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Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy

Open access
Inciardi, Riccardo M, Adamo, Marianna, Lupi, Laura, Cani, Dario S, Di Pasquale, Mattia, Tomasoni, Daniela, Italia, Leonardo, Zaccone, Gregorio, Tedino, Chiara, Fabbricatore, Davide, Curnis, Antonio, Faggiano, Pompilio, Gorga, Elio, Lombardi, Carlo M, Milesi, Giuseppe, Vizzardi, Enrico, Volpini, Marco, Nodari, Savina, Specchia, Claudia, Maroldi, Roberto, Bezzi, Michela, Metra, Marco·2020·European Heart Journal

Abstract

Aims: To compare demographic characteristics, clinical presentation, and outcomes of patients with and without concomitant cardiac disease, hospitalized for COVID-19 in Brescia, Lombardy, Italy. Methods and results: The study population includes 99 consecutive patients with COVID-19 pneumonia admitted to our hospital between 4 March and 25 March 2020. Fifty-three patients with a history of cardiac disease were compared with 46 without cardiac disease. Among cardiac patients, 40% had a history of heart failure, 36% had atrial fibrillation, and 30% had coronary artery disease. Mean age was 67 ± 12 years, and 80 (81%) patients were males. No differences were found between cardiac and non-cardiac patients except for higher values of serum creatinine, N-terminal probrain natriuretic peptide, and high sensitivity troponin T in cardiac patients. During hospitalization, 26% patients died, 15% developed thrombo-embolic events, 19% had acute respiratory distress syndrome, and 6% had septic shock. Mortality was higher in patients with cardiac disease compared with the others (36% vs. 15%, log-rank P = 0.019; relative risk 2.35; 95% confidence interval 1.08–5.09). The rate of thrombo-embolic events and septic shock during the hospitalization was also higher in cardiac patients (23% vs. 6% and 11% vs. 0%, respectively). Conclusions: Hospitalized patients with concomitant cardiac disease and COVID-19 have an extremely poor prognosis compared with subjects without a history of cardiac disease, with higher mortality, thrombo-embolic events, and septic shock rates.

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Metadata

Authors
Inciardi, R. M., Adamo, M., Lupi, L., Cani, D. S., Di Pasquale, M., Tomasoni, D., Italia, L., Zaccone, G., Tedino, C., Fabbricatore, D., Curnis, A., Faggiano, P., Gorga, E., Lombardi, C. M., Milesi, G., Vizzardi, E., Volpini, M., Nodari, S., Specchia, C., Maroldi, R., Bezzi, M., & Metra, M.
Venue
European Heart Journal
Published
2020-05-08
Volume
41
Issue
19
Pages
1821-1829
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
OpenAlex
W3022060959
Cited by
531
References
28
FWCI
14.37
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy. https://app.cochat.ai/papers/10.1093/eurheartj/ehaa388
The paper
Inciardi, R. M., Adamo, M., Lupi, L., Cani, D. S., Di Pasquale, M., Tomasoni, D., Italia, L., Zaccone, G., Tedino, C., Fabbricatore, D., Curnis, A., Faggiano, P., Gorga, E., Lombardi, C. M., Milesi, G., Vizzardi, E., Volpini, M., Nodari, S., Specchia, C., . . . Metra, M. (2020). Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy. European Heart Journal. https://doi.org/10.1093/eurheartj/ehaa388

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.