Adiponectin Levels and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis

Bias in meta-analysis detected by a simple, graphical test

Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works

Meta-analysis in clinical trials

DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works

Quantifying heterogeneity in a meta‐analysis

Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works

Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>

Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623 · see citing works

Operating characteristics of a rank correlation test for publication bias

Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955 · see citing works

Global and societal implications of the diabetes epidemic

Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883 · see citing works

Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia

Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541 · see citing works

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works

Methods for Trend Estimation from Summarized Dose-Response Data, with Applications to Meta-Analysis

Greenland, S., & Longnecker, M. P. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116237 · Cited by 2,353 · see citing works

Adipose tissue dysfunction in obesity, diabetes, and vascular diseases

Hajer, G. R., van Haeften, T. W., & Visseren, F. L. J. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn387 · Cited by 1,410 · see citing works

Generalized Least Squares for Trend Estimation of Summarized Dose–response Data

Orsini, N., Bellocco, R., & Greenland, S. (2006) · The Stata Journal Promoting communications on statistics and Stata · doi:10.1177/1536867x0600600103 · Cited by 1,245 · see citing works

Adiponectin and protection against type 2 diabetes mellitus

Spranger, J., Kroke, A., Möhlig, M., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12255-6 · Cited by 1,120 · see citing works

Adiponectin and development of type 2 diabetes in the Pima Indian population

Lindsay, R. S., Funahashi, T., Hanson, R. L., Matsuzawa, Y., Tanaka, S., Tataranni, P. A., Knowler, W. C., & Krakoff, J. A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09335-2 · Cited by 1,094 · see citing works

Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

Hotta, K., Funahashi, T., Bodkin, N. L., Ortmeyer, H. K., Arita, Y., Hansen, B. C., & Matsuzawa, Y. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1126 · Cited by 1,072 · see citing works

Adipokines and Insulin Resistance

Rabe, K., Lehrke, M., Parhofer, K. G., & Broedl, U. C. (2008) · Molecular Medicine · doi:10.2119/2008-00058.rabe · Cited by 814 · see citing works

Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans

Bruun, J. M., Lihn, A. S., Verdich, C., Pedersen, S. B., Toubro, S., Astrup, A. V., & Richelsen, B. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00110.2003 · Cited by 779 · see citing works

Statistical Evaluation of Prognostic versus Diagnostic Models: Beyond the ROC Curve

Cook, N. R. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2007.096529 · Cited by 691 · see citing works

Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism

Tschritter, O., Fritsche, A., Thamer, C., Haap, M. M., Shirkavand, F., Rahe, S., Staiger, H., Maerker, E., Häring, H. U., & Stümvoll, M. (2003) · Diabetes · doi:10.2337/diabetes.52.2.239 · Cited by 585 · see citing works

Meta-analysis of Epidemiologic Dose-Response Data

Berlin, J. A., Longnecker, M. P., & Greenland, S. (1993) · Epidemiology · doi:10.1097/00001648-199305000-00005 · Cited by 571 · see citing works

What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?

Smith, G. D., & Ebrahim, S. (2005) · BMJ · doi:10.1136/bmj.330.7499.1076 · Cited by 545 · see citing works

Decreased Serum Levels of Adiponectin Are a Risk Factor for the Progression to Type 2 Diabetes in the Japanese Population

Daimon, M., Oizumi, T., Saitoh, T., Kameda, W., Hirata, A., Yamaguchi, H., Ohnuma, H., Igarashi, M., Tominaga, M., & Kato, T. (2003) · Diabetes Care · doi:10.2337/diacare.26.7.2015 · Cited by 353 · see citing works

Adiponectin and the Development of Type 2 Diabetes

Duncan, B. B., Schmidt, M. I., Pankow, J. S., Bang, H., Couper, D. J., Ballantyne, C. M., Hoogeveen, R. C., & HEISS, G. M. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2473 · Cited by 323 · see citing works

Genetic Influences of Adiponectin on Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease

Menzaghi, C., Trischitta, V., & Doria, A. (2007) · Diabetes · doi:10.2337/db06-0506 · Cited by 276 · see citing works

Plasma Adiponectin Is an Independent Predictor of Type 2 Diabetes in Asian Indians

Snehalatha, C., Mukesh, B., Simon, M., Viswanathan, V., Haffner, S. M., & Ramachandran, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3226 · Cited by 274 · see citing works

Physiological, Pharmacological, and Nutritional Regulation of Circulating Adiponectin Concentrations in Humans

Swarbrick, M. M., & Havel, P. J. (2008) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2007.0029 · Cited by 237 · see citing works

Total and High-Molecular-Weight Adiponectin and Resistin in Relation to the Risk for Type 2 Diabetes in Women

Heidemann, C., Sun, Q., van Dam, R. M., Meigs, J. B., Zhang, C., Tworoger, S. S., Mantzoros, C. S., & Hu, F. B. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-149-5-200809020-00005 · Cited by 208 · see citing works

Adipokines and Risk of Type 2 Diabetes in Older Men

Wannamethee, S. G., Lowe, G. D. O., Rumley, A., Cherry, L., Whincup, P. H., & Sattar, N. A. (2007) · Diabetes Care · doi:10.2337/dc06-2416 · Cited by 194 · see citing works

Adiponectin Gene Polymorphisms and Adiponectin Levels Are Independently Associated With the Development of Hyperglycemia During a 3-Year Period

Fumeron, F., Aubert, R., Siddiq, A., Betoulle, D., Péan, F., Hadjadj, S., Tichet, J., Wilpart, E., Chesnier, M., Balkau, B., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1150 · Cited by 193 · see citing works

Serum Concentrations of Adiponectin and Risk of Type 2 Diabetes Mellitus and Coronary Heart Disease in Apparently Healthy Middle-Aged Men

Koenig, W., Khuseyinova, N., Baumert, J., Meisinger, C., & Löwel, H. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.06.053 · Cited by 166 · see citing works

Associations of Adiponectin Levels With Incident Impaired Glucose Metabolism and Type 2 Diabetes in Older Men and Women

Snijder, M. B., Heine, R. J., Seidell, J. C., Bouter, L. M., Stehouwer, C. D. A., Nijpels, G., Funahashi, T., Matsuzawa, Y., Shimomura, I., & Dekker, J. M. (2006) · Diabetes Care · doi:10.2337/dc06-0952 · Cited by 163 · see citing works

Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes Prevention Program

Mather, K. J., Funahashi, T., Matsuzawa, Y., Edelstein, S. L., Bray, G. A., Kahn, S. E., Crandall, J. P., Marcovina, S. M., Goldstein, B., Goldberg, R. B., et al. (2008) · Diabetes · doi:10.2337/db07-1419 · Cited by 160 · see citing works

Common Variants in the Adiponectin Gene ( ADIPOQ ) Associated With Plasma Adiponectin Levels, Type 2 Diabetes, and Diabetes-Related Quantitative Traits

Hivert, M., Manning, A. K., McAteer, J. B., Florez, J. C., Dupuis, J., Fox, C. S., O’Donnell, C. J., Cupples, L. A., & Meigs, J. B. (2008) · Diabetes · doi:10.2337/db08-0700 · Cited by 157 · see citing works

Decreased Total and High Molecular Weight Adiponectin Are Independent Risk Factors for the Development of Type 2 Diabetes in Japanese-Americans

Nakashima, R., Kamei, N., Yamane, K., Nakanishi, S., Nakashima, A., & Kohno, N. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1158 · Cited by 156 · see citing works

Serum adiponectin concentrations predict the developments of type 2 diabetes and the metabolic syndrome in elderly Koreans

Choi, K. M., Lee, J., Lee, K. W., Seo, J. A., Oh, J.-H., Kim, S. G., Kim, N. H., Choi, D. S., & Baik, S. H. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02063.x · Cited by 153 · see citing works

Novel biochemical risk factors for type 2 diabetes: pathogenic insights or prediction possibilities?

Sattar, N., Wannamethee, S. G., & Forouhi, N. G. (2008) · Diabetologia · doi:10.1007/s00125-008-0954-7 · Cited by 143 · see citing works

Adherence to healthy eating patterns is associated with higher circulating total and high-molecular-weight adiponectin and lower resistin concentrations in women from the Nurses’ Health Study

Fargnoli, J. L., Fung, T. T., Olenczuk, D. M., Chamberland, J. P., Hu, F. B., & Mantzoros, C. S. (2008) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26480 · Cited by 124 · see citing works

Adipocytokines and Incident Diabetes Mellitus in Older Adults

Kanaya, A. M., Fyr, C. W., Vittinghoff, E., Harris, T. B., Park, S. W., Goodpaster, B. H., Tylavsky, F., & Cummings, S. R. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.3.350 · Cited by 88 · see citing works

Adipokines and Incident Type 2 Diabetes in an Aboriginal Canadian Population

Ley, S. H., Harris, S. B., Connelly, P. W., Mamakeesick, M., Gittelsohn, J., Hegele, R. A., Retnakaran, R. R., Zinman, B., & Hanley, A. J. (2008) · Diabetes Care · doi:10.2337/dc08-0036 · Cited by 78 · see citing works

