Cited by 143Cancer-related Molecular PathwaysDNA Repair MechanismsMicrotubule and mitosis dynamics

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts

Open access

Baus, Fabienne, Gire, Véronique, Fisher, Daniel, Piette, Jacques, Dulić, Vjekoslav·2003·The EMBO Journal

Open this paper in CoChat — free account Open PDF

Abstract

Although the Cdk inhibitor p21(Waf1/Cip1), one of the transcriptional targets of p53, has been implicated in the maintenance of G(2) arrest after DNA damage, its function at this stage of the cell cycle is not really understood. Here, we show that the exposure of normal human fibroblasts (NHFs) to genotoxic agents provokes permanent cell cycle exit in G(2) phase, whereas mouse embryo fibroblasts and transformed human cells progress through mitosis and arrest in G(1) without intervening cytokinesis. p21(Waf1/Cip1) exerts a key role in driving this G(2) exit both by inhibiting cyclin B1-Cdk1 and cyclin A-Cdk1/2 complexes, which control G(2)/M progression, and by blocking the phosphorylation of pRb family proteins. NHFs with compromised pRb proteins could still efficiently arrest in G(2) but were unable to exit the cell cycle, resulting in cell death. Our experiments show that, when under continuous genotoxic stress, normal cells can reverse their commitment to mitotic progression due to passage through the restriction point and that mechanisms involving p21(Waf1/Cip1) and pocket proteins can induce exit in G(2) and G(1).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/emboj/cdg387

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.282.5393.1497 · Cited by 2,803
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
Scheffner, M., Huibregtse, J. M., Vierstra, R. D., & Howley, P. M. (1993) · Cell · doi:10.1016/0092-8674(93)90384-3 · Cited by 2,416
Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966
Regulation of the G2/M transition by p53
Taylor, W. R., & Stark, G. R. (2001) · Oncogene · doi:10.1038/sj.onc.1204252 · Cited by 1,584
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
Dulić, V., Kaufmann, W. K., Wilson, S. J., Tisty, T. D., Lees, E., Harper, J. W., Elledge, S. J., & Reed, S. I. (1994) · Cell · doi:10.1016/0092-8674(94)90379-4 · Cited by 1,465
Self-citation
Cyclin A is required at two points in the human cell cycle.
Pagano, M., Pepperkok, R., Verde, F., Ansorge, W. J., & Draetta, G. F. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05135.x · Cited by 1,403
Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216
Peng, C.-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S., & Piwnica-Worms, H. (1997) · Science · doi:10.1126/science.277.5331.1501 · Cited by 1,341

Show all 39 references

Sorted by citations

Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
Herbig, U., Jobling, W. A., Chen, B. P. C., Chen, D. J., & Sedivy, J. M. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00256-4 · Cited by 1,344
DNA damage-induced apoptosis
Norbury, C. J., & Zhivotovsky, B. (2004) · Oncogene · doi:10.1038/sj.onc.1207532 · Cited by 701
Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response
Cazzalini, O., Scovassi, A. I., Savio, M., Stivala, L. A., & Prosperi, E. (2010) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2010.01.009 · Cited by 445
Examination of the expanding pathways for the regulation of p21 expression and activity
Jung, Y.-S., Qian, Y., & Chen, X. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.01.013 · Cited by 428
Mechanisms and Regulation of Cellular Senescence
Roger, L., Tomas, F., & Gire, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313173 · Cited by 395
Self-citation
Cell-Cycle Regulation Accounts for Variability in Ki-67 Expression Levels
Sobecki, M., Mrouj, K., Colinge, J., Gerbe, F., Jay, P., Krasińska, L., Dulić, V., & Fisher, D. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-0707 · Cited by 388
Self-citation
p27 binds cyclin–CDK complexes through a sequential mechanism involving binding-induced protein folding
Lacy, E. R., Filippov, I. V., Lewis, W. S., Otieno, S. B., Xiao, L., Weiß, S. B., Hengst, L., & Kriwacki, R. W. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb746 · Cited by 305
Senescence from G2 arrest, revisited
Gire, V., & Dulić, V. (2015) · Cell Cycle · doi:10.1080/15384101.2014.1000134 · Cited by 300
Self-citation
Control of the G2/M Transition
Stark, G. R., & Taylor, W. R. (2006) · Molecular Biotechnology · doi:10.1385/mb:32:3:227 · Cited by 282
A Role for Proapoptotic BID in the DNA-Damage Response
Zinkel, S. S., Hurov, K. E., Ong, C., Abtahi, F. M., Gross, A., & Korsmeyer, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.06.022 · Cited by 239
Nuclear morphology is a deep learning biomarker of cellular senescence
Heckenbach, I., Mkrtchyan, G. V., Ezra, M. B., Bakula, D., Madsen, J. S., Nielsen, M. H., Oró, D., Osborne, B., Covarrubias, A. J., Idda, M. L., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00263-3 · Cited by 232
FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling
Lossaint, G., Larroque, M., Ribeyre, C., Bec, N., Larroque, C., Décaillet, C., Gari, K., & Constantinou, A. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.07.023 · Cited by 258
Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites
Tomaić, V. (2016) · Cancers · doi:10.3390/cancers8100095 · Cited by 234
Proapoptotic BID Is an ATM Effector in the DNA-Damage Response
Kamer, I., Sarig, R., Zaltsman, Y., Niv, H., Oberkovitz, G., Regev, L., Haimovich, G., Lerenthal, Y., Marcellus, R. C., & Gross, A. (2005) · Cell · doi:10.1016/j.cell.2005.06.014 · Cited by 226
Transient Activation of p53 in G2 Phase Is Sufficient to Induce Senescence
Krenning, L., Feringa, F. M., Shaltiel, I. A., van den Berg, J., & Medema, R. H. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.007 · Cited by 193
p21-Mediated Nuclear Retention of Cyclin B1-Cdk1 in Response to Genotoxic Stress
Charrier-Savournin, F. B., Château, M.-T., Gire, V., Sedivy, J., Piette, J., & Dulić, V. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-12-0871 · Cited by 202
Self-citation
Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR–CHK1, p21, and NF-κB
Aasland, D., Götzinger, L., Hauck, L., Berte, N., Meyer, J., Effenberger, M., Schneider, S., Reuber, E. E., Roos, W. P., Tomicic, M. T., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-1733 · Cited by 212
Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction
Johmura, Y., Shimada, M., Misaki, T., Naiki-Ito, A., Miyoshi, H., Motoyama, N., Ohtani, N., Hara, E., Nakamura, M., Morita, A., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.003 · Cited by 182
PR-Set7–dependent lysine methylation ensures genome replication and stability through S phase
Tardat, M., Murr, R., Herceg, Z., Sardet, C., & Julien, E. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200706179 · Cited by 175
DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
Leontieva, O. V., & Blagosklonny, M. V. (2010) · Aging · doi:10.18632/aging.100265 · Cited by 163
Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation
Shukla, S., & Gupta, S. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.02.007 · Cited by 163
Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft
Tin, M. M. Y., Cho, C.-H., Chan, K., James, A. E., & Ko, J. K.-S. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl238 · Cited by 159
A Novel Human p53 Isoform Is an Essential Element of the ATR-Intra-S Phase Checkpoint
Rohaly, G., Chemnitz, J., Dehde, S., Nunez, A. M., Heukeshoven, J., Deppert, W., & Dornreiter, I. (2005) · Cell · doi:10.1016/j.cell.2005.04.032 · Cited by 148
Nucleoplasmic LAP2α–lamin A complexes are required to maintain a proliferative state in human fibroblasts
Pekovic‐Vaughan, V., Harborth, J., Broers, J. L. V., Ramaekers, F. C. S., van Engelen, B. G. M., Lammens, M. M. Y., von Zglinicki, T., Foisner, R., Hutchison, C., & Markiewicz, E. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606139 · Cited by 129
Cell Cycle Regulation by the Nutrient-Sensing Mammalian Target of Rapamycin (mTOR) Pathway
Cuyàs, E., Corominas-Faja, B., Joven, J., & Menéndez, J. A. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0888-2_7 · Cited by 128
Less understood issues: p21Cip1 in mitosis and its therapeutic potential
Kreis, N., Louwen, F., & Yuan, J. (2014) · Oncogene · doi:10.1038/onc.2014.133 · Cited by 116
Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence
Crowe, E. P., Tuzer, F., Gregory, B. D., Donahue, G., Gosai, S. J., Cohen, J., Leung, Y. Y., Yetkin, E., Nativio, R., Wang, L.-S., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00208 · Cited by 110
Primary and Compensatory Roles for RB Family Members at Cell Cycle Gene Promoters That Are Deacetylated and Downregulated in Doxorubicin-Induced Senescence of Breast Cancer Cells
Jackson, J. G., & Pereira-Smith, O. M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.7.2501-2510.2006 · Cited by 108
p21WAF1/CIP1 Upregulation through the Stress Granule-Associated Protein CUGBP1 Confers Resistance to Bortezomib-Mediated Apoptosis
Gareau, C., Fournier, M., Filion, C., Coudert, L., Martel, D. T., Labelle, Y., & Mazrouï, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020254 · Cited by 102
The p21-Dependent Radiosensitization of Human Breast Cancer Cells by MLN4924, an Investigational Inhibitor of NEDD8 Activating Enzyme
Yang, D., Tan, M., Wang, G., & Sun, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034079 · Cited by 94
Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase
Müllers, E., Cascales, H. S., Jaiswal, H., Saurin, A. T., & Lindqvist, A. (2014) · Cell Cycle · doi:10.4161/15384101.2015.945831 · Cited by 84
p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2
Jackson, M. W., Agarwal, M. K., Yang, J., Bruss, P., Uchiumi, T., Agarwal, M. L., Stark, G. R., & Taylor (2005) · Journal of Cell Science · doi:10.1242/jcs.02307 · Cited by 92
Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells by inducing apoptosis and cell cycle arrest, and inhibiting the Raf/MEK/ERK cascade
Fu, H., Li, C., Chen, X., & Liu, X. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3531 · Cited by 95
Retracted
New Insights into PARP Inhibitors' Effect on Cell Cycle and Homology-Directed DNA Damage Repair
Jelinic, P., & Levine, D. A. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0906-t · Cited by 85
Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage
Bačević, K., Lossaint, G., Achour, T. N., Georget, V., Fisher, D., & Dulić, V. (2017) · Scientific Reports · doi:10.1038/s41598-017-12868-5 · Cited by 91
Self-citation
Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional
Lossaint, G., Besnard, E., Fisher, D., Piette, J., & Dulić, V (2011) · Oncogene · doi:10.1038/onc.2011.135 · Cited by 83
Self-citation
Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells
Park, C., Kim, G., Kim, G., Choi, B. T., Park, Y., & Choi, Y. H. (2006) · Oncology Reports · doi:10.3892/or.15.5.1225 · Cited by 83
The effect of triethylene glycol dimethacrylate on the cell cycle of mammalian cells
Schweikl, H., Altmannberger, I., Hanser, N., Hiller, K., Bolay, C., Brockhoff, G., Spagnuolo, G., Galler, K. M., & Schmalz, G. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.10.026 · Cited by 81
Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells
Moore, P. S., Barbi, S., Donadelli, M., Costanzo, C., Bassi, C., Palmieri, M., & Scarpa, A. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.07.001 · Cited by 77
p21 provides stage specific DNA damage control to preimplantation embryos
Adiga, S. K., Toyoshima, M., Shiraishi, K., Shimura, T., Takeda, J., Taga, M., Nagai, H., Kumar, P., & Niwa, O. (2007) · Oncogene · doi:10.1038/sj.onc.1210444 · Cited by 75
p53- and p21-dependent premature APC/C–Cdh1 activation in G2 is part of the long-term response to genotoxic stress
Wiebusch, L., & Hagemeier, C. (2010) · Oncogene · doi:10.1038/onc.2010.99 · Cited by 72
STAT3 Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts
Waters, D. W., Blokland, K. E. C., Pathinayake, P. S., Wei, L., Schuliga, M. J., Jaffar, J., Westall, G. P., Hansbro, P. M., Prêle, C. M., Mutsaers, S. E., et al. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0328oc · Cited by 75
