Cited by 656Cardiovascular Function and Risk FactorsCardiac Imaging and DiagnosticsCardiovascular Health and Disease Prevention

The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.

Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF

Open access

Shah, Sanjiv J, Lam, Carolyn S P, Svedlund, Sara, Saraste, Antti, Hage, Camilla, Tan, Ru-San, Beussink-Nelson, Lauren, Ljung Faxén, Ulrika, Fermer, Maria Lagerström, Broberg, Malin A, Gan, Li-Ming, Lund, Lars H·2018·European Heart Journal

DOI 10.1093/eurheartj/ehy531PMC PMC6927847

Open this paper in CoChat — free account Open PDF

Abstract

Aims: To date, clinical evidence of microvascular dysfunction in patients with heart failure (HF) with preserved ejection fraction (HFpEF) has been limited. We aimed to investigate the prevalence of coronary microvascular dysfunction (CMD) and its association with systemic endothelial dysfunction, HF severity, and myocardial dysfunction in a well defined, multi-centre HFpEF population. Methods and results: This prospective multinational multi-centre observational study enrolled patients fulfilling strict criteria for HFpEF according to current guidelines. Those with known unrevascularized macrovascular coronary artery disease (CAD) were excluded. Coronary flow reserve (CFR) was measured with adenosine stress transthoracic Doppler echocardiography. Systemic endothelial function [reactive hyperaemia index (RHI)] was measured by peripheral arterial tonometry. Among 202 patients with HFpEF, 151 [75% (95% confidence interval 69-81%)] had CMD (defined as CFR <2.5). Patients with CMD had a higher prevalence of current or prior smoking (70% vs. 43%; P = 0.0006) and atrial fibrillation (58% vs. 25%; P = 0.004) compared with those without CMD. Worse CFR was associated with higher urinary albumin-to-creatinine ratio (UACR) and NTproBNP, and lower RHI, tricuspid annular plane systolic excursion, and right ventricular (RV) free wall strain after adjustment for age, sex, body mass index, atrial fibrillation, diabetes, revascularized CAD, smoking, left ventricular mass, and study site (P < 0.05 for all associations). Conclusions: PROMIS-HFpEF is the first prospective multi-centre, multinational study to demonstrate a high prevalence of CMD in HFpEF in the absence of unrevascularized macrovascular CAD, and to show its association with systemic endothelial dysfunction (RHI, UACR) as well as markers of HF severity (NTproBNP and RV dysfunction). Microvascular dysfunction may be a promising therapeutic target in HFpEF.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/eurheartj/ehy531

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Corrigendum to: 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC.
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 20,604
Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American society of echocardiography and the European association of cardiovascular imaging
Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.10.003 · Cited by 12,362
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429
Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with the European Association of Echocardiography, a Branch of the European Society of Cardiology
Lang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J., Shanewise, J. S., et al. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.10.005 · Cited by 11,318
Guidelines for the Echocardiographic Assessment of the Right Heart in Adults: A Report from the American Society of Echocardiography
Rudski, L., Lai, W. W., Afilalo, J., Hua, L., Handschumacher, M. D., Chandrasekaran, K., Solomon, S. D., Louie, E. K., & Schiller, N. B. (2010) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2010.05.010 · Cited by 7,080
2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.592 · Cited by 5,866
Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American society of echocardiography and the European association of cardiovascular imaging
Nagueh, S. F., Smiseth, O. A., Appleton, C. P., Byrd, B. F., Dokainish, H., Edvardsen, T., Flachskampf, F. A., Gillebert, T. C., Klein, A. L., Lancellotti, P., et al. (2016) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2016.01.011 · Cited by 5,262
2013 ESC guidelines on the management of stable coronary artery disease
Task Force Members, Montalescot, G., Sechtem, U., Achenbach, S., Andreotti, F., Arden, C., Budaj, A., Bugiardini, R., Crea, F., Cuisset, T., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht296 · Cited by 4,510
Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography
Nagueh, S. F., Appleton, C. P., Gillebert, T. C., Marino, P. N., Oh, J. K., Smiseth, O. A., Waggoner, A. D., Flachskampf, F. A., Pellikka, P. A., & Evangelista, A. (2009) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2008.11.023 · Cited by 4,367
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564

Show all 45 references

Sorted by citations

2024 ESC Guidelines for the management of chronic coronary syndromes
Vrints, C. J., Andreotti, F., Koskinas, K. C., Rosselló, X., Adamo, M., Ainslie, J., BANNING, A. P., Budaj, A., Buechel, R. R., Chiariello, G. A., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae177 · Cited by 3,521
How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
Pieske, B. M., Tschöpe, C., de Boer, R. A., Fraser, A. G., Anker, S. D., Donal, E., Edelmann, F., Fu, M. L. X., Guazzi, M., Lam, C. S. P., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz641 · Cited by 1,961
Heart Failure With Preserved Ejection Fraction In Perspective
Pfeffer, M. A., Shah, A. M., & Borlaug, B. A. (2019) · Circulation Research · doi:10.1161/circresaha.119.313572 · Cited by 876
Sex differences in heart failure
Lam, C. S. P., Arnott, C. G., Beale, A. L., Chandramouli, C., Hilfiker‐Kleiner, D., Kaye, D. M., Ky, B., Santema, B. T., Sliwa, K. S., & Voors, A. A. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz835 · Cited by 873
Heart Failure With Preserved Ejection Fraction
Borlaug, B. A., Sharma, K., Shah, S. J., & Ho, J. E. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.01.049 · Cited by 742
Evaluation and management of heart failure with preserved ejection fraction
Borlaug, B. A. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0363-2 · Cited by 675
Heart Failure With Preserved Ejection Fraction: A Review
Redfield, M. M., & Borlaug, B. A. (2023) · JAMA · doi:10.1001/jama.2023.2020 · Cited by 662
Coronary Microvascular Dysfunction Across the Spectrum of Cardiovascular Diseases
Buono, M. G. D., Montone, R. A., Camilli, M., Carbone, S., Narula, J., Lavie, C. J., Niccoli, G., & Crea, F. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.07.042 · Cited by 680
The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: A multicenter randomized trial
Nassif, M. E., Windsor, S. L., Borlaug, B. A., Kitzman, D. W., Shah, S. J., Tang, F., Khariton, Y., Malik, A. O., Khumri, T., Umpierrez, G., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01536-x · Cited by 618
2023 ACC Expert Consensus Decision Pathway on Management of Heart Failure With Preserved Ejection Fraction
Kittleson, M. M., Panjrath, G. S., Amancherla, K., Davis, L. L., Deswal, A., Dixon, D. L., Januzzi, J. L., & Yancy, C. W. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.03.393 · Cited by 554
Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets
Borlaug, B. A., Jensen, M. D., Kitzman, D. W., Lam, C. S. P., Obokata, M., & Rider, O. J. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvac120 · Cited by 450
Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary
Shah, S. J., Borlaug, B. A., Kitzman, D. W., McCulloch, A. D., Blaxall, B. C., Agarwal, R., Chirinos, J. A., Collins, S., Deo, R. C., Gladwin, M. T., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.041886 · Cited by 436
From Systemic Inflammation to Myocardial Fibrosis
Paulus, W. J., & Zile, M. R. (2021) · Circulation Research · doi:10.1161/circresaha.121.318159 · Cited by 413
How to Diagnose Heart Failure with Preserved Ejection Fraction: The HFA–PEFF Diagnostic Algorithm: A Consensus Recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
Pieske, B. M., Tschöpe, C., de Boer, R. A., Fraser, A. G., Anker, S. D., Donal, E., Edelmann, F., Fu, M. L. X., Guazzi, M., Lam, C. S. P., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1741 · Cited by 410
Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials
Butler, J., Shah, S. J., Petrie, M. C., Borlaug, B. A., Abildstrøm, S. Z., Davies, M. J., Hovingh, G. K., Kitzman, D. W., Møller, D. V., Verma, S., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00469-0 · Cited by 386
Coronary Microvascular Dysfunction
Vancheri, F., Longo, G., Vancheri, S., & Henein, M. Y. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092880 · Cited by 354
Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging
Ng, A. C. T., Delgado, V., Borlaug, B. A., & Bax, J. J. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00465-5 · Cited by 350
Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction
Obokata, M., Reddy, Y. N. V., & Borlaug, B. A. (2019) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2018.12.034 · Cited by 324
