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Cited by 287Congenital heart defects researchMesenchymal stem cell researchTelomeres, Telomerase, and Senescence

Myocyte Turnover in the Aging Human Heart

Open access
Kajstura, Jan, Gurusamy, Narasimman, Ogórek, Barbara, Goichberg, Polina, Clavo-Rondon, Carlos, Hosoda, Toru, D'Amario, Domenico, Bardelli, Silvana +10 more·2010·Circulation Research
DOI 10.1161/circresaha.110.231498
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Abstract

RETRACTION: This article has been retracted: Circ Res . 2018;123:e00. DOI: 10.1161/RES.0000000000000247

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Crossref · 10.1161/circresaha.110.231498This paper is marked retracted.

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  • In humans, accumulation of senescent markers has been demonstrated in skin, T lymphocytes, atherosclerotic lesions, insulin-producing β cells, kidney, endothelium, visceral fat, joint cartilage, cardiac muscle, liver, and many other tissues.

    “In humans, the accumulation of senescent markers has been demonstrated in the skin, T lymphocytes, atherosclerotic lesions, insulin-producing β cells, kidney, endothelium, visceral fat, joint cartilage, cardiac muscle, liver, and many others tissues98,101–107.”

    From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [105]

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Research works printed but not linked: 25

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  7. Rota M, Padin-Iruegas ME, Misao Y, De Angelis A, Maestroni S, Ferreira-Martins J, Fiumana E, Rastaldo R, Arcarese ML, Mitchell TS, Boni A, Bolli R, Urbanek K, Hosoda T, Anversa P, Leri A, Kajstura J. Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function. Circ Res. 2008;103:107-116.
  8. Padin-Iruegas ME, Misao Y, Davis ME, Segers VF, Esposito G, Tokunou T, Urbanek K, Hosoda T, Rota M, Anversa P, Leri A, Lee RT, Kajstura J. Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction. Circulation. 2009;120:876-887.
  9. Bearzi C, Leri A, Lo Monaco F, Rota M, Gonzalez A, Hosoda T, Pepe M, Qanud K, Ojaimi C, Bardelli S, D'Amario D, D'Alessandro DA, Michler RE, Dimmeler S, Zeiher AM, Urbanek K, Hintze TH, Kajstura J, Anversa P. Identification of a coronary vascular progenitor cell in the human heart. Proc Natl Acad Sci USA. 2009;106:15885-15890.
  10. Quaini F, Urbanek K, Beltrami AP, Finato N, Beltrami CA, Nadal-Ginard B, Kajstura J, Leri A, Anversa P. Chimerism of the transplanted heart. N Engl J Med. 2002;346:5-15.
  11. Hosoda T, D'Amario D, Cabral-Da-Silva MC, Zheng H, Padin-Iruegas ME, Ogorek B, Ferreira-Martins J, Yasuzawa-Amano S, Amano K, Ide-Iwata N, Cheng W, Rota M, Urbanek K, Kajstura J, Anversa P, Leri A. Clonality of mouse and human cardiomyogenesis in vivo. Proc Natl Acad Sci USA. 2009;106:17169- 17174.
  12. D'Alessandro DA, Kajstura J, Hosoda T, Gatti A, Bello R, Mosna F, Bardelli S, Zheng H, D'Amario D, Padin-Iruegas ME, Carvalho AB, Rota M, Zembala MO, Stern D, Rimoldi O, Urbanek K, Michler RE, Leri A, Anversa P. Progenitor cells from the explanted heart generate immunocompatible myocardium within the transplanted donor heart. Circ Res. 2009;105:1128-1140.
  13. Urbanek K, Torella D, Sheikh F, De Angelis A, Nurzynska D, Silvestri F, Beltrami CA, Bussani R, Beltrami AP, Quaini F, Bolli R, Leri A, Kajstura J, Anversa P. Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci USA. 2005;102:8692-8697.
  14. Urbanek K, Cesselli D, Rota M, Nascimbene A, De Angelis A, Hosoda T, Bearzi C, Boni A, Bolli R, Kajstura J, Anversa P, Leri A. Stem cell niches in the adult mouse heart. Proc Natl Acad Sci USA. 2006;103:9226-9231.
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  20. Olivetti G, Giordano G, Corradi D, Melissari M, Lagrasta C, Gambert SR, Anversa P. Gender differences and aging: effects on the human heart. J Am Coll Cardiol. 1995;26:1068-1079.
  21. Olivetti G, Abbi R, Quaini F, Kajstura J, Cheng W, Nitahara JA, Quaini E, Di Loreto C, Beltrami CA, Krajewski S, Reed JC, Anversa P. Apoptosis in the failing human heart. N Engl J Med. 1997;336:1131-1141.
  22. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard B, Anversa P. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003;114:763-776.
  23. Savill NJ. Mathematical models of hierarchically structured cell populations under equilibrium with application to the epidermis. Cell Prolif. 2003;36:1-26.
  24. Logan JD, Ledder G, Wolesensky W. Type II functional response for continuous, physiologically structured models. J Theor Biol. 2009;259:373-381.
  25. Berenson ML, Levine DM, Rindskopf D. Simple linear regression and correlation. In: Berenson ML, Levine DM, Rindskopf D, eds. Applied Statistics. Englewood Cliffs, NJ: Prentice Hall; 1998:362-418. 39 F 63 176 20.3 220 174 cerebral aneurism 38 F 52 160 20.3 250 210 acute trauma 35 M 75 188 21.2 261 201 acute trauma 34 M 90 180 27.8 275 206 gastrointestinal hemorrhage 34 F 63 158 25.2 205 158 pneumonia 33 M 90 180 27.8 270 215 craniopharyngioma 32 M 75 180 23.1 194 143 acute trauma 32 M 70 175 22.9 215 160 suicide 31 M 75 165 27.5 280 205 acute trauma 31 M 80 170 27.7 320 240 abdominal aortic aneurism 30 M 65 177 20.7 200 150 suicide 29 M 80 187 22.9 215 160 acute trauma 28 M 100 190 27.7 360 210 thoracic aortic aneurism 26 F 53 158 21.2 192 142 pneumonia 24 M 70 177 22.3 270 200 acute trauma 23 M 80 195 21.0 390 300 acute trauma 21 F 50 165 18.4 210 170 acute trauma 20 M 81 183 24.2 193 149 acute trauma 19 M 70 185 20.5 340 300 cerebral aneurism ____________________________________________________________________________________________________________ Heart weight was determined following removal of epicardial fat. 39 F 63 176 20.3 220 174 cerebral aneurism 38 F 52 160 20.3 250 210 acute trauma 35 M 75 188 21.2 261 201 acute trauma 34 M 90 180 27.8 275 206 gastrointestinal hemorrhage 34 F 63 158 25.2 205 158 pneumonia 33 M 90 180 27.8 270 215 craniopharyngioma 32 M 75 180 23.1 194 143 acute trauma 32 M 70 175 22.9 215 160 suicide 31 M 75 165 27.5 280 205 acute trauma 31 M 80 170 27.7 320 240 abdominal aortic aneurism 30 M 65 177 20.7 200 150 suicide 29 M 80 187 22.9 215 160 acute trauma 28 M 100 190 27.7 360 210 thoracic aortic aneurism 26 F 53 158 21.2 192 142 pneumonia 24 M 70 177 22.3 270 200 acute trauma 23 M 80 195 21.0 390 300 acute trauma 21 F 50 165 18.4 210 170 acute trauma 20 M 81 183 24.2 193 149 acute trauma 19 M 70 185 20.5 340 300 cerebral aneurism ____________________________________________________________________________________________________________ Heart weight was determined following removal of epicardial fat.

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Authors
Kajstura, J., Gurusamy, N., Ogórek, B., Goichberg, P., Clavo-Rondon, C., Hosoda, T., D'Amario, D., Bardelli, S., Beltrami, A. P., Cesselli, D., Bussani, R., del Monte, F., Quaini, F., Rota, M., Beltrami, C. A., Buchholz, B. A., Leri, A., & Anversa, P.
Affiliations
  • Lawrence Livermore National Laboratory (US)
  • From the Departments of Anesthesia and Medicine and Cardiovascular Division (J.K., N.G., B.O., P.G., C.C.-R., T.H., D.D., S.B., F.Q., M.R., A.L., P.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Center for Regenerative Medicine (CIME) (A.P.B., D.C., C.A.B.), Udine Medical School, Italy; Department of Pathology (R.B.), University of Trieste Medical School, Italy; Cardiovascular Institute (F.d.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass;...
ORCID
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-11-26
Volume
107
Issue
11
Pages
1374-1386
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/circresaha.110.231498
OpenAlex
W2169908939
Cited by
287
References
51
Citations by year
2026: 3 · 2025: 2 · 2024: 9 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 7 · 2019: 12 · 2018: 16 · 2017: 24 · 2016: 22 · 2015: 20 · 2014: 41 · 2013: 43 · 2012: 51
FWCI
15.36
Type
journal article
Language
en
Status
Retracted
Update notices
Open access
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
  • University of North Texas Digital Library (University of North Texas) (submittedVersion)
  • Institutional Research Information System (University of Udine) (submittedVersion)
  • ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
Funders
  • National Institutes of Health (5r01hl091021-03)
  • U.S. Public Health Service (NCRR13641)
  • National Heart, Lung, and Blood Institute (R01-HL-091021)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords
cardiomyocyte turnover, cardiac aging, sex differences, telomere length, cellular senescence, cardiomyocyte regeneration, apoptosis, replicative potential
MeSH terms
Adult, Aged, Aged, 80 and over, Cell Differentiation, Cells, Cultured, Female, Heart, Humans, Male, Middle Aged, Sex Characteristics, Cellular Senescence, Cell Death, Apoptosis, Myocytes, Cardiac, Adult Stem Cells, Young Adult

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