Yield Prediction Through Integration of Genetic, Environment, and Management Data Through Deep Learning
Open accessPublished version of a preprint
Abstract
Accurate prediction of the phenotypic outcomes produced by different combinations of genotypes, environments, and management interventions remains a key goal in biology with direct applications to agriculture, research, and conservation. The past decades have seen an expansion of new methods applied toward this goal. Here we predict maize yield using deep neural networks, compare the efficacy of 2 model development methods, and contextualize model performance using conventional linear and machine learning models. We examine the usefulness of incorporating interactions between disparate data types. We find deep learning and best linear unbiased predictor (BLUP) models with interactions had the best overall performance. BLUP models achieved the lowest average error, but deep learning models performed more consistently with similar average error. Optimizing deep neural network submodules for each data type improved model performance relative to optimizing the whole model for all data types at once. Examining the effect of interactions in the best-performing model revealed that including interactions altered the model's sensitivity to weather and management features, including a reduction of the importance scores for timepoints expected to have a limited physiological basis for influencing yield-those at the extreme end of the season, nearly 200 days post planting. Based on these results, deep learning provides a promising avenue for the phenotypic prediction of complex traits in complex environments and a potential mechanism to better understand the influence of environmental and genetic factors.
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Claims the paper makes
5 of 17 cited sources checked · 5 supported · 0 flagged
- Premisecitation
Adding environmental-by-genomic interactions can improve prediction accuracy for new environments or cultivars.
“Including interaction effects between environmental and genomic data can improve predictive accuracy in novel environments or for new cultivars (Jarquin et al. 2021;Li et al. 2021).”
Quote in the paperSubstantial claim1 of 2 sources checked- cites Jarquin et al. 2021 source
- cites Li et al. 2021
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Premisecitation
The sole source of biological data in the study was the G2F initiative.
“The sole source of biological data in this study came from the G2F initiative (McFarland et al. 2020).”
Quote in the paperSubstantial claim1 of 1 sources checked- cites McFarland et al. 2020 source
- Findingown data
The authors' model also exhibits sensitivity that varies with time.
“A time-dependent sensitivity can be observed in our model as well (Fig. 3).”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites Khaki et al. 2020 source
- Findingown data
Separately optimizing DNN submodules by data type improved performance compared with optimizing the entire model for all data types together.
“Optimizing deep neural network submodules for each data type improved model performance relative to optimizing the whole model for all data types at once.”
Quote in the paperSubstantial claim - Findingown data
Models using deep learning and BLUP with interaction terms gave the best overall performance among the compared models.
“We find deep learning and best linear unbiased predictor (BLUP) models with interactions had the best overall performance.”
Quote in the paperSubstantial claim
- Findingown data
The salience map of weather and management data had fewer broadly salient timepoints when interactions were included than when they were not.
“In general, the salience map of the weather and management data features fewer broadly salient timepoints when interactions are included (Fig. 3a) than when they are not (Fig. 3b).”
Quote in the paperNot a substantial claim - Findingown data
Training durations were often considerably longer than the optimal values.
“These training durations were often considerably longer than the optimal values as seen in Fig. 1b.”
Quote in the paperNot a substantial claim - Findingown data
With genomic data only, only kNN outperformed a simple intercept model (RMSE 1.078 vs 1.088, nRMSE 16.548% vs 16.701%).
“When restricted to genomic data, only the kNN model outperforms a simple intercept model (RMSE 1.078 and 1.088, nRMSE of 16.548 and 16.701%).”
Quote in the paperNot a substantial claim - Findingown data
With soil data only, SVR performed best (RMSE 1.059, nRMSE 16.262%), followed by the linear fixed effects model (RMSE 1.071, nRMSE 16.441%).
“However, when restricted to only soil data, SVR performed best (RMSE 1.059, nRMSE 16.262%) followed by the linear fixed effects model (RMSE 1.071, nRMSE 16.441%).”
Quote in the paperNot a substantial claim - Findingown data
SVR performed poorly on genomic data (RMSE 1.212, nRMSE 18.718%).
“SVR performed particularly poorly on this data (RMSE 1.212, nRMSE 18.718%).”
Quote in the paperNot a substantial claim - Findingown data
After data cleaning, 96,137 yield measurements remained.
“Following data cleaning 96,137 yield measurements remained.”
Quote in the paperNot a substantial claim - Findingown data
Using only weather and management data, the BLUP and SVR models performed remarkably well (RMSE 0.945 and 0.985, nRMSE 14.500% and 15.114%).
“Using only weather and management data the BLUP and SVR models (RMSE 0.945 and 0.985, nRMSE 14.500 and 15.114%) performed remarkably well.”
Quote in the paperNot a substantial claim - Findingown data
When interactions were included, the majority of salient time points became less salient, except for the peak 6 days after planting.
“majority of the salient time points become less so with the exception of the peak 6 days after planting as highlighted through subtraction of the 2 salience maps (Fig. 3c).”
Quote in the paperNot a substantial claim - Findingown data
Among genomic data, no major trend in salience with respect to PC was observed.
“Among the genomic data we observe no major trend in salience with respect to PC (Supplementary Fig. 4a).”
Quote in the paperNot a substantial claim - Findingown data
Across the available datasets, no single model outperformed all others.
“Across available datasets, no one model outperforms all others (Fig. 2, Table 5).”
Quote in the paperSubstantial claim - Findingown data
Most models performed better when trained on weather/management data than exclusively on genomic or soil data.
“Most models performed better when trained on weather/management data than exclusively on genomic or soil data.”
Quote in the paperSubstantial claim - Findingown data
Despite sharing the same search space and data, the CO and SO strategies produced notably different final architectures.
“Despite this, the strategy applied resulted in notably different final architectures.”
Quote in the paperSubstantial claim - Findingown data
Model performance was not uniform across site-group-by-year combinations.
“Additionally, performance is not uniform with respect to site-group-by-year combinations (Supplementary Fig. 3, Supplementary Tables 2 and 3).”
Quote in the paperNot a substantial claim - Findingown data
Salience of genomic factors differed notably between the two networks.
“The salience of genomic factors differs notably between the 2 networks (Supplementary Fig. 4b).”
Quote in the paperSubstantial claim - Findingown data
The weather and management CO model contained a broadly salient time point around 25 days before planting and 6 days after planting.
“The weather and management CO model contains a broadly salient time point around 25 days before planting and 6 days after planting.”
Quote in the paperNot a substantial claim - Findingown data
The SO model appeared to have peaks of salience around 150, 183, and 199 days after planting.
“The SO model also appears to have peaks of salience around 150, 183, and 199 days after planting.”
Quote in the paperNot a substantial claim - Findingown data
Among soil factors, the five with highest average salience were soil pH (0.488), phosphorus ppm (0.487), potassium ppm (0.485), sulfate ppm (0.436), and percent organic matter (0.413).
“Among the soil factors, we find that the 5 with the highest average salience were soil pH (0.488), phosphorus ppm (0.487), potassium ppm (0.485), sulfate ppm (0.436), and percent organic matter (0.413) (Supplementary Fig. 4c).”
Quote in the paperNot a substantial claim - Findingown data
When all data sources were used, the CO DNN had the second-lowest average RMSE (0.948), slightly worse than the interaction-containing BLUP (0.937).
“When all data sources are incorporated, the CO DNN achieves the second lowest average RMSE (RMSE is in standard deviations, and when not otherwise specified, values refer to the average across replicates), surpassed only slightly by the interaction-containing BLUP model (RMSE of 0.948 and 0.937, nRMSE 14.554 and 14.388%, respectively).”
Quote in the paperSubstantial claim - Findingown data
Pearson r values for these models followed patterns similar to the RMSE results.
“Pearson r values for these models follow similar patterns to the RMSE results.”
Quote in the paperNot a substantial claim - Findingown data
Within weather and management data, five factors had average salience greater than 0.140: total water (0.245), average solar radiation (0.198), maximum temperature (0.175), average wind direction (0.174), and estimated vapor pressure (0.173).
“Within the weather and management data, considering the average salience across the season (Supplementary Fig. 4d) 5 factors achieved an average salience greater than 0.140-total water (0.245), average solar radiation (0.198), maximum temperature (0.175), average wind direction (0.174), and estimated vapor pressure (0.173).”
Quote in the paperNot a substantial claim - Findingown data
All 41 sites, 6 years, and 158 site-year combinations were represented across the training and test sets.
“Across these sets, all 41 sites, 6 years, and 158 site-year combinations were represented.”
Quote in the paperNot a substantial claim - Findingreasoning
41,513 measurements were used in training or evaluating the model after balancing by downsampling.
“Fewer than half of these (41,513 measurements) were used in training or evaluating the model due to balancing observations with respect to location-year combinations through downsampling.”
Quote in the paperNot a substantial claim - Findingown data
The other methods tested did not show improvement from increasing the number of data modalities used.
“The other methods tested do not show an improvement from increasing the number of data modalities used.”
Quote in the paperSubstantial claim - Findingown data
Differences in salience of soil factors were comparatively small, between -0.011 and 0.0156.
“We find comparatively small differences in the salience of soil factors being between -0.011 and 0.0156 (Supplementary Fig. 4c).”
Quote in the paperNot a substantial claim - Findingcitation
Both saliency maps show a strong peak in salience shortly after planting.
“A strong peak in salience shortly after planting is seen in both saliency maps which agrees with previously reported results (Washburn et al. 2021).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Washburn et al. 2021 source
- Findingown data
The network resulting from CO substantially outperformed the one generated through SO.
“We find that the network resulting from CO substantially outperforms the one generated through SO.”
Quote in the paperSubstantial claim - Findingcitation
Similar to previous modeling, they found that no single data grouping provides sufficient information to disregard all others.
“Similar to the results of previous modeling (Washburn et al. 2021), we find that no single data grouping provides sufficient information to disregard all others.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Washburn et al. 2021 source
- Findingown data
Adding interactions among genetic, environmental, and management factors seems to have improved the accuracy of the DNN and BLUP models.
“Incorporating interactions between genetic, environmental, and management factors appears to have benefitted the accuracy of the DNN and BLUP models.”
Quote in the paperSubstantial claim - Findingown data
Several broadly salient time points, two of which are at the extreme end of the season, have reduced salience when interactions are incorporated.
“Additionally, several broadly salient points in time, 2 of which are at the extreme end of the season, have diminished salience with the incorporation of interactions.”
Quote in the paperNot a substantial claim - Findingown data
Using weather and management data substantially improves the performance of these models.
“Performance for these models is substantially improved with the use of weather and management data.”
Quote in the paperSubstantial claim - Findingown data
Salience peaks shortly after planting in both models.
“Salience peaks shortly after planting in both models.”
Quote in the paperNot a substantial claim - Findingnone given
The difference between the two saliency maps indicates additional sensitivity times in the submodel (approximately -25, +180, +195) to which the interaction model is relatively insensitive.
“The difference between the 2 saliency maps indicates additional times of sensitivity in the submodel (approximately -25, +180, +195) that the interaction model is relatively insensitive to.”
Quote in the paperNot a substantial claim - Findingown data
Total water applied to the field (including irrigation and rainfall, termed WaterTotalInmm) is the most influential factor for determining yield.
“We find that the total water applied to the field (including irrigation and rainfall, termed”
Quote in the paperSubstantial claim - Findingown data
The reduction in salience is not uniform across all highly salient time points.
“This reduction is not uniform across all highly salient time points.”
Quote in the paperNot a substantial claim - Findingown data
Incorporating interactions appears to alter the salience of individual features.
“Interactions not only improve the accuracy of DNNs and consistency across replicates but also appear to be changed in the salience of individual features.”
Quote in the paperNot a substantial claim - Findingown data
Across the different datasets considered, fixed effects models generally performed well.
“Across the different datasets considered, fixed effects models generally performed well.”
Quote in the paperSubstantial claim - Premisecitation
In a large maize study with many sites and genotypes, genetic-by-environment interactions explained more grain yield variation than genetic main effects.
“within a large multisite, multigenotype maize (Zea mays) study, more variation in grain yield is explained by interactions between genetic and environmental factors than by genetic main effects (Rogers et al. 2021).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Rogers et al. 2021
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Premisecitation
DNNs can approximate any function if they are complex enough and have enough training examples.
“deep neural networks (DNNs) which have the capacity to approximate any function, provided they are sufficiently complex and have sufficient examples to learn from.This capability is present regardless of whether they are composed of dense fully connected (Hornik et al. 1989) or convolutional layers (Zhou 2020).”
Quote in the paperSubstantial claim0 of 2 sources checked - Premisecitation
DNN methods can combine static variables like genotype with dynamic variables like temperature in one model.
“The methodology is also flexible with respect to data type, allowing the combination of variables that are static over a growing season (e.g.genotype) and those that are dynamic (e.g.temperature) in a single model (Washburn et al. 2021).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Washburn et al. 2021 source
- Interpretationreasoning
This prevents the model from being trained and tested on the same weather and management data.
“In effect, this prevents the model from being trained and tested on the same weather and management data.”
Quote in the paperSubstantial claim - Study design and conductreasoning
Centering and scaling based on training data summary statistics avoids information leak from test set into training set.
“Centering and scaling based on summary statistics calculated from only the training data and not the full data set avoids this.”
Quote in the paperSubstantial claim - Study design and conductreasoning
Substantial effort was devoted to producing testing, training, and validation sets that would not lead to overconfidence in model accuracy.
“Substantial effort was devoted to producing testing, training, and validation sets that would not lead to overconfidence in the accuracy of our models.”
Quote in the paperSubstantial claim - Interpretationreasoning
Proceeding this way rather than selecting observations at random further reduces an already small number of weather and management conditions.
“Proceeding in this manner rather than selecting observations at random for the testing set further reduces an already small number of weather and management conditions.”
Quote in the paperNot a substantial claim - Interpretationown data
The length of overtraining appeared loosely proportional to the minimum average RMSE each model achieved.
“Furthermore, the length of overtraining appears loosely proportional to the present minimum average RMSE each model achieved.”
Quote in the paperNot a substantial claim - Interpretationreasoning
Using salience to implicate specific genes or gene loci is infeasible because saliences are relative to PCs.
“Given that these saliences are relative to PCs, using salience to implicate specific genes or gene loci is infeasible.”
Quote in the paperSubstantial claim - Interpretationreasoning
This balancing reduces the size of the dataset that can be used in training.
“This reduces the size of the dataset that can be used in training.”
Quote in the paperNot a substantial claim - Study design and conductreasoning
The authors approximately balanced site-by-year groups through downsampling to avoid overfitting DNNs to sites with more observations or biasing hyperparameter selection.
“Beyond including as many distinct locations and seasons as we could, we approximately balanced site-by-year groups through downsampling to avoid overfitting our DNNs to sites with more observations or biasing the selection of hyperparameters.”
Quote in the paperSubstantial claim - Interpretationreasoning
Because this method uses the performance of previously evaluated hyperparameters in selecting the next set, it does not permit parallelization in tuning a single network.
“However, because this method uses the performance of previously evaluated hyperparameters in selecting the next set, it does not permit parallelization in tuning a single network.”
Quote in the paperNot a substantial claim - Interpretationreasoning
This benefit is dependent on the tuning algorithm used.
“This benefit is dependent on the tuning algorithm used.”
Quote in the paperSubstantial claim - Interpretationreasoning
If an optimization procedure conducive to parallelization were used with enough computational resources, this benefit would be nonexistent.
“If an optimization procedure that is conducive to parallelization were used (e.g.hyperband or grid approximation) with enough computational resources this benefit would be nonexistent.”
Quote in the paperSubstantial claim - Interpretationreasoning
If two features in different data sets have a strong interaction effect, CO will not necessarily allow optimization to better capture this interaction.
“However, if 2 features in different data sets have a strong interaction effect (e.g. between genotype and weather patterns) then this approach will not necessarily allow for optimization to better capture this interaction.”
Quote in the paperSubstantial claim - Premiseown data
They focused on salience in weather and management data because it provided the best average performance when used without other datasets.
“Here we focus on salience in the weather and management data as it provided the best average performance when used without other datasets.”
Quote in the paperSubstantial claim
- May combine two claims. 73
- Classified as probably not a substantial claim. 51
- The quote only partly states this claim. 4
May combine two claims.
PremisecitationRecent deep learning yield prediction studies used relatively large datasets, with or without genetic data, and did little feature engineering.
“Several recent studies have applied these methods with a relatively large dataset either with (Washburn et al. 2021) or without (Khaki et al. 2020) a genetic component into the model, with little feature engineering performed.”
Quote in the paperNot a substantial claim1 of 2 sources checkedProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationA recent study using a hybrid machine learning and crop growth model prediction system found water-related features important, although not as important as the trend in genetic and management improvements over time.
“Additionally, in a recent study using a hybrid machine learning and crop growth model prediction system, the authors found that water-related features (e.g.average drought stress, average water table in season) were important, although not as important as the trend in genetic and management improvements over time (Shahhosseini et al. 2021).”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites Shahhosseini et al. 2021 source
May combine two claims.
Findingown dataBLUP models had the smallest average error, whereas deep learning models were more consistent and had similar average error.
“BLUP models achieved the lowest average error, but deep learning models performed more consistently with similar average error.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataIn the best model, adding interactions changed how sensitive the model was to weather and management features, including lower importance scores for late-season timepoints around 200 days after planting.
“Examining the effect of interactions in the best-performing model revealed that including interactions altered the model's sensitivity to weather and management features, including a reduction of the importance scores for timepoints expected to have a limited physiological basis for influencing yield-those at the extreme end of the season, nearly 200 days post planting.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe reported weather data showed evidence of equipment malfunction.
“Within the reported weather data, we observed evidence of equipment malfunction and imputed or adjusted values using linear models.”
Quote in the paperNot a substantial claimMay combine two claims.
FindingreasoningMany sites lacked measurements for many soil properties across the seasons considered, and the timing of fertilizer applications was absent in some cases.
“For example, many sites lack measurements for many soil properties across the seasons considered here, and the timing of fertilizer applications was absent in some cases.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataSalience of PCs differed by as much as 0.432 (PC 24), with differences for the first 8 PCs (31% variance explained) ranging from 0.200 (PC1) to 0.309 (PC7).
“Salience of PCs differs by as much as 0.432 (PC 24), with the differ- ence in the salience of the first 8 PCs (31% variance explained) ran- ging from 0.200 (PC1) to 0.309 (PC7).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe soil subnetwork from CO was notably deeper than the one from SO (7 vs 2 dense layers) but narrowed more by the last processing layer (2 vs 27 units).
“The soil subnetwork resulting from CO is notably deeper than the one from SO (7 and 2 dense layers, respectively) but also narrows more by the last processing layer (2 vs 27 units).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown dataFollowing training and test set definition, 41,513 observations remained: 37,273 in training and 4,240 in test.
“Following the training and test set definition, 41,513 observations remained: 37,273 in the training set and 4,240 in the test set.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe disagreement between epochs minimizing the two validation-loss criteria ranged from 2 epochs for CO Genomic and CO interaction models to 404 epochs for CO weather and management model.
“The disagreement between the epochs which minimized these values ranged from 2 epochs in the case of the CO Genomic model and CO interaction model up to 404 epochs for the CO weather and management model.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe genomic subnetworks from CO and SO both had 2 layers, but CO widened somewhat (layer 1 = 83 units, 16% dropout; layer 2 = 133 units, 23% dropout) while SO began over twice as wide and constricted more (layer 1 = 196 units, 15% dropout; layer 2 = 47 units, 6% dropout).
“Genomic subnetworks resulting from CO and SO are both 2 layers, but the CO model widens somewhat (layer 1 = 83 units, 16% dropout, layer 2 = 133 units 23% dropout) while the SO model begins over twice as wide and constricts more (layer 1 = 196 units, 15% dropout, layer 2 = 47 units 6% dropout).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown dataObservations per site in the full dataset ranged from 156 at GAH2 in 2016 to 3,589 at MNH1 in 2018, with median 498 and mean 608.5 observations per year.
“Observations per site ranged from 156 at”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown data28 of 41 total sites are exclusively in training data and account for 23,758 observations; shared sites account for 13,515 observations; no sites are exclusive to test.
“28 of the 41 total sites are exclusively found in the training data and account for 23,758 observations with the shared sites accounting for 13,515 observations.No sites are exclusive to the test set.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataExcept for the SO DNN, the alternate heuristic also resulted in longer training durations.
“With the exception of the SO DNN, this also resulted in longer training durations.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataOf 3,006 genotypes, 1,559 occur in both sets accounting for 27,131 training and 4,221 test observations; 1,435 genotypes (10,142 observations) are only in training; 12 genotypes (19 observations) are exclusive to test.
“Of the 3,006 genotypes present, 1,559 occur in both sets accounting for 27,131 observations in the training set and 4,221 in the test set.1,435 genotypes (10,142 observations) are only found in the training set whereas 12 genotypes (19 observations) are exclusive to the test set.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown dataWithin a location, 1-2 replicates per genotype was typical (median 2, mean 1.62), but could reach 46.
“Within a location 1-2 replicates per genotype is typical (median of 2, mean of 1.62) but ranges as high as 46 replicates (2369/LH123HT at”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown dataThe top 5 most represented genotypes had 503, 232, 184, 173, and 172 observations; median and mean genotype had 9 and 13.8 observations.
“The number of replicates for each genotype varies with the top 5 most represented genotypes being 2369/LH123HT (503), PHW52/PHN82 (232), PHW52/PHM49 (184), B73/PHN82 (173), and B73/MO17 (172) and the median and mean genotype having 9 and 13.8 observations, respectively.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe two training durations closest to optimum were the CO genomic model (2 epochs over) and the SO model (77 epochs over), performing at 100.2% and 101% of minimum.
“The 2 training durations closest to the optimum were the CO genomic model (2 epochs over) and the SO model (77 epochs over).These models performed at just 100.2 and 101% minimum.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown dataReplicate numbers per genotype varied from 1 to several hundred, with median 18 and mean 26.2 observations.
“The number of replicates for each genotype varies widely from 1 to several hundred (e.g.2369/LH123HT: 882, PHW52/ PHN82: 421, B37/H95: 333, PHW52/PHM49: 331, B73/PHN82: 328), with a median of 18 and mean of 26.2 observations.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe simple linear fixed effects model ranked third (RMSE 0.973, nRMSE 14.933%) and DNN-SO ranked fourth (RMSE 1.024, nRMSE 15.716%), followed by the machine learning models.
“The simple linear fixed effects model ranked third (RMSE 0.973, nRMSE 14.933%) and DNN-SO ranked fourth (RMSE 1.024, nRMSE 15.716%) followed by the machine learning models tested (Fig. 2, Table 5).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe first 8 genomic principal components explain 31% of variance, the first 50 explain 50%, and 1,725 PCs explain over 99%.
“We find that 31% of the variance is explainable by the first 8 principal components (PCs), 50% is explainable by the first 50 PCs, and >99% of the variance is explainable by 1,725 PCs.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe soil dataset has an average completion rate of 47% across all site-by-year combinations.
“The soil dataset contains many missing values, having an average completion rate of 47% across all site-by-year combinations.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe SO and CO weather models had the largest differences between optimal and used epoch numbers (697 and 563 epochs, respectively) and achieved 121% and 110% of the minimum possible RMSE.
“The SO and CO weather models had the largest differences between optimal and used epoch numbersdifferences of 697 and 563 epochs respectively and achieved 121 and 110% of the minimum possible RMSE.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown dataThe CO soil model trained 185 epochs beyond optimal but had RMSE at 102% of minimum.
“The CO soil model trained an excess of 185 epochs but only had RMSE at 102% minimum.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe BLUP had about four times the standard deviation in RMSE across replicates (0.058) as the CO DNN (0.013), making the CO DNN more consistent.
“However, the standard deviation in performance across replicates is about 4 times higher for the BLUP (SD RMSE 0.058) than the CO DNN (SD RMSE 0.013) making the CO DNN a more consistent performer than the BLUP model.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
FindingreasoningThe balancing resulted in 3,006 genotypes represented, a reduction of 665 genotypes.
“This also resulted in fewer genotypes being represented (3,006 total, a reduction of 665 genotypes).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown dataThe data were approximately balanced: all site-year groups in the test set had 265 observations, and no training site-year group exceeded this.
“These data were approximately balanced as described above with all site-year groups in the test set having 265 observations, and no site-year group in the training set exceeding this, although some did contain fewer observations.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe SO model overfits faster and to a greater extent than the full CO model, which did not show evidence of substantial overfitting.
“The SO model overfits faster and to a greater extent than the full CO model, which does not show evidence of substantial overfitting (Fig. 1b, d and e).”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataMost site-years contain a single replicate of a genotype (mean observations 1.27).
“Most site-years contain a single replicate of a genotype (mean observations: 1.27).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe SO model achieved a lower loss than the CO model, and its accuracy worsened rapidly with further training.
“The SO model achieves a loss lower than the CO model, and the accuracy worsens rapidly with further training.”
Quote in the paperSubstantial claimThe quote only partly states this claim.
Findingown dataAllowing multiple data types in the CO DNN reduced average RMSE by 0.070 (1.073% nRMSE) relative to the next best DNN, the CO weather/management model.
“Allowing the use of multiple data types in the CO DNN reduced average RMSE by 0.070 (1.073% nRMSE) relative to the next best DNN, the CO”
Quote in the paperSubstantial claimThe quote only partly states this claim.
Findingnone givenAll models outperformed the intercept model on soil data.
“All models outperformed the intercept model.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe RF model was an exception, with RMSE 0.373 and nRMSE 5.729% above the intercept model.
“The RF model was a clear exception to this, achieving an RMSE of 0.373, nRMSE 5.729% above the intercept model.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe CO network had higher average R2 (0.171 vs 0.032) and more consistent R2 across replicates (SD 0.022 vs 0.065).
“Similarly, average R 2 was higher in the CO network (CO: 0.171 vs SO: 0.032) and more consistent across replicates as well (standard deviation CO: 0.022 vs SO: 0.065).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe full dataset's 96,137 observations spanned 41 sites, 6 years (2014-2019), and 158 site-year combinations.
“In the full dataset (available at 10.5281/zenodo.6916775)the 96,137 observations were spread over 41 sites across 6 years (2014-2019) (158 site-year combinations).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe two most salient PCs were PC 26 (0.423) and PC 24 (0.402), which accounted for 0.350% and 0.392% of total genomic variance, respectively.
“The 2 most salient PCs are PC 26 (0.423) and PC 24 (0.402) which account for 0.350 and 0.392% of the total genomic variance respectively.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe most salient region of time was within the first few days after planting; 8 of the 10 days with highest average salience were days 2-9 following planting.
“Additionally, we find specific time points which appear to be salient broadly with the most salient region of time being within the first few days of planting, indeed 8 of the 10 days with the highest average salience are days 2-9 following planting.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown dataYield values had a mean of about 147.397 bushels per acre and standard deviation of about 48.169 bushels per acre.
“In the case of yield, these values were a mean of ∼147.397bushels per acre and a standard deviation of ∼48.169 bushels per acre, i.e. y = (y Original -147.397)/48.169.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe additional training durations ranged from 2 extra epochs for the CO genomic and interaction models to 404 extra epochs for the CO weather/management model.
“These ranged from an additional 2 epochs in the cases of the CO genomic and interaction models and as many as 404 epochs in the case of the CO weather/management, as shown in Table 6.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown dataIn the weather and management subnetwork, CO resulted in a notably deeper network (6 pairs vs 2 pairs of convolution layers) but used a similar number of filters in the final convolution layer pairs (CO 294 vs SO 303).
“Finally, in the weather and management subnetwork CO resulted in a notably deeper network (6 pairs vs 2 pairs of convolution layers) but used a similar number of filters in the final convolution layer pairs (CO 294 vs SO 303).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataAcross all observations, 3,671 unique genotypes were recorded, derived from 1,681 female and 223 male parent genotypes.
“Across all observations, 3,671 unique genotypes were recorded, derived from 1,681 female and 223 male parent genotypes.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe CO network had lower normalized errors (nRMSE 14.6% vs 15.7%) and lower standard deviation (0.197% vs 0.531%).
“Similar results were seen in the normalized errors (nRMSE CO: 14.6% SO: 15.7%, standard deviation CO: 0.197%, SO: 0.531%).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe CO network was better at predicting yield in the testing set, with lower mean RMSE (0.948 vs 1.024) and more consistent accuracy across replicates (SD 0.013 vs 0.035).
“The CO network was better at predicting yield in the testing set.It achieved a lower mean RMSE (CO: 0.948 vs SO: 1.024) and was more consistently accurate across replicates (standard deviation CO: 0.013 vs SO: 0.035).”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThese hybrids resulted from 1,238 female and 68 male parent genotypes.
“These hybrids resulted from 1,238 female and 68 male parent genotypes.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown data94,996 (98.8%) observations were from hybrids; inbreds accounted for 1,141.
“94,996 (98.8%) of the observations are from hybrids; inbreds account for the other 1,141.”
Quote in the paperNot a substantial claimMay combine two claims. The quote only partly states this claim.
Findingown dataThe majority of weather/management factors had average salience between 0.140 and 0.10, with six below that threshold: average soil temperature (0.095), maximum wind speed (0.084), average soil moisture (0.076), phosphorus applied (0.052), and potassium applied (0.033).
“The majority of factors had an average salience between 0.140 and 0.10 with 6 falling below this thresholdaverage soil temperature (0.095), maximum wind speed (0.084), average soil moisture (0.076), phosphorus applied (0.052), and potassium applied (0.033).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataIn linear models, the improvement relative to the next best model of the same type was 0.046 RMSE (0.699% nRMSE) for fixed effects models and 0.007 RMSE (0.111% nRMSE) for BLUPs.
“In linear models, the improvement relative to the next best model of the same type is 0.046 RMSE (0.699% nRMSE) for fixed effects models and 0.007 RMSE (0.111% nRMSE) for BLUPS.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataRF and RNR performed best with soil data only; using all data reduced performance by 0.024 RMSE (0.375% nRMSE) and 0.012 RMSE (0.185% nRMSE), respectively.
“RF and RNR perform best with soil data only the use of all data reduces performance by 0.024 RMSE (0.375% nRMSE) and 0.012 RMSE (0.185% nRMSE) respectively.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataWhile the best performance was achieved with a BLUP incorporating genomic, soil, weather, and management data, a DNN performed similarly to the BLUP and with less variance in accuracy between model replicates.
“While the best performance was achieved with a BLUP incorporating genomic, soil, weather, and management data, a DNN performed similarly to the BLUP model and with less variance in accuracy between model replicates (Fig. 2).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe SO DNN had a different weather submodule and a higher average RMSE than the weather/management model (by 0.006 RMSE, 0.089% nRMSE) but was more consistent (SD 0.035 vs 0.074).
“The SO DNN contains a different weather submodule and has a higher average RMSE than the weather/management model (by 0.006 RMSE, 0.089% nRMSE) but performed more consistently with a standard deviation of RMSEs 0.035 relative to 0.074.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown datakNN and SVR performed best with weather and management data only; using all data reduced performance by 0.014 RMSE (0.218% nRMSE) and 0.056 RMSE (0.862% nRMSE), respectively.
“kNN and SVR perform best with weather and management data only with the use of all data reducing performance by 0.014 RMSE (0.218% nRMSE) and 0.056 RMSE (0.862% nRMSE) respectively.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataIn the authors' hands, total time spent tuning was driven more by modules with computationally intensive components (convolution layers) rather than the number of modules to optimize.
“In our hands, the total time spent tuning was driven more by modules with computationally intensive components (convolution layers) rather than the number of modules to optimize.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe two DNNs with interactions are more consistent, with much lower RMSE dispersion: standard deviations of 0.013 for the CO model and 0.035 for the SO model, compared with 0.074 for the CO weather model.
“However, the 2 DNNs with interactions are more consistent having a far lower dispersion in RMSE, with standard deviations of 0.013 in the CO model and 0.035 in the SO model as compared with 0.074 in the CO weather model.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataCompared with the submodel, incorporating interactions appears to raise the salience of irrigation, though irrigation is highly salient in both models.
“Relative to the submodel, incorporating interactions appears to increase the salience of irrigation, although it is highly salient in both models (relative to other time-series factors).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataWith only genomic information, these models perform worse than a simple intercept-only model and improve only slightly when soil data are added.
“When restricted to exclusively genomic information these models underperform simple intercept-only models and only improve slightly with the use of soil data.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataWeather and management data reduces error substantially relative to genetic and soil data, but the variation in performance is large.
“We note that weather and management data does reduce error substantially relative to genetic and soil data, but the variation in performance is large (Fig. 2).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe consecutively optimized DNN model yields more consistent yield estimates than the best BLUP model, despite a slightly higher average error.
“The consecutively optimized DNN model developed here shows promise for complementing existing models for crop selection and improvement, as it produces more consistent estimates of yield, despite having a slightly higher average error than the best BLUP model.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataNitrogen's mean salience is comparable to that of relative humidity and photoperiod, whereas phosphorus and potassium have much lower mean salience.
“we observe that nitrogen does have a mean salience comparable to relative humidity and photoperiod, while phosphorus and potassium are far lower.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe BLUP required over 100 GB of RAM to fit while the DNN required GPUs, and fitting took hours to days instead of minutes.
“This is true in terms of hardware (the BLUP required over 100 GB of RAM to fit while the DNN required the use of GPUs) and time (hours to days instead of minutes to fit).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe daily average solar radiation is the next most salient feature of this dataset, followed by maximum temperature and average wind direction.
“The daily average of solar radiation (SolarRadiationMean) is the next most salient feature of this dataset, followed by the maximum temperature (TempMax) and the average wind direction (WindDirectionMean).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataBoth strategies failed to select the epoch that gave the minimum test-set loss for all submodels and led to apparent overfitting in the Weather and Management submodel and the SO model.
“Both strategies considered failed to select the epoch resulting in the minimum loss in the test set for all submodels and resulted in apparent overfitting in the Weather and Management submodel (c.) and the SO model (e.).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataInteraction-containing BLUPs have a lower average error (RMSE 0.937, nRMSE 14.388%) than the weather and management model (RMSE 0.945, nRMSE 14.500%), but a higher standard deviation of RMSE (0.058 vs 0.040).
“Allowing for interactions further improves performance with interaction-containing BLUPs having a lower average error (RMSE 0.937, nRMSE 14.388%) than the weather and management model (RMSE 0.945, nRMSE 14.500%), albeit with a higher standard deviation of RMSE (0.058 vs 0.040).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataA simple linear fixed effects model also performed fairly well and required substantially fewer computational resources and model selection efforts.
“A simple linear fixed effects model also performed fairly well and required substantially fewer computational resources and model selection efforts.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe simultaneously optimized model reaches a lower minimum error than the selected model and does so in far fewer epochs, but it overfits much faster.
“The simultaneously optimized model achieves a minimum error lower than our selected model (see Fig. 1b) and does so in far fewer epochs, but overfits much faster as well.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe CO DNN with interactions (RMSE 0.948, nRMSE 14.554%) and the weather and management model (RMSE 1.018, nRMSE 15.627%) both have lower average error than the SO Model (RMSE 1.024, nRMSE 15.715%).
“A similar result is seen between the CO DNN with interactions (RMSE 0.948, nRMSE 14.554%) and weather and management model (RMSE 1.018, nRMSE 15.627%), both of which achieve lower average error than the SO Model (RMSE 1.024, nRMSE 15.715%).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe CO and SO strategies produce substantially different hyperparameter values and therefore different network architectures, even though the training data are the same.
“Data available for training are the same but the CO and SO strategy result in substantially different hyperparameter values and thus network architecture.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe submodel has additional salience peaks before planting and near the end of the date range considered.
“The submodel contains additional peaks of salience prior to planting and near the end of the considered date range.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataDeep learning is a promising route for predicting complex traits in complex environments and may help reveal environmental and genetic influences.
“Based on these results, deep learning provides a promising avenue for the phenotypic prediction of complex traits in complex environments and a potential mechanism to better understand the influence of environmental and genetic factors.”
Quote in the paperSubstantial claimMay combine two claims.
PremisereasoningDNNs learn directly from data, which reduces the need for feature engineering and dimensionality reduction.
“Additionally, DNNs”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
InterpretationreasoningFor distortions not randomly distributed, filtering may bias the sample and result in a model that appears to perform well but generalizes poorly.
“Note, however, that for distortions that are not randomly distributed, filtering may bias the sample and result in a model that appears to perform well but generalizes poorly (e.g. to sites similar to those with a preponderance of observations excluded).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing). May combine two claims.
InterpretationreasoningIf balance were not a concern, or if it could be achieved without discarding observations, one could employ more strict data filtering without producing a dataset too small for machine learning.
“Indeed, if the balance were not a concern, or if it could be effectively achieved without discarding observations in some groups, one could potentially employ more strict data filtering without producing a dataset too small to benefit from machine learning.”
Quote in the paperNot a substantial claim- The authors state this as an assumption: The distribution of sites collected matches the distribution of sites of interest for prediction, and the number of observations per field site is representative of a future number of observations.
Classified as probably not a substantial claim.
Study design and conductnone givenTrain/test splits were generated randomly with the constraint that any location-year combination could appear in only the testing or training set.
“We generated train/test splits randomly, with the constraint that any location-year combination could appear in only the testing or training set.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductreasoningThe validation set was used to assess hyperparameter performance without compromising the test set, and this was repeated several times to prevent overfitting to a single validation set.
“The validation set is used to assess the performance of a considered set of hyperparameter values without compromising the test set.This was repeated several times to prevent overfitting to a single validation set.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenThe training set was split into training and validation sets stratifying by site-group-by-year groups for hyperparameter selection.
“For use in hyperparameter selection, the training set was split into a training and validation set, stratifying by site-group-by-year groups.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductown dataThe 41 experimental sites were grouped into 29 site groups using GPS distance such that no two groups were within 0.5 degree.
“The 41 experimental sites were grouped into 29 experimental site groups using the distance between their GPS coordinates such that no 2 groups were within 0.5 degree from each other.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Study design and conductreasoningObservations within site-by-year groups were kept in the same partition of the data.
“To this end, we kept observations within site-by-year groups in the same partition of the data.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
InterpretationreasoningExcept where soil features are static from season to season, the model will not be trained and tested on observations with identical soil features.
“Furthermore, except in cases where soil features are static from season to season, the model will not be trained and tested on observations with identical soil features.”
Quote in the paperSubstantial claimMay combine two claims.
Study design and conductreasoningData transformation before cross-validation folds may introduce a different information leak in hyperparameter selection, but this does not affect final evaluation because test set data were not used in those calculations.
“As data transformation occurs prior to determining cross-validation folds a different information leak is potentially introduced within the hyperparameter selection process but does not create an issue for the final evaluation of the model's performance because the test set data were not used in these calculations.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductown dataTraining and test sets do not overlap with respect to site-year combinations but share sites and genetics.
“The training and test sets do not overlap with respect to site-year combinations but share sites and genetics.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisereasoningDropout can reduce overfitting in fully connected layers.
“Where fully connected layers are used, overfitting can be reduced by randomly removing neurons from a layer with a certain”
Quote in the paperNot a substantial claim- Rests on an assumption: DNNs are prone to overfitting to training data, which can cause poor performance.
Classified as probably not a substantial claim. May combine two claims.
Study design and conductnone givenThe best-performing 4 hyperparameter sets for each model were trained for 1,000 epochs and evaluated on 10 defined testing/validation set splits.
“The best-performing 4 hyperparameter sets for each model were trained for 1,000 epochs and evaluated on 10 defined testing/validation set splits.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenA custom subclassed tuner randomly selected one of the previously defined validation folds to prevent overfitting to a single validation set without increasing computational cost.
“We used a custom subclassed version of the tuner to randomly select one of the previously defined validation folds to prevent overfitting to a single validation set without increasing the computational cost.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationNeural networks have been used for yield prediction since at least 2001.
“While neural networks have been applied to the problem of predicting yield since at least 2001 (Liu et al. 2001)”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Liu et al. 2001 source
Classified as probably not a substantial claim. May combine two claims.
Study design and conductreasoningAll site-group-by-year combinations were randomly downsampled so none had more observations than the smallest number in the testing set, to prevent overrepresentation.
“To prevent over representation of certain groups, all site-group-by-year combinations were randomly down sampled so that none had more observations than the smallest number in the testing set.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisereasoningConvolutional layers lower overfitting risk because they work well with fewer parameters than fully connected layers.
“For example, the use of convolutional layers minimizes the potential of overfitting because they perform well with fewer parameters relative to fully connected layers.”
Quote in the paperNot a substantial claim- Rests on an assumption: DNNs are prone to overfitting to training data, which can cause poor performance.
Probably not a substantial claim: may not pass S3 (load-bearing).
InterpretationreasoningThe scale of the G2F project increases the chances of data being absent or compromised due to equipment malfunction, logistical or procedural issues, and resource constraints.
“The scale of this ambitious project increases the chances of data being absent or compromised due to equipment malfunction, logistical or procedural issues, and resource constraints.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S4 (based).
Interpretationnone givenIncorporating multiple data sources and allowing interactions between data types generally appeared to improve accuracy for DNNs, linear fixed effects models, and BLUPs.
“Incorporating multiple data sources and allowing interactions between data types generally appears to improve accuracy for DNNs, linear fixed effects models, and BLUPs.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductnone givenInput data were centered and scaled based on the mean and standard deviation of each parameter in the training data prior to hyperparameter selection and training.
“Prior to hyperparameter selection and training the input data were centered and scaled based on the mean and standard deviation of each parameter in the training data.”
Quote in the paperSubstantial claimMay combine two claims.
InterpretationreasoningThe full CO model performed best by a small margin and allowed direct comparison of interaction effects on factor salience because the single-modality subnetworks were identical except for the prediction layer.
“The full CO model, in addition to performing best (albeit by a small margin), presents an opportunity to directly compare the influence of interactions between data modalities on the salience of factors because the single modality subnetworks are identical except for the prediction layer.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim. May combine two claims.
Premiseown dataThe CO and SO hyperparameter selection strategies had the same range of possible networks, the same data driving network selection, and both used Bayesian optimization.
“Two hyperparameter selection strategies were employed, CO and SO, which have the same range of possible networks (hyperparameter ranges are listed in Table 1), the same data driving network selection and both use Bayesian optimization.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S4 (based). May combine two claims.
Study design and conductnone givenThe 0.5 degree distance threshold is sufficient to group nearby locations while excluding distant ones.
“While this threshold is inconsistent with respect to location it is sufficient to group nearby locations while excluding distant ones.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
InterpretationreasoningDifferent network sizes (CO containing more layers) may account for the difference in overfitting.
“The different network sizes (CO containing more layers) may account for this difference.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone givenWith selected hyperparameters and training duration, each model was fit 10 times to account for random initialization, and each replicate and training history saved.
“With the selected hyperparameters and training duration we fit each model 10 times to account for random initialization and saved each replicate and its training history.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisereasoningCO reduces the range of possible combinations explored by allowing only one module to vary at a time.
“CO reduces the range of possible combinations that are explored by allowing only one module to vary at a time.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). The quote only partly states this claim.
Study design and conductreasoningSimilar to their decision to minimally transform and filter the data, they elected to avoid nudging the architecture of the network in any direction in order to allow the data to inform it instead.
“Similar to our decision to minimally transform and filter the data, we elected to avoid”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationreasoningDifferent models may be better suited to different goals such as achieving good predictive performance consistently (DNN-CO, multiple data types) or maximizing average predictive performance (BLUP, multiple data types) while potentially underperforming expectations due to variability in performance across model replicates.
“Furthermore, different models may be better suited to different goals such as achieving good predictive performance consistently (DNN-CO, multiple data types) or maximizing average predictive performance (BLUP, multiple data types) while potentially underperforming expectations due to variability in performance across model replicates.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataThe SO model is capable of performing comparably to the CO model, but overfits more rapidly.
“The SO model is capable of performing comparably to the CO model, but overfits more rapidly (Fig. 1b).”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
InterpretationreasoningAs a pragmatic matter, CO benefits from the capacity to tune multiple modules at once.
“As a pragmatic matter, CO benefits from the capacity to tune multiple modules at once.”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationreasoningThe observed performance differences suggest a substantial environmental effect, which is intensified by splitting observations from site-by-year groups exclusively into training or testing sets.
“These performance differences are suggestive of a substantial environmental effect, exacerbated by the stratifying observations from site-by-year groups into exclusively training or testing sets.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
InterpretationreasoningSO represents the reverse situation: with all features available, interactions between features in different tensors can be leveraged, but the hyperparameter space to explore is larger as all hyperparameters are free to vary.
“SO represents the reverse situation.With all features available, interactions between features in different tensors can be leveraged, but the hyperparameter space to explore is larger as all the hyperparameters are free to vary.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationLinear modeling results suggest a positive association between precipitation early in development and yield.
“Linear modeling results find similar results and suggest a positive association between precipitation early in development and yield (Rogers et al. 2021).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Rogers et al. 2021
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationPrevious DNNs developed with a subset of G2F data also identified precipitation as substantially influencing yield.
“Previous DNNs developed with a subset of G2F data also identified precipitation as substantially influencing yield (Washburn et al. 2021).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Washburn et al. 2021 source
May combine two claims.
Interpretationown dataOnly after integration of all data types do they see a relative reduction in error and consistency in this reduction in DNNs.
“Only after integration of all data types do we see a relative reduction in error and consistency in this reduction in DNNs.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenAlthough they aimed to broaden the range of possible architectures relative to previous modeling on G2F data, they constrained the overall structure to process each tensor individually then allow interactions between the final layer of each module.
“Although we aimed to broaden the range of possible architectures relative to previous modeling on G2F data (Washburn et al. 2021), we constrained the overall structure to process each tensor individually then allowing for interactions between the final layer of each module.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Washburn et al. 2021 source
May combine two claims.
Study design and conductreasoningThe SO DNN architecture was selected based on 40 trials whereas the CO DNN architecture was selected based on 40 trials for each module (160 trials across the whole network), which confounds the comparison.
“The SO DNN architecture was selected based on 40 trials whereas the CO DNN architecture was selected based on 40 trials for each module (160 trials across the whole network) which confounds the comparison.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Premisenone givenThey used a Bayesian optimization procedure that aims to produce useful hyperparameter combinations in fewer cycles than a simpler method such as grid approximation.
“We used a Bayesian optimization procedure that aims to produce useful hyperparameter combinations in fewer cycles than a simpler method such as grid approximation.”
Quote in the paperNot a substantial claim
The paper relies on this without support.
DNNs are robust to lower-quality data and benefit from an abundance of data.
“Furthermore, since DNNs are robust to lower-quality data and benefit from an abundance of data, we employ a strategy of minimal feature transformation and curation and maximal inclusion of observations.”
The paper relies on this without support.
DNNs require an abundance of data for training.
“DNNs require an abundance of data for training.”
The paper relies on this without support.
DNNs are prone to overfitting to training data, which can cause poor performance.
“DNNs are prone to overfitting to training data resulting in poor performance.”
The paper relies on this without support.
The complexity of DNNs can obscure which aspects of the data the model is using.
“Even when performing well, the complexity of these models can obscure what aspects of the data the model is using.”
The authors state this as an assumption.
All group-by-year combinations are equally likely to be of interest.
“For example, we assume that all group-by-year combinations are equally likely to be of interest.”
The authors state this as an assumption.
The distribution of sites collected matches the distribution of sites of interest for prediction, and the number of observations per field site is representative of a future number of observations.
“However, if we assume that the distribution of sites collected match those of interest for prediction (i.e. one is interested in predicting any future observation collected by G2F and the number of observations per field site is representative of a future number of observations) then downsampling can be skipped, resulting a larger dataset.”
The paper relies on this without support.
Machine learning models, particularly deep learning, often benefit from having an abundance of data from which to learn feature relationships.
“We elected to minimally filter observations because machine learning models, particularly deep learning, often benefit from having an abundance of data from which to learn feature relationships.”
The paper relies on this without support.
Many missing or distorted values in the dataset are not missing at random.
“Our aim was to minimally filter the dataset while preventing missing or distorted values (many of which are not missing at random) from altering model accuracy and feature salience.”
The paper relies on this without support.
DNNs tend to perform better when more data are available.
“DNNs tend to perform better with an abundance of data, so alternate approaches that retain more observations are of interest.”
The paper relies on this without support.
Deep learning models produce parameters that are less readily interpretable than those of standard statistical procedures and do not incorporate plant physiology as mechanistic crop growth models do.
“Deep learning models do not result in parameters which are as readily interpretable as those of more standard statistical procedures and do not incorporate the physiology of the plant as mechanistic crop growth models do.”
The paper relies on this without support.
In deep learning models, random weight initialization at the start of training causes performance to vary across trials.
“In deep learning models random initialization of weights at the beginning of training result in different performance across trials.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In Kick et al. (2023), soil conditions are treated as a separate modality from weather and management conditions, and a sub-model is trained for soil conditions before fusion.
“in the study by Kick et al. (2023), soil conditions, weather, and management conditions are all considered environmental factors. However, soil conditions are treated as a separate modality, and a sub-model is trained for soil conditions before the fusion process.”
From A review of multimodal deep learning methods for genomic-enabled prediction in plant breeding (2024) · cites this paper as Kick et al. (2023)
Kick et al. (2023) developed an MMDL model integrating genomic, weather, soil, and management data from G2F to analyze genotype, environment, and management effects on maize yield.
“Kick et al. (2023) developed an MMDL model integrating genomic, weather, soil, and management data from the G2F initiative to analyze genotype, environment, and management effects on maize yield (Supplementary Table 5).”
From A review of multimodal deep learning methods for genomic-enabled prediction in plant breeding (2024) · cites this paper as Kick et al. (2023)
Overall, MMDL models outperformed unimodal models.
“Overall, MMDL models outperformed unimodal models but did not always surpass traditional approaches.”
From A review of multimodal deep learning methods for genomic-enabled prediction in plant breeding (2024) · cites this paper as Kick et al. (2023)
The MMDL approach achieved RMSE 0.948 and NRMSE 14.554% for maize yield.
“The MMDL approach achieved a low RMSE (0.948) and normalized root mean square error (NRMSE) (14.554%), closely matching the BLUP model (RMSE 0.937 and NRMSE 14.388%) and showed greater consistency across replicates.”
From A review of multimodal deep learning methods for genomic-enabled prediction in plant breeding (2024) · cites this paper as Kick et al. (2023)
The MMDL approach showed greater consistency across replicates than BLUP.
“The MMDL approach achieved a low RMSE (0.948) and normalized root mean square error (NRMSE) (14.554%), closely matching the BLUP model (RMSE 0.937 and NRMSE 14.388%) and showed greater consistency across replicates.”
From A review of multimodal deep learning methods for genomic-enabled prediction in plant breeding (2024) · cites this paper as Kick et al. (2023)
MMDL models did not always surpass traditional approaches.
“Overall, MMDL models outperformed unimodal models but did not always surpass traditional approaches.”
From A review of multimodal deep learning methods for genomic-enabled prediction in plant breeding (2024) · cites this paper as Kick et al. (2023)
The MMDL approach closely matched BLUP (RMSE 0.937 and NRMSE 14.388%).
“The MMDL approach achieved a low RMSE (0.948) and normalized root mean square error (NRMSE) (14.554%), closely matching the BLUP model (RMSE 0.937 and NRMSE 14.388%) and showed greater consistency across replicates.”
From A review of multimodal deep learning methods for genomic-enabled prediction in plant breeding (2024) · cites this paper as Kick et al. (2023)
Some studies (Kick et al. 2023; Togninalli et al. 2023) have shown no clear superiority of MMDL over unimodal DL in terms of prediction accuracy.
“In some instances, studies such as Kick et al. (2023) and Togninalli et al. (2023) have shown no clear superiority of MMDL over unimodal DL in terms of prediction accuracy.”
From A review of multimodal deep learning methods for genomic-enabled prediction in plant breeding (2024) · cites this paper as Kick et al. (2023)
Kick et al. (2023) integrates genomics, environments, and management into the multimodal DL and examined the effect of various types of interactions.
“The recent study conducted by Kick et al. (2023) integrates genomics, environments, and management into the multimodal DL and examined the effect of various types of interactions.”
From Multimodal deep learning methods enhance genomic prediction of wheat breeding (2023) · cites this paper as Kick et al. (2023)
In Kick et al. (2023), DL and GBLUP provided similar prediction accuracy, but GBLUP had the lowest average error, whereas multimodal DL performed more consistently with similar average errors.
“Results show that although the DL and GBLUP provided similar prediction accuracy, the GBLUP has the lowest average error, whereas the multimodal DL performed more consistently with similar average errors.”
From Multimodal deep learning methods enhance genomic prediction of wheat breeding (2023) · cites this paper as Kick et al. (2023)
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Salience count lists only five factors
MinorThe text says six factors fall below the threshold, but names only five.
“with 6 falling below this thresholdaverage soil temperature (0.095), maximum wind speed (0.084), average soil moisture (0.076), phosphorus applied (0.052), and potassium applied (0.033).”
“average soil temperature (0.095), maximum wind speed (0.084), average soil moisture (0.076), phosphorus applied (0.052), and potassium applied (0.033).”
Seasonal window length does not add up
MinorThe stated window includes 75 days before planting, 204 days after planting, and the planting day itself. That totals 280 days, not 210.
Reported 210 · recomputed 280
“This resulted in a window of 75 days prior to planting and 204 days after (210 total including the planting day).”
Genomic SVR error differs from Table 5
MinorThe results prose reports a genomic SVR RMSE of 1.212, while Table 5 reports 1.219457. The difference is not explained by rounding to three decimal places.
“SVR performed particularly poorly on this data (RMSE 1.212, nRMSE 18.718%).”
“| | SVR | 1.219457 | 0.048874 | 18.71803 | 0.750191 | 0.059061 | 0.08288 |”
Selected SVR parameter exceeds its stated range
MinorThe reported soil-only value of C is 5.613996, outside the stated search range of 1-5.
“C = 1-5 (log uniformly distributed).”
“| | C | 1-5 (log uniform) | 2.772318 | 5.613996 | 4.623351 | 2.787589 |”
CO soil layer width conflicts with Table 2
MinorThe prose gives the final CO soil processing layer as 2 units, whereas Table 2 gives its seventh and final listed layer 4 units.
“The soil subnetwork resulting from CO is notably deeper than the one from SO (7 and 2 dense layers, respectively) but also narrows more by the last processing layer (2 vs 27 units).”
“| | | 5 | 4 | | | | | 6 | 4 | | | | | 7 | 4 | |”
Single-modality models are mislabeled as SO
MinorThe methods call the comparison models SO single-modality DNNs, but the figure caption says DNN-SO requires all data types and appears only in the multiple-types panel.
“To examine the influence of allowing interactions we contrast these saliences with the saliences of SO single modality DNNs.”
“Note that DNN-SO requires all data types and thus only appears in panel d.”
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A review of multimodal deep learning methods for genomic-enabled prediction in plant breeding
Montesinos-López, O. A., Chavira-Flores, M., Kiasmiantini, Crespo-Herrera, L., Saint Piere, C., Li, H., Fritsche-Neto, R., Al-Nowibet, K., Montesinos-López, A., & Crossa, J. (2024) · GENETICS · doi:10.1093/genetics/iyae161 · Cited by 47 · see citing works
Deep learning methods improve genomic prediction of wheat breeding
Montesinos‐López, A., Crespo‐Herrera, L., Dreisigacker, S., Gerard, G., Vitale, P., Pierre, C. S., Govindan, V., Tadesse, Z., Flores, M. C., Pérez‐Rodríguez, P., et al. (2024) · Frontiers in Plant Science · doi:10.3389/fpls.2024.1324090 · Cited by 43 · see citing works
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“Kick et al. (2023) utilized k-means with dynamic time warping to cluster the weather and management time-series data, which enhanced the performance of models that only used genomic data.”
BackgroundMethodLopez-Cruz, M. A., Aguate, F. M., Washburn, J. D., de León, N., Kaeppler, S. M., Lima, D. C., Tan, R., Thompson, A., Bretonne, L. W. D. L., & Campos, G. D. L. (2023) · Nature Communications · doi:10.1038/s41467-023-42687-4 · Cited by 44 · see citing works
Self-citationMultimodal deep learning methods enhance genomic prediction of wheat breeding
Montesinos-López, A., Rivera, C., Pinto, F., Piñera, F., Gonzalez, D., Reynolds, M., Pérez-Rodríguez, P., Li, H., Montesinos-López, O. A., & Crossa, J. (2023) · G3: Genes, Genomes, Genetics · doi:10.1093/g3journal/jkad045 · Cited by 41 · see citing works
Application of machine learning and genomics for orphan crop improvement
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“Kick et al. 39 utilised genetic data, environmental measurements, and recorded management interventions to predict maize yields, fi nding that DL models performed similarly to, but with greater consistency than, BLUP models.”
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Self-citationImproved genomic prediction performance with ensembles of diverse models
Tomura, S., Wilkinson, M. J., Cooper, M., & Powell, O. M. (2025) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkaf048 · Cited by 26 · see citing works
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Improving plant breeding through AI-supported data integration
Sangjan, W., Kick, D. R., & Washburn, J. D. (2025) · Theoretical and Applied Genetics · doi:10.1007/s00122-025-04910-2 · Cited by 24 · see citing works
“…accuracy by analyzing complex data-sets to uncover patterns and correlations that may be missed by other methods, leading to more robust predictive models and a more reliable selection of desirable traits (Yang et al. 2022; Kick et al. 2023; Montesinos-López et al. 2024; and many others).”
InfluentialSelf-citationThe role of artificial intelligence in crop improvement
Negus, K. L., Li, X., Welch, S. M., & Yu, J. (2024) · Advances in agronomy · doi:10.1016/bs.agron.2023.11.001 · Cited by 20 · see citing works
MegaLMM improves genomic predictions in new environments using environmental covariates
Hu, H., Rincent, R., & Runcie, D. E. (2024) · Genetics · doi:10.1093/genetics/iyae171 · Cited by 17 · see citing works
Jubair, S., Tremblay-Savard, O., & Domaratzki, M. (2023) · Artificial Intelligence in Agriculture · doi:10.1016/j.aiia.2023.05.001 · Cited by 16 · see citing works
Yu, T., Zhang, H., Chen, S., Gao, S., Liu, Z., Wang, J., Crossa, J. L., Montesinos-López, O. A., Hearne, S., & Li, H. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf414 · Cited by 16 · see citing works
Integrative multi-environmental genomic prediction in apple
Jung, M., Quesada‐Traver, C., Roth, M., Aranzana, M. J., Muranty, H., Rymenants, M., Guerra, W., Holzknecht, E. M., Pradas, N., Lozano, L., et al. (2024) · Horticulture Research · doi:10.1093/hr/uhae319 · Cited by 15 · see citing works
Breeding Smarter: Artificial Intelligence and Machine Learning Tools in Modern Breeding—A Review
Garcia‐Oliveira, A. L., Dwivedi, S. L., Chander, S., Nelimor, C., El-Moneim, D. A., & Ortiz, R. O. (2026) · Agronomy · doi:10.3390/agronomy16010137 · Cited by 14 · see citing works
Berlingeri, J. M., Fuentes, A., Ranario, E., Yun, H., Rim, E. Y., Garrett, O. D., Howard, A., LaPorte, M.-F., Lô, S., Pauli, D., et al. (2025) · Theoretical and Applied Genetics · doi:10.1007/s00122-025-04984-y · Cited by 13 · see citing works
Zou, Q., Tai, S., Yuan, Q., Nie, Y., Gou, H., Wang, L., Li, C., Jing, Y., Dong, F., Yue, Z., et al. (2024) · Computers and Electronics in Agriculture · doi:10.1016/j.compag.2024.109833 · Cited by 18 · see citing works
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Washburn, J. D., Adak, A., DeSalvio, A. J., Arik, M. A., & Murray, S. C. (2024) · The Plant Phenome Journal · doi:10.1002/ppj2.20113 · Cited by 10 · see citing works
“…and collects data on hundreds of maize hybrids in dozens of locations across the United States every year (AlKhalifah et al., 2018; Gage et al., 2017; Kick et al., 2023; Lawrence-Dill et al., 2019; Lima et al., 2023a,b,c; McFar-land et al., 2020; Rogers et al., 2021; Washburn et al., 2021).”
Self-citationMmbando, G. S. (2024) · Discover Applied Sciences · doi:10.1007/s42452-024-06212-6 · Cited by 11 · see citing works
“These datasets are analyzed by AI-driven algorithms, especially ML techniques, to find trends, correlations, and predictive insights related to GM crop risk assessment [9, 25, 74].”
Predicting enviromically adapted varieties with big data
Gogna, A., Kamali, B., Wimmer, V., Schmidt, R. H., Rezaei, E. E., Eckhoff, W. M., Reif, J. C., & Zhao, Y. (2026) · Genome biology · doi:10.1186/s13059-025-03914-x · Cited by 8 · see citing works
“Artificial intelligence approaches, including machine learning methods such as random forests [14, 15] and deep learning methods like convolutional neural networks [16] have also been proposed for this purpose.”
Plant microbiome engineering: from inoculation to genome editing
Yadav, J., Gehlot, P., Soni, P., et al. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1781381 · Cited by 6 · see citing works
“For crop yield prediction, machine learning models trained on soil and climate variables commonly achieve accuracies between 91% and 97%, with XGBoost emerging as a particularly robust framework (Jain and Srihari, 2022; Kick et al., 2023).”
Souaibou, M., Yán, H., Dai, P., Pān, J., Li, Y., Shi, Y., Gǒng, W., Shāng, H., Gōng, J., & Yuán, Y. (2025) · Plants · doi:10.3390/plants14132053 · Cited by 6 · see citing works
“…neural networks (CNNs) and dense neural networks (DNNs) are notable due to their ability to capture the non-linear correlation between genomic, environmental, and historical variables, demonstrated by their application to forecast grain yield [61] and the investigation of crop biochemistry [62].”
Sarzaeim, P., & Muñoz‐Arriola, F. (2024) · Agronomy · doi:10.3390/agronomy14040733 · Cited by 7 · see citing works
Fernandes, I. K., Vieira, C. C., Dias, K. O. D. G., & Fernandes, S. B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.08.579534 · Cited by 5 · see citing works
A Deep Autoencoder Compression-Based Genomic Prediction Method for Whole-Genome Sequencing Data
Song, H., Dong, T., Wang, W., Yan, X., Geng, C., Bai, S., & Hu, H. (2025) · Biology · doi:10.3390/biology14111622 · Cited by 4 · see citing works
“Similarly, Kick et al. [32] applied principal component analysis for dimensionality reduction, integrating the processed data into a multimodal deep learning model, achieving performance comparable to GBLUP.”
Gholizadeh, A., Mehravi, S., Hanifei, M., & Akbarpour, O. (2024) · Acta Physiologiae Plantarum · doi:10.1007/s11738-024-03754-5 · Cited by 4 · see citing works
“Therefore, when the genotype × environment interaction is significant, an ANN approach is recommended instead of regression in yield prediction because the yield is higher and the estimation is faster (Kick et al. 2023).”
CropCare: Advanced Crop Management System with Intelligent Advisory and Machine Learning Techniques
Rahman, M. J., Ahmed, S., Biswas, S., et al. (2024) · doi:10.1109/iceeict62016.2024.10534582 · Cited by 4 · see citing works
“Accurately predicting crop yield is a complex process due to the intricate interactions between factors such as soil variability, weather conditions, and the interplay between seed genetics, crop management decisions, and the environment [2], [3], [4].”
BackgroundPradhan, S., Wang, G., Xuan, J., Wang, P., Li, C., & Jie Lu, B. (2025) · IEEE Conference on Artificial Intelligence (CAI) · doi:10.1109/cai64502.2025.00059 · Cited by 3 · see citing works
“For instance, [19] proposed MMDL models that comprehensively integrate diverse data types for maize yield prediction by synergizing genomic, environmental, and management information.”
LSTM Autoencoder-Based Deep Neural Networks for Barley Genotype-to-Phenotype Prediction
Wang, G., Xuan, J., Wang, P., Li, C., & Lu, J. (2024) · Lecture notes in computer science · doi:10.1007/978-981-96-0348-0_25 · Cited by 4 · see citing works
Washburn, J. D., Varela, J. I., Xavier, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.13.612969 · Cited by 3 · see citing works
Self-citationWang, P., Zhang, X.-Q., Dang, V., Zhou, M., Shabala, S., He, T., & Li, C. (2026) · Plant Phenomics · doi:10.1016/j.plaphe.2026.100224 · Cited by 2 · see citing works
“This study also contributes to a new paradigm in haplotype-based breeding, an approach with growing success in other crops such as pigeon pea [57], wheat [6], and maize [30], highlighting its broad potential for genetic improvement across species.”
Improved Genomic Prediction Performance with Ensembles of Diverse ModelsPreprint
Tomura, S., Wilkinson, M. J., Cooper, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.06.611589 · Cited by 2 · see citing works
Integrative multi-environmental genomic prediction in applePreprint
Jung, M., Quesada‐Traver, C., Roth, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.20.599822 · Cited by 2 · see citing works
Sarzaeim, P., & Muñoz‐Arriola, F. (2024) · Preprints.org · doi:10.20944/preprints202403.0999.v1 · Cited by 2 · see citing works
Structured multimodal deep learning improves genomic prediction in future environments
Potze, A., van Eeuwijk, F. A., & Athanasiadis, I. N. (2026) · Genetics · doi:10.1093/genetics/iyag204 · Cited by 1 · see citing works
Kusmec, A., Negus, K. L., & Yu, J. (2025) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkaf314 · Cited by 4 · see citing works
A dynamic approach for corn yield prediction to ensure agricultural resilience in the U.S. Midwest
Mitra, A., Karki, S., Fleisher, D. H., Ray, C., & Reddy, V. R. (2025) · Smart Agricultural Technology · doi:10.1016/j.atech.2025.101295 · Cited by 1 · see citing works
Kusmec, A., Yeh, C., Initiative, T. G. T. F., & Schnable, P. S. (2020) · New Phytologist · doi:10.1111/nph.19937 · Cited by 2 · see citing works
MegaLMM improves genomic predictions in new environments using environmental covariatesPreprint
Hu, H., Rincent, R., & Runcie, D. E. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.06.583749 · Cited by 1 · see citing works
Leveraging Data from the Genomes to Fields Initiative to Investigate G×E in Maize in North AmericaPreprint
Lopez‐Cruz, M., Aguate, F. M., Washburn, J. D., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2922268/v1 · Cited by 1 · see citing works
Self-citationKick, D. R., & Washburn, J. D. (2023) · Research Square · doi:10.21203/rs.3.rs-2757632/v1 · Cited by 1 · see citing works
Self-citationCrossa, J. L., Sun, J., Montesinos‐López, A., Pérez‐Rodríguez, P., Vitale, P., Pérez‐Elizalde, S., Howard, R., & López, O. A. M. (2026) · The Plant Genome · doi:10.1002/tpg2.70278
“Multimodal data integration without explicit multimodule architecture: Kick et al. (2023) Kick et al. (2023) investigated yield prediction through integration of genetic, environmental, and management data.”
Eckhoff, W. M., Parat, F., Mujica, G. B., Flamm, C., Bustos‐Korts, D., & Piepho, H. (2026) · Theoretical and Applied Genetics · doi:10.1007/s00122-026-05280-z
“More recently Jubair et al. (2023), Kick et al. (2023) as well as different teams of the Genomes2Fields (G2F) challenge (Washburn et al. 2024) used DNNs for predictive GxE modeling in plant breeding.”
InfluentialZhou, S., Fang, W., Gao, R., Long, X., Chen, L., Hu, X., & Zhao, T. (2026) · Briefings in Bioinformatics · doi:10.1093/bib/bbag437
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Self-citationRaihan, T., Kim, C. H., Shimono, H., et al. (2026) · The Plant Genome · doi:10.1002/tpg2.70223
“They found that the performance of multimodal DL was comparable to that of GBLUP (Kick et al., 2023).”
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Big Data, Machine Learning, and Artificial Intelligence for Crop Improvement
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From data to discovery: The role of AI in advancing gene editing
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Dynamic Crop Recommendation Systems Using Reinforcement Learning and Real-Time Sensor Data
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Self-citation
- Authors
- Kick, D. R., Wallace, J. G., Schnable, J. C., Kolkman, J. M., Alaca, B., Beissinger, T. M., Edwards, J., Ertl, D., Flint-Garcia, S., Gage, J. L., Hirsch, C. N., Knoll, J. E., de Leon, N., Lima, D. C., Moreta, D. E., Singh, M. P., Thompson, A., Weldekidan, T., & Washburn, J. D.
- Affiliations
- Agricultural Research Service (US)
- University of Georgia (US)
- University of Nebraska–Lincoln (US)
- Cornell University (US)
- University of Göttingen (DE)
- Research and Business Development, Iowa Corn Promotion Board , Johnston, IA 50131 , USA
- North Carolina State University (US)
- University of Minnesota (US)
- Department of Agronomy, University of Wisconsin , Madison, WI 53706 , USA
- University of Wisconsin–Madison (US)
- Michigan State University (US)
- University of Delaware (US)
- Corresponding author
- Washburn, Jacob D
- ORCID
- Kick, Daniel R
- Wallace, Jason G
- Schnable, James C
- Kolkman, Judith M
- Alaca, Barış
- Beissinger, Timothy M
- Edwards, Jode
- Ertl, David
- Flint-Garcia, Sherry
- Gage, Joseph L
- Hirsch, Candice N
- Knoll, Joseph E
- de Leon, Natalia
- Lima, Dayane C
- Moreta, Danilo E
- Singh, Maninder P
- Thompson, Addie
- Weldekidan, Teclemariam
- Washburn, Jacob D
- Venue
- G3: Genes|Genomes|Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2023-01-10
- Volume
- 13
- Issue
- 4
- ISSN
- 2160-1836 (ISSN-L)
- PMC
- PMC10085787
- OpenAlex
- W4315436689
- Cited by
- 53
- References
- 41
- Citations by year
- 2026: 15 · 2025: 12 · 2024: 18 · 2023: 8
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- Locations
- G3 Genes Genomes Genetics (publishedVersion, public-domain)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Lincoln (University of Nebraska) (submittedVersion, public-domain)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Funders
- USDA Agricultural Research Service (5070-21000-041-000-D, 0500-00093-001-00-D)
- Nebraska Corn Board (88-R-1617-03)
- Iowa Corn Promotion Board
- Georgia Agricultural Commodity Commission for Corn
- Corn Marketing Program of Michigan
- National Corn Growers Association
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetics and Plant Breeding
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Crop Yield and Soil Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- maize yield prediction, deep neural network, BLUP, gene-environment interaction, genotype-by-management interaction, multi-omics integration, weather effects on yield, phenotype prediction, model performance comparison
- MeSH terms
- Machine Learning, Deep Learning, Genotype, Neural Networks, Computer, Multifactorial Inheritance
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-01.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-01.
Cited sources are checked by gpt-6-sol.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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