The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Circulating microRNAs are new and sensitive biomarkers of myocardial infarction
Open accessAbstract
AIMS: Circulating microRNAs (miRNAs) may represent a novel class of biomarkers; therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma levels in humans and mice. METHODS AND RESULTS: Healthy donors (n = 17) and patients (n = 33) with acute ST-segment elevation MI (STEMI) were evaluated. In one cohort (n = 25), the first plasma sample was obtained 517 ± 309 min after the onset of MI symptoms and after coronary reperfusion with percutaneous coronary intervention (PCI); miR-1, -133a, -133b, and -499-5p were ~15- to 140-fold control, whereas miR-122 and -375 were ~87-90% lower than control; 5 days later, miR-1, -133a, -133b, -499-5p, and -375 were back to baseline, whereas miR-122 remained lower than control through Day 30. In additional patients (n = 8; four treated with thrombolysis and four with PCI), miRNAs and troponin I (TnI) were quantified simultaneously starting 156 ± 72 min after the onset of symptoms and at different times thereafter. Peak miR-1, -133a, and -133b expression and TnI level occurred at a similar time, whereas miR-499-5p exhibited a slower time course. In mice, miRNAs plasma levels and TnI were measured 15 min after coronary ligation and at different times thereafter. The behaviour of miR-1, -133a, -133b, and -499-5p was similar to STEMI patients; further, reciprocal changes in the expression levels of these miRNAs were found in cardiac tissue 3-6 h after coronary ligation. In contrast, miR-122 and -375 exhibited minor changes and no significant modulation. In mice with acute hind-limb ischaemia, there was no increase in the plasma level of the above miRNAs. CONCLUSION: Acute MI up-regulated miR-1, -133a, -133b, and -499-5p plasma levels, both in humans and mice, whereas miR-122 and -375 were lower than control only in STEMI patients. These miRNAs represent novel biomarkers of cardiac damage.
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Cites
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Circulating microRNAs, potential biomarkers for drug-induced liver injury
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Self-citationmiR-375 maintains normal pancreatic α- and β-cell mass
Poy, M. N., Hausser, J., Trajkovski, M., Braun, M., Collins, S., Rorsman, P., Zavolan, M., & Stoffel, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810550106 · Cited by 740
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Cited by
Methodological challenges in utilizing mi RNA s as circulating biomarkers
Moldovan, L., Batte, K. E., Trgovcich, J., Wisler, J., Marsh, C. B., & Piper, M. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12236 · Cited by 436
Stability of Circulating Blood-Based MicroRNAs – Pre-Analytic Methodological Considerations
Glinge, C., Clauss, S., Boddum, K., Jabbari, R., Jabbari, J., Risgaard, B., Tomsits, P., Hildebrand, B., Kääb, S., Wakili, R., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0167969 · Cited by 351
Olivieri, F., Spazzafumo, L., Santini, G., Lazzarini, R., Albertini, M. C., Rippo, M. R., Galeazzi, R., Abbatecola, A. M., Marcheselli, F., Monti, D., et al. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.09.004 · Cited by 248
Self-citationCirculating microRNAs as potential biomarkers for endometriosis
Cho, S., Mutlu, L., Grechukhina, O., & Taylor, H. S. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.02.013 · Cited by 181
MicroRNAs and cardiovascular diseases
Ono, K., Kuwabara, Y., & Han, J. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2011.08090.x · Cited by 169
A unique plasma microRNA profile defines type 2 diabetes progression
de Candia, P., Spinetti, G., Specchia, C., Sangalli, E., La Sala, L., Uccellatore, A., Lupini, S., Genovese, S., Matarese, G., & Ceriello, A. (2017) · PLOS ONE · doi:10.1371/journal.pone.0188980 · Cited by 105
Circulating miR-1, miR-133a, and miR-206 levels are increased after a half-marathon run
Gomes, C. P. C., Oliveira-Jr, G. P., Madrid, B., Almeida, J. A., Franco, O. L., & Pereira, R. W. (2014) · Biomarkers · doi:10.3109/1354750x.2014.952663 · Cited by 92
Extracellular RNAs: A Secret Arm of Immune System Regulation
de Candia, P., De Rosa, V., Casiraghi, M., & Matarese, G. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.708842 · Cited by 53
Røsjø, H., Dahl, M. B., Bye, A., Andreassen, J., Jørgensen, M., Wisløff, U., Christensen, G., Edvardsen, T., & Omland, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091812 · Cited by 41
“Circulating miR-210 levels have also been found elevated in patients with myocardial infarction [22] and peripheral artery disease [23], and to provide prognostic information independently of established risk indices in patients with acute kidney injury [24].”
BackgroundGaravelli, S., Bruzzaniti, S., Tagliabue, E., Di Silvestre, D., Prattichizzo, F., Mozzillo, E., Fattorusso, V., La Sala, L., Ceriello, A., Puca, A. A., et al. (2020) · Diabetologia · doi:10.1007/s00125-020-05237-x · Cited by 37
Osaki, M., Kosaka, N., Okada, F., & Ochiya, T. (2014) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-013-0065-0 · Cited by 13
Metadata
- Authors
- D'Alessandra, Y., Devanna, P., Limana, F., Straino, S., Di Carlo, A., Brambilla, P. G., Rubino, M., Carena, M. C., Spazzafumo, L., De Simone, M., Micheli, B., Biglioli, P., Achilli, F., Martelli, F., Maggiolini, S., Marenzi, G., Pompilio, G., & Capogrossi, M. C.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06-09
- Volume
- 31
- Issue
- 22
- Pages
- 2765-2773
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2060374902
- Cited by
- 797
- References
- 7
- FWCI
- 15.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
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