Hypoadiponectinemia Is Associated With Progression Toward Type 2 Diabetes and Genetic Variation in the ADIPOQ Gene Promoter

Schwarz, P. E. H., Towers, G. W., Fischer, S., Govindarajalu, S., Schulze, J., Bornstein, S. R., Hanefeld, M., & Vasseur, F. (2006) · Diabetes Care · doi:10.2337/dc05-2123 · Cited by 66 · see citing works

Low serum adiponectin level as a predictor of impaired glucose regulation and type 2 diabetes mellitus in a middle-aged Finnish population

Jalovaara, K., Santaniemi, M., Timonen, M., Jokelainen, J. J., Kesäniemi, Y. A., Ukkola, O. H., Keinanen-Kiukaanniemi, S. M., & Rajala, U. (2008) · Metabolism · doi:10.1016/j.metabol.2008.03.019 · Cited by 48 · see citing works

ADIPOSE TISSUE DYSFUNCTION IN OBESITY, DIABETES, AND VASCULAR DISEASES

Carlin, B. W., & Roitman, J. L. (2009) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/01.hcr.0000348169.97212.87 · Cited by 42 · see citing works

Low Serum Adiponectin Predicts 10-Year Risk of Type 2 Diabetes and HbA1c Independently of Obesity, Lipids, and Inflammation: Whitehall II Study

Tabák, Á. G., Brunner, E. J., Miller, M. A., Karanam, S., McTernan, P. G., Cappuccio, F. P., & Witte, D. R. (2009) · Hormone and Metabolic Research · doi:10.1055/s-0029-1216359 · Cited by 38 · see citing works

Plasma adiponectin levels and incident glucose intolerance in Japanese–Brazilians: A seven-year follow-up study

Vendramini, M. F., Ferreira, S. R. G., Gimeno, S. G. A., Kasamatsu, T. S., Miranda, W. L., & Moisés, R. S. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.02.002 · Cited by 13 · see citing works

Adipokines in inflammation and metabolic disease

Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works

Pathophysiology of human visceral obesity: an update

Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583 · see citing works

Type 2 diabetes mellitus

DeFronzo, R. A., Ferrannini, E., Groop, L., Henry, R. R., Herman, W. H., Holst, J. J., Hu, F. B., Kahn, C. R., Raz, I., Shulman, G. I., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.19 · Cited by 2,611 · see citing works

Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus

Kautzky-Willer, A., Harreiter, J., & Pacini, G. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1137 · Cited by 2,043 · see citing works

Obesity and inflammation: the linking mechanism and the complications

Ellulu, M. S., Patimah, I., Khaza’ai, H., Rahmat, A., & Abed, Y. (2017) · Archives of Medical Science · doi:10.5114/aoms.2016.58928 · Cited by 1,982 · see citing works

Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach

Floegel, A., Stefan, N., Yu, Z., Mühlenbruch, K., Drogan, D., Joost, H.-G., Fritsche, A., Häring, H.-U., Hrabě de Angelis, M., Peters, A., et al. (2013) · Diabetes · doi:10.2337/db12-0495 · Cited by 988 · see citing works

Trends in insulin resistance: insights into mechanisms and therapeutic strategy

Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939 · see citing works

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

Okada-Iwabu, M., Yamauchi, T., Iwabu, M., Honma, T., Hamagami, K.-I., Matsuda, K., Yamaguchi, M., Tanabe, H., Kimura-Someya, T., Shirouzu, M., et al. (2013) · Nature · doi:10.1038/nature12656 · Cited by 757 · see citing works

Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses

Bellou, V., Belbasis, L., Tzoulaki, I., & Evangelou, E. (2018) · PLOS ONE · doi:10.1371/journal.pone.0194127 · Cited by 713 · see citing works

Adipocytokines in Obesity and Metabolic Disease

Cao, H. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0339 · Cited by 705 · see citing works

Adipokines Mediate Inflammation and Insulin Resistance

Kwon, H., & Pessin, J. E. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00071 · Cited by 695 · see citing works

The Role of Adiponectin in Cancer: A Review of Current Evidence

Dalamaga, Μ., Diakopoulos, K. N., & Mantzoros, C. S. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1015 · Cited by 639 · see citing works

Curcumin Extract for Prevention of Type 2 Diabetes

Chuengsamarn, S., Rattanamongkolgul, S., Luechapudiporn, R., Phisalaphong, C., & Jirawatnotai, S. (2012) · Diabetes Care · doi:10.2337/dc12-0116 · Cited by 636 · see citing works