Hemodynamic and Functional Impact of Epicardial Adipose Tissue in Heart Failure With Preserved Ejection Fraction
Koepp, K. E., Obokata, M., Reddy, Y. N. V., Olson, T. P., & Borlaug, B. A. (2020) · JACC Heart Failure · doi:10.1016/j.jchf.2020.04.016 · Cited by 269
Proteomic Evaluation of the Comorbidity-Inflammation Paradigm in Heart Failure With Preserved Ejection Fraction
Wijk, S. S., Tromp, J., Beussink‐Nelson, L., Hage, C., Svedlund, S., Saraste, A., Swat, S. A., Sanchez, C., Njoroge, J. N., Tan, R., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.045810 · Cited by 268
Prevalence of Coronary Artery Disease and Coronary Microvascular Dysfunction in Patients With Heart Failure With Preserved Ejection Fraction
Rush, C. J., Berry, C., Oldroyd, K. G., Rocchiccioli, P., Lindsay, M. M., Touyz, R. M., Murphy, C., Ford, T. J., Sidik, N. P., McEntegart, M. B., et al. (2021) · JAMA Cardiology · doi:10.1001/jamacardio.2021.1825 · Cited by 262
Myocardial ischemia and coronary disease in heart failure
Pagliaro, B., Cannata, F., Stefanini, G. G., & Bolognese, L. (2019) · Heart Failure Reviews · doi:10.1007/s10741-019-09831-z · Cited by 251
Heart Failure with Preserved Ejection Fraction: Mechanisms and Treatment Strategies
Omote, K., Verbrugge, F. H., & Borlaug, B. A. (2021) · Annual Review of Medicine · doi:10.1146/annurev-med-042220-022745 · Cited by 232
Coronary microvascular dysfunction in hypertrophy and heart failure
Camici, P. G., Tschöpe, C., Carli, M. F. D., Rimoldi, O. E., & Linthout, S. V. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa023 · Cited by 217
Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin
Juni, R. P., Kuster, D. W. D., Goebel, M., Helmes, M., Musters, R. J. P., van der Velden, J., Koolwijk, P., Paulus, W. J., & van Hinsbergh, V. W. M. (2019) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.04.003 · Cited by 208
Metabolic syndrome – a new definition and management guidelines A joint position paper by the Polish Society of Hypertension, Polish Society for the Treatment of Obesity, Polish Lipid Association, Polish Association for Study of Liver, Polish Society of Family Medicine, Polish Society of Lifestyle Medicine, Division of Prevention and Epidemiology Polish Cardiac Society, “Club 30” Polish Cardiac Society, and Division of Metabolic and Bariatric Surgery Society of Polish Surgeons
Dobrowolski, P., Prejbisz, A., Kuryłowicz, A., Baska, A., Burchardt, P., Chlebus, K., Dzida, G. J., Jankowski, P., Jaroszewicz, J., Jaworski, P., et al. (2022) · Archives of Medical Science · doi:10.5114/aoms/152921 · Cited by 236
Patient Phenotype Profiling in Heart Failure with Preserved Ejection Fraction to Guide Therapeutic Decision Making. A Scientific Statement of the Heart Failure Association, the European Heart Rhythm Association of the European Society of Cardiology, and the European Society of Hypertension
Anker, S. D., Usman, M., Anker, M. S., Butler, J., Böhm, M., Abraham, W. T., Adamo, M., Chopra, V., Cicoira, M., Cosentino, F., et al. (2023) · European Journal of Heart Failure · doi:10.1002/ejhf.2894 · Cited by 215
JCS/CVIT/JCC 2023 Guideline Focused Update on Diagnosis and Treatment of Vasospastic Angina (Coronary Spastic Angina) and Coronary Microvascular Dysfunction
Hokimoto, S., Kaikita, K., Yasuda, S., Tsujita, K., Ishihara, M., Matoba, T., Matsuzawa, Y., Mitsutake, Y., Mitani, Y., Murohara, T., et al. (2023) · Circulation Journal · doi:10.1253/circj.cj-22-0779 · Cited by 213
Characterization of the Inflammatory-Metabolic Phenotype of Heart Failure with a Preserved Ejection Fraction: A Hypothesis to Explain Influence of Sex on the Evolution and Potential Treatment of the Disease
Packer, M., Lam, C. S. P., Lund, L. H., Maurer, M. S., & Borlaug, B. A. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1902 · Cited by 185
Self-citation
Endothelium-Dependent and Independent Coronary Microvascular Dysfunction in Patients with Heart Failure with Preserved Ejection Fraction
Yang, J. H., Obokata, M., Reddy, Y. N. V., Redfield, M. M., Lerman, A., & Borlaug, B. A. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1671 · Cited by 180
Heart failure with preserved ejection fraction
HAMO, C. E., DeJong, C., Hartshorne‐Evans, N., Lund, L. H., Shah, S. J., Solomon, S. D., & Lam, C. S. P. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00540-y · Cited by 197
Abdominal ultrasound in the assessment of extent and activity of Crohn's disease: clinical significance and implication of bowel wall thickening.
