K, Kasuga M, Jackson T, Claesson‐Welsh L and Stephens L (1994) Activation of phosphoinositide 3‐kinase is required for PDGF‐stimulated membrane ruffling. Curr Biol, 4, 385–393. · DOI
  56. Whitehead IP, Campbell S, Rossman KL and Der CJ (1997) Dbl family proteins. Biochim Biophys Acta, 1332, F1–F23.
  57. Xu N, McCormick F and Gutkind JS (1994) The non‐catalytic domain of ras‐GAP inhibits transformation induced by G protein coupled receptors. Oncogene, 9, 597–601.
  58. Yoshii S et al. (1999) αPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3‐kinase. Oncogene, 18, 5680–5690. · DOI
  59. Yuspa SH, Dlugosz AA, Cheng CK, Denning MF, Tennenbaum T, Glick AB and Weinberg WC (1994) Role of oncogenes and tumor suppressor genes in multistage carcinogenesis. J Invest Dermatol, 103, 90S–95S. · DOI
  60. Zheng Y, Bender A and Cerione RA (1995a) Interactions among proteins involved in bud‐site selection and bud‐site assembly in Saccharomyces cerevisiae. J Biol Chem, 270, 626–630. · DOI
  61. Zheng Y, Hart MJ and Cerione RA (1995b) Guanine nucleotide exchange catalyzed by dbl oncogene product. Methods Enzymol, 256, 77–84. · DOI
  62. Zhou K, Wang Y, Gorski JL, Nomura N, Collard J and Bokoch GM (1998) Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42. J Biol Chem, 273, 16782–16786. · DOI

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Metadata

Authors
Scita, G., Tenca, P., Frittoli, E., Tocchetti, A., Innocenti, M., Giardina, G., & Di Fiore, P. P.
Venue
The EMBO Journal
Published
2000-06-01
Volume
19
Issue
11
Pages
2393-2398
ISSN
  • 0261-4189
  • 1460-2075
Cited by
170
References
1
Language
en

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