The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.
Abstract
Chromosome rearrangements which place euchromatic genes adjacent to a heterochromatic breakpoint frequently result in gene repression (position-effect variegation). This repression is thought to reflect the spreading of a heterochromatic structure into neighboring euchromatin. Two allelic dominant suppressors of position-effect variegation were found to contain mutations within the gene encoding the heterochromatin-specific chromosomal protein HP-1. The site of mutation for each allele is given: one converts Lys169 into a nonsense (ochre) codon, while the other is a frameshift after Ser10. In flies heterozygous for one of the mutant alleles (Su(var)2-504), a truncated HP-1 protein was detectable by Western blot analysis. An HP-1 minigene, consisting of HP-1 cDNA under the control of an Hsp70 heat-inducible promoter, was transduced into flies by P element-mediated germ line transformation. Heat-shock driven expression of this minigene results in elevated HP-1 protein level and enhancement of position-effect variegation. Levels of variegating gene expression thus appear to depend upon the level of expression of a heterochromatin-specific protein. The implications of these observations for mechanism of heterochromatic position effects and heterochromatin function are discussed.
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“Reduced dosage of Drosophila HP1 and Su(var)3-9 results in suppression of position-effect variegation (PEV) [19–21].”
From Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling (2014) · cites this paper as [20]
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Metadata
- Authors
- Eissenberg, J. C., Morris, G. D., Reuter, G., & Hartnett, T.
- Affiliations
- Saint Louis University (US)
- ORCID
- Reuter, G
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-06-01
- Volume
- 131
- Issue
- 2
- Pages
- 345-352
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W1856601345
- Cited by
- 315
- References
- 39
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 12 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 10 · 2017: 1 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 6
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm040732-02)
- National Institute of General Medical Sciences (GM40732)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Keywords
- heterochromatin, position effect variegation, dose-dependent effects, heterochromatin spreading, gene repression, Drosophila
- MeSH terms
- Chromobox Protein Homolog 5, Alleles, Animals, Chromosomal Proteins, Non-Histone, DNA, Drosophila melanogaster, Epistasis, Genetic, Gene Expression Regulation, Genes, Lethal, Heterochromatin, Mutation, Recombinant Fusion Proteins, Genes, Suppressor
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