Cardiovascular risk and events in 17 low-, middle-, and high-income countries
Open accessAbstract
BACKGROUND: More than 80% of deaths from cardiovascular disease are estimated to occur in low-income and middle-income countries, but the reasons are unknown. METHODS: We enrolled 156,424 persons from 628 urban and rural communities in 17 countries (3 high-income, 10 middle-income, and 4 low-income countries) and assessed their cardiovascular risk using the INTERHEART Risk Score, a validated score for quantifying risk-factor burden without the use of laboratory testing (with higher scores indicating greater risk-factor burden). Participants were followed for incident cardiovascular disease and death for a mean of 4.1 years. RESULTS: The mean INTERHEART Risk Score was highest in high-income countries, intermediate in middle-income countries, and lowest in low-income countries (P<0.001). However, the rates of major cardiovascular events (death from cardiovascular causes, myocardial infarction, stroke, or heart failure) were lower in high-income countries than in middle- and low-income countries (3.99 events per 1000 person-years vs. 5.38 and 6.43 events per 1000 person-years, respectively; P<0.001). Case fatality rates were also lowest in high-income countries (6.5%, 15.9%, and 17.3% in high-, middle-, and low-income countries, respectively; P=0.01). Urban communities had a higher risk-factor burden than rural communities but lower rates of cardiovascular events (4.83 vs. 6.25 events per 1000 person-years, P<0.001) and case fatality rates (13.52% vs. 17.25%, P<0.001). The use of preventive medications and revascularization procedures was significantly more common in high-income countries than in middle- or low-income countries (P<0.001). CONCLUSIONS: Although the risk-factor burden was lowest in low-income countries, the rates of major cardiovascular disease and death were substantially higher in low-income countries than in high-income countries. The high burden of risk factors in high-income countries may have been mitigated by better control of risk factors and more frequent use of proven pharmacologic therapies and revascularization. (Funded by the Population Health Research Institute and others.).
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Data from the international Prospective Urban and Rural Epidemiological Study (PURE; 138,926 individuals in 628 communities 17 countries) suggest a need to consider the context and availability of specific foods before making food choice recommendations.
“Data from the international Prospective Urban and Rural Epidemiological Study (PURE; 138,926 individuals in 628 communities 17 countries) suggest a need to consider the context and availability of specific foods before making food choice recommendations (114).”
From Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System (2015) · cites this paper as [114]
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Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17018-9 · Cited by 12,026 · see citing works
Self-citationMurray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888 · see citing works
O'Donnell, M. J., Xavier, D., Liu, L., Zhang, H., Chin, S. L., Rao-Melacini, P., Rangarajan, S., Islam, S., Pais, P., McQueen, M. J., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60834-3 · Cited by 3,448 · see citing works
Self-citationChow, C. K. (2013) · JAMA · doi:10.1001/jama.2013.184182 · Cited by 2,000 · see citing works
Krishnamurthi, R., Feigin, V. L., Forouzanfar, M. H., Mensah, G. A., Connor, M., Bennett, D., Moran, A. E., Sacco, R. L., Anderson, L. M., Truelsen, T., et al. (2013) · The Lancet Global Health · doi:10.1016/s2214-109x(13)70089-5 · Cited by 1,355 · see citing works
Yusuf, S., Islam, S., Chow, C. K., Rangarajan, S., Dagenais, G., Diaz, R., Gupta, R., Kelishadi, R., Iqbal, R., Avezum, A., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61215-4 · Cited by 964 · see citing works
