Cited by 656Cardiovascular Function and Risk FactorsCardiac Imaging and DiagnosticsCardiovascular Health and Disease Prevention

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Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF

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Shah, Sanjiv J, Lam, Carolyn S P, Svedlund, Sara, Saraste, Antti, Hage, Camilla, Tan, Ru-San, Beussink-Nelson, Lauren, Ljung Faxén, Ulrika, Fermer, Maria Lagerström, Broberg, Malin A, Gan, Li-Ming, Lund, Lars H·2018·European Heart Journal

DOI 10.1093/eurheartj/ehy531PMC PMC6927847

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Abstract

Aims: To date, clinical evidence of microvascular dysfunction in patients with heart failure (HF) with preserved ejection fraction (HFpEF) has been limited. We aimed to investigate the prevalence of coronary microvascular dysfunction (CMD) and its association with systemic endothelial dysfunction, HF severity, and myocardial dysfunction in a well defined, multi-centre HFpEF population. Methods and results: This prospective multinational multi-centre observational study enrolled patients fulfilling strict criteria for HFpEF according to current guidelines. Those with known unrevascularized macrovascular coronary artery disease (CAD) were excluded. Coronary flow reserve (CFR) was measured with adenosine stress transthoracic Doppler echocardiography. Systemic endothelial function [reactive hyperaemia index (RHI)] was measured by peripheral arterial tonometry. Among 202 patients with HFpEF, 151 [75% (95% confidence interval 69-81%)] had CMD (defined as CFR <2.5). Patients with CMD had a higher prevalence of current or prior smoking (70% vs. 43%; P = 0.0006) and atrial fibrillation (58% vs. 25%; P = 0.004) compared with those without CMD. Worse CFR was associated with higher urinary albumin-to-creatinine ratio (UACR) and NTproBNP, and lower RHI, tricuspid annular plane systolic excursion, and right ventricular (RV) free wall strain after adjustment for age, sex, body mass index, atrial fibrillation, diabetes, revascularized CAD, smoking, left ventricular mass, and study site (P < 0.05 for all associations). Conclusions: PROMIS-HFpEF is the first prospective multi-centre, multinational study to demonstrate a high prevalence of CMD in HFpEF in the absence of unrevascularized macrovascular CAD, and to show its association with systemic endothelial dysfunction (RHI, UACR) as well as markers of HF severity (NTproBNP and RV dysfunction). Microvascular dysfunction may be a promising therapeutic target in HFpEF.

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Corrigendum to: 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC.
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 20,604
Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American society of echocardiography and the European association of cardiovascular imaging
Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.10.003 · Cited by 12,362
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429
Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with the European Association of Echocardiography, a Branch of the European Society of Cardiology
Lang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J., Shanewise, J. S., et al. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.10.005 · Cited by 11,318
Guidelines for the Echocardiographic Assessment of the Right Heart in Adults: A Report from the American Society of Echocardiography
Rudski, L., Lai, W. W., Afilalo, J., Hua, L., Handschumacher, M. D., Chandrasekaran, K., Solomon, S. D., Louie, E. K., & Schiller, N. B. (2010) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2010.05.010 · Cited by 7,080
2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.592 · Cited by 5,866
Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American society of echocardiography and the European association of cardiovascular imaging
Nagueh, S. F., Smiseth, O. A., Appleton, C. P., Byrd, B. F., Dokainish, H., Edvardsen, T., Flachskampf, F. A., Gillebert, T. C., Klein, A. L., Lancellotti, P., et al. (2016) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2016.01.011 · Cited by 5,262
2013 ESC guidelines on the management of stable coronary artery disease
Task Force Members, Montalescot, G., Sechtem, U., Achenbach, S., Andreotti, F., Arden, C., Budaj, A., Bugiardini, R., Crea, F., Cuisset, T., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht296 · Cited by 4,510
Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography
Nagueh, S. F., Appleton, C. P., Gillebert, T. C., Marino, P. N., Oh, J. K., Smiseth, O. A., Waggoner, A. D., Flachskampf, F. A., Pellikka, P. A., & Evangelista, A. (2009) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2008.11.023 · Cited by 4,367
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564