Adiponectin: mechanistic insights and clinical implications

Turer, A. T., & Scherer, P. E. (2012) · Diabetologia · doi:10.1007/s00125-012-2598-x · Cited by 636 · see citing works

Dietary pattern analysis and biomarkers of low-grade inflammation: a systematic literature review

Barbaresko, J., Koch, M., Schulze, M. B., & Nöthlings, U. (2013) · Nutrition Reviews · doi:10.1111/nure.12035 · Cited by 613 · see citing works

Insulin resistance and cancer risk: An overview of the pathogenetic mechanisms

Arcidiacono, B., Iiritano, S., Nocera, A., Possidente, K., Nevolo, M. T., Ventura, V., Foti, D., Chiefari, E., & Brunetti, A. (2012) · Experimental Diabetes Research · doi:10.1155/2012/789174 · Cited by 606 · see citing works

Adipokines: A link between obesity and cardiovascular disease

Nakamura, K., Fuster, J. J., & Walsh, K. X. (2013) · Journal of Cardiology · doi:10.1016/j.jjcc.2013.11.006 · Cited by 582 · see citing works

Whole grain and refined grain consumption and the risk of type 2 diabetes: a systematic review and dose–response meta-analysis of cohort studies

Aune, D., Norat, T., Romundstad, P., & Vatten, L. J. (2013) · European Journal of Epidemiology · doi:10.1007/s10654-013-9852-5 · Cited by 539 · see citing works

Estrogen: A master regulator of bioenergetic systems in the brain and body

Rettberg, J. R., Yao, J., & Brinton, R. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.08.001 · Cited by 534 · see citing works

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

Dastani, Z., Hivert, M., Timpson, N. J., Perry, J. R. B., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikäinen, L., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002607 · Cited by 490 · see citing works

Adiponectin, TNF-α and Inflammatory Cytokines and Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis

Liu, C., Feng, X., Li, Q., Wang, Y., Li, Q., & Hua, M. (2016) · Cytokine · doi:10.1016/j.cyto.2016.06.028 · Cited by 470 · see citing works

Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies

The InterAct Consortium (2015) · Diabetologia · doi:10.1007/s00125-015-3585-9 · Cited by 469 · see citing works

The gut microbiota and its relationship to diet and obesity

Clarke, S. F., Murphy, E. F., Nilaweera, K. N., Ross, R. P., Shanahan, F., O’Toole, P. W., & Cotter, P. D. (2012) · Gut Microbes · doi:10.4161/gmic.20168 · Cited by 458 · see citing works

Stress hormones: physiological stress and regulation of metabolism

Kyrou, I., & Tsigos, C. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.08.007 · Cited by 440 · see citing works

Epidemiologic relationship between periodontitis and type 2 diabetes mellitus

Wu, C., Yuan, Y., Liu, H.-H., Li, S.-S., Zhang, B., Chen, W., An, Z.-J., Chen, S., Wu, Y., Han, B., et al. (2020) · BMC Oral Health · doi:10.1186/s12903-020-01180-w · Cited by 432 · see citing works

Adiponectin in insulin resistance: lessons from translational research

Ziemke, F., & Mantzoros, C. S. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28449c · Cited by 422 · see citing works

Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β -Cell Dysfunction

Keane, K. N., Cruzat, V. F., Carlessi, R., de Bittencourt, P. I. H., & Newsholme, P. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/181643 · Cited by 385 · see citing works

Review: Diabetes, Obesity, and Cancer—Pathophysiology and Clinical Implications

Lega, I. C., & Lipscombe, L. L. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz014 · Cited by 374 · see citing works

Type 2-diabetes is associated with elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptin in a population of Mexican Americans: A cross-sectional study

Mirza, S., Hossain, M., Mathews, C., Martinez, P., Pino, P., Gay, J. L., Rentfro, A., McCormick, J. B., & Fisher-Hoch, S. P. (2012) · Cytokine · doi:10.1016/j.cyto.2011.09.029 · Cited by 358 · see citing works

Environmental Obesogens: Mechanisms and Controversies

Heindel, J. J., & Blumberg, B. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021304 · Cited by 341 · see citing works

Diabetes mellitus related bone metabolism and periodontal disease

Wu, Y., Xiao, E., & Graves, D. T. (2015) · International Journal of Oral Science · doi:10.1038/ijos.2015.2 · Cited by 314 · see citing works

Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): Evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation

Angle, B. M., Phuong, R., Ponzi, D., Stahlhut, R. W., Drury, B. E., Nagel, S. C., Welshons, W. V., Besch-Williford, C. L., Palanza, P., Parmigiani, S., et al. (2013) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.07.017 · Cited by 298 · see citing works

Risk assessment tools for identifying individuals at risk of developing type 2 diabetes

Buijsse, B., Simmons, R. K., Griffin, S. J., & Schulze, M. B. (2011) · Epidemiologic Reviews · doi:10.1093/epirev/mxq019 · Cited by 297 · see citing works

Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant

Gunawardana, S. C., & Piston, D. W. (2012) · Diabetes · doi:10.2337/db11-0510 · Cited by 290 · see citing works

The role of adiponectin in the pathogenesis and treatment of non‐alcoholic fatty liver disease

Pοlyzos, S. A., Kountouras, J., Zavos, C., & Tsiaousi, E. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2009.01176.x · Cited by 277 · see citing works

Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity

Stuart, M. J., & Baune, B. T. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.10.001 · Cited by 257 · see citing works

Lactation and Progression to Type 2 Diabetes Mellitus After Gestational Diabetes Mellitus

Gunderson, E. P., Hurston, S. R., Ning, X., Lo, J. C.-M., Crites, Y., WALTON, D. L., Dewey, K. G., Azevedo, R. A., Young, S., Fox, G., et al. (2015) · Annals of Internal Medicine · doi:10.7326/m15-0807 · Cited by 248 · see citing works

Epidemiology of selenium and type 2 diabetes: Can we make sense of it?

Rayman, M. P., & Stranges, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.003 · Cited by 220 · see citing works

Prevention and control of type 2 diabetes by Mediterranean diet: A systematic review

Esposito, K., Maiorino, M. I., Ceriello, A., & Giugliano, D. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2010.04.019 · Cited by 208 · see citing works

Biomarkers for Insulin Resistance and Inflammation and the Risk for All-Cause Dementia and Alzheimer Disease

van Himbergen, T. M. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.670 · Cited by 198 · see citing works

Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options (Review)

Varra, F., Varras, M. N., Varra, V., & Theodosis‐Nobelos, P. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13219 · Cited by 194 · see citing works

ANIMAL MODELS OF DISEASE: Classification and etiology of diabetes in dogs and cats

Nelson, R. W., & Reusch, C. E. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0202 · Cited by 185 · see citing works

First-Trimester Prediction of Gestational Diabetes Mellitus: Examining the Potential of Combining Maternal Characteristics and Laboratory Measures

Savvidou, M. D., Nelson, S. M., Makgoba, M., Messow, C., Sattar, N. A., & Nicolaides, K. H. (2010) · Diabetes · doi:10.2337/db10-0688 · Cited by 179 · see citing works

Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin?

Özdemir, B. C., & Dotto, G. P. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.02.002 · Cited by 178 · see citing works

Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial

Wedick, N. M., Brennan, A., Sun, Q., Hu, F. B., Mantzoros, C. S., & van Dam, R. M. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-93 · Cited by 174 · see citing works

The diabetogenic action of statins — mechanisms and clinical implications

Betteridge, D. J., & Carmena, R. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.194 · Cited by 173 · see citing works

Understanding the Physiological Links Between Physical Frailty and Cognitive Decline

Ma, L., & Chan, P. (2020) · Aging and Disease · doi:10.14336/ad.2019.0521 · Cited by 175 · see citing works

The Adiponectin Paradox for All-Cause and Cardiovascular Mortality

Menzaghi, C., & Trischitta, V. (2017) · Diabetes · doi:10.2337/dbi17-0016 · Cited by 172 · see citing works

Mediterranean Diet and Diabetes: Prevention and Treatment

Georgoulis, M., Kontogianni, M. D., & Yiannakouris, N. (2014) · Nutrients · doi:10.3390/nu6041406 · Cited by 172 · see citing works

Plasma Exosome MicroRNA Profiling Unravels a New Potential Modulator of Adiponectin Pathway in Diabetes: Effect of Glycemic Control

Santovito, D., Nardis, V. D., Marcantonio, P., Mandolini, C., Paganelli, C., Vitale, E., Buttitta, F., Bucci, M., Mezzetti, A., Consoli, A., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3843 · Cited by 171 · see citing works

Anti‐inflammatory cytokines and risk of type 2 diabetes

Herder, C., Carstensen, M., & Ouwens, D. M. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12155 · Cited by 171 · see citing works

Obesity, adipokines and neuroinflammation

Aguilar‐Valles, A., Inoue, W., Rummel, C. D., & Luheshi, G. N. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.023 · Cited by 166 · see citing works

Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy

Fernandes, R., Viana, S., Nunes, S., & Reis, F. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.032 · Cited by 172 · see citing works

