The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
Adipose tissue dysfunction in obesity, diabetes, and vascular diseases
Abstract
The classical perception of adipose tissue as a storage place of fatty acids has been replaced over the last years by the notion that adipose tissue has a central role in lipid and glucose metabolism and produces a large number of hormones and cytokines, e.g. tumour necrosis factor-alpha, interleukin-6, adiponectin, leptin, and plasminogen activator inhibitor-1. The increased prevalence of excessive visceral obesity and obesity-related cardiovascular risk factors is closely associated with the rising incidence of cardiovascular diseases and type 2 diabetes mellitus. This clustering of vascular risk factors in (visceral) obesity is often referred to as metabolic syndrome. The close relationship between an increased quantity of visceral fat, metabolic disturbances, including low-grade inflammation, and cardiovascular diseases and the unique anatomical relation to the hepatic portal circulation has led to an intense endeavour to unravel the specific endocrine functions of this visceral fat depot. The objective of this paper is to describe adipose tissue dysfunction, delineate the relation between adipose tissue dysfunction and obesity and to describe how adipose tissue dysfunction is involved in the development of diabetes mellitus type 2 and atherosclerotic vascular diseases. First, normal physiology of adipocytes and adipose tissue will be described.
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Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Research works printed but not linked: 6
- Cheung, 1997, Endocrinology, 138, 4489, 10.1210/en.138.10.4489 · DOI · Paper page
- 2007, American heart journal, 154, 750
- Tsigos, 1997, Journal of Clinical Endocrinology & Metabolism, 82, 4167, 10.1210/jc.82.12.4167 · DOI · Paper page
- Ozata, 1999, Journal of Clinical Endocrinology & Metabolism, 84, 3686, 10.1210/jc.84.10.3686 · DOI · Paper page
- 1995, International journal of obesity, 19, S16
- 2004, Circulation Research, 94, e27
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Manna, P., & Jain, S. K. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0095 · Cited by 1,211
The Effect of Mediterranean Diet on Metabolic Syndrome and its Components
Kastorini, C.-M., Milionis, H. J., Esposito, K., Giugliano, D., Goudevenos, J. A., & Panagiotakos, D. B. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.073 · Cited by 1,087
Adiponectin Levels and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis
Li, S., Shin, H. J., Ding, E. L., & van Dam, R. M. (2009) · JAMA · doi:10.1001/jama.2009.976 · Cited by 991
Obesity and cancer: the role of dysfunctional adipose tissue
van Kruijsdijk, R. C. M., van der Wall, E., & Visseren, F. L. J. (2009) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0372 · Cited by 715
Self-citationDu, T., Yuan, G., Zhang, M., Zhou, X., Sun, X., & Yu, X. (2014) · Cardiovascular Diabetology · doi:10.1186/s12933-014-0146-3 · Cited by 630
Metadata
- Authors
- Hajer, G. R., van Haeften, T. W., & Visseren, F. L. J.
- Affiliations
- University Medical Center Utrecht (NL)
- Corresponding author
- Visseren, F. L.J.
- ORCID
- Visseren, F. L.J.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-09-05
- Volume
- 29
- Issue
- 24
- Pages
- 2959-2971
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2100784798
- Semantic Scholar
- a5a791d646daf7a9ba3a727d27f953ec6ca43ec5
- Cited by
- 1,410
- References
- 136
- Citations by year
- 2026: 23 · 2025: 54 · 2024: 45 · 2023: 55 · 2022: 58 · 2021: 68 · 2020: 83 · 2019: 69 · 2018: 85 · 2017: 88 · 2016: 98 · 2015: 100 · 2014: 134 · 2013: 130 · 2012: 103
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- adipose tissue dysfunction, visceral obesity, type 2 diabetes, metabolic syndrome, cardiovascular disease, atherosclerosis, adipokines, adiponectin, leptin, TNF-α, interleukin-6, plasminogen activator inhibitor-1, low-grade inflammation, portal circulation, cardiovascular risk factors
- MeSH terms
- Adipose Tissue, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Energy Metabolism, Female, Humans, Male, Obesity, Transcription Factors, Adipocytes, Leptin, Metabolic Syndrome, Risk Reduction Behavior, Intra-Abdominal Fat, Atherosclerosis, Subcutaneous Fat, Abdominal
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