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Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF
Open accessAbstract
Aims: To date, clinical evidence of microvascular dysfunction in patients with heart failure (HF) with preserved ejection fraction (HFpEF) has been limited. We aimed to investigate the prevalence of coronary microvascular dysfunction (CMD) and its association with systemic endothelial dysfunction, HF severity, and myocardial dysfunction in a well defined, multi-centre HFpEF population. Methods and results: This prospective multinational multi-centre observational study enrolled patients fulfilling strict criteria for HFpEF according to current guidelines. Those with known unrevascularized macrovascular coronary artery disease (CAD) were excluded. Coronary flow reserve (CFR) was measured with adenosine stress transthoracic Doppler echocardiography. Systemic endothelial function [reactive hyperaemia index (RHI)] was measured by peripheral arterial tonometry. Among 202 patients with HFpEF, 151 [75% (95% confidence interval 69-81%)] had CMD (defined as CFR <2.5). Patients with CMD had a higher prevalence of current or prior smoking (70% vs. 43%; P = 0.0006) and atrial fibrillation (58% vs. 25%; P = 0.004) compared with those without CMD. Worse CFR was associated with higher urinary albumin-to-creatinine ratio (UACR) and NTproBNP, and lower RHI, tricuspid annular plane systolic excursion, and right ventricular (RV) free wall strain after adjustment for age, sex, body mass index, atrial fibrillation, diabetes, revascularized CAD, smoking, left ventricular mass, and study site (P < 0.05 for all associations). Conclusions: PROMIS-HFpEF is the first prospective multi-centre, multinational study to demonstrate a high prevalence of CMD in HFpEF in the absence of unrevascularized macrovascular CAD, and to show its association with systemic endothelial dysfunction (RHI, UACR) as well as markers of HF severity (NTproBNP and RV dysfunction). Microvascular dysfunction may be a promising therapeutic target in HFpEF.
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“Obesity and diabetes create a pro-inflammatory state and promote endothelial and coronary microvascular dysfunction. 1,7,8”
From Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials (2024) · cites this paper as [8]
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“Inhibition of systemic metabolic inflammation with glucose-lowering drugs is thought to enhance endothelial and cardiomyocyte function”
From The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF (2023) · cites this paper as [72]
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McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 20,604
Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.10.003 · Cited by 12,362
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429
Lang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J., Shanewise, J. S., et al. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.10.005 · Cited by 11,318
Rudski, L., Lai, W. W., Afilalo, J., Hua, L., Handschumacher, M. D., Chandrasekaran, K., Solomon, S. D., Louie, E. K., & Schiller, N. B. (2010) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2010.05.010 · Cited by 7,080
2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.592 · Cited by 5,866
Nagueh, S. F., Smiseth, O. A., Appleton, C. P., Byrd, B. F., Dokainish, H., Edvardsen, T., Flachskampf, F. A., Gillebert, T. C., Klein, A. L., Lancellotti, P., et al. (2016) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2016.01.011 · Cited by 5,262
2013 ESC guidelines on the management of stable coronary artery disease
Task Force Members, Montalescot, G., Sechtem, U., Achenbach, S., Andreotti, F., Arden, C., Budaj, A., Bugiardini, R., Crea, F., Cuisset, T., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht296 · Cited by 4,510
Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography
Nagueh, S. F., Appleton, C. P., Gillebert, T. C., Marino, P. N., Oh, J. K., Smiseth, O. A., Waggoner, A. D., Flachskampf, F. A., Pellikka, P. A., & Evangelista, A. (2009) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2008.11.023 · Cited by 4,367
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564
Cited by
Sorted by citations
Items 201–300 of 656
Seferović, P., Farmakis, D., Bayes-Genis, A., Ben Gal, T., Böhm, M., Chioncel, O., Ferrari, R., Filippatos, G., Hill, L., Jankowska, E., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2575 · Cited by 24
Self-citationDiabetes Mellitus and Heart Failure With Preserved Ejection Fraction: Role of Obesity
Dhore-Patil, A., Thannoun, T., Samson, R., & Jemtel, T. H. L. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.785879 · Cited by 27
Mordi, I. R., Tee, A., Palmer, C. N., McCrimmon, R. J., Doney, A. S. F., & Lang, C. C. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12669 · Cited by 22
Clinical Phenogroups in Heart Failure with Preserved Ejection Fraction
Sorimachi, H., Omote, K., & Borlaug, B. A. (2021) · Heart Failure Clinics · doi:10.1016/j.hfc.2021.02.009 · Cited by 24
Özcan, C., Allan, T. E., Besser, S. A., de la Pena, A., & Blair, J. E. (2021) · PubMed Central · Cited by 22
Shityakov, S., Nagai, M., Ergün, S., Braunger, B. M., & Förster, C. Y. (2022) · Biomolecules · doi:10.3390/biom12081113 · Cited by 23
Valentini, A., Cardillo, C., Della‐Morte, D., & Tesauro, M. (2023) · Biomedicines · doi:10.3390/biomedicines11113006 · Cited by 22
Riccardi, M., Čikeš, M., Adamo, M., Pagnesi, M., Lombardi, C., Solomon, S. D., Metra, M., & Inciardi, R. M. (2024) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2024.02.024 · Cited by 23
Shah, S. J. (2019) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2019.08.002 · Cited by 23
Mahfouz, R. A., Gouda, M., & Abdelhamid, M. (2020) · Echocardiography · doi:10.1111/echo.14799 · Cited by 22
Navigating the Landscape of Coronary Microvascular Research: Trends, Triumphs, and Challenges Ahead
Wang, Y., Wang, B., Ling, H., Li, Y., Fu, S., Xu, M., Li, B., Liu, X., Wang, Q., Li, A., et al. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2508288 · Cited by 21
Insights into the post-translational modifications in heart failure
Zhang, X., Wang, Y., Li, H., Wang, D. W., & Chen, C. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102467 · Cited by 26
Martinez, C. S., Zheng, A., & Xiao, Q. (2024) · Antioxidants · doi:10.3390/antiox13111330 · Cited by 26
Allan, T. E., Dryer, K., Fearon, W. F., Shah, S. J., & Blair, J. E. (2019) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2019.08.010 · Cited by 21
Gao, J., Meng, T., Li, M., Du, R., Ding, J., Li, A., Yu, S., Li, Y., & He, Q. (2022) · European journal of medical research · doi:10.1186/s40001-022-00869-8 · Cited by 21
Coronary Microvascular Dysfunction and the Role of Noninvasive Cardiovascular Imaging
Ayub, M. T., & Kalra, D. K. (2020) · Diagnostics · doi:10.3390/diagnostics10090679 · Cited by 21
Yu, J., Arnott, C. G., Neuen, B. L., Heersprink, H. J. L., Mahaffey, K. W., Cannon, C. P., Khan, S. S., Baldridge, A. S., Shah, S. J., Huang, Y., et al. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13236 · Cited by 21
Coronary microvascular disease in women: epidemiology, mechanisms, evaluation, and treatment
Steinberg, R. S., Dragan, A., Mehta, P. K., & Toleva, O. (2024) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2023-0414 · Cited by 20
Cardiac Effects of Modern Breast Radiation Therapy in Patients Receiving Systemic Cancer Therapy
Berlin, E. E., Ko, K., Ma, L., Messing, I., Hollawell, C., Smith, A. M., Taunk, N. K., Narayan, V., Upshaw, J. N., Clark, A. S., et al. (2025) · JACC CardioOncology · doi:10.1016/j.jaccao.2025.01.012 · Cited by 20
Tatekoshi, Y., Mahmoodzadeh, A., Shapiro, J. S., Liu, M., Bianco, G. M., Tatekoshi, A., Camp, S. D., Jesus, A. D., Koleini, N., Torre, S. D. L., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.04.001 · Cited by 20
Lala, A., Beavers, C. J., Blumer, V. L., Brewer, L. C., Oliveira-Gomes, D. D., Dunbar, S. B., Every, H., Ferraro, R., Ky, B., Januzzi, J. L., et al. (2025) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2025.06.013 · Cited by 26
Landsteiner, I., Verwerft, J., Belov, D., Verbrugge, F. H., & Lewis, G. D. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag175 · Cited by 22
Effect of Training on Vascular Function and Repair in Heart Failure With Preserved Ejection Fraction
Gevaert, A. B., Böhm, B., Hartmann, H., Goovaerts, I., Stoop, T., Heyning, C. M. V. D., Beckers, P. J., Baldassarri, F., Mueller, S., Oberhoffer, R., et al. (2023) · JACC Heart Failure · doi:10.1016/j.jchf.2022.12.011 · Cited by 20
Coronary microvascular dysfunction in heart failure patients
Toya, T., Nagatomo, Y., Ikegami, Y., Masaki, N., & Adachi, T. K. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1153994 · Cited by 19
Tromp, J., Hage, C., Ouwerkerk, W., Wijk, S. S., Svedlund, S., Saraste, A., Faxén, U. L., Fermer, M. L., Gan, L., Lund, L. H., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.042569 · Cited by 20
Risk of Incident Heart Failure and Heart Failure Subtypes in Patients With Rheumatoid Arthritis
Kawano, Y., Weber, B., Weisenfeld, D., Jeffway, M. I., Cai, T. A., McDermott, G. C., Liu, Q., Sparks, J. A., Stuart, J. J., Joseph, J., et al. (2024) · Arthritis Care & Research · doi:10.1002/acr.25481 · Cited by 21
Assessment and Treatment for Coronary Microvascular Dysfunction by Contrast Enhanced Ultrasound
Zhan, J., Zhong, L., & Wu, J. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.899099 · Cited by 19
Canto, E. D., van Deursen, L., Hoek, A. G., Elders, P. J. M., den Ruijter, H. M., van der Velden, J., van Empel, V. P. M., Serné, E. H., Eringa, E. C., & Beulens, J. W. J. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01935-z · Cited by 19
Vecchia, G. L., Fumarulo, I., Caffè, A., Chiatto, M., Montone, R. A., & Aspromonte, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147628 · Cited by 20
ANOCA updated: From pathophysiology to modern clinical practice
Dimitriadis, K. S., Pyrpyris, N., Sakalidis, A., Dri, E., Iliakis, P., Tsioufis, P., Tatakis, F., Beneki, E., Fragkoulis, C., Aznaouridis, K. A., et al. (2024) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2024.09.010 · Cited by 19
A window of opportunity on cardiovascular prevention: pre-eclampsia and fetal growth restriction
Sciatti, E., & Orabona, R. (2020) · European Journal of Preventive Cardiology · doi:10.1177/2047487320925646 · Cited by 19
Küçükseymen, S., Neisius, U., Rodriguez, J., Tsao, C. W., & Nezafat, R. (2020) · International journal of cardiac imaging · doi:10.1007/s10554-020-01915-4 · Cited by 19
Russell‐Hallinan, A., Watson, C. J., O’Dwyer, D., Grieve, D., & O’Neill, K. M. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07019-4 · Cited by 18
HFpEF and sex: understanding the role of sex differences
Smereka, Y., & Ezekowitz, J. A. (2024) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2023-0403 · Cited by 24
RADAKRISHNAN, A., AGRAWAL, S., SINGH, N., Barbieri, A., Shaw, L. J., Gulati, M., & Lala, A. (2025) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2025.01.008 · Cited by 19
The Role of Coronary Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction
Tzoumas, A., Tapp, D. N., Crousillat, D. R., Honigberg, M. C., Lozano, P. F. R., Aggarwal, N. R., Ebong, I., Briller, J. E., de Oliveira, G. M., Harrington, C. M., et al. (2025) · JACC Advances · doi:10.1016/j.jacadv.2025.102345 · Cited by 23
Orabona, R., Mohseni, Z., Sciatti, E., Mulder, E., Prefumo, F., Lorusso, R., Frusca, T., Ghossein‐Doha, C., & Spaanderman, M. E. A. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002496 · Cited by 18
Wu, P., Zhang, X.-L., Wu, Z.-F., Chen, H.-Z., Guo, X.-S., Jin, C.-R., Qin, G., Wang, R.-N., Wang, H.-L., Sun, Q.-T., et al. (2022) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05566-y · Cited by 13
Chung, Y. J., Choi, K. H., Lee, S. H., Shin, D., Hong, D., Park, S., Joh, H. S., Kim, H. K., Ha, S. J., Park, T. K., et al. (2022) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2022.11.014 · Cited by 19
Palazzuoli, A., Tramonte, F., & Beltrami, M. (2023) · Biomolecules · doi:10.3390/biom13010173 · Cited by 18
Bentea, G. P., Berdaoui, B., Morissens, M., van de Borne, P., & Rodriguez, J. C. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.124.037552 · Cited by 24
Ambrosino, P., Papa, A., Buonauro, A., Mosella, M., Calcaterra, I. L., Spedicato, G. A., Maniscalco, M., & Minno, M. N. D. D. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13552 · Cited by 18
Coronary Flow, Left Ventricular Contractile and Heart Rate Reserve in Non-Ischemic Heart Failure
Daros, C. B., Ciampi, Q., Cortigiani, L., Gaibazzi, N., Rigo, F., Wierzbowska-Drabik, K. A., Kasprzak, J. D., Dodi, C., Villari, B., Antonini‐Canterin, F., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153405 · Cited by 18
Exercise stress echocardiography with ABCDE protocol in unexplained dyspnoea
the Stress Echo 2020 study group of the Italian Society of Echocardiography, C. I., Zagatina, A., ZHURAVSKAYA, N., Шматов, Д. В., Ciampi, Q., Carpeggiani, C., & Picano, E. (2020) · International journal of cardiac imaging · doi:10.1007/s10554-020-01789-6 · Cited by 18
Lala, A., Beavers, C. J., Blumer, V. L., Brewer, L. C., Oliveira-Gomes, D. D., Dunbar, S. B., Every, H., Ferraro, R., Ky, B., Januzzi, J. L., et al. (2025) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2025.101069 · Cited by 19
Yüksel, S., Yüksel, E. P., & Meriç, M. (2020) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-200968 · Cited by 17
Xu, X., Divakaran, S., Weber, B., Hainer, J. M., Laychak, S. S., Auer, B., Kijewski, M. F., Blankstein, R., Dorbala, S., Trinquart, L., et al. (2024) · Circulation · doi:10.1161/circulationaha.123.067083 · Cited by 17
Hage, C., Wärdell, E., Linde, C. M., Donal, E., Lam, C. S. P., Daubert, J., Lund, L. H., & Månsson‐Broberg, A. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12615 · Cited by 17
Heart failure with preserved ejection fraction: insights from recent clinical researches
Kim, M., & Park, S. (2020) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2020.104 · Cited by 17
van de Bovenkamp, A. A., Bakermans, A. J., Allaart, C. P., Nederveen, A. J., Kok, W. E. M., van Rossum, A. C., & Handoko, M. L. (2020) · Netherlands Heart Journal · doi:10.1007/s12471-020-01407-z · Cited by 17
Coronary Microvascular Dysfunction: Insights on Prognosis and Future Perspectives
Gurgoglione, F. L., Benatti, G., Denegri, A., Donelli, D., Covani, M., Gregorio, M. D., Dallaglio, G., Navacchi, R., & Niccoli, G. (2025) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm25757 · Cited by 18
Etiology of Heart Failure Across the Ejection Fraction Spectrum and Association With Prognosis
Kozman, K., Ferrannini, G., Benson, L., Dahlström, U., Hage, C., Savarese, G., Shahim, B., & Lund, L. H. (2025) · JACC Heart Failure · doi:10.1016/j.jchf.2025.03.037 · Cited by 19
Li, F., Wang, J., Song, Y., Shen, D., Zhao, Y., Li, C., Fu, M., Wang, Y., Qi, B., Han, X., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119239 · Cited by 16
Faxén, J., Benson, L., Mantel, Ä., Savarese, G., Hage, C., Dahlström, U., Askling, J., Lund, L. H., & Andersson, D. C. (2023) · American Heart Journal · doi:10.1016/j.ahj.2023.02.001 · Cited by 17
Coronary Microvascular Dysfunction: Features and Prognostic Value
Kopeva, K. V., Grakova, E. V., Maltseva, A. N., Mochula, A. V., Гусакова, А. М., Smorgon, A., & Zavadovsky, K. V. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082964 · Cited by 16
Mohammed, A., Abdu, F. A., Su, Y., Liu, L., Yin, G., Feng, Y., Zhang, W., Xu, Y., Xu, D., & Che, W. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.04.011 · Cited by 17
Aldujeli, A., Patel, R. M., Grabauskytė, I., Hamadeh, A., Lieponyte, A., Tatarūnas, V., Khalifeh, H., Briedis, K., Skipskis, V., Aldujeili, M., et al. (2023) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd10050197 · Cited by 16
Saraste, A., Knuuti, J. M., & Bengel, F. M. (2023) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jead128 · Cited by 17
Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction
Jalink, E. A., Schonk, A. W., Boon, R. A., & Juni, R. P. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1300375 · Cited by 16
The impact of coronary sinus narrowing on diastolic function in patients with refractory angina
Szekely, Y., Topilsky, Y., Bazan, S., Revivo, M., Banai, S., & Konigstein, M. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.03.041 · Cited by 16
Shear, F. E. (2019) · Europe PMC (PubMed Central) · Cited by 16
Mahmood, E., Bae, S., Chaudhary, O., Feng, R., Mahmood, F. U., Robson, S. C., Lee, D., Kang, P. M., & Matyal, R. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173261 · Cited by 16
Therapeutic Stalemate in Heart Failure With Preserved Ejection Fraction
Samson, R., & Jemtel, T. H. L. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.021120 · Cited by 16
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Hillier, E. L., & Friedrich, M. G. (2021) · Current Heart Failure Reports · doi:10.1007/s11897-021-00525-y · Cited by 16
Wei, J., Nelson, M. D., Sharif, B., SHUFELT, C. L., & Merz, C. N. B. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy558 · Cited by 16
Khandait, H. V., Sodhi, S. S., Khandekar, N., & Bhattad, V. B. (2025) · Cardiorenal Medicine · doi:10.1159/000542633 · Cited by 17
Coronary microvascular disease in heart failure with preserved ejection fraction
Sen, P., Wang, L., d'Ambrosio, L., Bierschenk, S., Hamers, J., Ornek, I., Sittig, T., Zhang, H., Zhang, J., & Merkus, D. (2025) · Physiological Reports · doi:10.14814/phy2.70521 · Cited by 16
Yang, Z., Tian, R., Zhang, X., Cai, J., She, Z., & Li, H. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1120085 · Cited by 16
Ostrominski, J. W., & Vaduganathan, M. (2023) · The American Journal of Medicine · doi:10.1016/j.amjmed.2023.04.035 · Cited by 21
Liu, Y., Zhong, C., Chen, S., Xue, Y., Wei, Z., Li, D., & Kang, L. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02142-0 · Cited by 15
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Freund, O., Shetrit, A., Bar‐Shai, A., Zornitzki, L., Frydman, S., Banai, A., Shamir, R. A., Ben‐Shoshan, J., Arbel, Y., Banai, S., et al. (2024) · The American Journal of Medicine · doi:10.1016/j.amjmed.2024.02.034 · Cited by 15
Hemodynamic assessment in heart failure
Jain, C. C., & Borlaug, B. A. (2019) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.28490 · Cited by 15
Keulards, D. C. J., Bouwmeester, S., de Vos, A. M. J., Dekker, L., Pijls, N. H. J., & Houthuizen, P. (2021) · International Journal of Cardiology · doi:10.1016/j.ijcard.2021.02.055 · Cited by 15
Mancusi, C., Lembo, M., Manzi, M. V., Basile, C., Fucile, I., & Morisco, C. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11185377 · Cited by 15
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Bond, R. M., Ivy, K. N., Crumbs, T., Purewal, V., Obang, S., & Sraow, D. I. (2025) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2025.100983 · Cited by 15
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Abubakar, M., Saleem, A., Hajjaj, M., Faiz, H., Pragya, A., Jamil, R., Salim, S. S., Lateef, I. K., Singla, D. K., Ramar, R., et al. (2023) · Heart Failure Reviews · doi:10.1007/s10741-023-10369-4 · Cited by 16
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Krittanawong, C., Britt, W., Rizwan, A. M., Siddiqui, R., Khawaja, M., Khan, R., Joolharzadeh, P., Newman, N. A., Rivera, M. R. R., & Tang, W. H. W. (2024) · Current Heart Failure Reports · doi:10.1007/s11897-024-00679-5 · Cited by 17
Singh, A., Ashraf, S., Irfan, H., Venjhraj, F., Verma, A., Shaukat, A. F., Tariq, M. D., & Hamza, H. M. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002971 · Cited by 16
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Kim, M., & Park, S. (2020) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2020.104.e1 · Cited by 14
Feld, Y., Reisner, Y., Meyer-Brodnitz, G., & Hoefler, R. (2021) · Heart Failure Reviews · doi:10.1007/s10741-021-10104-x · Cited by 15
Lai, P., Nikolaev, V. O., & Jong, K. A. D. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9050163 · Cited by 13
Wan, J., Liu, S., Yang, Y., Wang, D., Ran, F., Xia, S., Ma, S., Hou, J., Zhou, P., Sun, Y., et al. (2019) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2019.1705319 · Cited by 14
Iyngkaran, P., Thomas, M. C., Neil, C., Jelinek, M. V., Cooper, M. E., Horowitz, J. D., Hare, D. L., & Kaye, D. M. (2020) · Current Heart Failure Reports · doi:10.1007/s11897-020-00454-2 · Cited by 14
Mendieta, G., Ridker, P. M., Borlaug, B. A., Ducharme, A., Lam, C. S. P., Voors, A. A., Auerbach, P., Čikeš, M., Fudim, M., Hvelplund, A., et al. (2026) · European Journal of Heart Failure · doi:10.1093/ejhf/xuag153 · Cited by 15
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Dixit, G., Blair, J. E., & Özcan, C. (2022) · PubMed · Cited by 15
Li, S., Zhu, X., Zhang, Y., Li, F., & Guo, S. (2023) · ESC Heart Failure · doi:10.1002/ehf2.14421 · Cited by 13
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Wodaje, T., Mahdi, A., Venkateshvaran, A., Häbel, H., Zenlander, R., Gaylard, B., Angelin, B., Pernow, J., & Brinck, J. W. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117439 · Cited by 13
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Kittipibul, V., & Lam, C. S. P. (2025) · Heart Failure Reviews · doi:10.1007/s10741-025-10488-0 · Cited by 16
Abramik, J., Mariathas, M., & Felekos, I. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14041128 · Cited by 16
Qi, Z., Wu, D., Yan, Z., Wang, Q., Li, Y., Zhao, J., & Xu, F. (2025) · Obesity Reviews · doi:10.1111/obr.13912 · Cited by 14
Lam, J. H., Quah, J. X., Davies, T., Boos, C. J., Nel, K., Anstey, C., Stanton, T., & Greaves, K. (2020) · Echocardiography · doi:10.1111/echo.14794 · Cited by 12
Anderson, T., Hummel, S. L., & Konerman, M. C. (2022) · Cardiology Clinics · doi:10.1016/j.ccl.2022.07.001 · Cited by 14
van Dinther, M., Bennett, J. B., Thornton, G. D., Voorter, P., Ezponda, A., Hughes, A. D., Captur, G., Holtackers, R. J., Staals, J., Backes, W. H., et al. (2023) · Cerebrovascular Diseases Extra · doi:10.1159/000529067 · Cited by 14
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Metadata
- Authors
- Shah, S. J., Lam, C. S. P., Svedlund, S., Saraste, A., Hage, C., Tan, R.-S., Beussink-Nelson, L., Ljung Faxén, U., Fermer, M. L., Broberg, M. A., Gan, L.-M., & Lund, L. H.
- Affiliations
- Northwestern University (US)
- University Medical Center Groningen (NL)
- Sahlgrenska University Hospital (SE)
- University of Turku (FI)
- Karolinska Institutet (SE)
- National University of Singapore (SG)
- Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
- Department of Medicine, Cardiology Unit and Heart and Vascular Theme, Karolinska Institutet, Stockholm, Sweden
- Early Clinical Development, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden
- AstraZeneca (Sweden) (SE)
- Corresponding author
- Gan, Li-Ming
- Lund, Lars H
- ORCID
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-08-27
- Volume
- 39
- Issue
- 37
- Pages
- 3439-3450
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- PMC
- PMC6927847
- OpenAlex
- W2889002990
- Cited by
- 656
- References
- 45
- Citations by year
- 2026: 79 · 2025: 91 · 2024: 100 · 2023: 98 · 2022: 93 · 2021: 73 · 2020: 67 · 2019: 48 · 2018: 5
- FWCI
- 36.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- European Heart Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- NIH
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- heart failure with preserved ejection fraction, coronary microvascular dysfunction, coronary flow reserve, endothelial dysfunction, reactive hyperaemia index, albumin-creatinine ratio, NT-proBNP, right ventricular dysfunction, atrial fibrillation, smoking, prevalence
- MeSH terms
- Aged, Aged, 80 and over, Coronary Vessels, Female, Humans, Male, Middle Aged, Prospective Studies, Echocardiography, Doppler, Heart Failure, Diastolic, Microvessels
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