Cited by 156Pharmacology and Obesity TreatmentCannabis and Cannabinoid ResearchRegulation of Appetite and Obesity

Long-term effect of CB1 blockade with rimonabant on cardiometabolic risk factors: two year results from the RIO-Europe Study.

Open access
Van Gaal, Luc F., Scheen, André J., Rissanen, Aila M., Rössner, Stephan, Hanotin, Corinne, Ziegler, Olivier·2008·European Heart Journal

Abstract

AIMS: Rimonabant, the first selective cannabinoid type 1 receptor blocker, has been shown to produce weight loss and improvements in several cardiometabolic risk factors over 1 year. We report the 2 year efficacy and tolerability data of rimonabant. METHODS AND RESULTS: Patients with a body mass index > or =30 or >27 kg/m(2) with treated/untreated hypertension, dyslipidaemia, or both, were randomized to double-blind treatment with placebo, rimonabant 5 or 20 mg once daily plus a calorie-restricted diet for 2 years. Weight loss from baseline to 2 years in the intention-to-treat population was significantly greater with rimonabant 20 mg (mean +/- SD: -5.5 +/- 7.7 kg; P < 0.001) and 5 mg (-2.9 +/- 6.5 kg; P = 0.002) than placebo (-1.2 +/- 6.8 kg). Rimonabant 20 mg produced significantly greater improvements than placebo in waist circumference, high-density lipoprotein cholesterol, triglycerides, fasting glucose and insulin levels, insulin resistance, and metabolic syndrome prevalence. Rimonabant 20 mg produced clinically meaningful improvements in all Impact of Weight on Quality of Life-Lite questionnaire domain scores at 2 years. Rimonabant was generally well tolerated and rates of adverse events, including depressed mood disorders and disturbances were similar to placebo during year 2. Proportions of patients with clinically significant depression (Hospital Anxiety and Depression Scale score >11) were similar in all treatment groups. CONCLUSION: Rimonabant 20 mg over 2 years promoted clinically relevant and durable weight loss and improvements in cardiometabolic risk factors.

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Crossref · 10.1093/eurheartj/ehn076

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Research works printed but not linked: 2

  1. Ware JE, Sherbourne CD. The MOS 36-Item Short-Form Health Survey (SF-36). Med Care 1992;30:473-483.
  2. Wadden TA, Frey DL. A multicenter evaluation of a proprietary weight loss program for the treatment of marked obesity: a five-year follow-up. Int J Eat Disord 1997;22:201-212.

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Authors
Van Gaal, L. F., Scheen, A. J., Rissanen, A. M., Rössner, S., Hanotin, C., & Ziegler, O.
Affiliations
  • University of Liège (BE)
  • Helsinki University Hospital (FI)
  • Karolinska University Hospital (SE)
  • Sanofi (France) (FR)
  • Centre Hospitalier Régional et Universitaire de Nancy (FR)
Venue
European Heart Journal
Published
2008-04-15
Volume
29
Issue
14
Pages
1761-1771
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
OpenAlex
W2059479437
Cited by
156
References
37
Citations by year
2025: 2 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 10 · 2013: 10 · 2012: 10
FWCI
17.55
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • European Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
  • Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
rimonabant, CB1 receptor antagonist, cannabinoid receptor antagonists, weight loss, obesity, cardiometabolic risk factors, metabolic syndrome, insulin resistance, dyslipidemia, hypertension, HDL cholesterol, triglycerides, fasting blood glucose, insulin, waist circumference, quality of life, depression, tolerability, long-term efficacy
MeSH terms
Rimonabant, Adult, Blood Glucose, Cardiovascular Diseases, Dose-Response Relationship, Drug, Epidemiologic Methods, Female, Humans, Insulin, Cholesterol, HDL, Male, Middle Aged, Obesity, Piperidines, Pyrazoles, Triglycerides, Weight Loss, Body Mass Index, Treatment Outcome, Anti-Obesity Agents, Metabolic Syndrome, Cannabinoid Receptor Antagonists

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