Adipokines, Metabolic Syndrome and Rheumatic Diseases

Abella, V., Scotece, M., Conde, J., López, V., Lazzaro, V., Pino, J., Gómez-Reino, J. J., & Gualillo, O. (2014) · Journal of Immunology Research · doi:10.1155/2014/343746 · Cited by 160 · see citing works

Diabetes and inflammation: Fundamental aspects and clinical implications

Garcia, C., Fève, B., Ferré, P., Halimi, S., Baïzri, H., Bordier, L., Guiu, G., Dupuy, O., Bauduceau, B., & Mayaudon, H. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.07.001 · Cited by 162 · see citing works

Prediabetes and associated disorders

Buysschaert, M., Medina, J. L., Bergman, M., Shah, A., & Lonier, J. (2014) · Endocrine · doi:10.1007/s12020-014-0436-2 · Cited by 159 · see citing works

Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: Results of genome-wide association analyses including 4659 European individuals

Heid, I. M., Henneman, P., Hicks, A. A., Coassin, S., Winkler, T. W., Aulchenko, Y. S., Fuchsberger, C., Song, K. S., Hivert, M., Waterworth, D. M., et al. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.11.035 · Cited by 159 · see citing works

Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis

Yusuf, E., Ioan‐Facsinay, A., Bijsterbosch, J., Klein‐Wieringa, I. R., Kwekkeboom, J. C., Slagboom, P. E., Huizinga, T. W. J., & Kloppenburg, M. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.146282 · Cited by 154 · see citing works

Adipose tissue depot and cell size dependency of adiponectin synthesis and secretion in human obesity

Meyer, L. K., Ciaraldi, T. P., Henry, R. R., Wittgrove, A. C., & Phillips, S. A. (2013) · Adipocyte · doi:10.4161/adip.24953 · Cited by 148 · see citing works

The role of obesity and adipose tissue dysfunction in osteoarthritis pain

Binvignat, M., Sellam, J., Berenbaum, F., & Felson, D. T. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01143-3 · Cited by 147 · see citing works

COMPANION ANIMALS SYMPOSIUM: Obesity in dogs and cats: What is wrong with being fat?1

Laflamme, D. P. (2011) · Journal of Animal Science · doi:10.2527/jas.2011-4571 · Cited by 144 · see citing works

Effect of adiponectin on bovine granulosa cell steroidogenesis, oocyte maturation and embryo development

Maillard, V., Uzbekova, S., Guignot, F., Perreau, C., Ramé, C., Coyral-Castel, S., & Dupont, J. (2010) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-8-23 · Cited by 143 · see citing works

From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome

Maiorino, M. I., Bellastella, G., Giugliano, D., & Esposito, K. (2018) · Journal of Endocrinological Investigation · doi:10.1007/s40618-018-0872-6 · Cited by 141 · see citing works

Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels

Abbenhardt, C., McTiernan, A., Alfano, C. M., Wener, M. H., Campbell, K. L., Duggan, C., Foster‐Schubert, K. E., Kong, A., Toriola, A. T., Potter, J. D., et al. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12062 · Cited by 137 · see citing works

Whole grain consumption and human health: an umbrella review of observational studies

Tieri, M., Ghelfi, F., Vitale, M., Vetrani, C., Marventano, S., Lafranconi, A., Godos, J., Titta, L., Gambera, A., Alonzo, E., et al. (2020) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2020.1715354 · Cited by 142 · see citing works

The Vasculature in Prediabetes

Wasserman, D. H., Wang, T. J., & Brown, N. J. (2018) · Circulation Research · doi:10.1161/circresaha.118.311912 · Cited by 137 · see citing works

Inflammatory Concepts of Obesity

Rocha, V. Z., & Folco, E. J. E. (2011) · International Journal of Inflammation · doi:10.4061/2011/529061 · Cited by 134 · see citing works

Modulation of adiponectin as a potential therapeutic strategy

Lim, S. K., Quon, M. J., & Koh, K. K. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.01.051 · Cited by 137 · see citing works

Systematic review and meta-analysis of the associations of vegan and vegetarian diets with inflammatory biomarkers

Menzel, J., Jabakhanji, A., Biemann, R., Mai, K., Abraham, K., & Weikert, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-78426-8 · Cited by 136 · see citing works

A Review on Oxidative Stress, Diabetic Complications, and the Roles of Honey Polyphenols

Pasupuleti, V. R., Arigela, C. S., Gan, S. H., Salam, S. K. N. M., Krishnan, K. T., Rahman, N. A., & Jeffree, M. S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8878172 · Cited by 141 · see citing works

Targeting metabolic disorders by natural products

Tabatabaei‐Malazy, O., Larijani, B. A., & Abdollahi, M. R. (2015) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-015-0184-8 · Cited by 133 · see citing works