Dietary Isothiocyanates Inhibit Caco-2 Cell Proliferation and Induce G2/M Phase Cell Cycle Arrest, DNA Damage, and G2/M Checkpoint Activation
Visanji, J. M., Thompson, D. G., Padfield, P. J., Duthie, S. J., & Pirie, L. P. (2004) · Journal of Nutrition · doi:10.1093/jn/134.11.3121 · Cited by 69
Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis
Liu, L., Yin, Y., Li, Y., Prevedel, L., Lacy, E., Ma, L., & Zhou, P. (2012) · Cell Research · doi:10.1038/cr.2012.48 · Cited by 66
The emerging role of cellular senescence in renal diseases
Zhou, B., Wan, Y., Chen, R., Zhang, C., Li, X., Meng, F., Glaser, S. S., Wu, N., Zhou, T., Li, S., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14952 · Cited by 65
Chlorpromazine activates p21Waf1/Cip1gene transcription via early growth response-1 (Egr-1) in C6 glioma cells
Shin, S. Y., Kim, C. G., Kim, S. H., Kim, Y. S., Lim, Y., & Lee, Y. H. (2010) · Experimental & Molecular Medicine · doi:10.3858/emm.2010.42.5.041 · Cited by 64
c-Jun-Deficient Cells Undergo Premature Senescence as a Result of Spontaneous DNA Damage Accumulation
MacLaren, A., Black, E. J., Clark, W. A., & Gillespie, D. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9006-9018.2004 · Cited by 68
c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells
Lee, S.-J., Moon, G., Jung, K., Kim, W., & Moon, S. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.09.042 · Cited by 63
Greatwall promotes cell transformation by hyperactivating AKT in human malignancies
Vera, J., Lartigue, L., Vigneron, S., Gadéa, G., Gire, V., Rio, M. D., Soubeyran, I., Chibon, F., Lorca, T., & Castro, A. (2015) · eLife · doi:10.7554/elife.10115 · Cited by 60
Self-citation
E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma
Crosby, M. E., Jacobberger, J. W., Gupta, D., Macklis, R. M., & Almasan, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209998 · Cited by 60
Multiple facets of p53 in senescence induction and maintenance
Johmura, Y., & Nakanishi, M. (2016) · Cancer Science · doi:10.1111/cas.13060 · Cited by 59
Residual Cdk1/2 activity after DNA damage promotes senescence
Müllers, E., Silva Cascales, H., Burdova, K., Macurek, L., & Lindqvist, A. (2017) · Aging Cell · doi:10.1111/acel.12588 · Cited by 56
Mitogen requirement for cell cycle progression in the absence of pocket protein activity
Foijer, F., Wolthuis, R. M. F., Doodeman, V., Medema, R. H., & te Riele, H. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.021 · Cited by 53
Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells
Çağlar, H. O., & Avcı, Ç. B. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05341-6 · Cited by 50
Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells
Linge, A., Weinhold, K., Bläsche, R., Kasper, M. E., & Barth, K. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.05.018 · Cited by 54
Cholesterol Depletion Reduces Entry of Campylobacter jejuni Cytolethal Distending Toxin and Attenuates Intoxication of Host Cells
Lin, C.-D., Lai, C.-K., Lin, Y.-H., Hsieh, J., Sing, Y.-T., Chang, Y.-C., Chen, K., Wang, W., Su, H.-L., & Lai, C. (2011) · Infection and Immunity · doi:10.1128/iai.05175-11 · Cited by 48
Olaquindox induces apoptosis through the mitochondrial pathway in HepG2 cells
Zou, J., Chen, Q., Jin, X., Tang, S., Chen, K., Zhang, T., & Xiao, X. (2011) · Toxicology · doi:10.1016/j.tox.2011.04.010 · Cited by 46
p21Waf1/Cip1 deficiency causes multiple mitotic defects in tumor cells
Kreis, N., Sanhaji, M., Rieger, M. A., Louwen, F., & Yuan, J. (2013) · Oncogene · doi:10.1038/onc.2013.518 · Cited by 45
Timosaponin AIII Induces G2/M Arrest and Apoptosis in Breast Cancer by Activating the ATM/Chk2 and p38 MAPK Signaling Pathways
Zhang, M., Qu, J., Gao, Z., Qi, Q., Yin, H., Zhu, L., Wu, Y., Liu, W., Yang, J., & Huang, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.601468 · Cited by 47
Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line
Pizarro, J. G., Folch, J., de la Torre, A. V., Verdaguer, E., Junyent, F., Jordán, J., Pallàs, M., & Camins, A. (2009) · Free Radical Research · doi:10.1080/10715760903159188 · Cited by 45
The p53/p21Cip1/ Waf1 pathway mediates the effects of SPARC on melanoma cell cycle progression
Fenouille, N., Robert, G., Tichet, M., Puissant, A., Dufies, M., Rocchi, S., Ortonne, J. P., Deckert, M., Ballotti, R., & Tartare‐Deckert, S. (2010) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2010.00790.x · Cited by 47
Analysis of p53 Dependent Damage Response in Sperm-irradiated Mouse Embryos
Toyoshima, M. (2009) · Journal of Radiation Research · doi:10.1269/jrr.08099 · Cited by 43
Senescence regulation by mTOR
Dulic, V. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-239-1_2 · Cited by 42
Self-citation
Cellular senescence in tissue repair: every cloud has a silver lining
Yun, M. H. (2018) · The International Journal of Developmental Biology · doi:10.1387/ijdb.180081my · Cited by 44
The ETS Family Transcription Factor ELK-1 Regulates Induction of the Cell Cycle-regulatory Gene p21 and the BAX Gene in Sodium Arsenite-exposed Human Keratinocyte HaCaT Cells
Shin, S. Y., Kim, C. G., Lim, Y., & Lee, Y. H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.216721 · Cited by 42
Reciprocal regulation of p21 and Chk1 controls the cyclin D1-RB pathway to mediate senescence onset after G2 arrest
Lossaint, G., Horvat, A., Gire, V., Bačević, K., Mrouj, K., Charrier‐Savournin, F., Georget, V., Fisher, D., & Dulić, V. (2022) · Journal of Cell Science · doi:10.1242/jcs.259114 · Cited by 40
Self-citation
E2F4 Function in G2 Maintaining G2-arrest to Prevent Mitotic Entry with Damaged DNA
Plesca, D. C., Crosby, M. E., Gupta, D., & Almasan, A. (2007) · Cell Cycle · doi:10.4161/cc.6.10.4259 · Cited by 37
To target cellular senescence in diabetic kidney disease: the known and the unknown
Wei, Y., Mou, S., Yang, Q., Liu, F., Cooper, M. E., & Chai, Z. (2024) · Clinical Science · doi:10.1042/cs20240717 · Cited by 41
MicroRNA‐139 is a predictor of prostate cancer recurrence and inhibits growth and migration of prostate cancer cells through cell cycle arrest and targeting IGF1R and AXL
Nam, R. K., Benatar, T., Wallis, C. J. D., Kobylecky, E., Amemiya, Y., Sherman, C., & Seth, A. K. (2019) · The Prostate · doi:10.1002/pros.23871 · Cited by 37
Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice
Yamazaki, H., Kasai, S., Mimura, J., Ye, P., Inose-Maruyama, A., Tanji, K., Wakabayashi, K., Mizuno, S., Sugiyama, F., Takahashi, S., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008693 · Cited by 37
Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage
Segeren, H. A., van Rijnberk, L. M., Moreno, E., Riemers, F. M., van Liere, E. A., Yuan, R., Wubbolts, R., de Bruin, A., & Westendorp, B. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108449 · Cited by 36
Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins
Yu, C., Xing, F., Tang, Z., Bronner, C., Lu, X., Di, J., Zeng, S., & Liu, J. L. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71019-3 · Cited by 35
Confluence-induced cell cycle exit involves pre-mitotic CDK inhibition by p27Kip1 and cyclin D1 downregulation
Chassot, A., Lossaint, G., Turchi, L., Meneguzzi, G., Fisher, D., Ponzio, G., & Dulić, V. (2008) · Cell Cycle · doi:10.4161/cc.7.13.6233 · Cited by 38
Self-citation
Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1
Trakala, M., Fernández‐Miranda, G., de Castro, I. P., Heeschen, C., & Malumbres, M. (2013) · Cell Cycle · doi:10.4161/cc.24004 · Cited by 31
Methanol extract of the seaweed Gloiopeltis furcata induces G2/M arrest and inhibits cyclooxygenase‐2 activity in human hepatocarcinoma HepG2 cells
Bae, S.-J., & Choi, Y. H. (2006) · Phytotherapy Research · doi:10.1002/ptr.2020 · Cited by 34
Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response
Jullien, L., Mestre, M., Roux, P., & Gire, V. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks1121 · Cited by 32
Self-citation
Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21
Muto, J., Fukuda, S., Watanabe, K., Dai, X., Tsuda, T., Kiyoi, T., Kameda, K., Kawakami, R., Mori, H., Shiraishi, K., et al. (2023) · Communications Biology · doi:10.1038/s42003-022-04408-3 · Cited by 33
The TGFβ/Notch axis facilitates Müller cell-to-epithelial transition to ultimately form a chronic glial scar
Conedera, F. M., Pousa, A. M. Q., Mercader, N., Tschopp, M., & Enzmann, V. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00482-z · Cited by 31
Controlling the response to DNA damage by the APC/C-Cdh1
de Boer, H. R., Llobet, S. G., & van Vugt, M. A. T. M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2096-7 · Cited by 32
Mahanine induces apoptosis, cell cycle arrest, inhibition of cell migration, invasion and PI3K/AKT/mTOR signalling pathway in glioma cells and inhibits tumor growth in vivo
Chen, M., Yin, X., Lü, C., Chen, X., Ba, H., Cai, J., & Sun, J. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.11.009 · Cited by 30
Retroviral microarray-based platform on nanostructured TiO2 for functional genomics and drug discovery
Carbone, R., Giorgetti, L., Zanardi, A., Marangi, I., Chierici, E., Bongiorno, G. A., Fiorentini, F., Faretta, M., Piseri, P., Pelicci, P. G., et al. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.12.026 · Cited by 29
Phosphanegold(I) thiolates, Ph3PAu[SC(OR)=NC6H4Me-4] for R = Me, Et and iPr, induce apoptosis, cell cycle arrest and inhibit cell invasion of HT-29 colon cancer cells through modulation of the nuclear factor-κB activation pathway and ubiquitination
Ooi, K. K., Yeo, C. I., Ang, K. P., Akim, A. M., Cheah, Y. K., Halim, S. N. A., Seng, H., & Tiekink, E. R. T. (2015) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-015-1271-5 · Cited by 29
CIP/KIP and INK4 families as hostages of oncogenic signaling
Csergeová, L., Krbušek, D., & Janoštiak, R. (2024) · Cell Division · doi:10.1186/s13008-024-00115-z · Cited by 31
Inhibition of CDC2/Cyclin B1 in response to selenium-induced oxidative stress during spermatogenesis: potential role of Cdc25c and p21
Kaushal, N., & Bansal, M. P. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-9360-y · Cited by 27
Action of bleomycin is affected by bleomycin hydrolase but not by caveolin-1
Chen, J., Chen, Y., & He, Q. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1668 · Cited by 26
A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma
González-Rajal, Á., Marzec, K. A., McCloy, R. A., Nobis, M., Chin, V. T., Hastings, J. F., Lai, K., Kennerson, M. L., Hughes, W. E., Vaghjiani, V., et al. (2021) · eLife · doi:10.7554/elife.65234 · Cited by 27
PIG3 Functions in DNA Damage Response through Regulating DNA-PKcs Homeostasis
Li, B., Shang, Z., Yin, J.-J., Xu, Q.-Z., Liu, X.-D., Wang, Y., Zhang, S.-M., Guan, H., & Zhou, P. (2013) · International Journal of Biological Sciences · doi:10.7150/ijbs.6068 · Cited by 26
Understanding cellular senescence: pathways involved, therapeutics and longevity aiding
Kumar, A., & Thirumurugan, K. (2023) · Cell Cycle · doi:10.1080/15384101.2023.2287929 · Cited by 31
Unbalanced Growth, Senescence and Aging
Polymenis, M., & Kennedy, B. K. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-57127-0_8 · Cited by 23
Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells
Srdić‐Rajić, T., Santibanez, J. F., Kanjer, K., Miletić, N. T., Cavic, M. R., Galun, D., Jevric, M., Kardum, N., Konić‐Ristić, A., & Zoranovic, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-03898-0 · Cited by 23
Gadd45b deficiency promotes premature senescence and skin aging
Magimaidas, A., Madireddi, P., Maifrede, S., Mukherjee, K., Hoffman‐Liebermann, B., & Liebermann, D. A. (2016) · Oncotarget · doi:10.18632/oncotarget.8854 · Cited by 21
Selective chemical inhibition as a tool to study Cdk1 and Cdk2 functions in the cell cycle
Krasińska, L., Cot, E., & Fisher, D. (2008) · Cell Cycle · doi:10.4161/cc.7.12.6101 · Cited by 20
Self-citation
ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner
Zhang, Z., Hong, Q., Zhang, Z., Xing, W.-Y., Xu, S., Tian, Q.-X., Ye, Q., Wang, H., Yu, D., Xie, D., et al. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111436 · Cited by 19
Restriction beyond the restriction point: mitogen requirement for G2 passage.