Teo, K. K., Chow, C. K., Vaz, M. A. P., Rangarajan, S., & Yusuf, S. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.04.019 · Cited by 603 · see citing works
Tunstall‐Pedoe, H., Vanuzzo, D., HOBBS, M. S. T., Mähönen, M., Čepaitis, Ž., Kuulasmaa, K., & Keil, U. (2000) · The Lancet · doi:10.1016/s0140-6736(99)11181-4 · Cited by 513 · see citing works
Prospective Study of One Million Deaths in India: Rationale, Design, and Validation Results
Jha, P., Gajalakshmi, V., Gupta, P. C., Kumar, R., Mony, P., Dhingra, N., Peto, R., & Collaborators, R.-C. P. S. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0030018 · Cited by 323 · see citing works
McGorrian, C., Yusuf, S., Islam, S., Jung, H., Rangarajan, S., Avezum, Á., Prabhakaran, D., Almahmeed, W. A., Rumboldt, Z., Budaj, A., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq448 · Cited by 282 · see citing works
O'Flaherty, M., Buchan, I., & Capewell, S. (2013) · Heart · doi:10.1136/heartjnl-2012-302300 · Cited by 165 · see citing works
Corsi, D. J., Subramanian, S. V., Chow, C. K., McKee, M., Chifamba, J., Dagenais, G., Díaz, R., Iqbal, R., Kelishadi, R., Kruger, A., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.04.019 · Cited by 155 · see citing works
Verbal autopsy of 80,000 adult deaths in Tamilnadu, South India
Gajalakshmi, V., & Peto, R. (2004) · BMC Public Health · doi:10.1186/1471-2458-4-47 · Cited by 126 · see citing works
Stringhini, S., Viswanathan, B., Gédéon, J., Paccaud, F. M., & Bovet, P. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.11.064 · Cited by 50 · see citing works
Wu, Z., Yao, C., Zhao, D. H., Wu, G., Wang, W., Liu, J., & Zeng, Z. (2004) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000136566.89429.63 · Cited by 49 · see citing works
Walker, A. R. P., Walker, B. F., & Segal, I. (2004) · The Journal of the Royal Society for the Promotion of Health · doi:10.1177/146642400312400112 · Cited by 33 · see citing works
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Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591 · see citing works
O'Donnell, M. J., Chin, S. L., Rangarajan, S., Xavier, D., Liu, L., Zhang, H., Rao-Melacini, P., Zhang, X., Pais, P., Agapay, S., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30506-2 · Cited by 2,296 · see citing works
Self-citationGroenewegen, A., Rutten, F. H., Mosterd, A., & Hoes, A. W. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1858 · Cited by 2,043 · see citing works
Leong, D. P., Teo, K. K., Rangarajan, S., Lopez-Jaramillo, P., Avezum, A., Orlandini, A., Seron, P., Ahmed, S. H., Rosengren, A., Kelishadi, R., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)62000-6 · Cited by 1,876 · see citing works
Epidemiology and aetiology of heart failure
Ziaeian, B., & Fonarow, G. C. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.25 · Cited by 1,888 · see citing works
Feigin, V. L., Roth, G. A., Naghavi, M., Parmar, P., Krishnamurthi, R., Chugh, S., Mensah, G. A., Norrving, B., Shiue, I., Ng, M., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30073-4 · Cited by 1,691 · see citing works
European Resuscitation Council Guidelines for Resuscitation 2015
Perkins, G. D., Handley, A. J., Koster, R. W., Castrén, M. K., Smyth, M. A., Olasveengen, T. M., Monsieurs, K. G., Raffay, V. I., Gräsner, J., Wenzel, V., et al. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2015.07.015 · Cited by 1,287 · see citing works
Dehghan, M., Mente, A., Zhang, X., Swaminathan, S., Li, W., Mohan, V., Iqbal, R., Kumar, R., Wentzel-Viljoen, E., Rosengren, A., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32252-3 · Cited by 1,101 · see citing works
Self-citationAnderson, J. L., & Morrow, D. A. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1606915 · Cited by 1,125 · see citing works
Reducing the Global Burden of Cardiovascular Disease, Part 1