Exercise Increases Adiponectin and Reduces Leptin Levels in Prediabetic and Diabetic Individuals: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Becic, T., Studenik, C., & Hoffmann, G. (2018) · Medical Sciences · doi:10.3390/medsci6040097 · Cited by 127 · see citing works

Fruit and vegetable consumption and risk of type 2 diabetes mellitus: A dose-response meta-analysis of prospective cohort studies

Wu, Y., Zhang, D., Jiang, X., & Jiang, W. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.10.004 · Cited by 128 · see citing works

A Genome-Wide Association Study Reveals a Quantitative Trait Locus of Adiponectin on CDH13 That Predicts Cardiometabolic Outcomes

Chung, C., Lin, T., Chen, J., Leu, H., Yang, H., Ho, H., Ting, C.-T., Sheu, S., Tsai, W., Chen, J.-H., et al. (2011) · Diabetes · doi:10.2337/db10-1321 · Cited by 126 · see citing works

Adipose tissue mass and location affect circulating adiponectin levels

Turer, A. T., Khera, A., Ayers, C. R., Turer, C. B., Grundy, S. M., Vega, G. L., & Scherer, P. E. (2011) · Diabetologia · doi:10.1007/s00125-011-2252-z · Cited by 125 · see citing works

Adiponectin Induces Pro-inflammatory Programs in Human Macrophages and CD4+ T Cells

Cheng, X., Folco, E. J. E., Shimizu, K., & Libby, P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.409516 · Cited by 122 · see citing works

Obesity and Metabolic Syndrome: An Inflammatory Condition

Scarpellini, E., & Tack, J. F. (2012) · Digestive Diseases · doi:10.1159/000336664 · Cited by 121 · see citing works

Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes

Yaghootkar, H., Lamina, C., Scott, R. A., Dastani, Z., Hivert, M., Warren, L. L., Stančáková, A., Buxbaum, S. G., Lyytikäinen, L., Henneman, P., et al. (2013) · Diabetes · doi:10.2337/db13-0128 · Cited by 121 · see citing works

Lower Adiponectin Levels at First Trimester of Pregnancy Are Associated With Increased Insulin Resistance and Higher Risk of Developing Gestational Diabetes Mellitus

Lacroix, M., Battista, M., Doyon, M., Ménard, J., Ardilouze, J., Perron, P., & Hivert, M. (2013) · Diabetes Care · doi:10.2337/dc12-1731 · Cited by 122 · see citing works

Adiponectin—Consideration for its Role in Skeletal Muscle Health

Krause, M. P., Milne, K. J., & Hawke, T. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071528 · Cited by 121 · see citing works

Systemic inflammation in childhood obesity: circulating inflammatory mediators and activated CD14++ monocytes

Schipper, H. S., Nuboer, R., Prop, S., van den Ham, H., de Boer, F. K., Keşmir, C., Mombers, I. M. H., van Bekkum, K. A., Woudstra, J., Kieft, J. H., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2641-y · Cited by 119 · see citing works

Association between adiponectin levels and coronary heart disease and mortality: a systematic review and meta-analysis

Lee, E. S., Park, S., Kim, E., Yoon, Y. S., Ahn, H. Y., Park, C., Yun, Y. H., & Oh, S. W. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dyt087 · Cited by 121 · see citing works

Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice

Lian, K., Du, C., Liu, Y., Zhu, D., Yan, W., Zhang, H., Hong, Z., Liu, P., Zhang, L., Pei, H., et al. (2014) · Diabetes · doi:10.2337/db14-0312 · Cited by 119 · see citing works

Adipokine Pattern in Subjects with Impaired Fasting Glucose and Impaired Glucose Tolerance in Comparison to Normal Glucose Tolerance and Diabetes

Tönjes, A., Faßhauer, M., Kratzsch, J., Stümvoll, M., & Blüher, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013911 · Cited by 119 · see citing works

Hypoadiponectinemia—Cause or Consequence of Human “Insulin Resistance”?

Cook, J. R., & Semple, R. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2286 · Cited by 117 · see citing works

Associations of a vegan diet with inflammatory biomarkers

Menzel, J., Biemann, R., Longree, A., Isermann, B., Mai, K., Schulze, M. B., Abraham, K., & Weikert, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-58875-x · Cited by 119 · see citing works

Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies

Yarmolinsky, J., Barbieri, N. B., Weinmann, T., Ziegelmann, P. K., Duncan, B. B., & Schmidt, M. I. (2016) · Scientific Reports · doi:10.1038/srep17714 · Cited by 119 · see citing works

A Prospective Study of Plasma Adiponectin and Pancreatic Cancer Risk in Five US Cohorts

Bao, Y., Giovannucci, E. L., Kraft, P. L., Stampfer, M. J., Ogino, S., Ma, J., Buring, J. E., Sesso, H. D., Lee, I.-M. M., Gaziano, J. M., et al. (2012) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djs474 · Cited by 117 · see citing works

Hepatokines and adipokines in NASH-related hepatocellular carcinoma

Kücükoglu, Ö., Sowa, J., Mazzolini, G. D., Syn, W., & Canbay, A. E. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.10.030 · Cited by 114 · see citing works

Association of coffee consumption with serum adiponectin, leptin, inflammation and metabolic markers in Japanese workers: a cross-sectional study

Yamashita, K., Yatsuya, H., Muramatsu, T., Toyoshima, H., Murohara, T., & Tamakoshi, K. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2012.6 · Cited by 113 · see citing works

The role of the inflammatory microenvironment in thyroid carcinogenesis

Cunha, L. L., Marcello, M. A., & Ward, L. S. (2013) · Endocrine Related Cancer · doi:10.1530/erc-13-0431 · Cited by 113 · see citing works

Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men

Knudsen, S. H., Hansen, L. S., Pedersen, M., Dejgaard, T., Hansen, J., Hall, G. V., Thomsen, C., Solomon, T. P. J., Pedersen, B. K., & Krogh-Madsen, R. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00189.2011 · Cited by 112 · see citing works

Low adiponectin concentration during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia

Retnakaran, R. R., Qi, Y., Connelly, P. W., Sermer, M., Hanley, A. J., & Zinman, B. (2009) · Diabetologia · doi:10.1007/s00125-009-1600-8 · Cited by 112 · see citing works

Accuracy of circulating adiponectin for predicting gestational diabetes: a systematic review and meta-analysis

Iliodromiti, S., Sassarini, J., Kelsey, T., Lindsay, R. S., Sattar, N. A., & Nelson, S. M. (2016) · Diabetologia · doi:10.1007/s00125-015-3855-6 · Cited by 113 · see citing works

Initial Dietary and Microbiological Environments Deviate in Normal‐weight Compared to Overweight Children at 10 Years of Age

Luoto, R., Kalliomäki, M. A., Laitinen, K., Delzenne, N. M., Cani, P. D., Salminen, S., & Isolauri, E. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181f3457f · Cited by 110 · see citing works

Adipose tissue changes in obesity and the impact on metabolic function

Sam, S., & Mazzone, T. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.008 · Cited by 111 · see citing works

Mechanisms of obesity-induced metabolic and vascular dysfunctions

Caldwell, R. W. (2019) · Frontiers in bioscience · doi:10.2741/4758 · Cited by 112 · see citing works

Obesity and asthma: beyond TH2 inflammation

Leiria, L. O., Martins, M. A., & Saad, M. J. A. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.002 · Cited by 110 · see citing works

The role of adiponectin in human vascular physiology

Vaiopoulos, G., Marinou, K., Christodoulides, C., & Koutsilieris, M. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.07.047 · Cited by 108 · see citing works

Novel metabolic biomarkers of cardiovascular disease

Jensen, M. K., Bertoia, M. L., Cahill, L. E., Agarwal, I., Rimm, E. B., & Mukamal, K. J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.155 · Cited by 107 · see citing works

Adiponectin and protection against type 2 diabetes mellitus

Spranger, J., Kroke, A., Möhlig, M., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12255-6 · Cited by 1,120 · see citing works

Plasma adiponectin levels and type 2 diabetes risk: a nested case-control study in a Chinese population and an updated meta-analysis

Wang, Y., Meng, R., Kunutsor, S. K., Chowdhury, R., Yuan, J., Koh, W., & Pan, A. (2018) · Scientific Reports · doi:10.1038/s41598-017-18709-9 · Cited by 97 · see citing works

Association of Adiponectin Level and Type 2 Diabetes Mellitus (T2DM): A Systematic Review and Meta-Analysis

Nathan, D. S., & Yumilia, H. (2022) · International Journal For Research In Health Sciences And Nursing

Circulating adiponectin levels and risk of type 2 diabetes in the Japanese

Yamamoto, S., Matsushita, Y., Nakagawa, T., Hayashi, T., Noda, M., & Mizoue, T. (2014) · Nutrition and Diabetes · doi:10.1038/nutd.2014.27 · Cited by 76 · see citing works

Large sample case-control study of association between adiponectin and susceptibility to type 2 diabetes mellitus

Ling, Z. (2010) · Acta Universitatis Medicinalis Nanjing