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Cited by 281

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Estimating modifiable coronary heart disease risk in multiple regions of the world: the INTERHEART Modifiable Risk Score

Open access
McGorrian, C., Yusuf, S., Islam, S., Jung, H., Rangarajan, S., Avezum, A., Prabhakaran, D., Almahmeed, W., Rumboldt, Z., Budaj, A., Dans, A. L., Gerstein, H. C., Teo, K., Anand, S. S., on behalf of the INTERHEART Investigators·2011·European Heart Journal
DOI 10.1093/eurheartj/ehq448
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Abstract

AIMS: Summating risk factor burden is a useful approach in the assessment of cardiovascular risk among apparently healthy individuals. We aimed to derive and validate a new score for myocardial infarction (MI) risk using modifiable risk factors, derived from the INTERHEART case-control study (n = 19 470). METHODS AND RESULTS: Multiple logistic regression was used to create the INTERHEART Modifiable Risk Score (IHMRS). Internal validation was performed using split-sample methods. External validation was performed in an international prospective cohort study. A risk model including apolipoproteins, smoking, second-hand smoke exposure, hypertension, and diabetes was developed. Addition of further modifiable risk factors did not improve score discrimination in an external cohort. Split-sample validation studies showed an area under the receiver-operating characteristic (ROC) curve c-statistic of 0.71 [95% confidence interval (CI): 0.70, 0.72]. The IHMRS was positively associated with incident MI in a large cohort of people at low risk for cardiovascular disease [12% increase in MI risk (95% CI: 8, 16%) with a 1-point increase in score] and showed appropriate discrimination in this cohort (ROC c-statistic 0.69, 95% CI: 0.64, 0.74). Results were consistent across ethnic groups and geographic regions. A non-laboratory-based score is also supplied. CONCLUSIONS: Using multiple modifiable risk factors from the INTERHEART case-control study, we have developed and validated a simple score for MI risk which is applicable to an international population.

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Metadata

Authors
McGorrian, C., Yusuf, S., Islam, S., Jung, H., Rangarajan, S., Avezum, A., Prabhakaran, D., Almahmeed, W., Rumboldt, Z., Budaj, A., Dans, A. L., Gerstein, H. C., Teo, K., Anand, S. S., & on behalf of the INTERHEART Investigators
Venue
European Heart Journal
Publisher
Oxford University Press (OUP)
Published
2010-12-22
Volume
32
Issue
5
Pages
581-589
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
DOI
10.1093/eurheartj/ehq448
OpenAlex
W2098756497
Cited by
281
References
13
FWCI
6.54
Type
journal article
Language
en
Open access
bronze

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