Cited by 656Cardiovascular Function and Risk FactorsCardiac Imaging and DiagnosticsCardiovascular Health and Disease Prevention

The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.

Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF

Open access

Shah, Sanjiv J, Lam, Carolyn S P, Svedlund, Sara, Saraste, Antti, Hage, Camilla, Tan, Ru-San, Beussink-Nelson, Lauren, Ljung Faxén, Ulrika, Fermer, Maria Lagerström, Broberg, Malin A, Gan, Li-Ming, Lund, Lars H·2018·European Heart Journal

DOI 10.1093/eurheartj/ehy531PMC PMC6927847

Open this paper in CoChat — free account Open PDF

Abstract

Aims: To date, clinical evidence of microvascular dysfunction in patients with heart failure (HF) with preserved ejection fraction (HFpEF) has been limited. We aimed to investigate the prevalence of coronary microvascular dysfunction (CMD) and its association with systemic endothelial dysfunction, HF severity, and myocardial dysfunction in a well defined, multi-centre HFpEF population. Methods and results: This prospective multinational multi-centre observational study enrolled patients fulfilling strict criteria for HFpEF according to current guidelines. Those with known unrevascularized macrovascular coronary artery disease (CAD) were excluded. Coronary flow reserve (CFR) was measured with adenosine stress transthoracic Doppler echocardiography. Systemic endothelial function [reactive hyperaemia index (RHI)] was measured by peripheral arterial tonometry. Among 202 patients with HFpEF, 151 [75% (95% confidence interval 69-81%)] had CMD (defined as CFR <2.5). Patients with CMD had a higher prevalence of current or prior smoking (70% vs. 43%; P = 0.0006) and atrial fibrillation (58% vs. 25%; P = 0.004) compared with those without CMD. Worse CFR was associated with higher urinary albumin-to-creatinine ratio (UACR) and NTproBNP, and lower RHI, tricuspid annular plane systolic excursion, and right ventricular (RV) free wall strain after adjustment for age, sex, body mass index, atrial fibrillation, diabetes, revascularized CAD, smoking, left ventricular mass, and study site (P < 0.05 for all associations). Conclusions: PROMIS-HFpEF is the first prospective multi-centre, multinational study to demonstrate a high prevalence of CMD in HFpEF in the absence of unrevascularized macrovascular CAD, and to show its association with systemic endothelial dysfunction (RHI, UACR) as well as markers of HF severity (NTproBNP and RV dysfunction). Microvascular dysfunction may be a promising therapeutic target in HFpEF.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/eurheartj/ehy531

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Corrigendum to: 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC.
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 20,604
Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American society of echocardiography and the European association of cardiovascular imaging
Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.10.003 · Cited by 12,362
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429
Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with the European Association of Echocardiography, a Branch of the European Society of Cardiology
Lang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J., Shanewise, J. S., et al. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.10.005 · Cited by 11,318
Guidelines for the Echocardiographic Assessment of the Right Heart in Adults: A Report from the American Society of Echocardiography
Rudski, L., Lai, W. W., Afilalo, J., Hua, L., Handschumacher, M. D., Chandrasekaran, K., Solomon, S. D., Louie, E. K., & Schiller, N. B. (2010) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2010.05.010 · Cited by 7,080
2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.592 · Cited by 5,866
Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American society of echocardiography and the European association of cardiovascular imaging
Nagueh, S. F., Smiseth, O. A., Appleton, C. P., Byrd, B. F., Dokainish, H., Edvardsen, T., Flachskampf, F. A., Gillebert, T. C., Klein, A. L., Lancellotti, P., et al. (2016) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2016.01.011 · Cited by 5,262
2013 ESC guidelines on the management of stable coronary artery disease
Task Force Members, Montalescot, G., Sechtem, U., Achenbach, S., Andreotti, F., Arden, C., Budaj, A., Bugiardini, R., Crea, F., Cuisset, T., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht296 · Cited by 4,510
Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography
Nagueh, S. F., Appleton, C. P., Gillebert, T. C., Marino, P. N., Oh, J. K., Smiseth, O. A., Waggoner, A. D., Flachskampf, F. A., Pellikka, P. A., & Evangelista, A. (2009) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2008.11.023 · Cited by 4,367
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564

