Hacking the host: exploitation of macrophage polarization by intracellular bacterial pathogens

Global tuberculosis report (2014)

Gabbasova, L. A., & Who, E. R. E. (2014) · Cited by 12,702 · see citing works

Foodborne illness acquired in the United States—Major pathogens

Scallan, E., Hoekstra, R. M., Angulo, F. J., Tauxe, R. V., Widdowson, M.-A., Roy, S. L., Jones, J. L., & Griffin, P. M. (2011) · Emerging Infectious Diseases · doi:10.3201/eid1701.p11101 · Cited by 7,657 · see citing works

The chemokine system in diverse forms of macrophage activation and polarization

MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534 · see citing works

Macrophage activation and polarization: nomenclature and experimental guidelines

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337 · see citing works

Macrophage biology in development, homeostasis and disease

Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · see citing works

NITRIC OXIDE AND MACROPHAGE FUNCTION

MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,184 · see citing works

Macrophage activation and polarization

Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160 · see citing works

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Mills, E. L., Kelly, B., Logan, A., Costa, A. S. H., Varma, M., Bryant, C. E., Tourlomousis, P., Däbritz, J. H. M., Gottlieb, E., Latorre, I., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.064 · Cited by 2,291 · see citing works

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

Xue, J., Schmidt, S. V., Sander, J., Draffehn, A., Krebs, W., Quester, I., De Nardo, D., Gohel, T. D., Emde, M., Schmidleithner, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.006 · Cited by 2,210 · see citing works

Q Fever

Maurin, M., & Raoult, D. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.4.518 · Cited by 1,820 · see citing works

Origin and functions of tissue macrophages

Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585 · see citing works

Macrophage Polarization in Bacterial Infections

Benoit, M. E., Desnues, B., & Mège, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3733 · Cited by 1,317 · see citing works

IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling

Kobayashi, K. S., Hernandez, L. D., Galán, J. E., Janeway, C. A., Medzhitov, R. M., & Flavell, R. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00827-9 · Cited by 1,289 · see citing works

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

Huang, S. C., Everts, B., Ivanova, Y., O’Sullivan, D., Nascimento, M., Smith, A. M., Beatty, W. L., Love-Gregory, L. D., Lam, W. Y., O’Neill, C. M., et al. (2014) · Nature Immunology · doi:10.1038/ni.2956 · Cited by 1,215 · see citing works

Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones

Salgame, P. R., Abrams, J. S., Clayberger, C., Goldstein, H., Convit, J., Modlin, R. L., & Bloom, B. R. (1991) · Science · doi:10.1126/science.1681588 · Cited by 1,027 · see citing works

Macrophage defense mechanisms against intracellular bacteria

Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989 · see citing works

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

Verreck, F. A. W., de Boer, T., Langenberg, D. M. L., Hoeve, M. A., Kramer, M., Vaisberg, E., Kastelein, R., Kolk, A. H. J., Malefyt, R. D. W., & Ottenhoff, T. H. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400983101 · Cited by 969 · see citing works

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

Flannagan, R. S., Cosío, G., & Grinstein, S. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2128 · Cited by 947 · see citing works

Tissue-specific signals control reversible program of localization and functional polarization of macrophages

Okabe, Y., & Medzhitov, R. (2014) · Cell · doi:10.1016/j.cell.2014.04.016 · Cited by 884 · see citing works

Salmonella : A review on pathogenesis, epidemiology and antibiotic resistance

Eng, S.-K., Pusparajah, P., Mutalib, N. A., Ser, H., Chan, K., & Lee, L. (2015) · Frontiers in Life Science · doi:10.1080/21553769.2015.1051243 · Cited by 861 · see citing works

Chlamydia pneumoniae (TWAR)

Kuo, C. C., Jackson, L. A., Campbell, L. A., & Grayston, J. T. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.4.451 · Cited by 819 · see citing works

“Re-educating” tumor-associated macrophages by targeting NF-κB

Hagemann, T., Lawrence, T., McNeish, I., Charles, K. A., Kulbe, H., Thompson, R. G., Robinson, S. C., & Balkwill, F. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080108 · Cited by 792 · see citing works

Krüppel-like factor 4 regulates macrophage polarization

Liao, X., Sharma, N., Kapadia, F., Zhou, G., Lu, Y., Hong, H., Paruchuri, K., Mahabeleshwar, G. H., Dalmas, E., Venteclef, N., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45444 · Cited by 778 · see citing works

Macrophage phenotypes in atherosclerosis

Colin, S., Chinetti‐Gbaguidi, G., & Staels, B. (2014) · Immunological Reviews · doi:10.1111/imr.12218 · Cited by 657 · see citing works

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

Yao, Y., Jeyanathan, M., Haddadi, S., Barra, N. G., Vaseghi‐Shanjani, M., Damjanovic, D., Lai, R., Afkhami, S., Chen, Y., Dvorkin‐Gheva, A., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.042 · Cited by 520 · see citing works

Ehrlichia chaffeensis: a Prototypical Emerging Pathogen

Paddock, C. D., & Childs, J. E. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.1.37-64.2003 · Cited by 520 · see citing works

Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis

Behar, S. M., Martin, C. J., Booty, M. G., Nishimura, T., Zhao, X., Gan, H.-X., Divangahi, M., & Remold, H. G. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.3 · Cited by 447 · see citing works

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

Xu, H., Zhu, J., Smith, S. M., Foldi, J., Zhao, B., Chung, A. Y., Outtz, H. H., Kitajewski, J., Shi, C., Weber, S., et al. (2012) · Nature Immunology · doi:10.1038/ni.2304 · Cited by 438 · see citing works

The Adenosine-Dependent Angiogenic Switch of Macrophages to an M2-Like Phenotype is Independent of Interleukin-4 Receptor Alpha (IL-4Rα) Signaling

Ferrante, C. J., Pinhal-Enfield, G., Elson, G., Cronstein, B. N., Hasko, G., Outram, S., & Leibovich, S. J. (2013) · Inflammation · doi:10.1007/s10753-013-9621-3 · Cited by 375 · see citing works

Intracellular survival of Burkholderia pseudomallei

Jones, A. L., Beveridge, T. J., & Woods, D. E. (1996) · Infection and Immunity · doi:10.1128/iai.64.3.782-790.1996 · Cited by 354 · see citing works

Macrophage Phenotype Modulation by CXCL4 in Atherosclerosis

Gleissner, C. A. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00001 · Cited by 346 · see citing works

Salmonella persisters undermine host immune defenses during antibiotic treatment

Stapels, D. A. C., Hill, P. W. S., Westermann, A. J., Fisher, R. A., Thurston, T. L. M., Saliba, A., Blommestein, I., Vogel, J., & Hélaine, S. (2018) · Science · doi:10.1126/science.aat7148 · Cited by 341 · see citing works

Interferon‐γ reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor‐associated macrophages

Duluc, D., Corvaisier, M., Blanchard, S., Catala, L., Descamps, P., Gamelin, E. C., Ponsoda, S., Delneste, Y., Hebbar, M., & Jeannin, P. (2009) · International Journal of Cancer · doi:10.1002/ijc.24401 · Cited by 328 · see citing works

Stationary phase-associated protein expression in Mycobacterium tuberculosis: function of the mycobacterial alpha-crystallin homolog

Yuan, Y., Crane, D. D., & Barry, C. E. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.15.4484-4492.1996 · Cited by 320 · see citing works

Listeria monocytogenes: epidemiology, human disease, and mechanisms of brain invasion

Drevets, D. A., & Bronze, M. S. (2008) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2008.00404.x · Cited by 303 · see citing works

CXC Chemokine Ligand 4 Induces a Unique Transcriptome in Monocyte-Derived Macrophages

Gleissner, C. A., Shaked, I., Little, K. M., & Ley, K. F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901368 · Cited by 281 · see citing works

Cytokine patterns of immunologically mediated tissue damage

Yamamura, M., Wang, X., Ohmen, J. D., et al. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.4.1470 · Cited by 277 · see citing works

Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype

Malyshev, I. Y., & Malyshev, Y. (2015) · BioMed Research International · doi:10.1155/2015/341308 · Cited by 276 · see citing works

infection:overview and immune responses

Seong, S., Choi, M., & Kim, I.-S. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(00)01352-6 · Cited by 270 · see citing works

Autophagy and inflammasomes

Harris, J., Lang, T., Thomas, J., Sukkar, M. B., Nabar, N. R., & Kehrl, J. H. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.02.013 · Cited by 224 · see citing works

Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells

Rikihisa, Y. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2318 · Cited by 213 · see citing works

Macrophage polarization and bacterial infections

Mège, J., Mehraj, V., & Capo, C. (2011) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e328344b73e · Cited by 211 · see citing works

Divergence of Macrophage Phagocytic and Antimicrobial Programs in Leprosy

Montoya, D. J., Cruz, D., Teles, R. M. B., Lee, D. J., Ochoa, M. T., Krutzik, S. R., Chun, R. F., Schenk, M., Zhang, X., Ferguson, B. G., et al. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.09.002 · Cited by 197 · see citing works

Mycobacterium tuberculosis-Induced Polarization of Human Macrophage Orchestrates the Formation and Development of Tuberculous Granulomas In Vitro

Huang, Z., Luo, Q., Guo, Y., Chen, J., Xiong, G., Peng, Y., Ye, J., & Li, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129744 · Cited by 197 · see citing works

Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages

He, H., Xu, J., Warren, C. M., Duan, D., Li, X., Wu, L., & Iruela‐Arispe, M. L. (2012) · Blood · doi:10.1182/blood-2012-04-422758 · Cited by 195 · see citing works

Macrophage Polarization Drives Granuloma Outcome during Mycobacterium tuberculosis Infection

Marino, S., Cilfone, N. A., Mattila, J. T., Linderman, J. J., Flynn, J. L., & Kirschner, D. E. (2014) · Infection and Immunity · doi:10.1128/iai.02494-14 · Cited by 193 · see citing works

Tick-Borne Emerging Infections

Ismail, N., & McBride, J. W. (2017) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2017.01.006 · Cited by 191 · see citing works

Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis

Kahnert, A., Seiler, P. J., Stein, M., Bandermann, S., Hahnke, K., Mollenkopf, H., & Kaufmann, S. H. E. (2006) · European Journal of Immunology · doi:10.1002/eji.200535496 · Cited by 187 · see citing works

Biphasic Dynamics of Macrophage Immunometabolism during Mycobacterium tuberculosis Infection

Shi, L., Jiang, Q., Bushkin, Y., Subbian, S., & Tyagi, S. (2019) · mBio · doi:10.1128/mbio.02550-18 · Cited by 169 · see citing works

Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy

Cruz, D., Watson, A. D., Miller, C. S., Montoya, D. J., Ochoa, M. T., Sieling, P. A., Gutierrez, M. A., Navab, M., Reddy, S. T., Witztum, J. L., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34189 · Cited by 161 · see citing works

MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection

Sahu, S. K., Kumar, M., Chakraborty, S., Banerjee, S. K., Kumar, R., Gupta, P., Jana, K., Gupta, U. D., Ghosh, Z., Kundu, M., et al. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006410 · Cited by 158 · see citing works

The role of the activated macrophage in clearing Listeria monocytogenes infection

Lee, M. S. (2006) · Frontiers in bioscience · doi:10.2741/2364 · Cited by 146 · see citing works

M2 Polarization of Human Macrophages Favors Survival of the Intracellular Pathogen Chlamydia pneumoniae

Buchacher, T., Ohradanova‐Repic, A., Stockinger, H. S. J., Fischer, M. B., & Weber, V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143593 · Cited by 136 · see citing works

Rickettsiae as Emerging Infectious Agents

Fang, R., Blanton, L. S., & Walker, D. H. (2017) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2017.01.009 · Cited by 134 · see citing works

Stimulation of autophagy suppresses the intracellular survival ofBurkholderia pseudomalleiin mammalian cell lines

Cullinane, M., Gong, L., Li, X., Adler, N. R. L., Tra, T., Wolvetang, E. J., Prescott, M., Boyce, J. D., Devenish, R. J., & Adler, B. (2008) · Autophagy · doi:10.4161/auto.6246 · Cited by 132 · see citing works

Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization

Panagi, I., Jennings, E., Zeng, J., Günster, R. A., Stones, C. D., Mak, H., Jin, E., Stapels, D. A. C., Subari, N. Z., Pham, T. H. M., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.11.002 · Cited by 125 · see citing works

Living on the Edge: Inhibition of Host Cell Apoptosis by Mycobacterium Tuberculosis

Briken, V., & Miller, J. L. (2008) · Future Microbiology · doi:10.2217/17460913.3.4.415 · Cited by 120 · see citing works

Coxiella burnetii, the agent of Q fever, stimulates an atypical M2 activation program in human macrophages

Benoit, M. E., Barbarat, B., Bernard, A., Olive, D., & Mège, J. (2008) · European Journal of Immunology · doi:10.1002/eji.200738067 · Cited by 117 · see citing works

IL-10 is required for polarization of macrophages to M2-like phenotype by mycobacterial DnaK (heat shock protein 70)

Lopes, R. L., Borges, T. J., Zanin, R. F., & Bonorino, C. (2016) · Cytokine · doi:10.1016/j.cyto.2016.06.018 · Cited by 108 · see citing works

Dysregulation of Cytokines in Acute Q Fever: Role of Interleukin‐10 and Tumor Necrosis Factor in Chronic Evolution of Q Fever

Honstettre, A., Imbert, G., Ghigo, É., et al. (2003) · The Journal of Infectious Diseases · doi:10.1086/368129 · Cited by 106 · see citing works

Suppression of PLCβ2 by Endotoxin Plays a Role in the Adenosine A2A Receptor-Mediated Switch of Macrophages from an Inflammatory to an Angiogenic Phenotype

Grinberg, S., Haskó, G., Wu, D., & Leibovich, S. J. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090290 · Cited by 105 · see citing works

Persistent Coxiella burnetii Infection in Mice Overexpressing IL-10: An Efficient Model for Chronic Q Fever Pathogenesis

Meghari, S., Bechah, Y., Capo, C., Lépidi, H., Raoult, D., Murray, P. J., & Mège, J. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040023 · Cited by 100 · see citing works

Burkholderia pseudomallei Interferes with Inducible Nitric Oxide Synthase (iNOS) Production: A Possible Mechanism of Evading Macrophage Killing

Utaisincharoen, P., Tangthawornchaikul, N., Kespichayawattana, W., et al. (2001) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2001.tb02623.x · Cited by 96 · see citing works

Experimental infection of mouse peritoneal mesothelium with scrub typhus rickettsiae: an ultrastructural study

Ewing, E. P., Takeuchi, A., Shirai, A., et al. (1978) · Infection and Immunity · doi:10.1128/iai.19.3.1068-1075.1978 · Cited by 94 · see citing works

Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10

Jaslow, S. L., Gibbs, K. D., Fricke, W. F., Wang, L., Pittman, K. J., Mammel, M. K., Thaden, J. T., Fowler, V. G., Hammer, G. E., Elfenbein, J. R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.072 · Cited by 90 · see citing works

Role of autophagy in IL-1β export and release from cells

Claude‐Taupin, A., Bissa, B., Jia, J., Gu, Y., & Deretic, V. P. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.03.012 · Cited by 86 · see citing works

AttenuatedListeria monocytogenesreprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis

Lizotte, P. H., Baird, J. R., Stevens, C. A., et al. (2014) · OncoImmunology · doi:10.4161/onci.28926 · Cited by 85 · see citing works

Ehrlichia subversion of host innate responses

Rikihisa, Y. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2005.12.003 · Cited by 85 · see citing works

Listeria-based hepatocellular carcinoma vaccine facilitates anti-PD-1 therapy by regulating macrophage polarization

Xu, G., Feng, D., Yao, Y., Li, P., Sun, H., Yang, H., Li, C., Jiang, R., Sun, B., & Chen, Y. (2019) · Oncogene · doi:10.1038/s41388-019-1072-3 · Cited by 84 · see citing works

Expression of Chemokine Genes in Murine Macrophages Infected withOrientia tsutsugamushi

Cho, N., Seong, S., Huh, M.-S., et al. (2000) · Infection and Immunity · doi:10.1128/iai.68.2.594-602.2000 · Cited by 82 · see citing works

Production of interleukin-10 and transforming growth factor beta by peripheral blood mononuclear cells in Q fever endocarditis

Capo, C., Zaffran, Y., Zugun, F., Houpikian, P., Raoult, D., & Mège, J. (1996) · Infection and Immunity · doi:10.1128/iai.64.10.4143-4147.1996 · Cited by 81 · see citing works

Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells

Goldberg, M. F., Roeske, E., Ward, L. N., Pengo, T., Dileepan, T., Kotov, D. I., & Jenkins, M. K. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.009 · Cited by 81 · see citing works

Orientia tsutsugamushi Stimulates an Original Gene Expression Program in Monocytes: Relationship with Gene Expression in Patients with Scrub Typhus

Tantibhedhyangkul, W., Prachason, T., Waywa, D., Filali, A. E., Ghigo, É., Thongnoppakhun, W., Raoult, D., Suputtamongkol, Y., Capo, C., Limwongse, C., et al. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001028 · Cited by 80 · see citing works

Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections

Lim, Y.-J., Yi, M., Choi, J.-A., Lee, J., Han, J.-Y., Jo, S.-H., Oh, S., Cho, H. J., Kim, D. W., Kang, M., et al. (2016) · Scientific Reports · doi:10.1038/srep37211 · Cited by 80 · see citing works

B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis

Bénard, A., Sakwa, I., Schierloh, P., Colom, A., Mercier, I., Tailleux, L., Jouneau, L., Boudinot, P., Al‐Saati, T., Lang, R., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201707-1475oc · Cited by 79 · see citing works

Vanin‐1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection

Meghari, S., Berruyer, C., Lepidi, H., Galland, F., Naquet, P., & Mege, J. (2007) · European Journal of Immunology · doi:10.1002/eji.200636054 · Cited by 72 · see citing works

Chlamydia pneumoniae Infection and Inflammatory Diseases

Porritt, R. A., & Crother, T. R. (2016) · Forum on Immunopathological Diseases and Therapeutics · doi:10.1615/forumimmundisther.2017020161 · Cited by 71 · see citing works

Ehrlichia chaffeensis TRP120 Interacts with a Diverse Array of Eukaryotic Proteins Involved in Transcription, Signaling, and Cytoskeleton Organization

Luo, T., Kuriakose, J. A., Zhu, B., Wakeel, A., & McBride, J. W. (2011) · Infection and Immunity · doi:10.1128/iai.05608-11 · Cited by 69 · see citing works

Actin‐based motility allows Listeria monocytogenes to avoid autophagy in the macrophage cytosol

