The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Roles of exosomes in cardioprotection
Open accessAbstract
Exosomes are extracellular vesicles of endosomal origin which have emerged as key mediators of intercellular communication. All major cardiac cell types-including cardiomyocytes, endothelial cells, and fibroblasts-release exosomes that modulate cellular functions. Exosomes released from human cardiac progenitor cells (CPCs) are cardioprotective and improve cardiac function after myocardial infarction to an extent comparable with that achieved by their parent cells. Cardiac progenitor cell-derived exosomes are enriched in cardioprotective microRNAs, particularly miR-146a-3p. Circulating exosomes mediate remote ischaemic preconditioning. Moreover, they currently are being investigated as diagnostic markers. The discovery that cell-derived extracellular signalling organelles mediate the paracrine effects of stem cells suggests that cell-free strategies could supplant cell transplantation. This review discusses emerging roles of exosomes in cardiovascular physiology, with a focus on cardioprotective activities of CPC-derived exosomes.
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Cites
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Cited by
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Longterm Exercise-Derived Exosomal miR-342-5p: A Novel Exerkine for Cardioprotection
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Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression
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Metadata
- Authors
- Barile, L., Moccetti, T., Marbán, E., & Vassalli, G.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-07-21
- Volume
- 38
- Issue
- 18
- Pages
- ehw304
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2497469513
- Cited by
- 294
- References
- 46
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- green
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