Joseph, P. G., Leong, D. P., McKee, M., Anand, S. S., Schwalm, J.-D., Teo, K. K., Mente, A., & Yusuf, S. (2017) · Circulation Research · doi:10.1161/circresaha.117.308903 · Cited by 1,089 · see citing works
Cardiovascular Diseases in India
Prabhakaran, D., Jeemon, P., & Roy, A. (2016) · Circulation · doi:10.1161/circulationaha.114.008729 · Cited by 928 · see citing works
Global and Regional Patterns in Cardiovascular Mortality From 1990 to 2013
Roth, G. A., Huffman, M. D., Moran, A. E., Feigin, V. L., Mensah, G. A., Naghavi, M., & Murray, C. J. L. (2015) · Circulation · doi:10.1161/circulationaha.114.008720 · Cited by 883 · see citing works
The war against heart failure: the Lancet lecture
D, E. B. M. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61889-4 · Cited by 808 · see citing works
Dagenais, G. R., Leong, D. P., Rangarajan, S., Lanas, F. T., López-Jaramillo, P. A., Gupta, R., Díaz, R., Avezum, Á., Oliveira, G. B. F., Wielgosz, A. T., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)32007-0 · Cited by 657 · see citing works
Global Public Health Burden of Heart Failure: An Updated Review
Shahim, B., Kapelios, C., Savarese, G., & Lund, L. (2023) · Cardiac failure review · doi:10.15420/cfr.2023.05 · Cited by 655 · see citing works
European Resuscitation Council Guidelines for Resuscitation 2015
Bossaert, L. L., Perkins, G. D., Askitopoulou, H., Raffay, V. I., Greif, R., Haywood, K. L., Mentzelopoulos, S. D., Nolan, J. P., Van de Voorde, P., Xanthos, T. T., et al. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2015.07.033 · Cited by 625 · see citing works
Rosengren, A., Smyth, A., Rangarajan, S., Ramasundarahettige, C. F., Bangdiwala, S. I., AlHabib, K. F., Avezum, Á., Boström, K. B., Chifamba, J., Güleç, S., et al. (2019) · The Lancet Global Health · doi:10.1016/s2214-109x(19)30045-2 · Cited by 625 · see citing works
Prabhakaran, D., Jeemon, P., Sharma, M., Roth, G. A., Johnson, C. O., Harikrishnan, S., Gupta, R., Pandian, J. D., Naik, N., Roy, A., et al. (2018) · The Lancet Global Health · doi:10.1016/s2214-109x(18)30407-8 · Cited by 542 · see citing works
Pu, L., Wang, L., Zhang, R., Zhao, T., Jiang, Y., & Han, L. (2023) · Stroke · doi:10.1161/strokeaha.122.040073 · Cited by 525 · see citing works
Anand, S. S., Hawkes, C., de Souza, R. J., Mente, A., Dehghan, M., Nugent, R., Zulyniak, M. A., Weis, T., Bernstein, A. M., Krauss, R. M., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.07.050 · Cited by 507 · see citing works
“Data from the international PURE study (138,926 individuals in 628 communities in 17 countries) suggest a need to consider the context and availability of specific foods before making food choice recommendations (114).”
MethodBergmark, B. A., Mathenge, N., Merlini, P. A., Lawrence-Wright, M. B., & Giugliano, R. P. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02391-6 · Cited by 518 · see citing works
Mente, A., O'Donnell, M., Rangarajan, S., Dagenais, G., Lear, S., McQueen, M., Diaz, R., Avezum, A., Lopez-Jaramillo, P., Lanas, F., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30467-6 · Cited by 483 · see citing works
Mobile technology and the digitization of healthcare
Bhavnani, S. P., Narula, J., & Sengupta, P. P. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv770 · Cited by 460 · see citing works
Structured telephone support or non-invasive telemonitoring for patients with heart failure
Inglis, S. C., Clark, R. A., Dierckx, R., Prieto-Merino, D., & Cleland, J. G. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007228.pub3 · Cited by 453 · see citing works
Dehghan, M., Mente, A., Rangarajan, S., Sheridan, P., Mohan, V., Iqbal, R., Gupta, R., Lear, S. A., Wentzel‐Viljoen, E., Avezum, Á., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31812-9 · Cited by 429 · see citing works
Reducing the Global Burden of Cardiovascular Disease, Part 2
Leong, D. P., Joseph, P. G., McKee, M., Anand, S. S., Teo, K. K., Schwalm, J.-D., & Yusuf, S. (2017) · Circulation Research · doi:10.1161/circresaha.117.311849 · Cited by 423 · see citing works
Khatib, R., McKee, M., Shannon, H. S., Chow, C. K., Rangarajan, S., Teo, K. K., Li, W., Mony, P. K., Mohan, V., Gupta, R., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00469-9 · Cited by 393 · see citing works
López-Jaramillo, P. A., Gómez-Arbeláez, D., Martínez-Bello, D., Abat, M. E. M., AlHabib, K. F., Avezum, Á., Барбараш, О. Л., Chifamba, J., Díaz, M. L., Güleç, S., et al. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00247-1 · Cited by 392 · see citing works
Fernández-Friera, L., Fuster, V., López-Melgar, B., Oliva, B., García-Ruiz, J. M., Mendiguren, J., Bueno, H., Pocock, S., Ibáñez, B., Fernández-Ortiz, A., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.10.024 · Cited by 378 · see citing works
Understanding the rise of cardiometabolic diseases in low- and middle-income countries
Miranda, J. J., Barrientos‐Gutiérrez, T., Corvalán, C., Hyder, A. A., Lazo-Porras, M., Oni, T., & Wells, J. C. K. (2019) · Nature Medicine · doi:10.1038/s41591-019-0644-7 · Cited by 379 · see citing works
Cardiovascular Risk Factors and Prevention: A Perspective From Developing Countries
Teo, K. K., & Rafiq, T. (2021) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2021.02.009 · Cited by 386 · see citing works
Mente, A., O'Donnell, M., Rangarajan, S., McQueen, M., Dagenais, G., Wielgosz, A., Lear, S., Ah, S. T. L., Wei, L., Diaz, R., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31376-x · Cited by 332 · see citing works
Walli-Attaei, M., Joseph, P. G., Rosengren, A., Chow, C. K., Rangarajan, S., Lear, S. A., AlHabib, K. F., Davletov, K., Dans, A., Lanas, F. T., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30543-2 · Cited by 332 · see citing works
Trends in Coronary Heart Disease Epidemiology in India
Gupta, R., Mohan, I., & Narula, J. (2016) · Annals of Global Health · doi:10.1016/j.aogh.2016.04.002 · Cited by 323 · see citing works
A Community-Based Intervention for Managing Hypertension in Rural South Asia
Jafar, T. H., Gandhi, M., de Silva, H. A., Jehan, I., Naheed, A., Finkelstein, E. A., Turner, E. L., Morisky, D. E., Kasturiratne, A., Khan, A. H., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1911965 · Cited by 315 · see citing works
Li, Y., Cao, G., Jing, W., Liu, J., & Liu, M. (2022) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwac285 · Cited by 299 · see citing works
Hajifathalian, K., Ueda, P., Lu, Y., Woodward, M., Ahmadvand, A., Aguilar-Salinas, C. A., Azizi, F., Cifkova, R., Di Cesare, M., Eriksen, L., et al. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00081-9 · Cited by 287 · see citing works
Norheim, O. F., Jha, P., Admasu, K., Godal, T., Hum, R. J., Kruk, M. E., Gómez‐Dantés, O., Mathers, C. D., Pan, H., Sepúlveda, J., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61591-9 · Cited by 291 · see citing works
Mente, A., Dehghan, M., Rangarajan, S., McQueen, M., Dagenais, G., Wielgosz, A., Lear, S., Li, W., Chen, H., Yi, S., et al. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30283-8 · Cited by 268 · see citing works
Grip strength and mortality: a biomarker of ageing?
Sayer, A. A., & Kirkwood, T. B. L. (2015) · The Lancet · doi:10.1016/s0140-6736(14)62349-7 · Cited by 263 · see citing works
Prevention of stroke: a strategic global imperative
Feigin, V. L., Norrving, B., George, M. G., Foltz, J. L., Roth, G. A., & Mensah, G. A. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.107 · Cited by 250 · see citing works
Ruan, Y., Guo, Y., Zheng, Y., Huang, Z., Sun, S., Kowal, P. R., Shi, Y., & Wu, F. (2018) · BMC Public Health · doi:10.1186/s12889-018-5653-9 · Cited by 250 · see citing works
The household economic burden of non-communicable diseases in 18 countries
Murphy, A., Palafox, B., Walli-Attaei, M., Powell‐Jackson, T., Rangarajan, S., AlHabib, K. F., Avezum, Á., Tümerdem, B. Ç., Chifamba, J., Choudhury, T., et al. (2020) · BMJ Global Health · doi:10.1136/bmjgh-2019-002040 · Cited by 234 · see citing works
Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality
Jenkins, D. J. A., Dehghan, M., Mente, A., Bangdiwala, S. I., Rangarajan, S., Srichaikul, K., Mohan, V., Avezum, Á., Díaz, R., Rosengren, A., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2007123 · Cited by 234 · see citing works
Smyth, A., Teo, K. K., Rangarajan, S., O'Donnell, M., Zhang, X., Rana, P., Leong, D. P., Dagenais, G., Seron, P., Rosengren, A., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00235-4 · Cited by 230 · see citing works
Self-citationAdvances in tissue engineering of nanocellulose-based scaffolds: A review
Luo, H., Cha, R., Li, J., Hao, W., Zhang, Y., & Zhou, F. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115144 · Cited by 228 · see citing works
Attaei, M. W., Khatib, R., McKee, M., Lear, S., Dagenais, G., Igumbor, E. U., AlHabib, K. F., Kaur, M., Kruger, L., Teo, K., et al. (2017) · The Lancet Public Health · doi:10.1016/s2468-2667(17)30141-x · Cited by 209 · see citing works
Hystad, P., Larkin, A., Rangarajan, S., AlHabib, K. F., Avezum, Á., Tümerdem, B. Ç., Chifamba, J., Dans, A., Díaz, R., du Plessis, J., et al. (2020) · The Lancet Planetary Health · doi:10.1016/s2542-5196(20)30103-0 · Cited by 208 · see citing works
Machine Learning Approach to Detect Cardiac Arrhythmias in ECG Signals: A Survey
Sahoo, S. K., Dash, M., Behera, S., & Sabut, S. (2020) · IRBM · doi:10.1016/j.irbm.2019.12.001 · Cited by 198 · see citing works
International Impact of COVID-19 on the Diagnosis of Heart Disease
Einstein, A. J., Shaw, L. J., Hirschfeld, C. B., Williams, M. A., Villines, T. C., Better, N., Vitola, J. V., Cerci, R., Dorbala, S., Raggi, P., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.10.054 · Cited by 190 · see citing works
Won, K., Park, E. J., Han, D., Lee, J. H., Choi, S., Chun, E. J., Park, S. H., Han, H., Sung, J., Jung, H. O., et al. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01008-5 · Cited by 193 · see citing works
Hystad, P., Duong, M., Brauer, M. D., Larkin, A., Arku, R. E., Kurmi, O., Fan, W. Q., Avezum, Á., Azam, I., Chifamba, J., et al. (2019) · Environmental Health Perspectives · doi:10.1289/ehp3915 · Cited by 182 · see citing works
Addressing disparities in the global epidemiology of stroke
Prust, M., Forman, R., & Ovbiagele, B. I. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-023-00921-z · Cited by 191 · see citing works
Cardiovascular diseases in Africa in the twenty-first century: Gaps and priorities going forward
Minja, N. W., Nakagaayi, D., Aliku, T. O., Zhang, W., Ssinabulya, I., Nabbaale, J., Amutuhaire, W., de Loizaga, S. R., Ndagire, E., Rwebembera, J., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1008335 · Cited by 183 · see citing works
SIRT3: A New Regulator of Cardiovascular Diseases
Sun, W., Liu, C., Chen, Q., Liu, N., Yan, Y., & Liu, B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7293861 · Cited by 170 · see citing works
Long-Term Evolution of Premature Coronary Artery Disease
Collet, J., Zeitouni, M., Procopi, N., Hulot, J., Silvain, J., Kernéis, M., Thomas, D., Lattuca, B., Barthélémy, O., Badie, Y. L., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.08.1002 · Cited by 170 · see citing works
Sarangadharan, I., Regmi, A., Chen, Y.-W., Hsu, C.-P., Chen, P., Chang, W.-H., Lee, G.-Y., Chyi, J., Shiesh, S., Lee, G., et al. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.09.018 · Cited by 169 · see citing works
AlHabib, K. F., Batais, M. A., Almigbal, T. H., Alshamiri, M. Q., Altaradi, H. B., Rangarajan, S., & Yusuf, S. (2020) · BMC Public Health · doi:10.1186/s12889-020-09298-w · Cited by 167 · see citing works
Johnson, C. B., Davis, M. K., Law, A., & Sulpher, J. A. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.04.008 · Cited by 164 · see citing works
Li, F., Wang, Y., Shi, B., Sun, S., Wang, S., Pang, S., & Wu, X. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02114-w · Cited by 164 · see citing works
