Cited by 315Genomics and Chromatin DynamicsNuclear Structure and FunctionChromosomal and Genetic Variations

The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.

The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.

Eissenberg, J C, Morris, G D, Reuter, G, Hartnett, T·1992·Genetics

Open this paper in CoChat — free account

Abstract

Chromosome rearrangements which place euchromatic genes adjacent to a heterochromatic breakpoint frequently result in gene repression (position-effect variegation). This repression is thought to reflect the spreading of a heterochromatic structure into neighboring euchromatin. Two allelic dominant suppressors of position-effect variegation were found to contain mutations within the gene encoding the heterochromatin-specific chromosomal protein HP-1. The site of mutation for each allele is given: one converts Lys169 into a nonsense (ochre) codon, while the other is a frameshift after Ser10. In flies heterozygous for one of the mutant alleles (Su(var)2-504), a truncated HP-1 protein was detectable by Western blot analysis. An HP-1 minigene, consisting of HP-1 cDNA under the control of an Hsp70 heat-inducible promoter, was transduced into flies by P element-mediated germ line transformation. Heat-shock driven expression of this minigene results in elevated HP-1 protein level and enhancement of position-effect variegation. Levels of variegating gene expression thus appear to depend upon the level of expression of a heterochromatin-specific protein. The implications of these observations for mechanism of heterochromatic position effects and heterochromatin function are discussed.

Integrity signals

Registry

Crossref · 10.1093/genetics/131.2.345

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter
Melton, D. A., Krieg, P. A., Rebagliati, M. R., Maniatis, T., Zinn, K., & Green, M. R. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.18.7035 · Cited by 6,324
Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.
Wahl, G. M., Stern, M., & Stark, G. R. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.8.3683 · Cited by 3,159
Genetic Transformation of Drosophila with Transposable Element Vectors
Rubin, G. M., & Spradling, A. C. (1982) · Science · doi:10.1126/science.6289436 · Cited by 2,996
Genetic variations of Drosophila melanogaster.
Lindsley, D. L., & Grell, E. H. (1968) · Biodiversity Heritage Library (Smithsonian Institution) · doi:10.5281/zenodo.10755360 · Cited by 2,623

Show all 39 references

Sorted by citations

Regulation of chromatin structure by site-specific histone H3 methyltransferases
Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845
Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability
Peters, A. H. F. M., O'Carroll, D., Scherthan, H., Mechtler, K., Sauer, S., Schöfer, C., Weipoltshammer, K., Pagani, M., Lachner, M., Kohlmaier, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00542-6 · Cited by 1,766
Central role of Drosophila SU(VAR)3–9 in histone H3‐K9 methylation and heterochromatic gene silencing
Schotta, G., Ebert, A., Krauss, V., Fischer, A., Hoffmann, J., Rea, S., Jenuwein, T., Dorn, R., & Reuter, G. (2002) · The EMBO Journal · doi:10.1093/emboj/21.5.1121 · Cited by 714
Self-citation
Histone methylation versus histone acetylation: new insights into epigenetic regulation
Rice, J. C., & Allis, C. D. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00208-8 · Cited by 701
The protein encoded by the Drosophila position‐effect variegation suppressor gene Su(var)3‐9 combines domains of antagonistic regulators of homeotic gene complexes.
Tschiersch, B., Hofmann, A., Krauss, V., Dorn, R., Korge, G., & Reuter, G. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06693.x · Cited by 567
Self-citation
HETEROCHROMATIN AND GENE EXPRESSION IN DROSOPHILA
Weiler, K. S., & Wakimoto, B. T. (1995) · Annual Review of Genetics · doi:10.1146/annurev.ge.29.120195.003045 · Cited by 533
Position-Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila
Elgin, S. C. R., & Reuter, G. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a017780 · Cited by 499
Self-citation
Epigenetics and cancer
Lund, A. H., & van Lohuizen, M. (2004) · Genes & Development · doi:10.1101/gad.1232504 · Cited by 489
Position effect variegation in Drosophila is associated with an altered chromatin structure.Preprint
Wallrath, L. L., & Elgin, S. C. R. (1995) · Genes & Development · doi:10.1101/gad.9.10.1263 · Cited by 465
The HP1 protein family: getting a grip on chromatin
Eissenberg, J. C., & Elgin, S. C. R. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00058-7 · Cited by 461
Self-citation
Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.Preprint
Allshire, R. C., Nimmo, E. R., Ekwall, K., Javerzat, J., & Cranston, G. (1995) · Genes & Development · doi:10.1101/gad.9.2.218 · Cited by 450
Functional mammalian homologues of the Drosophila PEV‐modifier Su(var)3‐9 encode centromere‐associated proteins which complex with the heterochromatin component M31
Aagaard, L., Laible, G., Selenko, P., Schmid, M., Dorn, R., Schotta, G., Kuhfittig, S., Wolf, A., Lebersorger, A., Singh, P. B., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1923 · Cited by 441
Self-citation
Association of the Origin Recognition Complex with Heterochromatin and HP1 in Higher Eukaryotes
Pak, D. T. S., Pflumm, M. F., Chesnokov, I. N., Huang, D. W., Kellum, R., Marr, J., Romanowski, P., & Botchan, M. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80415-8 · Cited by 408
Heterochromatin: new possibilities for the inheritance of structure
Grewal, S. I. S., & Elgin, S. C. R. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00284-8 · Cited by 408
SET domain proteins modulate chromatin domains in eu- and heterochromatin
Jenuwein, T., Laible, G., Dorn, R., & Reuter, G. (1998) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050127 · Cited by 395
Self-citation
KAP-1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins: a Potential Role for Krüppel-Associated Box–Zinc Finger Proteins in Heterochromatin-Mediated Gene Silencing
Ryan, R. F., Schultz, D., Ayyanathan, K., Singh, P. B., Friedman, J. R., Fredericks, W. J., & Rauscher, F. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4366 · Cited by 382
Heterochromatin Formation in Mammalian Cells
Nielsen, A. L., Oulad‐Abdelghani, M., Ortiz, J. A., Remboutsika, E., Chambon, P., & Losson, R. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00218-0 · Cited by 383
Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegationPreprint
Ayyanathan, K., Lechner, M. S., Bell, P., Maul, G. G., Schultz, D., Yamada, Y., Tanaka, K., Torigoe, K., & Rauscher, F. J. (2003) · Genes & Development · doi:10.1101/gad.1102803 · Cited by 356
Drosophila PIWI associates with chromatin and interacts directly with HP1a
Brower-Toland, B., Findley, S. D., Jiang, L., Liu, L., Yin, H., Dus, M., Zhou, P., Elgin, S. C. R., & Lin, H. (2007) · Genes & Development · doi:10.1101/gad.1564307 · Cited by 350
Position effect variegation at fission yeast centromeres
Allshire, R. C., Javerzat, J., Redhead, N. J., & Cranston, G. (1994) · Cell · doi:10.1016/0092-8674(94)90180-5 · Cited by 331
Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies
Sun, W., Samimi, H., Gamez, M., Zare, H., & Frost, B. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0194-1 · Cited by 300
Enhanced Specificity and Efficiency of the CRISPR/Cas9 System with Optimized sgRNA Parameters in Drosophila
Ren, X., Yang, Z., Jiang, X., Sun, J., Mao, D., Hu, Y., Yang, S., Qiao, H., Wang, X., Hu, Q., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.044 · Cited by 310
Pattern formation by local self-activation and lateral inhibition
Meinhardt, H., & Gierer, A. (2000) · BioEssays · doi:10.1002/1521-1878(200008)22:8 · Cited by 629
The Chromodomain Protein Swi6: A Key Component at Fission Yeast Centromeres
Ekwall, K., Javerzat, J., Lorentz, A., Schmidt, H., Cranston, G., & Allshire, R. C. (1995) · Science · doi:10.1126/science.7660126 · Cited by 299
Plasmodium falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors
Flueck, C., Bártfai, R., Volz, J. C., Niederwieser, I., Salcedo‐Amaya, A. M., Alako, B., Ehlgen, F., Ralph, S. A., Cowman, A. F., Bozdech, Z., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000569 · Cited by 299
Modulation of Heterochromatin Protein 1 Dynamics in Primary Mammalian Cells
Festenstein, R., Pagakis, S. N., Hiragami, K., Lyon, D., Verreault, A., Sekkali, B., & Kioussis, D. (2003) · Science · doi:10.1126/science.1078694 · Cited by 283
Mutations inLIKE HETEROCHROMATIN PROTEIN 1affect flowering time and plant architecture inArabidopsis
Gaudin, V., Libault, M., Pouteau, S., Juul, T., Zhao, G., Lefebvre, D., & Grandjean, O. (2001) · Development · doi:10.1242/dev.128.23.4847 · Cited by 285
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
Larson, K., Yan, S.-J., Tsurumi, A., Liu, J., Zhou, J., Gaur, K., Guo, D., Eickbush, T. H., & Li, W. X. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002473 · Cited by 284
Mammalian homologues of the Polycomb‐group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S.cerevisiae telomeres
Laible, G., Wolf, A., Dorn, R., Reuter, G., Nislow, C., Lebersorger, A., Popkin, D., Pillus, L., & Jenuwein, T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3219 · Cited by 279
Self-citation
Chromatin dynamics at DNA replication, transcription and repair
Ehrenhofer‐Murray, A. E. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04162.x · Cited by 282
The Heterochromatin Protein 1 Prevents Telomere Fusions in Drosophila
Fanti, L., Giovinazzo, G., Berloco, M. F., & Pimpinelli, S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80152-5 · Cited by 273
Functional analysis of the chromo domain of HP1.
Platero, J. S., Hartnett, T., & Eissenberg, J. C. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00069.x · Cited by 270
Self-citation
Dimerisation of a chromo shadow domain and distinctions from the chromodomain as revealed by structural analysis
Cowieson, N. P., Partridge, J. F., Allshire, R. C., & McLaughlin, P. J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00467-x · Cited by 255
Specific destruction of kinetochore protein CENP‐C and disruption of cell division by herpes simplex virus immediate‐early protein Vmw110
Everett, R. D., Earnshaw, W. C., Findlay, J., & Lomonte, P. (1999) · The EMBO Journal · doi:10.1093/emboj/18.6.1526 · Cited by 245
Position-effect variegation and the new biology of heterochromatin
Karpen, G. H. (1994) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80055-3 · Cited by 235
HP1 Is Essential for DNA Methylation in Neurospora
Freitag, M., Hickey, P. C., Khlafallah, T. K., Read, N. D., & Selker, E. U. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00024-3 · Cited by 236
The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax.
Jones, R. S., & Gelbart, W. M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6357 · Cited by 236
Heterochromatin and gene regulation in Drosophila
Elgin, S. C. R. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)80050-5 · Cited by 229
Chromatin signatures of cancerPreprint
Morgan, M. A., & Shilatifard, A. (2015) · Genes & Development · doi:10.1101/gad.255182.114 · Cited by 218
Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain–KAP-1 Corepressor Interaction Is Essential
Lechner, M. S., Begg, G. E., Speicher, D. W., & Rauscher, F. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.17.6449-6465.2000 · Cited by 210
Structure-Function Analysis of SUV39H1 Reveals a Dominant Role in Heterochromatin Organization, Chromosome Segregation, and Mitotic Progression
Melcher, M., Schmid, M., Aagaard, L., Selenko, P., Laible, G., & Jenuwein, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3728-3741.2000 · Cited by 206
The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain
Lechner, M. S., Schultz, D., Negorev, D. G., Maul, G. G., & Rauscher, F. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.04.016 · Cited by 211
polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila.Preprint
Fauvarque, M., & Dura, J. (1993) · Genes & Development · doi:10.1101/gad.7.8.1508 · Cited by 198
The contradictory definitions of heterochromatin: transcription and silencing
Huisinga, K. L., Brower‐Toland, B. D., & Elgin, S. C. R. (2006) · Chromosoma · doi:10.1007/s00412-006-0052-x · Cited by 224
Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling
Herz, H.-M., Morgan, M., Gao, X., Jackson, J., Rickels, R., Swanson, S. K., Florens, L., Washburn, M. P., Eissenberg, J. C., & Shilatifard, A. (2014) · Science · doi:10.1126/science.1255104 · Cited by 199
Self-citation
Heterochromatin Protein 1 Is Required for the Normal Expression of Two Heterochromatin Genes in Drosophila
Lu, B. Y., Emtage, P. C. R., Duyf, B., Hilliker, A. J., & Eissenberg, J. C. (2000) · Genetics · doi:10.1093/genetics/155.2.699 · Cited by 187
Self-citation
The chromo superfamily: new members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin
Koonin, E. V., Zhou, S., & Lucchesi, J. C. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.21.4229 · Cited by 182
The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatinPreprint
Swaminathan, J., Baxter, E. M., & Corces, V. G. (2005) · Genes & Development · doi:10.1101/gad.1259105 · Cited by 185
Heterochromatin protein 1 is required for correct chromosome segregation in Drosophila embryos
Kellum, R., & Alberts, B. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.4.1419 · Cited by 169
Structure of the chromatin binding (chromo) domain from mouse modifier protein 1
Ball, L., Murzina, N. V., Broadhurst, R. W., Raine, A. R. C., Archer, S. J., Stott, F. J., Murzin, A. G., Singh, P. B., Domaille, P. J., & Laue, E. D. (1997) · The EMBO Journal · doi:10.1093/emboj/16.9.2473 · Cited by 168
HP1 Controls Telomere Capping, Telomere Elongation, and Telomere Silencing by Two Different Mechanisms in Drosophila
Perrini, B., Piacentini, L., Fanti, L., Fabio Altieri, F., Chichiarelli, S., Berloco, M. F., Turano, C., Ferraro, A., & Pimpinelli, S. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.06.036 · Cited by 166
Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity
Saunders, W. S., Chue, C., Goebl, M. G., Craig, C. A., Clark, R. F., Powers, J. A., Eissenberg, J. C., Elgin, S. C. R., Rothfield, N. F., & Earnshaw, W. C. (1993) · Journal of Cell Science · doi:10.1242/jcs.104.2.573 · Cited by 164
Self-citation
Epigenetic regulation of autosomal gene expression by sex chromosomes
Wijchers, P. J., & Festenstein, R. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.01.004 · Cited by 165
Degradation of Nucleosome-associated Centromeric Histone H3-like Protein CENP-A Induced by Herpes Simplex Virus Type 1 Protein ICP0
Lomonte, P., Sullivan, K. F., & Everett, R. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008547200 · Cited by 164
The control of gene expression and cell identity by H3K9 trimethylation
Ninova, M., Tóth, K. F., & Aravin, A. A. (2019) · Development · doi:10.1242/dev.181180 · Cited by 170
Repression of viral transcription during herpes simplex virus latency
Preston, C. M. (2000) · Microbiology · doi:10.1099/0022-1317-81-1-1 · Cited by 161
Positive Selection Drives the Evolution of rhino, a Member of the Heterochromatin Protein 1 Family in Drosophila
Vermaak, D., Henikoff, S., & Malik, H. S. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010009 · Cited by 151
Silencing at Drosophila telomeres: nuclear organization and chromatin structure play critical roles
Cryderman, D. E., Morris, E. J., Biessmann, H., Elgin, S. C. R., & Wallrath, L. L. (1999) · The EMBO Journal · doi:10.1093/emboj/18.13.3724 · Cited by 155
Inner nuclear membrane proteins: functions and targeting
Holmer, L. E., & Worman, H. J. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000813 · Cited by 153
Heterochromatin Protein 1 (HP1a) Positively Regulates Euchromatic Gene Expression through RNA Transcript Association and Interaction with hnRNPs in Drosophila
Piacentini, L., Fanti, L., Negri, R., Vescovo, V. D., Fatica, A., Fabio Altieri, F., & Pimpinelli, S. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000670 · Cited by 144
The Heterochromatin Protein 1 (HP1) Family: Put Away a Bias toward HP1
Kwon, S. H., & Workman, J. L. (2008) · Molecules and Cells · doi:10.1016/s1016-8478(23)13988-4 · Cited by 142
Locus control regions: overcoming heterochromatin-induced gene inactivation in mammals
Kioussis, D., & Festenstein, R. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80008-1 · Cited by 144
SU(VAR)3‐7, a Drosophila heterochromatin‐associated protein and companion of HP1 in the genomic silencing of position‐effect variegation
Cléard, F., Delattre, M., & Spierer, P. (1997) · The EMBO Journal · doi:10.1093/emboj/16.17.5280 · Cited by 140
Sexual Dimorphism in Mammalian Autosomal Gene Regulation Is Determined Not Only by Sry but by Sex Chromosome Complement As Well
Wijchers, P. J., Yandım, C., Panousopoulou, E., Ahmad, M., Harker, N., Saveliev, A., Burgoyne, P. S., & Festenstein, R. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.08.005 · Cited by 137
Heterochromatin Protein 1 Binds to Nucleosomes and DNA in Vitro
Zhao, T., Heyduk, T., Allis, C. D., & Eissenberg, J. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003493200 · Cited by 132
Self-citation
Chapter 1 Chromatin Structure and the Regulation of Gene Expression: The Lessons of PEV in Drosophila
Girton, J. R., & Johansen, K. M. (2008) · Advances in genetics · doi:10.1016/s0065-2660(07)00001-6 · Cited by 140
Linking Heterochromatin Protein 1 (HP1) to cancer progression
Dialynas, G. K., Vitalini, M. W., & Wallrath, L. L. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.09.007 · Cited by 131
The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity
Daubresse, G., Deuring, R., Moore, L., Papoulas, O., Zakrajsek, I., Waldrip, W. R., Scott, M. P., Kennison, J. A., & Tamkun, J. W. (1999) · Development · doi:10.1242/dev.126.6.1175 · Cited by 132
Heterochromatin protein 1: a pervasive controlling influence
Hiragami, K., & Festenstein, R. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5287-9 · Cited by 130
Long-Range Nucleosome Ordering Is Associated with Gene Silencing in Drosophila melanogaster Pericentric Heterochromatin
Sun, F.-L., Cuaycong, M. H., & Elgin, S. C. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.8.2867-2879.2001 · Cited by 126
Down-regulation of HP1Hsalpha expression is associated with the metastatic phenotype in breast cancer.
Kirschmann, D. A., Lininger, R. A., Gardner, L. M., Seftor, E. A., Odero, V. A., Ainsztein, A. M., Earnshaw, W. C., Wallrath, L. L., & Hendrix, M. J. C. (2000) · PubMed · Cited by 124
Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context- dependent manner
Festenstein, R., Sharghi-Namini, S., Fox, M., Roderick, K., Tolaini, M., Norton, T., Saveliev, A., Kioussis, D., & Singh, P. B. (1999) · Nature Genetics · doi:10.1038/70579 · Cited by 123
Actin-Related Proteins
Schafer, D. A., & Schroer, T. A. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.341 · Cited by 123
Gene function beyond the single trait: natural variation, gene effects, and evolutionary ecology in Arabidopsis thaliana
Tonsor, S. J., Alonso‐Blanco, C., & Koornneef, M. (2004) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2004.01264.x · Cited by 123
Molecular biology of the chromo domain: an ancient chromatin module comes of age
Eissenberg, J. C. (2001) · Gene · doi:10.1016/s0378-1119(01)00628-x · Cited by 120
Self-citation
Balance between Distinct HP1 Family Proteins Controls Heterochromatin Assembly in Fission Yeast
Sadaie, M., Kawaguchi, R., Ohtani, Y., Arisaka, F., Tanaka, K., Shirahige, K., & Nakayama, J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00791-08 · Cited by 120
Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres
Aagaard, L., Schmid, M., Warburton, P. E., & Jenuwein, T. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.5.817 · Cited by 110
Telomeric Trans-Silencing: An Epigenetic Repression Combining RNA Silencing and Heterochromatin Formation
Josse, T., Teysset, L., Todeschini, A., Sidor, C., Anxolabéhère, D., & Ronsseray, S. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0030158 · Cited by 117
Differentially expressed genes associated with the metastatic phenotype in breast cancer
Kirschmann, D. A., Seftor, E. A., Nieva, D. R. C., Mariano, E. A., & Hendrix, M. J. C. (1999) · Breast Cancer Research and Treatment · doi:10.1023/a:1006188129423 · Cited by 108
Self-interaction of heterochromatin protein 1 is required for direct binding to histone methyltransferase, SUV39H1
Yamamoto, K., & Sonoda, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)03021-8 · Cited by 115
Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers
Hwang, K.-K., Eissenberg, J. C., & Worman, H. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211303598 · Cited by 110
Self-citation
Heterochromatin Protein 1 Is Involved in Control of Telomere Elongation in Drosophila melanogaster
Savitsky, M., Кравчук, О. И., Melnikova, L. S., & Georgiev, P. G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.9.3204-3218.2002 · Cited by 113
Polytene Chromosomes, Heterochromatin, and Position Effect Variegation
Zhimulev, I. F. (1997) · Advances in genetics · doi:10.1016/s0065-2660(08)60341-7 · Cited by 109
A dynamic connection between centromeres and ND10 proteins
Everett, R. D., Earnshaw, W. C., Pluta, A. F., Sternsdorf, T., Ainsztein, A. M., Carmena, M., Ruchaud, S., Hsu, W., & Orr, A. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.20.3443 · Cited by 105
P-Element Repression in Drosophila melanogaster by a Naturally Occurring Defective Telomeric P Copy
Marin, L., Lehmann, M., Nouaud, D., Izaabel, H., Anxolabéhère, D., & Ronsseray, S. (2000) · Genetics · doi:10.1093/genetics/155.4.1841 · Cited by 99
Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation
Wang, X., Pan, L., Wang, S., Zhou, J., McDowell, W., Park, J., Haug, J., Staehling‐Hampton, K., Tang, H., & Xie, T. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002426 · Cited by 96
Polytene Chromosomes: 70 Years of Genetic Research
Zhimulev, I. F., Belyaeva, E. S., Semeshin, V. F., Koryakov, D. E., Demakov, S. A., Demakova, O. V., Pokholkova, G. V., & Andreyeva, E. N. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)41004-3 · Cited by 100
Selective interaction between the chromatin‐remodeling factor BRG1 and the heterochromatin‐associated protein HP1α
Nielsen, A. L., Sanchez, C., Ichinose, H., Cerviño, M., Lerouge, T., Chambon, P., & Losson, R. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf560 · Cited by 99
SU(VAR)3-9 is a Conserved Key Function in Heterochromatic Gene Silencing
Schotta, G., Ebert, A., & Reuter, G. (2003) · Genetica · doi:10.1023/a:1022923508198 · Cited by 102
Self-citation
N-Terminal Phosphorylation of HP1α Promotes Its Chromatin Binding
Hiragami-Hamada, K., Shinmyozu, K., Hamada, D., Tatsu, Y., Uegaki, K., Fujiwara, S., & Nakayama, J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01012-10 · Cited by 95
The Drosophila Polycomb Group proteins ESC and E(Z) bind directly to each other and co-localize at multiple chromosomal sites
Tie, F., Furuyama, T., & Harte, P. J. (1998) · Development · doi:10.1242/dev.125.17.3483 · Cited by 97
Cell differentiation induces TIF1β association with centromeric heterochromatin via an HP1 interaction
Cammas, F. M., Oulad‐Abdelghani, M., Vonesch, J., Huss-Garcia, Y., Chambon, P., & Losson, R. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.17.3439 · Cited by 96
Chromatin architectural proteins
McBryant, S. J., Adams, V. H., & Hansen, J. C. (2006) · Chromosome Research · doi:10.1007/s10577-006-1025-x · Cited by 101
Overlapping domains of the heterochromatin-associated protein HP1 mediate nuclear localization and heterochromatin binding.
Powers, J. A., & Eissenberg, J. C. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.2.291 · Cited by 93
Self-citation
Position effect and related phenomena
Henikoff, S. (1992) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80114-5 · Cited by 91
Morphology and Structure of Polytene Chromosomes
Zhimulev, I. F. (1996) · Advances in genetics · doi:10.1016/s0065-2660(08)60533-7 · Cited by 88
Characterization of sequences associated with position-effect variegation at pericentric sites in Drosophila heterochromatin
Cryderman, D. E., Cuaycong, M. H., Elgin, S. C. R., & Wallrath, L. L. (1998) · Chromosoma · doi:10.1007/s004120050309 · Cited by 88
Epigenetic effects on yeast transcription caused by mutations in an actin-related protein present in the nucleus.Preprint
Jiang, Y. W., & Stillman, D. J. (1996) · Genes & Development · doi:10.1101/gad.10.5.604 · Cited by 88
Structural biology of the chromodomain: Form and function
Eissenberg, J. C. (2012) · Gene · doi:10.1016/j.gene.2012.01.003 · Cited by 86
Self-citation
Increased phosphorylation of HP1, a heterochromatin-associated protein of Drosophila, is correlated with heterochromatin assembly.
Eissenberg, J. C., GE, Y. ‐., & Hartnett, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31964-6 · Cited by 85
Self-citation

Authors: Eissenberg, J. C., Morris, G. D., Reuter, G., & Hartnett, T.
Affiliations: Saint Louis University (US)
ORCID: Reuter, G
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 1992-06-01
Volume: 131
Issue: 2
Pages: 345-352
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/131.2.345
OpenAlex: W1856601345
Cited by: 315
References: 39
Citations by year: 2026: 4 · 2025: 5 · 2024: 12 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 10 · 2017: 1 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 6
FWCI: 3.84
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01gm040732-02)
National Institute of General Medical Sciences (GM40732)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords: heterochromatin, position effect variegation, dose-dependent effects, heterochromatin spreading, gene repression, Drosophila
MeSH terms: Chromobox Protein Homolog 5, Alleles, Animals, Chromosomal Proteins, Non-Histone, DNA, Drosophila melanogaster, Epistasis, Genetic, Gene Expression Regulation, Genes, Lethal, Heterochromatin, Mutation, Recombinant Fusion Proteins, Genes, Suppressor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks