The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design
Open accessAbstract
Targeted manipulation of the gut flora is increasingly being recognized as a means to improve human health. Yet, the temporal dynamics and intra- and interindividual heterogeneity of the microbiome represent experimental limitations, especially in human cross-sectional studies. Therefore, rodent models represent an invaluable tool to study the host-microbiota interface. Progress in technical and computational tools to investigate the composition and function of the microbiome has opened a new era of research and we gradually begin to understand the parameters that influence variation of host-associated microbial communities. To isolate true effects from confounding factors, it is essential to include such parameters in model intervention studies. Also, explicit journal instructions to include essential information on animal experiments are mandatory. The purpose of this review is to summarize the factors that influence microbiota composition in mice and to provide guidelines to improve the reproducibility of animal experiments.
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Cited by
Gut microbiota, metabolites and host immunity
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Metadata
- Authors
- Laukens, D., Brinkman, B. M., Raes, J., De Vos, M., & Vandenabeele, P.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-08-30
- Volume
- 40
- Issue
- 1
- Pages
- 117-132
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W1716352502
- Cited by
- 379
- References
- 166
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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