Prabhakaran, D., Anand, S., Watkins, D., Gaziano, T., Wu, Y., Mbanya, J. C., Nugent, R., Ajay, V. S., Afshin, A., Adler, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)32471-6 · Cited by 162 · see citing works
Self-citationThe Situation-Specific Theory of Heart Failure Self-care
Riegel, B. J., Dickson, V. V., & Vellone, E. (2022) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000919 · Cited by 176 · see citing works
Li, S., Liu, Z., Joseph, P. G., Hu, B., Yin, L., Tse, L. A., Rangarajan, S., Wang, C., Wang, Y., Islam, S., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac268 · Cited by 162 · see citing works
Recent trends in epidemiology of dyslipidemias in India
Gupta, R., Rao, R. S., Misra, A., & Sharma, S. K. (2017) · Indian Heart Journal · doi:10.1016/j.ihj.2017.02.020 · Cited by 166 · see citing works
Bhavnani, S. P., Parakh, K., Atreja, A., Druz, R. S., Graham, G. N., Hayek, S. S., Krumholz, H. M., Maddox, T. M., Majmudar, M. D., Rumsfeld, J. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.10.018 · Cited by 162 · see citing works
Diet, cardiovascular disease, and mortality in 80 countries
Mente, A., Dehghan, M., Rangarajan, S., O'Donnell, M. J., Hu, W., Dagenais, G. R., Wielgosz, A. T., Lear, S. A., Li, W., Díaz, R., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad269 · Cited by 161 · see citing works
Kalra, A., Jose, A. P., Prabhakaran, P., Kumar, A., Agrawal, A., Roy, A., Bhargava, B., Tandon, N., & Prabhakaran, D. (2023) · The Lancet Regional Health - Southeast Asia · doi:10.1016/j.lansea.2023.100156 · Cited by 167 · see citing works
Bhowmik, B., Siddiquee, T., Mujumder, A., Afsana, F., Ahmed, T., Mdala, I., Moreira, N. C., Khan, A., Hussain, A., Holmboe-Ottesen, G., et al. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15091944 · Cited by 157 · see citing works
Okop, K., Mukumbang, F. C., Mathole, T., Levitt, N. S., & Puoane, T. R. (2016) · BMC Public Health · doi:10.1186/s12889-016-3028-7 · Cited by 155 · see citing works
The World Heart Federation's vision for worldwide cardiovascular disease prevention
Yusuf, S., Wood, D., Ralston, J., & Reddy, K. S. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60265-3 · Cited by 154 · see citing works
Primary prevention of ischaemic heart disease: populations, individuals, and health professionals
Gupta, R., & Wood, D. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31893-8 · Cited by 154 · see citing works
Resource Effective Strategies to Prevent and Treat Cardiovascular Disease
Schwalm, J.-D., McKee, M., Huffman, M. D., & Yusuf, S. (2016) · Circulation · doi:10.1161/circulationaha.115.008721 · Cited by 152 · see citing works
Ueda, P., Woodward, M., Lu, Y., Hajifathalian, K., Al‐Wotayan, R., Aguilar-Salinas, C. A., Ahmadvand, A., Azizi, F., Bentham, J., Cífková, R., et al. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30015-3 · Cited by 150 · see citing works
Proteomics and lipidomics in atherosclerotic cardiovascular disease risk prediction
Nurmohamed, N. S., Kraaijenhof, J. M., Mayr, M., Nicholls, S. J., Köenig, W., Catapano, A. L., & Stroes, E. S. G. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad161 · Cited by 154 · see citing works
Mohan, D., Mente, A., Dehghan, M., Rangarajan, S., O'Donnell, M. J., Hu, W., Dagenais, G. R., Wielgosz, A. T., Lear, S. A., Li, W., et al. (2021) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2021.0036 · Cited by 147 · see citing works
Langhorne, P., O'Donnell, M. J., Chin, S. L., Zhang, H., Xavier, D., Avezum, Á., Mathur, N., Turner, M. E., MacLeod, M. J., López-Jaramillo, P. A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30802-x · Cited by 146 · see citing works
Park, G., Cho, Y., Won, K., Yang, Y. J., Park, S., Ann, S. H., Kim, Y., Park, E. J., Kim, S., Lee, S.-G., et al. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-1187-0 · Cited by 144 · see citing works
Walli-Attaei, M., Rosengren, A., Rangarajan, S., Breet, Y., Abdul-Razak, S., Sharief, W., AlHabib, K. F., Avezum, Á., Chifamba, J., Díaz, R., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01441-6 · Cited by 144 · see citing works
The Stroke Riskometer™ App: Validation of a Data Collection Tool and Stroke Risk Predictor
Parmar, P. G. K., Krishnamurthi, R., Ikram, M. A., Albert Hofman, D., Mirza, S. S., Varakin, Y. Y., Kravchenko, M. A., Пирадов, М. А., Thrift, A. G., Norrving, B. G., et al. (2014) · International Journal of Stroke · doi:10.1111/ijs.12411 · Cited by 137 · see citing works
Liver X receptors at the intersection of lipid metabolism and atherogenesis
Lee, S. D., & Tontonoz, P. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.06.042 · Cited by 133 · see citing works
NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes
Hong, P., Gu, R., Li, F., Xiong, X., Liang, W., You, Z.-J., & Zhang, H. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1498-0 · Cited by 136 · see citing works
Improved cardiovascular risk prediction using targeted plasma proteomics in primary prevention
Hoogeveen, R. M., Pereira, J. P. B., Nurmohamed, N. S., Zampoleri, V., Bom, M. J., Baragetti, A., Boekholdt, S. M., Knaapen, P., Khaw, K., Wareham, N. J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa648 · Cited by 130 · see citing works
Jacob, M. A., Ekker, M. S., Allach, Y., Cai, M., Aarnio, K., Araúz, A., Arnold, M., Bae, H., Bandeo, L., Barboza, M. A., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000013195 · Cited by 131 · see citing works
Seid, M. A., Abdela, O. A., & Zeleke, E. G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211768 · Cited by 128 · see citing works
Incidence of Major Cardiovascular Events in Immigrants to Ontario, Canada
Tu, J. V., Chu, A., Rezai, M. R., Guo, H., Maclagan, L. C., Austin, P. C., Booth, G. L., Manuel, D. G., Chiu, M., Ko, D. T., et al. (2015) · Circulation · doi:10.1161/circulationaha.115.015345 · Cited by 126 · see citing works
Li, S., Lear, S. A., Rangarajan, S., Hu, B., Yin, L., Bangdiwala, S. I., AlHabib, K. F., Rosengren, A., Gupta, R., Mony, P. K., et al. (2022) · JAMA Cardiology · doi:10.1001/jamacardio.2022.1581 · Cited by 131 · see citing works
O'Donnell, M. J., Mente, A., Rangarajan, S., McQueen, M., O’Leary, N., Yin, L., Liu, X., Swaminathan, S., Khatib, R., Rosengren, A., et al. (2019) · BMJ · doi:10.1136/bmj.l772 · Cited by 128 · see citing works
Chow, C. K., Nguyen, T. N., Marschner, S. L., Díaz, R., Rahman, O., Avezum, Á., Lear, S. A., Teo, K. K., Yeates, K., Lanas, F. T., et al. (2020) · BMJ Global Health · doi:10.1136/bmjgh-2020-002640 · Cited by 125 · see citing works
Naito, R., Leong, D. P., Bangdiwala, S. I., McKee, M., Subramanian, S. V., Rangarajan, S., Islam, S., Avezum, Á., Yeates, K., Lear, S. A., et al. (2021) · BMJ Global Health · doi:10.1136/bmjgh-2020-004124 · Cited by 128 · see citing works
Xavier, D., Gupta, R., Kamath, D. Y., Sigamani, A., Devereaux, P. J., George, N. A., Joshi, R. P., Pogue, J. M., Pais, P. S., & Yusuf, S. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00480-5 · Cited by 125 · see citing works
Cardiovascular Diseases in India Compared With the United States
Prabhakaran, D., Singh, K., Roth, G. A., Banerjee, A., Pagidipati, N. J., & Huffman, M. D. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.04.042 · Cited by 125 · see citing works
World Heart Federation Roadmap for Secondary Prevention of Cardiovascular Disease: 2023 Update
Laranjo, L., Lanas, F. T., Sun, M. C., Chen, D. A., Hynes, L., Imran, T. F., Kazi, D. S., Kengne, A. P., Komiyama, M., Kuwabara, M., et al. (2024) · Global Heart · doi:10.5334/gh.1278 · Cited by 133 · see citing works
Perel, P., Avezum, Á., Huffman, M. D., Pais, P. S., Rodgers, A., Vedanthan, R., Wood, D., & Yusuf, S. (2015) · Global Heart · doi:10.1016/j.gheart.2015.04.003 · Cited by 118 · see citing works
Predictive role of circulating endothelial-derived microparticles in cardiovascular diseases.
Berezin, A., Zulli, A., Kerrigan, S., Petrovič, D., & Kruzliak, P. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.02.003 · Cited by 112 · see citing works
Owolabi, M. O., Yaria, J. O., Daivadanam, M., Makanjuola, A., Parker, G., Oldenburg, B. F., Vedanthan, R., Norris, S. A., Oguntoye, A. R., Osundina, M. A., et al. (2018) · Diabetes Care · doi:10.2337/dc17-1795 · Cited by 114 · see citing works
Lu, Y., Zollner-Kiechl, S., Wang, J., Xu, Q., Kiechl, S. J., Pechlaner, R., Aguilar, D. A., Al-Hashmi, K., Alvim, R. D. O., Al-Zakwani, I. S., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104619 · Cited by 114 · see citing works
Palafox, B., McKee, M., Balabanova, D., AlHabib, K. F., Avezum, Á., Bahonar, A., Ismail, N. H., Chifamba, J., Chow, C. K., Corsi, D. J., et al. (2016) · International Journal for Equity in Health · doi:10.1186/s12939-016-0478-6 · Cited by 111 · see citing works
Cardiovascular disease (CVD): assessment, prediction and policy implications
Rehman, S., Rehman, E., Ikram, M., & Jianglin, Z. (2021) · BMC Public Health · doi:10.1186/s12889-021-11334-2 · Cited by 118 · see citing works
Yan, R., Li, W., Yin, L., Wang, Y., Bo, J., Liu, L., Liu, B., Hu, B., Chen, C., Guo, J., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004445 · Cited by 108 · see citing works
Alma Ata at 40 years: reflections from the Lancet Commission on Investing in Health
Watkins, D. A., Yamey, G., Schäferhoff, M., Adeyi, O., Alleyne, G., Alwan, A., Berkley, S., Feachem, R., Frenk, J., Ghosh, G., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32389-4 · Cited by 105 · see citing works
- Authors
- Yusuf, S., Rangarajan, S., Teo, K., Islam, S., Li, W., Liu, L., Bo, J., Lou, Q., Lu, F., Liu, T., Yu, L., Zhang, S., Mony, P., Swaminathan, S., Mohan, V., Gupta, R., Kumar, R., Vijayakumar, K., Lear, S., Anand, S., Wielgosz, A., Diaz, R., Avezum, A., Lopez-Jaramillo, P., Lanas, F., Yusoff, K., Ismail, N., Iqbal, R., Rahman, O., Rosengren, A., Yusufali, A., Kelishadi, R., Kruger, A., Puoane, T., Szuba, A., Chifamba, J., Oguz, A., McQueen, M., McKee, M., & Dagenais, G.
- Affiliations
- University of Ottawa (CA)
- Population Health Research Institute (CA)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shandong First Medical University (CN)
- St. John's Research Institute (IN)
- Madras Diabetes Research Foundation (IN)
- Fortis Escorts Hospital (IN)
- Post Graduate Institute of Medical Education and Research (IN)
- Health Action by People (IN)
- Simon Fraser University (CA)
- Universidad de La Frontera (CL)
- UCSI University (MY)
- Aga Khan University (PK)
- Independent University, Bangladesh (BD)
- University of Gothenburg (SE)
- Dubai Health Authority (AE)
- Isfahan University of Medical Sciences (IR)
- North-West University (ZA)
- University of the Western Cape (ZA)
- Wroclaw Medical University (PL)
- University of Zimbabwe (ZW)
- London School of Hygiene & Tropical Medicine (GB)
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- ORCID
- Yusuf, Salim
- Rangarajan, Sumathy
- Teo, Koon
- Islam, Shofiqul
- Li, Wei
- Liu, Lisheng
- Liu, Tianlu
- Mony, Prem
- Swaminathan, Sumathi
- Mohan, Viswanathan
- Gupta, Rajeev
- Kumar, Rajesh
- Lear, Scott
- Anand, Sonia
- Wielgosz, Andreas
- Lanas, Fernando
- Yusoff, Khalid
- Iqbal, Romaina
- Rahman, Omar
- Rosengren, Annika
- Yusufali, Afzalhussein
- Kelishadi, Roya
- Puoane, Thandi
- Szuba, Andrzej
- Chifamba, Jephat
- McKee, Martin
- Dagenais, Gilles
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-08-28
- Volume
- 371
- Issue
- 9
- Pages
- 818-827
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2151739272
- Cited by
- 983
- References
- 17
- Citations by year
- 2026: 48 · 2025: 64 · 2024: 123 · 2023: 84 · 2022: 73 · 2021: 87 · 2020: 109 · 2019: 78 · 2018: 75 · 2017: 79 · 2016: 80 · 2015: 70 · 2014: 12
- FWCI
- 55.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Repositorio Universidad de Santander (submittedVersion, cc-by-nc)
- Omeka S (Universidad de La Frontera) (submittedVersion, cc-by-nc-nd)
- Boloka Institutional Repository (North-west University) (submittedVersion)
- UWC Research Repository (University of the Western Cape) (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
- Keywords
- cardiovascular disease, cardiovascular risk, risk factor burden, low-income countries, middle-income countries, high-income countries, cardiovascular mortality, myocardial infarction, stroke, heart failure, case fatality, urban-rural differences, revascularization, global health disparities
- MeSH terms
- Cardiovascular Diseases, Female, Humans, Income, Male, Middle Aged, Risk Factors, Rural Health, Urban Health, Global Health, Risk Assessment
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