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The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements

Mojica, Francisco J.M., D�ez-Villase�or, Chc)sar, Garc�a-Mart�nez, Jes�s, Soria, Elena·2005·Journal of Molecular Evolution
DOI 10.1007/s00239-004-0046-3
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Abstract

Prokaryotes contain short DN repeats known as CRISPR, recognizable by the regular spacing existing between the recurring units. They represent the most widely distributed family of repeats among prokaryotic genomes suggesting a biological function. The origin of the intervening sequences, at present unknown, could provide clues about their biological activities. Here we show that CRISPR spacers derive from preexisting sequences, either chromosomal or within transmissible genetic elements such as bacteriophages and conjugative plasmids. Remarkably, these extrachromosomal elements fail to infect the specific spacer-carrier strain, implying a relationship between CRISPR and immunity against targeted DNA. Bacteriophages and conjugative plasmids are involved in prokaryotic population control, evolution, and pathogenicity. All these biological traits could be influenced by the presence of specific spacers. CRISPR loci can be visualized as mosaics of a repeated unit, separated by sequences at some time present elsewhere in the cell.

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Crossref · 10.1007/s00239-004-0046-3

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  • Mojica hypothesized that CRISPR loci include fragments of foreign DNA and are part of the immune system of bacteria and archaea.

    “Mojica noticed the similarity of the elements he described in archaea with previously found DNA repeats in bacterial genomes, and was one of the first scientists to hypothesize that these unusual loci include fragments of foreign DNA and are, in fact, a part of the immune system of bacteria and archaea [5].”

    From CRISPR–Cas9: A History of Its Discovery and Ethical Considerations of Its Use in Genome Editing (2022) · cites this paper as [5]

Citations

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Metadata

Authors
Mojica, F. J. M., D�ez-Villase�or, C., Garc�a-Mart�nez, J., & Soria, E.
Venue
Journal of Molecular Evolution
Publisher
Springer Science and Business Media LLC
Published
2005-02
Volume
60
Issue
2
Pages
174-182
ISSN
  • 0022-2844
  • 1432-1432
DOI
10.1007/s00239-004-0046-3
Cited by
2,042
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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