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Kong, H., Cao, J., An, J., Tian, J., Yong, J., Song, X., & He, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1727072/v1
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Xie, X., Zhao, S., Chen, Y., Yu, T., Xie, S., Zhu, B., Wei, Z., Wang, J. E., Pu, W., Geng, M., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3990407/v1
Additional file 1 of Elevated postprandial triglyceride-rich lipoproteins in patients with diabetes and stable coronary artery disease correlated with early renal damage and systemic inflammation
Guo, X., Zhai, Y., Song, C., Zhen, M., Peng, J., Guo, J., Teng, X., & Zhang, D. (2023) · Figshare · doi:10.6084/m9.figshare.22757233
Advances in the Diagnosis and Treatment of Heart Failure with Preserved Ejection Fraction
曹, 淋. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1441258
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Weerts, J. (2024) · Research Publications (Maastricht University) · doi:10.26481/dis.20240626jw
Sex/Gender Differences in Heart Failure
Park, S., & Kim, M. (2024) · Springer eBooks · doi:10.1007/978-981-97-0130-8_10
The additional value of relative assessment of quantitative myocardial blood flow
Maaniitty, T., & Knuuti, J. M. (2024) · Journal of Nuclear Cardiology · doi:10.1016/j.nuclcard.2024.101886
Diversity in heart failure management: Quo Vadis, guideline-directed medical therapy?
Meguro, T. (2024) · International Journal of Cardiology · doi:10.1016/j.ijcard.2024.132325
La sfida della prevenzione in medicina interna: a call for action | The challenge of prevention in internal medicine: a call for action
Dentali, F., & Rotunno, S. (2024) · Italian Journal of Medicine · doi:10.4081/itjm.q.2024.4
Alternative Factors in Possible Involvement of Coronary Microvascular Dysfunction in Older Patients with HFpEF
Hoshida, S., Watanabe, T., Masunaga, N., Shinoda, Y., Seo, M., Hayashi, T., Yano, M., Yamada, T., Yasumura, Y., Hikoso, S., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13195911
Coronary microvascular disease is a risk factor for left ventricular diastolic dysfunction: An AWARD substudyPreprint
Wen, W. X., Gao, M., Chi, Y., Liu, M., Xie, B., Jiang, L., Chen, K., & Zhao, F. (2024) · Research Square · doi:10.21203/rs.3.rs-5344277/v1
Cardiac tissue perfusion at rest correlates with systemic microvascular function in those with and without atherosclerotic coronary artery disease; a cross-sectional studyPreprint
Wilcox, J., Gosling, O. B., Casanova, F., He, J., Gooding, K. M., Pitt, A., Ball, C., Morgan-Hughes, G. J., Bellenger, N. G., Shore, A. C., et al. (2024) · medRxiv · doi:10.1101/2024.12.10.24318777
Artificial intelligence in cardiac imaging
Foldyna, B. (2024) · Research Publications (Maastricht University) · doi:10.26481/dis.20241212bf
Diagnostic capabilities of magnetic resonance imaging in assessing the myocardial perfusion in cases of ischemic disorders
Pogrebnichenko, E. R., Mameshova, A. S., Akhmedbekova, Z. A., Tedurova, P. T., Kamilov, M. A., Абдулмаджидович, А. Э., Gazimagomedov, K. M., Saipullaev, C. S., Popov, N. Y., Abdulaev, A. L., et al. (2025) · Journal of clinical practice · doi:10.17816/clinpract648672
Coronary Artery Spasm as a Contributor to Heart Failure: Lessons from Three Cases
Naito, A., Toya, T., Kawai, A., Mizutani, K., Kuinose, K., Nagatomo, Y., & Adachi, T. K. (2025) · Internal Medicine · doi:10.2169/internalmedicine.5057-24
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Lenz, T., & Kessler, T. (2025) · CardioVasc · doi:10.1007/s15027-025-3748-7
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Marek‐Iannucci, S., Oliveros, E., Fedele, F., & Rajapreyar, I. N. (2025) · CJC Open · doi:10.1016/j.cjco.2025.04.017
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Tanaka, H. (2025) · Echocardiography · doi:10.1111/echo.70197
ANMCO position paper: diagnosis and treatment of heart failure with preserved systolic function
Iacovoni, A., Navazio, A., Luca, L. D., Gori, M., Corda, M., Milli, M., Iacoviello, M., Lenarda, A. D., Tano, G. D., Marini, M., et al. (2025) · European Heart Journal Supplements · doi:10.1093/eurheartjsupp/suaf070
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Shiraki, T., Kioka, H., Ueda‐Hayakawa, I., Takahara, M., Tonomura, K., Maekawa, A., Kotobuki, Y., Enchi, Y., Ueda, M., Takahari, K., et al. (2025) · The Journal of Dermatology · doi:10.1111/1346-8138.17783
Dietary Habits, Anthropometric Values, and Microvascular Reactivity in Older Persons of Both Sexes Living at Retirement Home in Osijek, Croatia
Drenjančević, I., Prošić, I., Firi, L., Stupin, A., & Jukić, I. (2025) · Clinical Interventions in Aging · doi:10.2147/cia.s514573
Treatment Progress of Heart Failure with Preserved Ejection Fraction
王, 义. (2025) · Asian Case Reports in Vascular Medicine · doi:10.12677/acrvm.2025.132002
The association between fragmented QRS and left ventricular diastolic dysfunction in type 2 diabetes patients with or without microalbuminuria
Wang, L., Zheng, L., Hu, J., & Zhao, N. (2025) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2025.501623
Demographic disparities in heart failure with preserved ejection fraction
Pingili, A., Mylavarapu, M., Vadiyala, M. R., Vempati, R., Parmar, P., Machineni, N. V. K., Shaik, M. Y., Puli, S., Devarala, B. L., Gummadi, J., et al. (2025) · Heart Failure Reviews · doi:10.1007/s10741-025-10547-6
Research Progress on the Impact of Cardiac Rehabilitation Exercise on the Quality of Life of Elderly Patients with HFpEF
吕, 佳. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1572118
Seeding the Soil for HFpEF
Xu, L., & Zhao, W. (2025) · JACC CardioOncology · doi:10.1016/j.jaccao.2025.06.010
Regulation of Coronary Microvascular Resistance in Health and Disease
Shin, S. Y., Goodwill, A. G., Ohanyan, V. A., Yin, L., Dong, F., Zhang, P., Choban, L., Domingo, C. N., Godel, S., Kodash, E., et al. (2025) · Physiology in health and disease · doi:10.1007/978-3-031-99609-2_8
The association between fragmented QRS and left ventricular diastolic dysfunction in type 2 diabetes patients with or without microalbuminuria
Wang, L., Zheng, L., Hu, J., & Zhao, N. (2025) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endien.2025.501623
Additional file 1 of High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction
Zhou, Q., Yang, J., Tang, H., Guo, Z., Dong, W., Wang, Y., Meng, X., Zhang, K., Wang, W., Shao, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24223723
Additional file 1 of Circulating exosomal mir-16-2-3p is associated with coronary microvascular dysfunction in diabetes through regulating the fatty acid degradation of endothelial cells
Liu, Y., Zhong, C., Chen, S., Xue, Y., Wei, Z., Dong, L., & Kang, L. I. N. A. (2024) · Figshare · doi:10.6084/m9.figshare.25200666
Hypertensive Heart
Lim, P. O. (2025) · Springer eBooks · doi:10.1007/978-3-032-10734-3_10
Imaging Abnormalities in HFpEF: Do They Truly Reflect Pathophysiology?
Marwick, T. H., & Chandrashekhar, Y. (2026) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2025.12.001
Microvascular dysfunction and heart failure with preserved ejection fraction
Velollari, O., Biancofiore, A., Olschewski, M., Ullrich, H., Münzel, T. F., Rommel, K., Lurz, P. C., Gori, T., & Kresoja, K. (2026) · Clinical Research in Cardiology · doi:10.1007/s00392-025-02822-1
Endothelial function in patients with heart failure with preserved ejection fraction undergoing multicomponent drug therapy
Рафхатовна, З. А., Koshurnikova, M., Погорелова, О. А., Tripoten, M. I., Filatova, A. Y., Sobolevskaya, M. S., Николаевна, С. О., Ovchinnikov, A. G., Balakhonova, T. V., & Рогоза, А. Н. (2025) · Russian Cardiology Bulletin · doi:10.17116/cardiobulletin202520042135
Endothelial dysfunction and cardiovascular diseases. Part 1. Microvascular and structural changes
Shimokhina, N. Y., Petrova, M. M., Zhadovets, Y. E., Kurskova, A. D., Prokopyeva, E. S., & Kalmykova, K. D. (2025) · Russian Journal of Preventive Medicine · doi:10.17116/profmed202528121118
Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression
Chen, L., Wang, Q., Shen, M., Li, M., Zhu, Y., Zheng, C., Ma, S., Lin, H., Fu, X., Zhang, R., et al. (2026) · Interdisciplinary medicine · doi:10.1002/inmd.70090
Defining Population at Risk and Assessment of Patients With Presumed Coronary Microvascular and Vasomotor Dysfunction
Boivin‐Proulx, L., Schampaert, É., Bainey, K. R., Chong, A. Y., Saw, J., Eckstein, J., Lavoie, A., Abuzeid, W., Schwalm, J., Cieza, T., et al. (2026) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2025.12.062

Authors: Shah, S. J., Lam, C. S. P., Svedlund, S., Saraste, A., Hage, C., Tan, R.-S., Beussink-Nelson, L., Ljung Faxén, U., Fermer, M. L., Broberg, M. A., Gan, L.-M., & Lund, L. H.
Affiliations: Northwestern University (US)
University Medical Center Groningen (NL)
Sahlgrenska University Hospital (SE)
University of Turku (FI)
Karolinska Institutet (SE)
National University of Singapore (SG)
Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Department of Medicine, Cardiology Unit and Heart and Vascular Theme, Karolinska Institutet, Stockholm, Sweden
Early Clinical Development, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden
AstraZeneca (Sweden) (SE)
Corresponding author: Gan, Li-Ming
Lund, Lars H
ORCID: Shah, Sanjiv J
Lam, Carolyn S P
Svedlund, Sara
Saraste, Antti
Hage, Camilla
Tan, Ru-San
Gan, Li-Ming
Lund, Lars H
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2018-08-27
Volume: 39
Issue: 37
Pages: 3439-3450
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/eurheartj/ehy531
PMC: PMC6927847
OpenAlex: W2889002990
Cited by: 656
References: 45
Citations by year: 2026: 79 · 2025: 91 · 2024: 100 · 2023: 98 · 2022: 93 · 2021: 73 · 2020: 67 · 2019: 48 · 2018: 5
FWCI: 36.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: European Heart Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders: NIH
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: heart failure with preserved ejection fraction, coronary microvascular dysfunction, coronary flow reserve, endothelial dysfunction, reactive hyperaemia index, albumin-creatinine ratio, NT-proBNP, right ventricular dysfunction, atrial fibrillation, smoking, prevalence
MeSH terms: Aged, Aged, 80 and over, Coronary Vessels, Female, Humans, Male, Middle Aged, Prospective Studies, Echocardiography, Doppler, Heart Failure, Diastolic, Microvessels

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Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF

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