Foijer, F., & Riele, H. T. (2006) · Cell Division · doi:10.1186/1747-1028-1-8 · Cited by 22
Sulforaphane Increases Cyclin-Dependent Kinase Inhibitor, p21 Protein in Human Oral Carcinoma Cells and Nude Mouse Animal Model to Induce G2/M Cell Cycle Arrest
Jun-Hee, K., Ki, H. K., Jung, J., Han, H., Shim, J., Oh, S., Choi, K., Choi, E., Shin, J., Leem, D., et al. (2009) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.09-65 · Cited by 19
A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-κB in HCT116 human colon cancer cells
Kim, M. K., Kang, Y. J., Kim, D. H., Hossain, M. A., Jang, J. Y., Lee, S. H., Yoon, J.-H., Chun, P., Moon, H. R., Kim, H. S., et al. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2163 · Cited by 19
La sénescence cellulaire
Brondello, J., Prieur, A., Philipot, D., Lemaı̂tre, J.-M., Lenaers, G., Piette, J., & Dulić, V. (2012) · médecine/sciences · doi:10.1051/medsci/2012283017 · Cited by 28
Self-citation
New origin firing is inhibited by APC/CCdh1activation in S-phase after severe replication stress
Ercilla, A., Llopis, A., Feu, S., Aranda, S., Ernfors, P., Freire, R., & Agell, N. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw132 · Cited by 16
Abnormal mitosis in hypertetraploid cells causes aberrant nuclear morphology in association with H2O2‐induced premature senescence
Ohshima, S. (2008) · Cytometry Part A · doi:10.1002/cyto.a.20604 · Cited by 17
ISWI ATPase Smarca5 Regulates Differentiation of Thymocytes Undergoing β-Selection
Zikmund, T., Kokavec, J., Turková, T., Savvulidi, F. G., Paszeková, H., Vodenková, S., Sedláček, R., Skoultchi, A. I., & Stopka, T. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801684 · Cited by 16

Authors: Baus, F., Gire, V., Fisher, D., Piette, J., & Dulić, V.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Dulić, Vjekoslav
ORCID: Gire, Véronique
Fisher, Daniel
Dulić, Vjekoslav
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 2003-08-01
Volume: 22
Issue: 15
Pages: 3992-4002
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1093/emboj/cdg387
PMC: PMC169060
OpenAlex: W2035568149
Cited by: 143
References: 39
Citations by year: 2025: 1 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 10 · 2019: 3 · 2018: 7 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 6 · 2013: 11 · 2012: 9
FWCI: 3.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: The EMBO Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Israel Cancer Research Fund
Ligue Contre le Cancer
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: G2 phase, DNA damage, p21, p53, normal human fibroblasts, CDK1-cyclin B1, retinoblastoma protein phosphorylation, restriction point, genotoxic stress, cell death, G2/M transition, mitotic progression
MeSH terms: Bleomycin, Cells, Cultured, DNA Damage, Fibroblasts, Humans, Mitosis, Piperazines, G2 Phase, Cyclins, Cyclin-Dependent Kinases, Cyclin-Dependent Kinase Inhibitor p21, Diketopiperazines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks