The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Post-operative atrial fibrillation: a maze of mechanisms
Open accessAbstract
Post-operative atrial fibrillation (POAF) is one of the most frequent complications of cardiac surgery and an important predictor of patient morbidity as well as of prolonged hospitalization. It significantly increases costs for hospitalization. Insights into the pathophysiological factors causing POAF have been provided by both experimental and clinical investigations and show that POAF is 'multi-factorial'. Facilitating factors in the mechanism of the arrhythmia can be classified as acute factors caused by the surgical intervention and chronic factors related to structural heart disease and ageing of the heart. Furthermore, some proarrhythmic mechanisms specifically occur in the setting of POAF. For example, inflammation and beta-adrenergic activation have been shown to play a prominent role in POAF, while these mechanisms are less important in non-surgical AF. More recently, it has been shown that atrial fibrosis and the presence of an electrophysiological substrate capable of maintaining AF also promote the arrhythmia, indicating that POAF has some proarrhythmic mechanisms in common with other forms of AF. The clinical setting of POAF offers numerous opportunities to study its mechanisms. During cardiac surgery, biopsies can be taken and detailed electrophysiological measurements can be performed. Furthermore, the specific time course of POAF, with the delayed onset and the transient character of the arrhythmia, also provides important insight into its mechanisms. This review discusses the mechanistic interaction between predisposing factors and the electrophysiological mechanisms resulting in POAF and their therapeutic implications.
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Citations
Cites
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BackgroundInflammation as a risk factor for atrial fibrillation
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Cited by
Postoperative atrial fibrillation: mechanisms, manifestations and management
Dobrev, D., Aguilar, M., Heijman, J., Guichard, J.-B., & Nattel, S. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0166-5 · Cited by 608
Perioperative Rosuvastatin in Cardiac Surgery
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Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation
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Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery
Zakkar, M., Ascione, R., James, A. F., Angelini, G. D., & Suleiman, M. S. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.009 · Cited by 274
Phan, K., Ha, H. S. K., Phan, S., Medi, C., Thomas, S. P., & Yan, T. D. (2015) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezu551 · Cited by 143
Metadata
- Authors
- Maesen, B., Nijs, J., Maessen, J., Allessie, M., & Schotten, U.
- Venue
- Europace
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-08-06
- Volume
- 14
- Issue
- 2
- Pages
- 159-174
- ISSN
- 1099-5129 (ISSN-L)
- 1532-2092
- OpenAlex
- W2110286409
- Cited by
- 451
- References
- 14
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- green
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