Insomnia and risk of cardiovascular disease: a meta-analysis
Abstract
OBJECTIVE: Increasing evidence suggests an association between insomnia and cardiovascular disease. We performed a systematic review with meta-analysis of all the available prospective studies that investigated the association between insomnia and risk of developing and/or dying from cardiovascular disease. DESIGN: Systematic review and meta-analysis of prospective cohort studies. METHODS: We conducted an electronic literature search through MedLine, Embase, Google Scholar, Web of Science, The Cochrane Library and bibliographies of retrieved articles up to December 2011. Studies were included if they were prospective, had assessment of insomnia or sleep complaints at baseline, evaluated subjects free of cardiovascular disease at baseline and measured the association between insomnia and risk of developing and/or dying from cardiovascular disease. RESULTS: After the review process 13 prospective studies were included in the final analysis. These studies included 122,501 subjects followed for a time ranging from three to 20 years. A total of 6332 cardiovascular events occurred during the follow-up. Insomnia was assessed through questionnaire and defined as either difficulty of initiating or maintaining sleep or presence of restless, disturbed nights. The cumulative analysis for all the studies under a random-effects model showed that insomnia determined an increased risk (+45%) of developing or dying from cardiovascular disease during the follow-up (relative risk 1.45, 95% confidence interval 1.29-1.62; p < 0.00001), with no evidence of heterogeneity across the studies (I 2: 19%; p = 0.14). CONCLUSION: Insomnia is associated with an increased risk of developing and/or dying from cardiovascular disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studies have shown a significant association between insomnia, mainly "poor sleep", and cardiovascular disease risk.
“Although these studies have shown a significant association between insomnia, mainly “poor sleep”, and CVD risk, the effect sizes reported were modest and most studies did not include PSG and could not control for SDB.”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [176]
The estimated risk for incident myocardial infarction and coronary heart disease associated with "poor sleep" or insomnia ranges between 41% and 55%, respectively.
“and that for incident myocardial infarction (MI) and coronary heart disease (CHD) between 41% and 55%, respectively(176, 177)”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [176]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Epidemiology of insomnia: what we know and what we still need to learn
Ohayon, M. M. (2002) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0186 · Cited by 3,743 · cited 1× · see citing works
“It has been estimated that over 30% of all adults have a current symptom of sleep disturbance, with a prevalence that reaches 50% among subjects older than 65 years.(1) During the last years, a considerable number of studies investigated the possible association between both qualitative and quantitative sleep disturba…”
BackgroundTaheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010062 · Cited by 2,477 · cited 1× · see citing works
“On one hand, epidemiologic studies reported that poorquality sleep, as well as short duration or presence of non-restorative sleep, is associated with metabolic or endocrine changes through sympathetic activation or through elevated levels of inflammatory cytokines.(19,20) A population study conducted recently by Frie…”
BackgroundSpiegel, K., Tasali, E., Penev, P., & Cauter, E. V. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-11-200412070-00008 · Cited by 2,459 · see citing works