Maconi, G., Parente, F., Bollani, S., Cesana, B. M., & Porro, G. B. (1996) · PubMed · Cited by 177
SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob−/− mice
Adingupu, D. D., Göpel, S., Grönros, J., Behrendt, M., Soták, M., Miliotis, T., Dahlqvist, U., Gan, L., & Jönsson‐Rylander, A. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0820-6 · Cited by 176
Cardiac mechanisms of the beneficial effects of SGLT2 inhibitors in heart failure: Evidence for potential off-target effects
Dyck, J. R. B., Sossalla, S. T., Hamdani, N., Coronel, R., Weber, N. C., Light, P. E., & Zuurbier, C. J. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.03.005 · Cited by 181
Ischemic Heart Disease and Heart Failure: Role of Coronary Ion Channels
Severino, P., D’Amato, A., Pucci, M., Infusino, F., Birtolo, L. I., Mariani, M. V., Lavalle, C., Maestrini, V., Mancone, M., & Fedele, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093167 · Cited by 167
Sex Differences in Heart Failure With Preserved Ejection Fraction Pathophysiology
Beale, A. L., Nanayakkara, S., Segan, L. A., Mariani, J. A., Maeder, M. T., van Empel, V. P. M., Vizi, D., Evans, S., Lam, C. S. P., & Kaye, D. M. (2019) · JACC Heart Failure · doi:10.1016/j.jchf.2019.01.004 · Cited by 152
Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction
Woolley, R. J., Ceelen, D. C. H., Ouwerkerk, W., Tromp, J., Figarska, S. M., Anker, S. D., Dickstein, K., Filippatos, G. S., Zannad, F. M., Metra, M., et al. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2144 · Cited by 146
Heart failure with preserved ejection fraction in humans and mice: embracing clinical complexity in mouse models
Withaar, C., Lam, C. S. P., Schiattarella, G. G., de Boer, R. A., & Meems, L. M. G. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab389 · Cited by 150
Cardiac metabolism in HFpEF: from fuel to signalling
Capone, F., Sotomayor-Flores, C., Bode, D., Wang, R., Rodolico, D., Strocchi, S., & Schiattarella, G. G. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac166 · Cited by 145
Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction
D’Amario, D., Migliaro, S., Borovac, J. A., Restivo, A., Vergallo, R., Galli, M., Leone, A. M., Montone, R. A., Niccoli, G., Aspromonte, N., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01347 · Cited by 138
Immunometabolic mechanisms of heart failure with preserved ejection fraction
Schiattarella, G. G., Alcaide, P., Condorelli, G., Gillette, T. G., Heymans, S. R. B., Jones, E. A. V., Kallikourdis, M., Lichtman, A. H., Marelli‐Berg, F. M., Shah, S. J., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00032-w · Cited by 137
Ischemia and no obstructive coronary arteries (INOCA): A narrative review
Mehta, P. K., Huang, J., Levit, R. D., Malas, W., Waheed, N., & Merz, C. N. B. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.11.009 · Cited by 133
Amelioration of diastolic dysfunction by dapagliflozin in a non-diabetic model involves coronary endothelium
Cappetta, D., Angelis, A. D., Ciuffreda, L. P., Coppini, R., Cozzolino, A., Miccichè, A., Dell’Aversana, C., D’Amario, D., Cianflone, E., Scavone, C., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104781 · Cited by 129
Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction
Ford, T. J., Corcoran, D. S., Padmanabhan, S., Aman, A., Rocchiccioli, P., Good, R., McEntegart, M. B., Maguire, J. J., Watkins, S., Eteiba, H., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz915 · Cited by 127
Chronic low‐grade inflammation in heart failure with preserved ejection fraction
Mesquita, T., Lin, Y., & Ibrahim, A. G.-E. (2021) · Aging Cell · doi:10.1111/acel.13453 · Cited by 118
Macrophages in Heart Failure with Reduced versus Preserved Ejection Fraction
DeBerge, M., Shah, S. J., Wilsbacher, L. D., & Thorp, E. B. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.01.002 · Cited by 109
Inflammation in Metabolic Cardiomyopathy
Wenzl, F. A., Ambrosini, S., Mohammed, S. A., Kraler, S. C., Lüscher, T. F., Costantino, S., & Paneni, F. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.742178 · Cited by 115
Cardiovascular Imaging Techniques to Assess Microvascular Dysfunction
Mathew, R. C., Bourque, J. M., Salerno, M., & Kramer, C. M. (2019) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2019.09.006 · Cited by 108
Coronary microvascular dysfunction: A review of recent progress and clinical implications
Rehan, R., Yong, A. S. C., Ng, M., Weaver, J. C., & Puranik, R. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1111721 · Cited by 102
High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction
Zhou, Q., Yang, J., Tang, H., Guo, Z., Dong, W., Wang, Y., Meng, X., Zhang, K., Wang, W., Shao, C., et al. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02001-4 · Cited by 93
Coronary microvascular dysfunction is associated with exertional haemodynamic abnormalities in patients with heart failure with preserved ejection fraction
Ahmad, A., Corban, M., Toya, T., Verbrugge, F. H., Sara, J. D. S., Lerman, L. O., Borlaug, B. A., & Lerman, A. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.2010 · Cited by 91
Coronary Microvascular Disease in Contemporary Clinical Practice
Smilowitz, N. R., Toleva, O., Chieffo, A., Perera, D., & Berry, C. (2023) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.122.012568 · Cited by 91
Human cardiac metabolism
Bornstein, M. R., Tian, R., & Arany, Z. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.06.003 · Cited by 98
Metabolomic Profile in HFpEF vs HFrEF Patients
Hage, C., Löfgren, L., Michopoulos, F., nilsson, R., Davidsson, P., Kumar, C., Ekström, M., Eriksson, M. J., Lyngå, P., Persson, B., et al. (2020) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2020.07.010 · Cited by 87
Coronary flow velocity reserve predicts adverse prognosis in women with angina and no obstructive coronary artery disease: results from the iPOWER study
Schrøder, J., Michelsen, M. M., Mygind, N. D., Suhrs, H. E., Bove, K. B., Bechsgaard, D. F., Aziz, A. A., Gustafsson, I., Kastrup, J., & Prescott, E. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa944 · Cited by 89
Microvascular Disease in Patients With Diabetes With Heart Failure and Reduced Ejection Versus Preserved Ejection Fraction
Tromp, J., Lim, S. L., Tay, W. T., Teng, T. K., Chandramouli, C., Ouwerkerk, W., Wander, G., Sawhney, J. P. S., Yap, J. J. L., MacDonald, M. R., et al. (2019) · Diabetes Care · doi:10.2337/dc18-2515 · Cited by 87
Heart Failure With Preserved Ejection Fraction: A Comprehensive Review and Update of Diagnosis, Pathophysiology, Treatment, and Perioperative Implications
Pagel, P. S., Tawil, J. N., Boettcher, B. T., Izquierdo, D. A., Lazicki, T. J., Crystal, G. J., & Freed, J. K. (2020) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2020.07.016 · Cited by 86
Reduced lymphatic reserve in heart failure with preserved ejection fraction
Rossitto, G., Mary, S., McAllister, C., Neves, K. B., Haddow, L., Rocchiccioli, J. P., Lang, N. N., Murphy, C. L., Touyz, R. M., Petrie, M. C., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.10.022 · Cited by 77
Untangling the pathophysiologic link between coronary microvascular dysfunction and heart failure with preserved ejection fraction
Sinha, A., Rahman, H., Webb, A., Shah, A. M., & Perera, D. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab653 · Cited by 85
EASIX (endothelial activation and stress index) predicts mortality in patients with coronary artery disease
Finke, D., Hund, H., Frey, N., Luft, T., & Lehmann, L. (2024) · Clinical Research in Cardiology · doi:10.1007/s00392-024-02534-y · Cited by 80
Cardiac remodelling – Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology
González, A., Richards, M., de Boer, R. A., Thum, T., Arfsten, H., Hülsmann, M., Falcão‐Pires, I., Dı́ez, J., Foo, R., Chan, M. Y., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2493 · Cited by 82
Lipotoxicity: a driver of heart failure with preserved ejection fraction?
Leggat, J., Bidault, G., & Vidal‐Puig, A. (2021) · Clinical Science · doi:10.1042/cs20210127 · Cited by 74
Epicardial adipose tissue related to left atrial and ventricular function in heart failure with preserved versus reduced and mildly reduced ejection fraction
Jin, X., Hung, C., Tay, W. T., Soon, D. K. N., Sim, D., Sung, K., Loh, S. Y., Lee, S., Jaufeerally, F. R., Ling, L. H., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2513 · Cited by 77
Hypertensive coronary microvascular dysfunction: a subclinical marker of end organ damage and heart failure
Zhou, W., Brown, J. M., Bajaj, N. S., Chandra, A., Divakaran, S., Weber, B., Bibbo, C. F., Hainer, J. M., Taqueti, V. R., Dorbala, S., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa191 · Cited by 75
Heart failure with preserved ejection fraction based on aging and comorbidities
Lin, Y. H., Fu, S., Yao, Y., Li, Y., Zhao, Y., & Luo, L. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02935-x · Cited by 81
Comorbidities in heart failure with preserved ejection fraction
Deichl, A. S., Wachter, R., & Edelmann, F. (2022) · Herz · doi:10.1007/s00059-022-05123-9 · Cited by 80
Sex differences in heart failure with preserved ejection fraction: From traditional risk factors to sex-specific risk factors
Kaur, G., & Lau, E. S. (2022) · Women s Health · doi:10.1177/17455057221140209 · Cited by 83
The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF
Withaar, C., Meems, L. M. G., Nollet, E. E., Schouten, E. M., Schroeder, M. A., Knudsen, L. B., Niss, K., Madsen, C. T., Hoegl, A., Mazzoni, G., et al. (2023) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2023.05.012 · Cited by 74
Prevalence and Prognostic Significance of Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction
Arnold, J. R., Kanagala, P., Budgeon, C. A., Jerosch‐Herold, M., Gulsin, G. S., Singh, A., Khan, J. N., Chan, D. C. S., Squire, I. B., Ng, L. L., et al. (2022) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2021.11.022 · Cited by 77
Myeloperoxidase Inhibition in Heart Failure With Preserved or Mildly Reduced Ejection Fraction: SATELLITE Trial Results
Lam, C. S. P., Lund, L. H., Shah, S. J., Voors, A. A., Erlinge, D., Saraste, A., Pirazzi, C., Grove, E. L., Barasa, A. L., Schou, M., et al. (2023) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2023.04.003 · Cited by 74
Non-coding RNAs as therapeutic targets and biomarkers in ischaemic heart disease
Caporali, A., Anwar, M., Devaux, Y., Katare, R., Martelli, F., Srivastava, P. K., Pedrazzini, T., & Emanueli, C. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01001-5 · Cited by 73
Prioritising the primary prevention of heart failure
Khan, S. S., Berwanger, O., Fiuzat, M., McMurray, J. J. V., Narula, J., Prabhakaran, D., Sliwa, K. S., Tromp, J., & Vaduganathan, M. (2025) · The Lancet · doi:10.1016/s0140-6736(25)01393-5 · Cited by 79
Myocardial Energetics in Heart Failure With Preserved Ejection Fraction
AbouEzzeddine, O. F., Kemp, B. J., Borlaug, B. A., Mullan, B. P., Behfar, A., Pislaru, S. V., Fudim, M., Redfield, M. M., & Chareonthaitawee, P. (2019) · Circulation Heart Failure · doi:10.1161/circheartfailure.119.006240 · Cited by 67
Cardiovascular Benefits from Gliflozins: Effects on Endothelial Function
Salvatore, T., Caturano, A., Galiero, R., Martino, A. D., Albanese, G., Vetrano, E., Sardu, C., Marfella, R., Rinaldi, L., & Sasso, F. C. (2021) · Biomedicines · doi:10.3390/biomedicines9101356 · Cited by 72
Endothelial Dysfunction in Heart Failure With Preserved Ejection Fraction: What are the Experimental Proofs?
Cornuault, L., Rouault, P., Duplàa, C., Couffinhal, T., & Renault, M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.906272 · Cited by 72
Endothelial cell dysfunction in cardiac disease: driver or consequence?
Allbritton‐King, J. D., & García‐Cardeña, G. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1278166 · Cited by 69
Haemodynamic and Metabolic Phenotyping of Hypertensive Patients with and without Heart Failure by Combining Cardiopulmonary and Echocardiographic Stress Test
Pugliese, N. R., Mazzola, M., Fabiani, I., Gargani, L., Biase, N. D., Pedrinelli, R., Natali, A., & Dini, F. L. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1739 · Cited by 69
Nitric oxide and endothelium‐dependent hyperpolarization mediated by hydrogen peroxide in health and disease
Shimokawa, H., & Godo, S. (2019) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13377 · Cited by 68
Myeloperoxidase and Related Biomarkers are Suggestive Footprints of Endothelial Microvascular Inflammation in HFpEF Patients
Hage, C., Michaëlsson, E., Kull, B., Miliotis, T., Svedlund, S., Linde, C. M., Donal, E., Daubert, J., Gan, L., & Lund, L. H. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12700 · Cited by 69
Disproportionate left atrial myopathy in heart failure with preserved ejection fraction among participants of the PROMIS-HFpEF study
Patel, R. B., Lam, C. S. P., Svedlund, S., Saraste, A., Hage, C., Tan, R., Beussink‐Nelson, L., Tromp, J., Sanchez, C., Njoroge, J. N., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-84133-9 · Cited by 67
Extreme Heat and Cardiovascular Health: What a Cardiovascular Health Professional Should Know
Chaseling, G. K., Iglesies‐Grau, J., Juneau, M., Nigam, A., Kaiser, D., & Gagnon, D. (2021) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2021.08.008 · Cited by 70
Mechanisms and clinical implications of endothelium-dependent vasomotor dysfunction in coronary microvasculature
Sabe, S. A., Feng, J., Sellke, F. W., & Abid, M. R. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00603.2021 · Cited by 67
Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction in Patients With Nonalcoholic Fatty Liver Disease
Packer, M. (2019) · The American Journal of Medicine · doi:10.1016/j.amjmed.2019.09.002 · Cited by 63
Association of epicardial adipose tissue with proteomics, coronary flow reserve, cardiac structure and function, and quality of life in heart failure with preserved ejection fraction: insights from the PROMIS‐HFpEF study
Venkateshvaran, A., Faxén, U. L., Hage, C., Michaëlsson, E., Svedlund, S., Saraste, A., Beussink‐Nelson, L., Fermer, M. L., Gan, L., Tromp, J., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2709 · Cited by 67
Drugs That Ameliorate Epicardial Adipose Tissue Inflammation May Have Discordant Effects in Heart Failure With a Preserved Ejection Fraction as Compared With a Reduced Ejection Fraction
Packer, M. (2019) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2019.09.002 · Cited by 65
Sex Differences in Cardiovascular Aging and Heart Failure
Oneglia, A. P., Nelson, M. D., & Merz, C. N. B. (2020) · Current Heart Failure Reports · doi:10.1007/s11897-020-00487-7 · Cited by 65
Preventing Heart Failure: A Position Paper of the Heart Failure Association in Collaboration with the European Association of Preventive Cardiology
Piepoli, M. F., Adamo, M., Barison, A., Bestetti, R. B., Biegus, J., Böhm, M., Butler, J., Carapetis, J. R., Ceconi, C., Chioncel, O. D., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2351 · Cited by 73
The NO-cGMP-PKG Axis in HFpEF: From Pathological Mechanisms to Potential Therapies
Cai, Z., Wu, C., Xu, Y., Cai, J., Zhao, M., & Zu, L. (2022) · Aging and Disease · doi:10.14336/ad.2022.0523 · Cited by 69
Metabolic and Immune Crosstalk in Cardiovascular Disease
Mohanta, S. K., Heron, C., Klaus‐Bergmann, A., Horstmann, H., Bråkenhielm, E., Giannarelli, C., Habenicht, A. J. R., Gerhardt, H., & Weber, C. (2025) · Circulation Research · doi:10.1161/circresaha.125.325496 · Cited by 68
Association Between Circulating Troponin Concentrations, Left Ventricular Systolic and Diastolic Functions, and Incident Heart Failure in Older Adults
Myhre, P. L., Claggett, B. L., Ballantyne, C. M., Selvin, E., Røsjø, H. R., Omland, T., Solomon, S. D., Skali, H., & Shah, A. M. (2019) · JAMA Cardiology · doi:10.1001/jamacardio.2019.3113 · Cited by 63
Do Most Patients with Obesity or Type 2 Diabetes, and Atrial Fibrillation, Also have Undiagnosed Heart Failure? A Critical Conceptual Framework for Understanding Mechanisms and Improving Diagnosis and Treatment
Packer, M. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1646 · Cited by 67
Sex-Based Differences in Heart Failure
Khan, S. S., Beach, L. B., & Yancy, C. W. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.02.013 · Cited by 65
Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models
van Ham, W. B., Kessler, E. L., Oerlemans, M. I. F. J., Handoko, M. L., Sluijter, J. P. G., van Veen, T. A. B., den Ruijter, H. M., & de Jager, S. C. A. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.12.009 · Cited by 60
The vasculature: a therapeutic target in heart failure?
Luxán, G., & Dimmeler, S. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab047 · Cited by 61
Stress Echo 2030: The Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging
Picano, E., Ciampi, Q., Cortigiani, L., Arruda-Olson, A. M., Daros, C. B., Pretto, J. L. D. C. E. S., Cocchia, R., Bossone, E., Merli, E., Kane, G. C., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163641 · Cited by 60
Endothelium in Coronary Macrovascular and Microvascular Diseases
Godo, S., Takahashi, J., Yasuda, S., & Shimokawa, H. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001089 · Cited by 56
Adverse Pregnancy Outcomes and Incident Heart Failure in the Women’s Health Initiative
Hansen, A. L., Søndergaard, M. M., Hlatky, M. A., Vittinghoff, E., Nah, G., Stefanick, M. L., Manson, J. E., Farland, L. V., Wells, G., Mongraw‐Chaffin, M., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.38071 · Cited by 55
Chinese expert consensus on the diagnosis and treatment of coronary microvascular diseases (2023 Edition)
Chen, W., Ni, M., Huang, H., Cong, H., Fu, X., Gao, W. D., Yang, Y., Yu, M., Song, X., Liu, M., et al. (2023) · MedComm · doi:10.1002/mco2.438 · Cited by 59
2026 ESC Guidelines for the management of heart failure
Køber, L., Adamo, M., Ruwald, A., Tomasoni, D., Anderson, L., Andersson, C., Brugts, J. J., Chioncel, O. D., Donal, E., Ferdinandy, P., et al. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag100 · Cited by 109
Association of Coronary Microvascular Dysfunction With Heart Failure Hospitalizations and Mortality in Heart Failure With Preserved Ejection Fraction: A Follow-up in the PROMIS-HFpEF Study
Hage, C., Svedlund, S., Saraste, A., Faxén, U. L., Benson, L., Fermer, M. L., Gan, L., Shah, S. J., Lam, C. S. P., & Lund, L. H. (2020) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2020.08.010 · Cited by 55

Authors: Shah, S. J., Lam, C. S. P., Svedlund, S., Saraste, A., Hage, C., Tan, R.-S., Beussink-Nelson, L., Ljung Faxén, U., Fermer, M. L., Broberg, M. A., Gan, L.-M., & Lund, L. H.
Affiliations: Northwestern University (US)
University Medical Center Groningen (NL)
Sahlgrenska University Hospital (SE)
University of Turku (FI)
Karolinska Institutet (SE)
National University of Singapore (SG)
Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Department of Medicine, Cardiology Unit and Heart and Vascular Theme, Karolinska Institutet, Stockholm, Sweden
Early Clinical Development, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden
AstraZeneca (Sweden) (SE)
Corresponding author: Gan, Li-Ming
Lund, Lars H
ORCID: Shah, Sanjiv J
Lam, Carolyn S P
Svedlund, Sara
Saraste, Antti
Hage, Camilla
Tan, Ru-San
Gan, Li-Ming
Lund, Lars H
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2018-08-27
Volume: 39
Issue: 37
Pages: 3439-3450
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/eurheartj/ehy531
PMC: PMC6927847
OpenAlex: W2889002990
Cited by: 656
References: 45
Citations by year: 2026: 79 · 2025: 91 · 2024: 100 · 2023: 98 · 2022: 93 · 2021: 73 · 2020: 67 · 2019: 48 · 2018: 5
FWCI: 36.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: European Heart Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders: NIH
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: heart failure with preserved ejection fraction, coronary microvascular dysfunction, coronary flow reserve, endothelial dysfunction, reactive hyperaemia index, albumin-creatinine ratio, NT-proBNP, right ventricular dysfunction, atrial fibrillation, smoking, prevalence
MeSH terms: Aged, Aged, 80 and over, Coronary Vessels, Female, Humans, Male, Middle Aged, Prospective Studies, Echocardiography, Doppler, Heart Failure, Diastolic, Microvessels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks