The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression
Abstract
Extracellular communication in the tumor microenvironment is critical. Results of qRT-PCR show that circ-0051443 is significantly lower in the plasma exosomes and tissues from patients with hepatocellular carcinoma (HCC) than healthy controls. Compared with the producer cells, circ-0051443 is mainly packaged into exosomes. A receiver operating characteristic curve (ROC) shows that the patients with HCC can be distinguished from the controls by exosomal circ-0051443. The role of exosomal circ-0051443 in HCC was determined by animal and cell analyses. Circ-0051443 is transmitted from normal cells to HCC cells via exosomes and suppresses the malignant biological behaviors by promoting cell apoptosis and arresting the cell cycle. Exosomal circ-0051443 decreases the weight and volume of the xenograft tumors in nude mice via BAK1 upregulation in these tumors. BAK1 expression is mediated by exosomal circ-0051443 through competitive bound to miR-331-3p. Therefore, exosomal circ-0051443 can serve as a predictor and potential therapeutic target for HCC.
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1 retracted
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family
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CircRNA: a novel type of biomarker for cancer
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Exosome mediated communication within the tumor microenvironment
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Li, C., Ni, Y.-Q., Xu, H., Xiang, Q.-Y., Zhao, Y., Zhan, J.-K., He, J.-Y., Li, S., & Liu, Y.-S. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00779-x · Cited by 406
The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs
Zhang, L., Hou, C., Chen, C., Guo, Y., Yuan, W., Yin, D., Liu, J., & Sun, Z. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01224-3 · Cited by 331
Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies
Wang, S., Zhang, K., Tan, S., Xin, J., Yuan, Q., Xu, H., Xu, X., Liang, Q., Christiani, D. C., Wang, M., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-020-01298-z · Cited by 331
Recent advances in exosome-mediated nucleic acid delivery for cancer therapy
Zhang, Y., Liu, Q., Zhang, X., Huang, H., Tang, S., Chai, Y., Xu, Z., Li, M., Chen, X., Liu, J., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01472-z · Cited by 306
Self-citationRecent Advances in Exosome-Based Drug Delivery for Cancer Therapy
Kim, H., Jang, H., Cho, H., Choi, J., Hwang, K. Y., Choi, Y., Kim, S. H., & Yang, Y. (2021) · Cancers · doi:10.3390/cancers13174435 · Cited by 152
Metadata
- Authors
- Chen, W., Quan, Y., Fan, S., Wang, H., Liang, J., Huang, L., Chen, L., Liu, Q., He, P., & Ye, Y.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 475
- Pages
- 119-128
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W3003969359
- Cited by
- 268
- References
- 34
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, W., Quan, Y., Fan, S., Wang, H., Liang, J., Huang, L., Chen, L., Liu, Q., He, P., & Ye, Y. (2020). Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression. Cancer Letters. https://doi.org/10.1016/j.canlet.2020.01.022
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