Cappuccio, F. P., Cooper, D., D'Elia, L., Strazzullo, P., & Miller, M. A. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr007 · Cited by 2,146 · see citing works
Quantity and Quality of Sleep and Incidence of Type 2 Diabetes
Cappuccio, F. P., D'Elia, L., Strazzullo, P., & Miller, M. A. (2010) · Diabetes Care · doi:10.2337/dc09-1124 · Cited by 1,670 · see citing works
Slow-wave sleep and the risk of type 2 diabetes in humans
Tasali, E., Leproult, R., Ehrmann, D. A., & Van Cauter, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706446105 · Cited by 921 · see citing works
Mallon, L., Broman, J. ‐., & Hetta, J. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.00941.x · Cited by 495 · see citing works
Bollinger, G. K. (1975) · Cited by 440 · see citing works
Insomnia and the Risk of Acute Myocardial Infarction: A Population Study
Laugsand, L. E., Vatten, L. J., Platou, C., & Janszky, I. (2011) · Circulation · doi:10.1161/circulationaha.111.025858 · Cited by 438 · see citing works
Eaker, E. D., Pinsky, J. L., & Castelli, W. P. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116381 · Cited by 383 · see citing works
Chien, K.-L., Chen, P.-C., Hsu, H.-C., Su, T.-C., Sung, F.-C., Chen, M.-F., & Lee, Y.-T. (2010) · SLEEP · doi:10.1093/sleep/33.2.177 · Cited by 350 · see citing works
Meisinger, C., Heier, M., Löwel, H., Schneider, A., & Döring, A. (2007) · Sleep · doi:10.1093/sleep/30.9.1121 · Cited by 305 · see citing works
Schwartz, S. W., Anderson, W. M., Cole, S. R., Cornoni‐Huntley, J. C., Hays, J. C., & Blazer, D. G. (1999) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(99)00029-x · Cited by 302 · see citing works
Chandola, T., Ferrie, J. E., Perski, A., Akbaraly, T., & Marmot, M. G. (2010) · Sleep · doi:10.1093/sleep/33.6.739 · Cited by 284 · see citing works
Prevalence and Polysomnographic Correlates of Insomnia Comorbid with Medical Disorders
Budhiraja, R., Roth, T., Hudgel, D. W., Budhiraja, P., & Drake, C. L. (2011) · Sleep · doi:10.5665/sleep.1114 · Cited by 255 · see citing works
Sleep disturbance, stroke, and heart disease events: evidence from the Caerphilly cohort
Elwood, P. C., Hack, M., Pickering, J., Hughes, J., & Gallacher, J. (2005) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2005.039057 · Cited by 236 · see citing works
Do Insomnia Complaints Cause Hypertension or Cardiovascular Disease?
Phillips, B. A., & Mannino, D. M. (2007) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26913 · Cited by 227 · see citing works
Metabolic and endocrine effects of sleep deprivation.
Copinschi, G. (2005) · PubMed · Cited by 182 · see citing works
Sleep Disturbances and Cause-Specific Mortality: Results From the GAZEL Cohort Study
Rod, N. H., Vahtera, J., Westerlund, H., Mika Kivimaki, B., Zins, M., Goldberg, M., & Lange, T. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq371 · Cited by 178 · see citing works
Suzuki, E., Yorifuji, T., Ueshima, K., Takao, S., Sugiyama, M., Ohta, T., Ishikawa‐Takata, K., & Doi, H. (2009) · Preventive Medicine · doi:10.1016/j.ypmed.2009.06.016 · Cited by 177 · see citing works
Are Sleep Complaints an Independent Risk Factor for Myocardial Infarction?
Schwartz, S. W., Cornoni‐Huntley, J. C., Cole, S. R., Hays, J. C., Blazer, D. G., & Schocken, D. D. (1998) · Annals of Epidemiology · doi:10.1016/s1047-2797(97)00238-x · Cited by 135 · see citing works
Friedman, E. M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06040.x · Cited by 80 · see citing works
Kornerup, H., Osler, M., Boysen, G., Barefoot, J. C., Schnohr, P., & Prescott, E. (2010) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3283359c18 · Cited by 64 · see citing works
Are sleep complaints predictive of future myocardial infarction?
Appels, A., VOS, Y. D., van Diest, R., Höppner, P., Mulder, P., & de Groen, J. H. M. (1987) · PubMed · Cited by 57 · see citing works
Sleep Disturbances and Their Relationship to Cardiovascular Disease
Quan, S. F. (2009) · American Journal of Lifestyle Medicine · doi:10.1177/1559827609331709 · Cited by 35 · see citing works
Hamer, M., Batty, G. D., & Mika Kivimaki, B. (2011) · European Journal of Preventive Cardiology · doi:10.1177/1741826711426092 · Cited by 34 · see citing works
What We Know and What We Still Need to Learn
Humphreys, J. C., Sharps, P. W., & Campbell, J. C. (2004) · Journal of Interpersonal Violence · doi:10.1177/0886260504268766 · Cited by 33 · see citing works
Loponen, M., Hublin, C., Kalimo, R., Mänttäri, M., & Tenkanen, L. (2009) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2009.07.022 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Benetos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab484 · Cited by 6,485 · see citing works
European guideline for the diagnosis and treatment of insomnia
Riemann, D., Baglioni, C., Bassetti, C., Bjorvatn, B., Dolenc Groselj, L., Ellis, J. G., Espie, C. A., Garcia‐Borreguero, D., Gjerstad, M., Gonçalves, M., et al. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12594 · Cited by 2,049 · see citing works
Health consequences of shift work and insufficient sleep
Kecklund, G., & Axelsson, J. (2016) · BMJ · doi:10.1136/bmj.i5210 · Cited by 1,195 · see citing works
St-Onge, M.-P., Grandner, M. A., Brown, D., Conroy, M. B., Jean-Louis, G., Coons, M., & Bhatt, D. L. (2016) · Circulation · doi:10.1161/cir.0000000000000444 · Cited by 1,044 · see citing works
Morin, C. M., & Jarrin, D. C. (2022) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2022.03.003 · Cited by 907 · see citing works
The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023
Riemann, D., Espie, C. A., Altena, E., Arnardottir, E. S., Baglioni, C., Bassetti, C. L. A., Bastien, C., Berzina, N., Bjorvatn, B., Dikeos, D., et al. (2023) · Journal of Sleep Research · doi:10.1111/jsr.14035 · Cited by 834 · see citing works
“Insomnia is highly prevalant also in medical disorders including diabetes (LeBlanc et al., 2018) and cardiovascular disease/ hypertension (Li, Gan, et al., 2021; Li, Li, et al., 2021; Sofi et al., 2014).”
BackgroundInsomnia and Risk of Cardiovascular Disease
Javaheri, S., & Redline, S. S. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.01.026 · Cited by 731 · see citing works
Fan, M., Sun, D., Zhou, T., Heianza, Y., Lv, J., Li, L., & Qi, L. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz849 · Cited by 708 · see citing works
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Bénétos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwab154 · Cited by 565 · see citing works
Rusch, H. L., Rosario, M., Levison, L. M., Olivera, A., Livingston, W. S., Wu, T., & Gill, J. M. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13996 · Cited by 500 · see citing works
Validation of a Korean Version of the Insomnia Severity Index
Cho, Y. W., Song, M. L., & Morinc, C. M. (2014) · Journal of Clinical Neurology · doi:10.3988/jcn.2014.10.3.210 · Cited by 472 · see citing works
Comorbidities and the impact of atopic dermatitis
Silverberg, J. I. (2019) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2019.04.020 · Cited by 431 · see citing works
Insomnia disorder in adolescence: Diagnosis, impact, and treatment
de Zambotti, M., Goldstone, A., Colrain, I. M., & Baker, F. C. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.06.009 · Cited by 400 · see citing works
Li, H., Zheng, D., Li, Z., Wu, Z., Feng, W., Cao, X., Wang, J., Gao, Q., Li, X., Wang, W., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.16591 · Cited by 395 · see citing works
Wang, C., Bangdiwala, S. I., Rangarajan, S., Lear, S. A., AlHabib, K. F., Mohan, V., Teo, K., Poirier, P., TSE, L. A., Liu, Z., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehy695 · Cited by 385 · see citing works
Biological Rhythm and Chronotype: New Perspectives in Health
Montaruli, A., Castelli, L., Mulè, A., Scurati, R., Esposito, F., Galasso, L., & Roveda, E. (2021) · Biomolecules · doi:10.3390/biom11040487 · Cited by 366 · see citing works
S3-Leitlinie Nicht erholsamer Schlaf/Schlafstörungen
Riemann, D. W., Baum, E., Cohrs, S., Crönlein, T., Hajak, G., Hertenstein, E., Klose, P., Langhorst, J., Mayer, G., Nissen, C., et al. (2017) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1007/s11818-016-0097-x · Cited by 339 · see citing works
Sleep problems during the menopausal transition: prevalence, impact, and management challenges
Baker, F. C., de Zambotti, M., Colrain, I. M., & Bei, B. (2018) · Nature and Science of Sleep · doi:10.2147/nss.s125807 · Cited by 305 · see citing works
Health economics of insomnia treatments: The return on investment for a good night's sleep
Wickwire, E. M., Shaya, F. T., & Scharf, S. M. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.11.004 · Cited by 290 · see citing works
Baglioni, C., Altena, E., Bjorvatn, B., Blom, K., Bothelius, K., Devoto, A., Espie, C. A., Frase, L., Gavriloff, D., Tuuliki, H., et al. (2020) · Journal of Sleep Research · doi:10.1111/jsr.12967 · Cited by 259 · see citing works
Incidence, Persistence, and Remission Rates of Insomnia Over 5 Years
Morin, C. M., Jarrin, D. C., Ivers, H., Mérette, C., LeBlanc, M., & Savard, J. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.18782 · Cited by 234 · see citing works
Morin, C. M., & Jarrin, D. C. (2013) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2013.05.002 · Cited by 216 · see citing works
Insomnia and risk of cardiovascular disease: a meta-analysis of cohort studies
Li, M., Zhang, X.-W., Hou, W.-S., & Tang, Z.-Y. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.07.284 · Cited by 201 · see citing works
Obstructive Sleep Apnea, Oxidative Stress, and Cardiovascular Disease: Evidence from Human Studies
Eisele, H.-J., Markart, P., & Schulz, R. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/608438 · Cited by 200 · see citing works
The translational neuroscience of sleep: A contextual framework
Grandner, M. A., & Fernandez, F. (2021) · Science · doi:10.1126/science.abj8188 · Cited by 197 · see citing works
Ge, L., Guyatt, G. H., Tian, J., Pan, B., Chang, Y., Chen, Y., Li, H., Zhang, J., Li, Y., Ling, J., et al. (2019) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2019.101215 · Cited by 197 · see citing works
Sleep: important considerations for the prevention of cardiovascular disease
Grandner, M. A., Alfonso-Miller, P., Fernandez-Mendoza, J., Shetty, S., Shenoy, S., & Combs, D. (2016) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000324 · Cited by 166 · see citing works
Johnson, K. A., Gordon, C. J., Chapman, J. L., Hoyos, C. M., Marshall, N. S., Miller, C. B., & Grunstein, R. R. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101456 · Cited by 169 · see citing works
Rozanski, A. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.047 · Cited by 162 · see citing works
The microstructure of sleep in primary insomnia: An overview and extension
Feige, B., Baglioni, C., Spiegelhalder, K., Hirscher, V., Nissen, C., & Riemann, D. W. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.04.002 · Cited by 165 · see citing works
The social and economic cost of sleep disorders
Streatfeild, J., Smith, J. A., Mansfield, D. R., Pezzullo, L., & Hillman, D. R. (2021) · SLEEP · doi:10.1093/sleep/zsab132 · Cited by 160 · see citing works
Rubio-Arias, J. Á., Marín-Cascales, E., Ramos-Campo, D. J., Hernandez, A. V., & Pérez-López, F. R. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.04.003 · Cited by 159 · see citing works
Duration, timing and quality of sleep are each vital for health, performance and safety
Czeisler, C. A. (2015) · Sleep Health · doi:10.1016/j.sleh.2014.12.008 · Cited by 156 · see citing works
Sympathetic neural responses to sleep disorders and insufficiencies
Greenlund, I. M., & Carter, J. R. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00590.2021 · Cited by 158 · see citing works
Sleep duration and obesity in adulthood: An updated systematic review and meta-analysis
Bacaro, V., Ballesio, A., Cerolini, S., Vacca, M., Poggiogalle, E., Donini, L. M., Lucidi, F., & Lombardo, C. (2020) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2020.03.004 · Cited by 152 · see citing works
Personality and sleep quality: Evidence from four prospective studies.
Stéphan, Y., Sutin, A. R., Bayard, S., Križan, Z., & Terracciano, A. (2017) · Health Psychology · doi:10.1037/hea0000577 · Cited by 147 · see citing works
Sands‐Lincoln, M., Loucks, E. B., Lü, B., Carskadon, M. A., Sharkey, K. M., Stefanick, M. L., Ockene, J. K., Shah, N. A., Hairston, K. G., Robinson, J. G., et al. (2013) · Journal of Women s Health · doi:10.1089/jwh.2012.3918 · Cited by 140 · see citing works
Benz, F., Knoop, T., Ballesio, A., Bacaro, V., Johann, A. F., Rücker, G., Feige, B., Riemann, D., & Baglioni, C. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101873 · Cited by 142 · see citing works
“, 2012), an increased risk for developing cardiovascular diseases (Sofi et al., 2014) as well as psychiatric disorders, especially depression and anxiety disorders (Baglioni et al.”
