Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.
Open accessAbstract
We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects.
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Reduced dosage of Drosophila HP1 and Su(var)3-9 results in suppression of position-effect variegation (PEV).
“Reduced dosage of Drosophila HP1 and Su(var)3-9 results in suppression of position-effect variegation (PEV) [19–21].”
From Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling (2014) · cites this paper as [19]
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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
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- Authors
- Eissenberg, J. C., James, T. C., Foster-Hartnett, D. M., Hartnett, T., Ngan, V, & Elgin, S. C.
- Affiliations
- Saint Louis University (US)
- E. A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, MO 63104.
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1990-12
- Volume
- 87
- Issue
- 24
- Pages
- 9923-9927
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC55286
- OpenAlex
- W1978395898
- Cited by
- 588
- References
- 1
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 18 · 2023: 7 · 2022: 9 · 2021: 34 · 2020: 10 · 2019: 12 · 2018: 11 · 2017: 8 · 2016: 13 · 2015: 17 · 2014: 19 · 2013: 22 · 2012: 9
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01hd023844-11, 5r01gm040732-02, 5f32gm009214-03, HD 23844)
- National Institute of General Medical Sciences (GM 09214, GM40732)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-23844)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- position effect variegation, point mutations, mRNA splicing, intron mutations, heterochromatin, Drosophila melanogaster
- MeSH terms
- Chromobox Protein Homolog 5, Alleles, Amino Acid Sequence, Animals, Base Sequence, Chromosomal Proteins, Non-Histone, Cloning, Molecular, DNA, Drosophila melanogaster, Heterochromatin, Molecular Sequence Data, Mutation, Suppression, Genetic, Blotting, Southern, Restriction Mapping, Oligonucleotide Probes, Gene Library, Polymerase Chain Reaction
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