Cheng, M. I., Chen, C., Engström, P., Portnoy, D. A., & Mitchell, G. (2018) · Cellular Microbiology · doi:10.1111/cmi.12854 · Cited by 63 · see citing works

Alterations of Surface Properties by Macrophage Activation: Expression of Receptors for Fc and Mannose-Terminal Glycoproteins and Differentiation Antigens

Alan, R., Ezekowitz, B., & Gordon, S. (1984) · Springer eBooks · doi:10.1007/978-1-4757-1445-6_2 · Cited by 62 · see citing works

Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei

Vanaporn, M., Wand, M. E., Michell, S. L., et al. (2011) · Microbiology · doi:10.1099/mic.0.050823-0 · Cited by 58 · see citing works

IL ‐37 Expression is Upregulated in Patients with Tuberculosis and Induces Macrophages Towards an M2‐like Phenotype

Huang, Z. W., Gao, C., Chi, X., Hu, Y., Zheng, L., Zeng, T., & Wang, Q. (2015) · Scandinavian Journal of Immunology · doi:10.1111/sji.12326 · Cited by 58 · see citing works

Entry, Intracellular Survival, and Multinucleated-Giant-Cell-Forming Activity of Burkholderia pseudomallei in Human Primary Phagocytic and Nonphagocytic Cells

Whiteley, L., Meffert, T., Haug, M., et al. (2017) · Infection and Immunity · doi:10.1128/iai.00468-17 · Cited by 57 · see citing works

Brucella Dysregulates Monocytes and Inhibits Macrophage Polarization through LC3-Dependent Autophagy

Wang, Y., Li, Y., Li, H., Song, H., Zhai, N., Lou, L., Wang, F., Zhang, K., Bao, W., Jin, X., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00691 · Cited by 56 · see citing works

Intracellular Tryptophan Pool Sizes May Account for Differences in Gamma Interferon-Mediated Inhibition and Persistence of Chlamydial Growth in Polarized and Nonpolarized Cells

Kane, C. D., Vena, R. M., Ouellette, S. P., et al. (1999) · Infection and Immunity · doi:10.1128/iai.67.4.1666-1671.1999 · Cited by 55 · see citing works

Exit Mechanisms of the Intracellular Bacterium Ehrlichia

Thomas, S., Popov, V., & Walker, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015775 · Cited by 51 · see citing works

Ehrlichia chaffeensis Uses Its Surface Protein EtpE to Bind GPI-Anchored Protein DNase X and Trigger Entry into Mammalian Cells

Kumar, D. M., Yamaguchi, M., Miura, K., Lin, M.-Q., Los, M. J., Coy, J. F., & Rikihisa, Y. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003666 · Cited by 51 · see citing works

Endocytosis of Mycobacterium tuberculosis Heat Shock Protein 60 Is Required to Induce Interleukin-10 Production in Macrophages*

Parveen, N., Varman, R., Nair, S., Das, G., Ghosh, S., & Mukhopadhyay, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.461004 · Cited by 50 · see citing works

Entry of Rickettsia tsutsugamushi into polymorphonuclear leukocytes

Rikihisa, Y., & Ito, S. (1982) · Infection and Immunity · doi:10.1128/iai.38.1.343-350.1982 · Cited by 50 · see citing works

In Situ Type 1 Cytokine Gene Expression and Mechanisms Associated with Early Leprosy Progression

Stefani, M. M. A., Martelli, C. M. T., Gillis, T. P., et al. (2003) · The Journal of Infectious Diseases · doi:10.1086/378410 · Cited by 50 · see citing works

Ehrlichia type IV secretion system effector Etf-2 binds to active RAB5 and delays endosome maturation

Yan, Q., Lin, M., Huang, W., Teymournejad, O., Johnson, J. M., Hays, F. A., Liang, Z., Li, G., & Rikihisa, Y. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806904115 · Cited by 48 · see citing works

Live Mycobacterium leprae inhibits autophagy and apoptosis of infected macrophages and prevents engulfment of host cell by phagocytes.

Ma, Y., Qin, P., Zhang, L., Lu, J., Shui, T., Chen, J., Shi, C., Yang, J. H., Smith, M., Liu, Y., et al. (2018) · Europe PMC (PubMed Central) · Cited by 48 · see citing works

Orientia tsutsugamushi, the causative agent of scrub typhus, induces an inflammatory program in human macrophages

Tantibhedhyangkul, W., Amara, A. B., Textoris, J., Gorvel, L., Ghigo, É., Capo, C., & Mège, J. (2012) · Microbial Pathogenesis · doi:10.1016/j.micpath.2012.10.001 · Cited by 47 · see citing works

Effect of Apoptotic Cell Recognition on Macrophage Polarization and Mycobacterial Persistence

Fulco, T. D. O., Andrade, P., Barbosa, M. G. D. M., Pinto, T. M. G., Ferreira, P., Ferreira, H., Nery, J. A. D. C., Real, S. C., Borges, V., Moraes, M., et al. (2014) · Infection and Immunity · doi:10.1128/iai.02194-14 · Cited by 46 · see citing works

Treatment of murine macrophages with interferon-γ inhibits their ability to bind leishmania promastigotes

Mosser, D. M., & Handman, E. (1992) · Journal of Leukocyte Biology · doi:10.1002/jlb.52.4.369 · Cited by 45 · see citing works

Scrub Typhus and the Misconception of Doxycycline Resistance

Wangrangsimakul, T., Phuklia, W., Newton, P. N., et al. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz972 · Cited by 45 · see citing works

Intracellular Survival and Persistence of Chlamydia muridarum Is Determined by Macrophage Polarization

Gracey, E., Lin, A., Akram, A., Chiu, B., & Inman, R. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069421 · Cited by 44 · see citing works

Intracellular Invasion of Orientia tsutsugamushi Activates Inflammasome in ASC-Dependent Manner

Koo, J., Hong, H.-J., Dearth, A. T., Kobayashi, K. S., & Koh, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039042 · Cited by 43 · see citing works

mTORC1-mediated polarization of M1 macrophages and their accumulation in the liver correlate with immunopathology in fatal ehrlichiosis

Haloul, M., Oliveira, E., Kader, M., Wells, J. Z., Tominello, T. R., Andaloussi, A. E., Yates, C. C., & Ismail, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-50320-y · Cited by 43 · see citing works

Penetration of Rickettsia tsutsugamushi into Cultured Mouse Fibroblasts (L Cells): An Electron Microscopic Observation

Urakami, H., Tsuruhara, T., & Tamura, A. (1983) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1983.tb03587.x · Cited by 42 · see citing works

Mycobacterium tuberculosis Heat-Shock Protein 16.3 Induces Macrophage M2 Polarization Through CCRL2/CX3CR1

Zhang, Y., Li, S., Liu, Q., Long, R. L., Feng, J., Qin, H., Mao, L., Liu, L., & Luo, J. (2019) · Inflammation · doi:10.1007/s10753-019-01132-9 · Cited by 42 · see citing works

Host-Cell Survival and Death During Chlamydia Infection

Ying, S., Pettengill, M. A., Ojcius, D. M., & Häcker, G. A. (2007) · Current Immunology Reviews · doi:10.2174/157339507779802179 · Cited by 41 · see citing works

Porin of Shigella dysenteriae activates mouse peritoneal macrophage through Toll-like receptors 2 and 6 to induce polarized type I response

BISWAS, A., BANERJEE, P., Mukherjee, G., et al. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.04.007 · Cited by 37 · see citing works

A Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Trigger Differential Proteome Signatures in Macrophages

Curto, P., Santa, C., Allen, P. E., Manadas, B. J., Simões, I., & Martinez, J. J. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00043 · Cited by 37 · see citing works

Immunohistochemical characterization of the M4 macrophage population in leprosy skin lesions

de Sousa, J. R., Neto, F. D. L., Sotto, M. N., & Quaresma, J. A. S. (2018) · BMC Infectious Diseases · doi:10.1186/s12879-018-3478-x · Cited by 36 · see citing works

Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth

Fletcher, H. A., Keyser, A. T., Bowmaker, M., et al. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-10 · Cited by 35 · see citing works

Extracellular Mycobacterial DnaK Polarizes Macrophages to the M2-Like Phenotype

Lopes, R. L., Borges, T., Araujo, J. F., Pinho, N. G., Bergamin, L., Battastini, A. M., Muraro, S., Souza, A., Zanin, R., & Bonorino, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113441 · Cited by 35 · see citing works

Macrophage Polarization during Murine Lyme Borreliosis

Lasky, C. E., Olson, R. M., & Brown, C. R. (2015) · Infection and Immunity · doi:10.1128/iai.00369-15 · Cited by 35 · see citing works

Immune Response and Coxiella burnetii Invasion

Amara, A. B., Bechah, Y., & Mège, J. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-4315-1_15 · Cited by 33 · see citing works

Jagged1 Instructs Macrophage Differentiation in Leprosy

Kibbie, J. J., Teles, R. M. B., Wang, Z., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005808 · Cited by 33 · see citing works

Murine Alveolar Macrophages Are Highly Susceptible to Replication of Coxiella burnetii Phase IIIn Vitro

Fernandes, T. D., Cunha, L. D., Ribeiro, J. M., Massis, L. M., Lima-Junior, D. S., Newton, H. J., & Zamboni, D. S. (2016) · Infection and Immunity · doi:10.1128/iai.00411-16 · Cited by 31 · see citing works

IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis

Shen, P., Li, Q., Ma, J., Tian, M., Hong, F., Zhai, X.-J., Li, J.-R., Huang, H.-J., & Shi, C.-W. (2017) · BMC Microbiology · doi:10.1186/s12866-017-1095-2 · Cited by 30 · see citing works

Characterization of Early Stages of Human Alveolar Infection by the Q Fever Agent Coxiella burnetii

Dragan, A. L., Kurten, R. C., & Voth, D. E. (2019) · Infection and Immunity · doi:10.1128/iai.00028-19 · Cited by 30 · see citing works

Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte

Dunphy, P. S., Luo, T., & McBride, J. W. (2013) · Microbes and Infection · doi:10.1016/j.micinf.2013.09.011 · Cited by 29 · see citing works

Regulation of Inflammasome by Autophagy

Liu, T. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-0606-2_7 · Cited by 29 · see citing works

Mycobacterium leprae alters classical activation of human monocytes in vitro

Fallows, D. A., Peixoto, B., Kaplan, G., & Manca, C. (2016) · Journal of Inflammation · doi:10.1186/s12950-016-0117-4 · Cited by 26 · see citing works

Burkholderia pseudomallei modulates host iron homeostasis to facilitate iron availability and intracellular survival

Schmidt, I. H. E., Gildhorn, C., Böning, M. A. L., Kulow, V. A., Steinmetz, I., & Bast, A. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006096 · Cited by 22 · see citing works

Characterization of secreted sphingosine‐1‐phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei

Custódio, R., McLean, C. J., Scott, A., et al. (2016) · Molecular Microbiology · doi:10.1111/mmi.13531 · Cited by 21 · see citing works

Lipid A Remodeling Is a Pathoadaptive Mechanism That Impacts Lipopolysaccharide Recognition and Intracellular Survival of Burkholderia pseudomallei

Norris, M. H., Somprasong, N., Schweizer, H. P., et al. (2018) · Infection and Immunity · doi:10.1128/iai.00360-18 · Cited by 21 · see citing works

Overlapping Roles for Interleukin-36 Cytokines in Protective Host Defense against MurineLegionella pneumophilaPneumonia

Nanjo, Y., Newstead, M. W., Aoyagi, T., et al. (2018) · Infection and Immunity · doi:10.1128/iai.00583-18 · Cited by 21 · see citing works

Autophagy and Burkholderia

Devenish, R. J., & Lai, S.-C. A. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.87 · Cited by 20 · see citing works

Triggering of protease-activated receptors (PARs) induces alternative M2 macrophage polarization with impaired plasticity

García‐González, G., Sánchez-González, A., Hernández‐Bello, R., González, G. M., Franco-Molina, M. Á., Coronado-Cerda, E. E., & Palma‐Nicolás, J. P. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.08.004 · Cited by 20 · see citing works

Ixodes ovatus Ehrlichia Exhibits Unique Ultrastructural Characteristics in Mammalian Endothelial and Tick‐derived Cells

Munderloh, U. G., Silverman, D. J., MacNamara, K. C., et al. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04520.x · Cited by 20 · see citing works

Augmented Macrophage Differentiation and Polarization of Tumor-associated Macrophages Towards M1 Subtype in Listeria-administered Tumor-bearing Host

Rai, R. K., Vishvakarma, N. K., Mohapatra, T. M., et al. (2012) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3182661afa · Cited by 19 · see citing works

Robust growth of avirulent phase II Coxiella burnetii in bone marrow-derived murine macrophages

Cockrell, D. C., Long, C. M., Robertson, S. J., Shannon, J. G., Miller, H. E., Myers, L. M., Larson, C. L., Starr, T., Beare, P. A., & Heinzen, R. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173528 · Cited by 18 · see citing works

Antigen Display, T-Cell Activation, and Immune Evasion during Acute and Chronic Ehrlichiosis

Nandi, B., Chatterjee, M., Hogle, K., et al. (2009) · Infection and Immunity · doi:10.1128/iai.01433-08 · Cited by 17 · see citing works

Potential Role of Gr-1+ CD8+ T Lymphocytes as a Source of Interferon-γ and M1/M2 Polarization during the Acute Phase of Murine Legionella pneumophila Pneumonia

Kusaka, Y., Kajiwara, C., Shimada, S., et al. (2018) · Journal of Innate Immunity · doi:10.1159/000490585 · Cited by 17 · see citing works

The spreading process of Ehrlichia canis in macrophages is dependent on actin cytoskeleton, calcium and iron influx and lysosomal evasion

Alves, R. N., Levenhagen, M. A., Levenhagen, M. M. M. D., et al. (2013) · Veterinary Microbiology · doi:10.1016/j.vetmic.2013.11.030 · Cited by 16 · see citing works

Interleukin‐4 Induces Coxiella burnetii Replication in Human Monocytes but not in Macrophages

Ghigo, É., Imbert, G., Capo, C., Raoult, D., & Mège, J. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07410.x · Cited by 16 · see citing works

Inhibitors of Apoptosis Protein Antagonists (Smac Mimetic Compounds) Control Polarization of Macrophages during Microbial Challenge and Sterile Inflammatory Responses

Nadella, V., Mohanty, A., Sharma, L., Yellaboina, S., Mollenkopf, H., Mazumdar, V. B., Palaparthi, R., Mylavarapu, M. B., Maurya, R., Kurukuti, S., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01792 · Cited by 16 · see citing works

Living dangerously: Burkholderia pseudomallei modulates phagocyte cell death to survive

Krakauer, T. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.09.028 · Cited by 14 · see citing works

MyD88 acts as an adaptor protein for inflammatory signalling induced by amyloid-β in macrophages

O’Halloran, S., O’Leary, A., Kuijper, T., & Downer, E. J. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.08.001 · Cited by 13 · see citing works

An immunoperoxidase study of immunological factors in high immune and low resistance granulomas in leprosy

Ridley, M. J., & Russell, D. (1982) · The Journal of Pathology · doi:10.1002/path.1711370208 · Cited by 12 · see citing works

Inactivation of bpsl1039-1040 ATP-binding cassette transporter reduces intracellular survival in macrophages, biofilm formation and virulence in the murine model of Burkholderia pseudomallei infection

Pinweha, P., Pumirat, P., Cuccui, J., Jitprasutwit, N., Muangsombut, V., Srinon, V., Boonyuen, U., Thiennimitr, P., Vattanaviboon, P., Cia, F., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196202 · Cited by 11 · see citing works

Co-Infection with TB and HIV: Converging Epidemics, Clinical Challenges, and Microbial Synergy

Huante, M. B., Nusbaum, R. J., & Endsley, J. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-25381-3_7 · Cited by 11 · see citing works

Nitric oxide enhanced the growth of an obligated intracellular bacterium Orientia tsutsugamushi in murine macrophages

Ogawa, M., Satoh, M., Kataoka, M., et al. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.04.012 · Cited by 10 · see citing works

A proteasome inhibitor produced by Burkholderia pseudomallei modulates intracellular growth

Wagley, S., Vanaporn, M., Rinchai, D., et al. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.03.015 · Cited by 9 · see citing works

Kinetic studies of bioactive products nitric oxide and 8-iso-PGF2αinBurkholderia pseudomalleiinfected human macrophages, and their role in the intracellular survival of these organisms

Nathan, S. A., Qvist, R., & Puthucheary, S. D. A. (2004) · FEMS Immunology & Medical Microbiology · doi:10.1016/j.femsim.2004.08.001 · Cited by 7 · see citing works

Molecular characterization of Orientia tsutsugamushi causing scrub typhus among febrile patients in north-central Bangladesh

Amin, M. M. A., Paul, S. K., Aung, M. S., et al. (2019) · New Microbes and New Infections · doi:10.1016/j.nmni.2019.100595 · Cited by 7 · see citing works

Mitogen-activated protein kinases (MAPKs) are modulated during in vitro and in vivo infection with the intracellular bacterium Burkholderia pseudomallei

D’Elia, R. V., Saint, R. J., Newstead, S. L., Clark, G. C., & Atkins, H. S. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-3038-0 · Cited by 5 · see citing works

Recent advances in the pathogenesis and prevention strategies of dental calculus

Wei, Y., Dang, G.-P., Ren, Z.-Y., Wan, M.-C., Wang, C.-Y., Li, H.-B., Zhang, T., Tay, F. R., & Niu, L.-N. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00529-1 · Cited by 43 · see citing works

Artificially induced in situ macrophage polarization: An emerging cellular therapy for immuno-inflammatory diseases

Chatterjee, O., & Sur, D. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176006 · Cited by 19 · see citing works

Macrophage polarization in atherosclerosis

Yang, S., Yuan, H., Hao, Y., Ren, Z., Qu, S.-L., Liu, L., Wei, D., Tang, Z., Zhang, J., & Jiang, Z. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.10.034 · Cited by 219 · see citing works

LAIR-1 activation inhibits inflammatory macrophage phenotype in vitro

Jin, J., Wang, Y., Ma, Q., Wang, N., Guo, W., Jin, B., Fang, L., & Chen, L. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.05.011 · Cited by 40 · see citing works

Multiple roles of macrophage in skin

Nakai, K. (2021) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2021.08.008 · Cited by 89 · see citing works

Relationship between macrophage polarization and age-related macular degeneration

Liu, F., & Li, J. (2016) · Zhonghua shiyan yanke zazhi · doi:10.3760/cma.j.issn.2095-0160.2016.01.019