The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy
Open accessAbstract
Aims: To compare demographic characteristics, clinical presentation, and outcomes of patients with and without concomitant cardiac disease, hospitalized for COVID-19 in Brescia, Lombardy, Italy. Methods and results: The study population includes 99 consecutive patients with COVID-19 pneumonia admitted to our hospital between 4 March and 25 March 2020. Fifty-three patients with a history of cardiac disease were compared with 46 without cardiac disease. Among cardiac patients, 40% had a history of heart failure, 36% had atrial fibrillation, and 30% had coronary artery disease. Mean age was 67 ± 12 years, and 80 (81%) patients were males. No differences were found between cardiac and non-cardiac patients except for higher values of serum creatinine, N-terminal probrain natriuretic peptide, and high sensitivity troponin T in cardiac patients. During hospitalization, 26% patients died, 15% developed thrombo-embolic events, 19% had acute respiratory distress syndrome, and 6% had septic shock. Mortality was higher in patients with cardiac disease compared with the others (36% vs. 15%, log-rank P = 0.019; relative risk 2.35; 95% confidence interval 1.08–5.09). The rate of thrombo-embolic events and septic shock during the hospitalization was also higher in cardiac patients (23% vs. 6% and 11% vs. 0%, respectively). Conclusions: Hospitalized patients with concomitant cardiac disease and COVID-19 have an extremely poor prognosis compared with subjects without a history of cardiac disease, with higher mortality, thrombo-embolic events, and septic shock rates.
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Metadata
- Authors
- Inciardi, R. M., Adamo, M., Lupi, L., Cani, D. S., Di Pasquale, M., Tomasoni, D., Italia, L., Zaccone, G., Tedino, C., Fabbricatore, D., Curnis, A., Faggiano, P., Gorga, E., Lombardi, C. M., Milesi, G., Vizzardi, E., Volpini, M., Nodari, S., Specchia, C., Maroldi, R., Bezzi, M., & Metra, M.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-05-08
- Volume
- 41
- Issue
- 19
- Pages
- 1821-1829
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W3022060959
- Cited by
- 531
- References
- 28
- FWCI
- 14.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Inciardi, R. M., Adamo, M., Lupi, L., Cani, D. S., Di Pasquale, M., Tomasoni, D., Italia, L., Zaccone, G., Tedino, C., Fabbricatore, D., Curnis, A., Faggiano, P., Gorga, E., Lombardi, C. M., Milesi, G., Vizzardi, E., Volpini, M., Nodari, S., Specchia, C., . . . Metra, M. (2020). Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy. European Heart Journal. https://doi.org/10.1093/eurheartj/ehaa388
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