The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants
Open accessAbstract
Aims: To quantify the association of combined sleep behaviours and genetic susceptibility with the incidence of cardiovascular disease (CVD). Methods and results: This study included 385 292 participants initially free of CVD from UK Biobank. We newly created a healthy sleep score according to five sleep factors and defined the low-risk groups as follows: early chronotype, sleep 7–8 h per day, never/rarely insomnia, no snoring, and no frequent excessive daytime sleepiness. Weighted genetic risk scores of coronary heart disease (CHD) or stroke were calculated. During a median of 8.5 years of follow-up, we documented 7280 incident CVD cases including 4667 CHD and 2650 stroke cases. Compared to those with a sleep score of 0–1, participants with a score of 5 had a 35% (19–48%), 34% (22–44%), and 34% (25–42%) reduced risk of CVD, CHD, and stroke, respectively. Nearly 10% of cardiovascular events in this cohort could be attributed to poor sleep pattern. Participants with poor sleep pattern and high genetic risk showed the highest risk of CHD and stroke. Conclusion: In this large prospective study, a healthy sleep pattern was associated with reduced risks of CVD, CHD, and stroke among participants with low, intermediate, or high genetic risk.
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The UK Biobank resource with deep phenotyping and genomic data
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Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease
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Insomnia and risk of cardiovascular disease: a meta-analysis
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Social jetlag, chronotype, and cardiometabolic risk
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Cited by
Huang, B.-H., Duncan, M. J., Cistulli, P. A., Nassar, N., Hamer, M., & Stamatakis, E. (2022) · British Journal of Sports Medicine · doi:10.1136/bjsports-2021-104046 · Cited by 345
del Pozo Cruz, B., Ahmadi, M. N., Lee, I.-M., & Stamatakis, E. (2022) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2022.4000 · Cited by 265
Genetics of circadian rhythms and sleep in human health and disease
Lane, J. M., Qian, J., Mignot, E., Redline, S., Scheer, F. A. J. L., & Saxena, R. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-022-00519-z · Cited by 236
Li, L., Yao, H., Zhang, L., Garcia‐Argibay, M., Du Rietz, E., Brikell, I., Solmi, M., Cortese, S., Ramos‐Quiroga, J. A., Ribasés, M., et al. (2023) · JCPP Advances · doi:10.1002/jcv2.12158 · Cited by 55
Self-citation
Metadata
- Authors
- Fan, M., Sun, D., Zhou, T., Heianza, Y., Lv, J., Li, L., & Qi, L.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-12-18
- Volume
- 41
- Issue
- 11
- Pages
- 1182-1189
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2994728250
- Cited by
- 702
- References
- 15
- FWCI
- 45.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Fan, M., Sun, D., Zhou, T., Heianza, Y., Lv, J., Li, L., & Qi, L. (2020). Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants. European Heart Journal. https://doi.org/10.1093/eurheartj/ehz849
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