Cited by 144Telomeres, Telomerase, and SenescenceT-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

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Impaired germinal center reaction in mice with short telomeres

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Herrera, Eloísa, Martínez‐A, Carlos, Blasco, María A.·2000·The EMBO Journal

DOI 10.1093/emboj/19.3.472PMC PMC305584

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Abstract

Reduction of germinal center reactivity is a landmark of immunosenescence and contributes to immunological dysfunction in the elderly. Germinal centers (GC) are characterized by extensive clonal expansion and selection of B lymphocytes to generate the pool of memory B cells. Telomere maintenance by telomerase has been proposed to allow the extensive proliferation undergone by B lymphocytes in the GC during the immune response. We show here that late generation mTR(-/-) mice, which lack the mouse telomerase RNA (mTR) and have short telomeres, present a dramatic reduction in GC number following antigen immunization. Upon immunization with an antigen, wild-type splenocyte telomeres are elongated and this is accompanied by a high expression of the telomerase catalytic subunit in the spleen GC. In contrast, telomerase-deficient mTR(-/-) splenocytes show telomere shortening after immunization, presumably due to cell proliferation in the absence of telomerase. All together, these results demonstrate the importance of telomere maintenance for antibody-mediated immune responses and support the notion that telomere elongation detected in wild-type spleens following immunization is mediated by telomerase.

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Authors: Herrera, E., Martínez‐A, C., & Blasco, M. A.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
Corresponding author: Blasco, María A.
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 2000-02-01
Volume: 19
Issue: 3
Pages: 472-481
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1093/emboj/19.3.472
PMC: PMC305584
OpenAlex: W1995491393
Cited by: 144
References: 54
Citations by year: 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 2 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 3
FWCI: 11.82
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: The EMBO Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: germinal center, telomere shortening, telomerase, immunosenescence, B cell proliferation, antibody-mediated immune response, memory B cells, telomere maintenance
MeSH terms: Animals, B-Lymphocytes, Cell Cycle, Chromosomes, Flow Cytometry, Histocytochemistry, Immunization, Lipopolysaccharides, Mitogens, Spleen, Telomere, Apoptosis, In Situ Hybridization, Fluorescence, Mice, Knockout, Germinal Center, Telomerase, Mice

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Impaired germinal center reaction in mice with short telomeres

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