BackgroundWickwire, E. M., Tom, S. E., Scharf, S. M., Vadlamani, A., Bulatao, I. G., & Albrecht, J. S. (2019) · Sleep · doi:10.1093/sleep/zsz007 · Cited by 139 · see citing works
Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults
Zheng, B., Yu, C., Lv, J., Guo, Y., Bian, Z., Zhou, M., Yang, L., Chen, Y., Li, X., Zou, J., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000008581 · Cited by 139 · see citing works
Sleep characteristics and cardiovascular risk in children and adolescents: an enumerative review
Matthews, K. A., & Pantesco, E. J. M. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2015.06.004 · Cited by 136 · see citing works
EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke
Bassetti, C. L. A., Randerath, W., Vignatelli, L., Ferini-Strambi, L., Brill, A.-K., Bonsignore, M. R., Grote, L., Jennum, P., Leys, D., Minnerup, J., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.01104-2019 · Cited by 132 · see citing works
Simon, L., Steinmetz, L., Feige, B., Benz, F., Spiegelhalder, K., & Baumeister, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-28853-0 · Cited by 135 · see citing works
He, Q., Zhang, P., Li, G., Dai, H., & Shi, J. (2017) · European Journal of Preventive Cardiology · doi:10.1177/2047487317702043 · Cited by 130 · see citing works
Lallukka, T. M., Sivertsen, B., Kronholm, E., Bin, Y. S., Øverland, S. N., & Glozier, N. (2018) · Sleep Health · doi:10.1016/j.sleh.2017.11.006 · Cited by 125 · see citing works
Bathgate, C. J., Edinger, J. D., & Andrew D. Krystal, M. (2016) · SLEEP · doi:10.1093/sleep/zsw012 · Cited by 127 · see citing works
Comorbid Insomnia With Obstructive Sleep Apnea: Clinical Characteristics and Risk Factors
Cho, Y. W., Kim, K. T., Moon, H.-J., Korostyshevskiy, V. R., Motamedi, G. K., & Yang, K. I. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6988 · Cited by 114 · see citing works
The Association Between Insomnia and Increased Future Cardiovascular Events
Hsu, C., Chen, Y., Chen, M., Huang, C., Chiang, C.-H., Huang, P., Chen, J., Chen, T., Lin, S., Leu, H., et al. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000199 · Cited by 111 · see citing works
Kwon, Y., Gharib, S. A., Biggs, M. L., Jacobs, D. R., Alonso, A., Duprez, D., Lima, J., Lin, G.-M., Soliman, E. Z., Mehra, R., et al. (2015) · Thorax · doi:10.1136/thoraxjnl-2014-206655 · Cited by 110 · see citing works
EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke
Bassetti, C. L. A., Randerath, W., Vignatelli, L., Ferini‐Strambi, L., Brill, A. ‐., Bonsignore, M. R., Grote, L., Jennum, P., Leys, D., Minnerup, J., et al. (2020) · European Journal of Neurology · doi:10.1111/ene.14201 · Cited by 109 · see citing works
Smartphone use and sleep quality in Chinese college students: a preliminary study
Huang, Q., Li, Y., Huang, S., Qi, J., Shao, T., Chen, X., Liao, Z., Lin, S., Zhang, X., Cai, Y., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00352 · Cited by 108 · see citing works
Wu, T., Zou, Y., Xu, K. D., Jiang, X. R., Zhou, M., Zhang, S. B., & Song, C. (2023) · Public Health · doi:10.1016/j.puhe.2022.11.021 · Cited by 107 · see citing works
Chinese Guideline on the Primary Prevention of Cardiovascular Diseases
Chinese Society of Cardiology of Chinese Medical Association, C. D. P. A. R. C. O. C. A. O. R. M. (2021) · Cardiology Discovery · doi:10.1097/cd9.0000000000000025 · Cited by 109 · see citing works
Tseng, T.-H., Chen, H., Wang, L., & Chien, M. (2020) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.8560 · Cited by 112 · see citing works
Arousal From Sleep and Sympathetic Excitation During Wakefulness
Taylor, K. S., Murai, H., Millar, P. J., Haruki, N., Kimmerly, D. S., Morris, B. L., TOMLINSON, G. A., Bradley, T. D., & Floras, J. S. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.08212 · Cited by 99 · see citing works
Seow, L. S. E., Tan, X. W., Chong, S. A., Vaingankar, J. A., Abdin, E., Shafie, S., Chua, B. Y., Heng, D., & Subramaniam, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235816 · Cited by 97 · see citing works
RetractedBathgate, C. J., & Fernández‐Mendoza, J. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0850-6 · Cited by 99 · see citing works
Longitudinal associations between loneliness, social isolation and cardiovascular events
Bu, F., Zaninotto, P., & Fancourt, D. E. (2020) · Heart · doi:10.1136/heartjnl-2020-316614 · Cited by 94 · see citing works
Insomnia and Poor Sleep in CKD: A Systematic Review and Meta-analysis
Tan, L.-H., Chen, P., Chiang, H., King, E., Yeh, H., Hsiao, Y., Chang, D. R., Chen, S.-H., Wu, M.-Y., & Kuo, C. (2022) · Kidney Medicine · doi:10.1016/j.xkme.2022.100458 · Cited by 94 · see citing works
McCurry, S. M., Song, Y., & Martin, J. L. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000205 · Cited by 93 · see citing works
Simonelli, G., Dudley, K. A., Weng, J. F., Gallo, L. C., Perreira, K. M., Shah, N. A., Alcántara, C., Zee, P. C., Ramos, A. R., Llabre, M. M., et al. (2016) · SLEEP · doi:10.1093/sleep/zsw025 · Cited by 90 · see citing works
Top-down control of arousal and sleep: Fundamentals and clinical implications
Krone, L. B., Frase, L., Piosczyk, H., Selhausen, P., Zittel, S., Jahn, F., Kühn, M., Feige, B., Mainberger, F., Klöppel, S., et al. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.12.005 · Cited by 89 · see citing works
Regen, W., Kyle, S. D., Nissen, C., Feige, B., Baglioni, C., Hennig, J., Riemann, D. W., & Spiegelhalder, K. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140290 · Cited by 89 · see citing works
Ni, X., Shergis, J. L., Guo, X., Zhang, A. L., Li, Y., Lu, C., & Xue, C. C. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.08.012 · Cited by 87 · see citing works
Reduced anterior internal capsule white matter integrity in primary insomnia
Spiegelhalder, K., Regen, W., Prem, M., Baglioni, C., Nissen, C., Feige, B., Schnell, S., Kiselev, V. G., Hennig, J., & Riemann, D. W. (2013) · Human Brain Mapping · doi:10.1002/hbm.22412 · Cited by 84 · see citing works
Altered ultradian cortisol rhythmicity as a potential neurobiologic substrate for chronic insomnia
Vargas, I., Vgontzas, A., Abelson, J., Faghih, R., Morales, K., & Perlis, M. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.03.003 · Cited by 74 · see citing works
Long-term and Short-term Effects of Insomnia in Cancer and Effective Interventions
Davis, M. P., & Goforth, H. W. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000071 · Cited by 83 · see citing works
Dong, H., Zhang, Q., Zhu, C., & Lv, Q. (2020) · Health and Quality of Life Outcomes · doi:10.1186/s12955-020-01374-4 · Cited by 84 · see citing works
Chronic Pain and Sleep Disorders in Primary Care
Jank, R., Gallee, A., Boeckle, M., Fiegl, S., & Pieh, C. (2017) · Pain Research and Treatment · doi:10.1155/2017/9081802 · Cited by 83 · see citing works
Do Older Adults Need Sleep? A Review of Neuroimaging, Sleep, and Aging Studies
Scullin, M. K. (2017) · Current Sleep Medicine Reports · doi:10.1007/s40675-017-0086-z · Cited by 82 · see citing works
Guía ESC 2021 sobre la prevención de la enfermedad cardiovascular en la práctica clínica
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Bénétos, A., Biffi, A., Boavida, J. M., Capodanno, D., et al. (2022) · Revista Española de Cardiología · doi:10.1016/j.recesp.2021.10.016 · Cited by 80 · see citing works
Help-seeking behaviors for insomnia in Hong Kong Chinese: a community-based study
Liu, Y., Zhang, J., Lam, S. P., Yu, M. W. M., Li, S. X., Zhou, J., Chan, J. W. Y., Chan, N. Y., Li, A. M., & Wing, Y. K. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.01.006 · Cited by 77 · see citing works
van der Zweerde, T., Lancee, J., Slottje, P., Bosmans, J. E., Someren, E. J. W. V., & van Straten, A. (2020) · Psychotherapy and Psychosomatics · doi:10.1159/000505600 · Cited by 76 · see citing works
Insomnia symptoms and incident heart failure: a population-based cohort study
Mahmood, A., Ray, M. A., Dobalian, A., Ward, K. D., & Ahn, S. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab500 · Cited by 75 · see citing works
Neuroimaging Insights into Insomnia
Spiegelhalder, K., Regen, W., Baglioni, C., Nissen, C., Riemann, D. W., & Kyle, S. D. (2015) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-015-0527-3 · Cited by 75 · see citing works
Physical activity, smoking, and the incidence of clinically diagnosed insomnia
Chen, L., Steptoe, A., Chen, Y.-H., Ku, P., & Lin, C. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.06.040 · Cited by 75 · see citing works
Strand, L. B., Tsai, M. K., Gunnell, D., Janszky, I., Wen, C. P., & Chang, S. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.01.044 · Cited by 73 · see citing works
Macêdo, P. J. O. M., Oliveira, P. S., Foldvary‐Schaefer, N., & Gomes, M. D. M. (2017) · Epilepsy Research · doi:10.1016/j.eplepsyres.2017.05.014 · Cited by 74 · see citing works
The course of cancer-related insomnia: don't expect it to disappear after cancer treatment
Schieber, K., Niecke, A., Geiser, F., Erim, Y., Bergelt, C., Büttner‐Teleagă, A., Maatouk, I., Stein, B., Teufel, M., Wickert, M., et al. (2019) · Sleep Medicine · doi:10.1016/j.sleep.2019.02.018 · Cited by 74 · see citing works
Helbig, A. K., Stöckl, D., Heier, M., Ladwig, K., & Meisinger, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134480 · Cited by 71 · see citing works
Fulk, G. D., Boyne, P., Hauger, M., Ghosh, R. K., Romano, S., Thomas, J. O., Slutzky, A. R., & Klingman, K. J. (2020) · Neurorehabilitation and neural repair · doi:10.1177/1545968320962501 · Cited by 71 · see citing works
Prognostic Significance of Insomnia in Heart Failure
Kanno, Y., Yoshihisa, A., Watanabe, S., Takiguchi, M., Yokokawa, T., Sato, A., Miura, S., Shimizu, T., Nakamura, Y., Abe, S., et al. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-0205 · Cited by 71 · see citing works
Bacaro, V., Chiabudini, M., Buonanno, C., Bartolo, P. D., Riemann, D. W., Mancini, F., & Baglioni, C. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.579107 · Cited by 70 · see citing works
Sleep disorders, nocturnal blood pressure, and cardiovascular risk: A translational perspective
Silvani, A. (2019) · Autonomic Neuroscience · doi:10.1016/j.autneu.2019.02.006 · Cited by 68 · see citing works
Yuan, S., Mason, A. M., Burgess, S., & Larsson, S. C. (2021) · European Journal of Epidemiology · doi:10.1007/s10654-021-00737-5 · Cited by 65 · see citing works
Bassetti, C. L., Ferini‐Strambi, L., Brown, S. A., Adamantidis, A., Benedetti, F., Bruni, O., Cajochen, C., Dolenc‐Grošelj, L., Ferri, R., Gais, S., et al. (2015) · European Journal of Neurology · doi:10.1111/ene.12781 · Cited by 68 · see citing works
Silva‐Costa, A., Griep, R. H., & Rotenberg, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126844 · Cited by 67 · see citing works
Selected psychological comorbidities in coronary heart disease: Challenges and grand opportunities.
Davidson, K. W., Alcántara, C., & Miller, G. E. (2018) · American Psychologist · doi:10.1037/amp0000239 · Cited by 66 · see citing works
Dean, Y. E., Shebl, M. A., Rouzan, S. S., Bamousa, B. A. A., Talat, N. E., Ansari, S. A., Tanas, Y., Aslam, M., Gebril, S., Sbitli, T., et al. (2023) · Clinical Cardiology · doi:10.1002/clc.23984 · Cited by 65 · see citing works
Garland, S. N., Rowe, H. L., Repa, L. M., Fowler, K., Zhou, E. S., & Grandner, M. A. (2018) · Sleep Health · doi:10.1016/j.sleh.2018.01.003 · Cited by 63 · see citing works
Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review
Heyat, M. B. B., Akhtar, F., Ansari, M. A., Khan, A. H., Alkahtani, F., Khan, H. Z., & Lai, D. (2020) · Current Drug Targets · doi:10.2174/1389450121666201027125828 · Cited by 63 · see citing works
Clinical relevance of sleep duration: results from a cross-sectional analysis using NHANES
Cepeda, M. S., Stang, P., Blacketer, C., Kent, J. M., & Wittenberg, G. M. (2016) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.5876 · Cited by 62 · see citing works
Smith, T. W., & Baucom, B. (2017) · American Psychologist · doi:10.1037/amp0000123 · Cited by 62 · see citing works
Neuroimaging Studies in Insomnia
Spiegelhalder, K., Regen, W., Baglioni, C., Riemann, D. W., & Winkelman, J. W. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0405-0 · Cited by 61 · see citing works
Sleepless in the hospital: A systematic review of non-pharmacological sleep interventions
Miller, M. A., Renn, B. N., Chu, F., & Torrence, N. D. (2019) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2019.05.006 · Cited by 62 · see citing works
Huang, T., Zeleznik, O. A., Poole, E. M., Clish, C. B., Deik, A., Scott, J. M., Vetter, C., Schernhammer, E. S., Brunner, R. L., Hale, L. E., et al. (2018) · International Journal of Epidemiology · doi:10.1093/ije/dyy234 · Cited by 56 · see citing works
Rösner, S., Englbrecht, C., Wehrle, R., Hajak, G., & Soyka, M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010703.pub2 · Cited by 60 · see citing works
Insomnia Really Hurts: Effect of a Bad Night's Sleep on Pain Increases With Insomnia Severity
Wei, Y., Blanken, T. F., & Someren, E. J. W. V. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00377 · Cited by 56 · see citing works
The burden of untreated insomnia disorder in a sample of 1 million adults: a cohort study
Grandner, M. A., Olivieri, A., Ahuja, A., Büsser, A., Freidank, M., & McCall, W. V. (2023) · BMC Public Health · doi:10.1186/s12889-023-16329-9 · Cited by 55 · see citing works
Benz, F., Meneo, D., Baglioni, C., & Hertenstein, E. (2023) · Journal of Sleep Research · doi:10.1111/jsr.13984 · Cited by 54 · see citing works
- Authors
- Sofi, F., Cesari, F., Casini, A., Macchi, C., Abbate, R., & Gensini, G. F.
- Affiliations
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Don Carlo Gnocchi Foundation (IT)
- University of Florence (IT)
- Corresponding author
- Sofi, Francesco
- Venue
- European Journal of Preventive Cardiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-08-31
- Volume
- 21
- Issue
- 1
- Pages
- 57-64
- ISSN
- 2047-4873 (ISSN-L)
- 2047-4881
- OpenAlex
- W2121052523
- Cited by
- 713
- References
- 28
- Citations by year
- 2026: 50 · 2025: 70 · 2024: 70 · 2023: 78 · 2022: 66 · 2021: 84 · 2020: 58 · 2019: 60 · 2018: 38 · 2017: 44 · 2016: 40 · 2015: 30 · 2014: 12 · 2013: 13
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Preventive Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- insomnia, cardiovascular disease, cardiovascular mortality, sleep disorders, sleep complaints, risk factors
- MeSH terms
- Cardiovascular Diseases, Humans, Sleep Initiation and Maintenance Disorders, Risk Factors, Sleep, Chi-Square Distribution, Odds Ratio, Risk Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
