Development of life-expectancy tables for people with type 2 diabetes
Open accessAbstract
AIMS: To develop tables that report the life expectancy associated with levels of major modifiable risk factors for patients with type 2 diabetes. METHODS AND RESULTS: A set of tables reporting life-expectancy stratified by age-sex groups for combinations of modifiable risk was constructed based on predictions from the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model. This model is based on a system of parametric proportional hazards risk equations for estimating mortality and vascular complications of diabetes that have been estimated from 3642 patients from the UKPDS. The tables show substantial potential gains in life expectancy within every age group from modifying major risk factors. The estimated life expectancy of men at age of 55 years with type 2 diabetes, 5 years after diagnosis, varies between 13.2 years for a patient who smokes, has systolic blood pressure of 180 mmHg, a total:HDL cholesterol ratio of 8, and HbA(1c) of 10%, and 21.1 years for a non-smoker with SBP of 120 mmHg, total/HDL ratio of 4, and HbA(1c) of 6%. CONCLUSION: Life expectancy tables provide a potentially useful tool of conveying prognostic information to people with type 2 diabetes and suggest substantial scope for increasing longevity by improving modifiable risk factors.
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Cardiovascular disease accounts for 75% of all related deaths in diabetic patients and on average individuals with T2D have an increased risk of shorter life expectancy.
“Cardiovascular disease (CVD) accounts for 75% of all related deaths in diabetic patients and on average individuals with T2D have an increased risk of shorter life expectancy.44,45”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [45]
UKPDS-OM2 takes a completely transparent approach, in which the development, the equations that determine all outcomes and the algorithm used to bring the elements of the model together have been fully reported.
“By contrast, the UKPDS-OM2 takes a completely transparent approach [6, 26], in which we have fully reported its development, the equations that determine all outcomes and the algorithm used to bring the elements of the model together.”
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Using diabetes technology in older adults
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Health outcomes in diabetics measured with Minnesota Community Measurement quality metrics
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Diabetes and sudden cardiac death: a Danish nationwide study
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Hospital costs associated with adverse events in people with diabetes in the UK
Keng, M. J., Leal, J., Bowman, L. J., Armitage, J., Mihaylova, B., & ASCEND Study Collaborative Group (2022) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14796 · Cited by 9 · see citing works
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Lipoprotein ( a ) and Atherogenic Indices in Sudanese Patients with Type 2 Diabetes
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La prevención cardiovascular en la diabetes mellitus: un reto multifactorial
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Lack of Reality: Positive Self-Perceptions of Health in the Presence of Disease
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Applying the Payoff Time Framework to Carotid Artery Disease Management
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Considering metformin as a second-line treatment for children and adolescents with prediabetes
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Towards Social Group Optimization and Machine Learning Based Diabetes Prediction
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Search for Novel Therapeutic Targets of Type 2 Diabetes Mellitus
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Physical Activity Supports Provided by Healthcare Providers to Patients with Type 2 Diabetes
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Using neonatal skin to study the developmental programming of aging
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Efficacy of iGlarLixi on 5-year risk of diabetes-related complications: A simulation study
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Vascular disease burden in Indian subjects with vascular dementia
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- Authors
- Leal, J., Gray, A. M., & Clarke, P. M.
- Affiliations
- University of Oxford (GB)
- The University of Sydney (AU)
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-12-24
- Volume
- 30
- Issue
- 7
- Pages
- 834-839
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- PMC
- PMC2663724
- OpenAlex
- W2107098508
- Cited by
- 128
- References
- 40
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 9 · 2021: 12 · 2020: 11 · 2019: 12 · 2018: 5 · 2017: 8 · 2016: 12 · 2015: 7 · 2014: 13 · 2013: 12 · 2012: 3
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Heart Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Diabetes Australia
- Medical Research Council
- National Health and Medical Research Council (512463)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 2 diabetes, life expectancy, modifiable risk factors, mortality prediction, vascular complications, smoking, systolic blood pressure, TC/HDL-C ratio, HbA1c, prognosis
- MeSH terms
- Aged, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Female, United Kingdom, Health Status, Health Surveys, Humans, Life Expectancy, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors
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