The DOI matches its Crossref record; 172 of the 172 references it cites were found in a registry or an index.
Mechanisms and clinical importance of bacteriophage resistance
Open accessAbstract
We are in the midst of a golden age of uncovering defense systems against bacteriophages. Apart from the fundamental interest in these defense systems, and revolutionary applications that have been derived from them (e.g. CRISPR-Cas9 and restriction endonucleases), it is unknown how defense systems contribute to resistance formation against bacteriophages in clinical settings. Bacteriophages are now being reconsidered as therapeutic agents against bacterial infections due the emergence of multidrug resistance. However, bacteriophage resistance through defense systems and other means could hinder the development of successful phage-based therapies. Here, we review the current state of the field of bacteriophage defense, highlight the relevance of bacteriophage defense for potential clinical use of bacteriophages as therapeutic agents and suggest new directions of research.
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Cites
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Cited by
Wang, Y., Gallagher, L. A., Andrade, P. A., Liu, A., Humphreys, I. R., Turkarslan, S., Cutler, K. J., Arrieta-Ortiz, M. L., Li, Y., Radey, M. C., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.017 · Cited by 108
Lam, H. Y. P., Lai, M.-J., Wang, P.-C., Wu, W.-J., Chen, L.-K., Fan, H.-W., Tseng, C.-C., Peng, S.-Y., & Chang, K.-C. (2025) · Antibiotics · doi:10.3390/antibiotics14010045 · Cited by 29
Metadata
- Authors
- Egido, J. E., Costa, A. R., Aparicio-Maldonado, C., Haas, P.-J., & Brouns, S. J. J.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-09-24
- Volume
- 46
- Issue
- 1
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W4229051450
- Cited by
- 325
- References
- 172
- FWCI
- 21.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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