Show all 45 references

Sorted by citations

Items 601–656 of 656

Research on latent class of multisymptom characteristics and transition mechanism of patients with coronary heart disease after PCI: protocol for a multicentre cross-sectional and prospective longitudinal study
You, J., Li, Q., Chen, R., Zhang, W., Liu, Y.-Q., Zeng, W., & Huang, Y.-J. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-108103
Assessment of Coronary Flow Reserve in a Mouse Model of Heart Failure with Preserved Ejection Fraction Using Doppler Echocardiography
Li, Y., Chen, J., Zhao, J., & Xu, B. (2026) · Journal of Visualized Experiments · doi:10.3791/70135
Invasive Assessment of Coronary Microvascular Dysfunction in Patients With Wild-Type Transthyretin Amyloid Cardiomyopathy
Sunohara, D., Ueki, Y., Minamisawa, M., Sato, M., FUJIMORI, K., Nagae, A., Aoki, T., NISHIKAWA, K., Suzuki, S., Itagaki, T., et al. (2026) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2026.03.020
Diabète et insuffisance cardiaque : approche épidémiologique par l’analyse croisée de différentes sources de données de santé
Wargny, M. (2022) · doi:10.70675/5d8d8ab5z24f5z4395zbcdfz1c90d9ca526d
Rôle des péricytes et des cellules endothéliales dans l'insuffisance cardiaque
Cornuault, L. (2022) · theses.fr (ABES) · doi:10.70675/902151b1zd809z4b09z9562zd16a859cc3f2
Protective effect of SGLT2 inhibitors on cardiovascular remodeling
Matsushita, K. (2022) · theses.fr (ABES) · doi:10.70675/a461e811zf66fz4443za0efz481618885013
Quantitative Assessment in Nuclear Cardiology
Franquet, E., Lau, H. C., Ng, T. S. C., & Carli, M. F. D. (2026) · Springer eBooks · doi:10.1007/978-3-032-14103-3_7
Cardiac Magnetic Resonance to Define Myocardial Structure in Obesity-Associated Heart Failure
Cutts, J. A., Epstein, F. H., & Patel, A. R. (2026) · Current Cardiology Reports · doi:10.1007/s11886-026-02372-6
Cardiovascular Risk Considerations in Postmenopausal Women: Ischemia and No Obstructive Coronary Arteries, Coronary Microvascular Dysfunction, and Heart Failure with Preserved Ejection Fraction
Mehta, P. K., Gulati, M., & Merz, C. N. B. (2026) · Springer eBooks · doi:10.1007/978-3-032-18203-6_13
Incorporating angina into the H 2 FPEF score improves diagnostic performance for HFpEF in women
Qu, K., Onland‐Moret, N. C., de Vos, A., van Ommen, A. M. L. N., van Mourik, Y., van Riet, E. E. S., Winter, L. B., Handoko, M. L., Cramer, M. J., Teske, A. J., et al. (2026) · Open Heart · doi:10.1136/openhrt-2026-004054
Incremental Prognostic Power of Coronary Flow Reserve and Artificial Intelligence–Enabled ECG–Derived Filling Pressure in Angina With Nonobstructive Coronary Arteries
Kalhor, P., Manzato, M., Hellou, E., Nogami, K., Nardi, V., Borlaug, B. A., Lerman, L. O., & Lerman, A. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.047946
The Relationship of Coronary Microvascular Dysfunction and Left Ventricular Systolic and Diastolic Dysfunction: A Systematic Review and Meta‐Analysis
Wang, Q., Pan, L., Sha, A., Zhang, Y., Shan, L., Fang, X., Wu, Y., & Sun, D. (2026) · Echocardiography · doi:10.1111/echo.70496
Immunometabolic Organ Crosstalk in Heart Failure with Preserved Ejection Fraction: The Role of Dietary Patterns in Obesity-Related Inflammation
Kalisz, M., Litwiniuk, A., Sławkowska, N., Stępień, D., & Bik, W. (2026) · Nutrients · doi:10.3390/nu18111720
Etiology of heart failure across the ejection fraction spectrum and association with mortality – insight from the HEart failuRe ObsErvational study (HEROES)
Tarnowski, M., Molenda, K., Morawiec, R., Galas, A. A., Byczkowska, K., Siniarski, A., Tymińska, A., Żarek-Starzewska, A., Kasprzak, J. D., Dróżdż, J., et al. (2026) · Advances in Medical Sciences · doi:10.1016/j.advms.2026.06.002
Aortic Stenosis and Heart Failure With Preserved Ejection Fraction: A Cautionary Tale of Common Partners
Zhou, J., Nanayakkara, S., Kaye, D. M., & Stub, D. A. (2026) · Circulation Heart Failure · doi:10.1161/circheartfailure.126.014249
Prognostic value of albuminuria in heart failure with preserved ejection fraction: A systematic review
Barbagelata, L., Masson, W. M., Decotto, S., Diez, G. R., Lillo, E., & Pizarro, R. (2026) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2026.103391
HFpEF as a diabetic complication: the central role of microvascular dysfunction
Nagai, Y., Matoba, K., & Nishimura, R. (2026) · Discover Endocrinology and Metabolism · doi:10.1007/s44417-026-00023-6
Микрососудистая стенокардия: патогенез, диагностика и лечение (обзор литературы)
Адзерихо, И. Э. (2025) · Кардиология в Беларуси · doi:10.34883/pi.2026.18.2.007
Metabolic Dysfunction–Associated Steatotic Liver Disease as a Systemic Driver of Heart Failure With Preserved Ejection Fraction: Mechanistic Insights and Emerging Therapeutic Perspectives
Wu, J., Zheng, W., Qi, Q., He, C., Zhai, C., & Fan, H. (2026) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm51234
Challenges in Cardiac Risk Stratification for Bariatric Surgery: A Single-Centre Experience
Kannan, S. S., Jambulingam, P. S., Kyeremateng, C., Adil, T., & Kumar, G. (2026) · Obesity Surgery · doi:10.1007/s11695-026-08832-w
Tirzepatide and SGLT2 Inhibitors for Heart Failure With Preserved Ejection Fraction and Obesity: Entering a New Cardiometabolic Therapeutic Era
Mohamed, Z. I., Shidane, A. A., Abdiasis, A. M., Hussein, M. H., Ibrahim, A. O., Abdi, A. A., Hashi, K. I., Mohamud, M. A., & Mohamed, A. J. (2026) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.70298
Endocrine regulation of cardiac fibrosis: implications for HFpEF
Chaturvedi, R., & Atreja, S. M. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1911465
Impact of estimated total blood volume on NT-proBNP response to angiotensin receptor–neprilysin inhibition in acute heart failure: Insights from the PREMIER study
Nogi, K., Tanaka, A., Imai, T., Doi, S., Kamishita, K., Kawai, H., Obokata, M., Kida, K., Matsue, Y., Izawa, H., et al. (2026) · American Heart Journal · doi:10.1016/j.ahj.2026.107549
Prognostic effect of invasively diagnosed coronary microvascular dysfunction: a systematic review and meta-analysis
Kyriakoulis, K. G., Dimitriadis, K. P., Sakalidis, A., Pyrpyris, N., Adamopoulou, E., Σουλαϊδόπουλος, Σ., Tsioufis, P., Doundoulakis, I., Papanikolaou, A., Aznaouridis, K. A., et al. (2026) · Journal of Cardiology · doi:10.1016/j.jjcc.2026.07.020
A clinical prediction model integrating cardiovascular-kidney-metabolic biomarkers for the composite outcome of quality-of-life deterioration and rehospitalization in elderly HFpEF patients
He, C., Zhao, H., Liu, H., Zhao, X., Zhang, M.-T., & Li, J. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1861971
Association of Left Atrial Strain With One-Year Clinical Outcomes in Patients Hospitalized With Acute Decompensated Heart Failure With Preserved Ejection Fraction
Brigić, L., Džubur, A., & Dervišević, L. (2026) · Cureus · doi:10.7759/cureus.113911
Sex Differences in Ischemic Heart Disease: A Focus on Nonobstructive Coronary Artery Disease
Chuckaree, I., Agusala, V., Dave, E. K., & Mehta, P. K. (2026) · Physiology in health and disease · doi:10.1007/978-3-032-26472-5_22
Heart failure and metabolic syndrome: the role of sodium-glucose cotransporter-2 inhibitors in clinical practice
Ждан, В. М., Kіtura, Y. M., Babanina, М. Y., Volchenko, G. V., Kyrian, O. A., Ткаченко, М. В., Ivanytskyi, I. V., & Lebed, V. G. (2026) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.22.5.2026.1748
HFpEF in Asia
Balasa, E. A., Capone, F., Vacca, A., Fioretto, P., Catena, C., Tromp, J., Foo, R., Wang, Y., Lam, C. S. P., & Schiattarella, G. G. (2026) · JACC Asia · doi:10.1016/j.jacasi.2026.06.030
Coronary microvascular dysfunction and heart failure with preserved ventricular function: still an elusive link
Lanza, G. A., & Marino, A. G. (2026) · International Journal of Cardiology · doi:10.1016/j.ijcard.2026.134724
Assessment of Exercise Intolerance and Evaluation for HFpEF: A Literature Review of Pathophysiology, Diagnosis, and Management
Moradi, A., Ramey, K., Tabbaa, K., Sahyouni, A., Garcez, K. S., KUMAR, S., Pan, E. H., Barton, G., Oyesanmi, O., & Subbiondo, R. J. (2026) · Pathophysiology · doi:10.3390/pathophysiology33030063
Coronary Microvascular Disease in Heart Failure With Preserved Systolic Function: Pathogenic Mechanisms and Therapeutic Options-A Narrative Review
Li, S. (2026) · Cardiology in Review · doi:10.1097/crd.0000000000001442
The effect of Dapagliflozin on coronary microcirculation in patients with heart failure with preserved ejection fraction: Controlled experiments before and afterPreprint
Chen, S., Liu, B., Wu, J., Li, Y., Ma, G., 欧卫谦, Yang, K., Yang, J., Li, S., & Zhang, Z. (2026) · Research Square · doi:10.21203/rs.3.rs-10637200/v1
Candidate Residual Inflammatory Risk in HFpEF: A Multiorgan Framework for Longitudinal Phenotyping, Trial Enrichment, and Therapeutic Evidence Appraisal
Yan, Z., Pu, X., Ren, T., Cai, Y., Xu, Y., Chen, J., Chang, X., Wang, Y., Liu, Z., & Liu, R. (2026) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-026-07941-z
Bidirectional impact between cardiovascular comorbidities and heart failure: an updated position paper from the Italian society of cardiology (SIC) working group on heart failure
Salzano, A., Tricarico, L., Beltrami, M., Mercurio, V., Carella, M. C., Ambrosio, G., Attanasio, U., Armentaro, G., Badagliacca, R., Ciccarelli, M., et al. (2026) · Heart Failure Reviews · doi:10.1007/s10741-026-10667-7
Women’s heart and echocardiography
Kim, S. R., & Park, S. (2026) · Journal of Cardiovascular Imaging · doi:10.1186/s44348-026-00091-8
Coronary Microvascular Dysfunction: Pathophysiology, Clinical Phenotypes, and Mechanism-Guided Diagnostic Strategies
Sharma, D., Bishev, D., Chakraborty, S., Dicaro, M. V., Shao, R., Lee, K., Lei, K., Shah, O., Malhotra, S., & Ahsan, C. H. (2026) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd13090426
Early‐stage myocardial changes are not aggravated by Western diet or ageing in Mybpc3 c.2373insG heterozygous mice
van den Dolder, F. W., Nollet, E. E., Warnaar, V. A. J., Jansen, V. J., Eringa, E. C., Coolen, B. F., Strijkers, G. J., Kuster, D. W. D., & van der Velden, J. (2026) · The Journal of Physiology · doi:10.1113/jp291248
Coronary microvascular dysfunction in HFpEF: pathophysiologic mechanisms, diagnosis, treatments, and the amplifying potential of sepsis
Chattha, S. S., Kapadia, K., Lynch, D., & McWhorter, Y. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1812235
Bidirectional Crosstalk Between Vulnerable Coronary Plaque and Coronary Microvascular Dysfunction: A Narrative Review
Anwar, M., Davenport, A. P., & Hoole, S. P. (2026) · Biomedicines · doi:10.3390/biomedicines14102179
Chronic Inflammation and Coronary Microvascular Dysfunction
Yao, H., Cheng, J., Yang, L., Wang, R., & Lin, Y. (2026) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm51873
Clinical trials in a dish: cardiometabolic drug development with biological and digital twins
Patra, D., Sayed, I. M., Venkateshappa, R., Palaniappan, L. P., McLaughlin, T., & Wu, J. C. (2026) · Journal of Clinical Investigation · doi:10.1172/jci209668
EASIX for Long-Term Prognostication in Hospitalized Heart Failure with Preserved Ejection Fraction: Incremental Value Beyond Clinical Risk Markers
Alak, Ç., Turhan, K., Hunutlu, F. Ç., Kumral, Z., & Şentürk, T. (2026) · Biomedicines · doi:10.3390/biomedicines14102228
Empagliflozin Improves Angina and Endothelial Dysfunction Indices in Angina and No Obstructive Coronary Arteries (ANOCA)
Tapp, D. N., Kaur, S., Toleva, O., Tipler, P., Ashokprabhu, N. D., Acharya, P., Schmidt, C. W., Korbee, L. L., Hamstra, M. S., Tranter, M., et al. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.126.324735
Bidirectional metabolic-vascular feedback loops in heart failure: From myocardial energetics to multisystem cardiometabolic crosstalk
Wang, H., Li, Y., Qin, C., Chen, X., Wang, K., Zhang, M., & Cheng, W. (2026) · iScience · doi:10.1016/j.isci.2026.117553
The Comorbidity-Driven Interleukin-6-Mediated Systemic Inflammation Hypothesis of Heart Failure With Preserved Ejection Fraction: A Decade of Testing Ends in Disappointment
Packer, M., Butler, J., Zannad, F., Vaduganathan, M., & Borlaug, B. A. (2026) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2026.09.029
Stress Echocardiography Beyond Wall Motion in ANOCA/INOCA: Coronary Microvascular Dysfunction and Multiparametric Assessment
Carabetta, N., Durante, P., Costanzo, A. D., Sportelli, M., Canino, G., Strangio, A., Leo, I., Salerno, N., Sabatino, J., Abdelwahed, Y. S., et al. (2026) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd13100500
Mechanometabolic endothelial senescence as a translational framework for cardiometabolic vascular disease and vascular ageing
Li, L., Fan, G., Zhao, R., Zhao, X., Yitong, C., Zhao, J., Lei, L., & Jianhua, F. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12792-w
Gender Differences in the Clinical and Metabolic Manifestations of Anemia in Chronic Heart Failure
Қонысбек, Е., Тұрар, А., Molotov-Luchanskiy, V. B., & Ponamareva, O. A. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15207961
Potential roles for transient receptor potential vanilloid 1 in heart failure with preserved ejection fraction
Gao, Z., Bao, J., He, C., Pan, H., Zhang, H., & Zhai, C. (2026) · Channels · doi:10.1080/19336950.2026.2746860
Coronary microvascular disease as potential mechanism of coronary epicardial atherogenesis: an overview of current evidence
Salameh, E., Hoballah, M., Ebrahimihoor, E., Zadeh, A., Schuijf, J. D., & Lima, J. A. C. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1946683
Heart failure with supranormal ejection fraction: is it the new Ariadne's string?
Katsi, V. K., Maragkoudakis, S., Lilikaki, G., Marketou, M., Farmakis, D. T., & Tsioufis, K. (2026) · Heart Failure Reviews · doi:10.1007/s10741-026-10685-5
Beneficial effects of nicorandil on exercise capacity in heart failure with preserved ejection fraction patients with concomitant coronary microvascular dysfunction
Gu, J., Wang, M., Hu, J.-C., Tang, Z., Wang, C., & Zhang, J. (2026) · Hellenic Journal of Cardiology · doi:10.1016/j.hjc.2026.10.003
BindingDB Entry 50016538: Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction.
BindingDB (2023) · UC San Diego · doi:10.7270/q2wd44km
Heart failure with preserved ejection fraction: From pathophysiology to a practical approach to diagnosis and treatment
Fernández‐Cisnal, A., Lorenzo, M., Palau, P., & Núñez, J. E. (2026) · Medicina Clínica · doi:10.1016/j.medcli.2026.107617
Angina with Non-obstructive Coronary Arteries: Diagnostic Evaluation and Endotype-guided Management
Reddy, T. K., Sejo, C. S., Garber, R., Kassab, J. T., Gangavelli, A., Donisan, T., Vasilakis, G. M., & Raphael, C. E. (2026) · US Cardiology Review · doi:10.15420/usc.2026.02

Authors: Shah, S. J., Lam, C. S. P., Svedlund, S., Saraste, A., Hage, C., Tan, R.-S., Beussink-Nelson, L., Ljung Faxén, U., Fermer, M. L., Broberg, M. A., Gan, L.-M., & Lund, L. H.
Affiliations: Northwestern University (US)
University Medical Center Groningen (NL)
Sahlgrenska University Hospital (SE)
University of Turku (FI)
Karolinska Institutet (SE)
National University of Singapore (SG)
Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Department of Medicine, Cardiology Unit and Heart and Vascular Theme, Karolinska Institutet, Stockholm, Sweden
Early Clinical Development, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden
AstraZeneca (Sweden) (SE)
Corresponding author: Gan, Li-Ming
Lund, Lars H
ORCID: Shah, Sanjiv J
Lam, Carolyn S P
Svedlund, Sara
Saraste, Antti
Hage, Camilla
Tan, Ru-San
Gan, Li-Ming
Lund, Lars H
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2018-08-27
Volume: 39
Issue: 37
Pages: 3439-3450
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/eurheartj/ehy531
PMC: PMC6927847
OpenAlex: W2889002990
Cited by: 656
References: 45
Citations by year: 2026: 79 · 2025: 91 · 2024: 100 · 2023: 98 · 2022: 93 · 2021: 73 · 2020: 67 · 2019: 48 · 2018: 5
FWCI: 36.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: European Heart Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders: NIH
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: heart failure with preserved ejection fraction, coronary microvascular dysfunction, coronary flow reserve, endothelial dysfunction, reactive hyperaemia index, albumin-creatinine ratio, NT-proBNP, right ventricular dysfunction, atrial fibrillation, smoking, prevalence
MeSH terms: Aged, Aged, 80 and over, Coronary Vessels, Female, Humans, Male, Middle Aged, Prospective Studies, Echocardiography, Doppler, Heart Failure, Diastolic, Microvessels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks