The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Antibiotic resistance in Staphylococcus aureus. Current status and future prospects
Open accessAbstract
The major targets for antibiotics in staphylococci are (i) the cell envelope, (ii) the ribosome and (iii) nucleic acids. Several novel targets emerged from recent targeted drug discovery programmes including the ClpP protease and FtsZ from the cell division machinery. Resistance can either develop by horizontal transfer of resistance determinants encoded by mobile genetic elements viz plasmids, transposons and the staphylococcal cassette chromosome or by mutations in chromosomal genes. Horizontally acquired resistance can occur by one of the following mechanisms: (i) enzymatic drug modification and inactivation, (ii) enzymatic modification of the drug binding site, (iii) drug efflux, (iv) bypass mechanisms involving acquisition of a novel drug-resistant target, (v) displacement of the drug to protect the target. Acquisition of resistance by mutation can result from (i) alteration of the drug target that prevents the inhibitor from binding, (ii) derepression of chromosomally encoded multidrug resistance efflux pumps and (iii) multiple stepwise mutations that alter the structure and composition of the cell wall and/or membrane to reduce drug access to its target. This review focuses on development of resistance to currently used antibiotics and examines future prospects for new antibiotics and informed use of drug combinations.
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Citations
Cites
Waves of resistance: Staphylococcus aureus in the antibiotic era
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“does not prevent RNA polymerase from binding to the promoter and initiating transcription (Campbell et al. 2001).”
BackgroundRibosome-targeting antibiotics and mechanisms of bacterial resistance
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Vancomycin Resistance in Gram-Positive Cocci
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Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance
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Cited by
Antimicrobial Resistance: A Growing Serious Threat for Global Public Health
Salam, M. A., Al-Amin, M. Y., Salam, M. T., Pawar, J. S., Akhter, N., Rabaan, A. A., & Alqumber, M. A. A. (2023) · Healthcare · doi:10.3390/healthcare11131946 · Cited by 2,338
Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects
Uddin, T. M., Chakraborty, A. J., Khusro, A., Zidan, B. R. M., Mitra, S., Emran, T. B., Dhama, K., Ripon, M. K. H., Gajdács, M., Sahibzada, M. U. K., et al. (2021) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2021.10.020 · Cited by 1,311
Antibiotic resistance and persistence—implications for human health and treatment perspectives
Huemer, M., Mairpady Shambat, S., Brugger, S. D., & Zinkernagel, A. S. (2020) · The EMBO Reports · doi:10.15252/embr.202051034 · Cited by 850
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Metadata
- Authors
- Foster, T. J.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-04-13
- Volume
- 41
- Issue
- 3
- Pages
- 430-449
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W2605699627
- Cited by
- 845
- References
- 16
- FWCI
- 40.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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