The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans.
Abstract
We studied the control of pharyngeal excitation in Caenorhabditis elegans. By laser ablating subsets of the pharyngeal nervous system, we found that the MC neuron type is necessary and probably sufficient for rapid pharyngeal pumping. Electropharyngeograms showed that MC transmits excitatory postsynaptic potentials, suggesting that MC acts as a neurogenic pacemaker for pharyngeal pumping. Mutations in genes required for acetylcholine (ACh) release and an antagonist of the nicotinic ACh receptor (nAChR) reduced pumping rates, suggesting that a nAChR is required for MC transmission. To identify genes required for MC neurotransmission, we screened for mutations that cause slow pumping but no other defects. Mutations in two genes, eat-2 and eat-18, eliminated MC neurotransmission. A gain-of-function eat-18 mutation, ad820sd, and a putative loss-of-function eat-18 mutation, ad1110, both reduced the excitation of pharyngeal muscle in response to the nAChR agonists nicotine and carbachol, suggesting that eat-18 is required for the function of a pharyngeal nAChR. Fourteen recessive mutations in eat-2 fell into five complementation classes. We found allele-specific genetic interactions between eat-2 and eat-18 that correlated with complementation classes of eat-2. We propose that eat-18 and eat-2 function in a multisubunit protein complex involved in the function of a pharyngeal nAChR.
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Cites
A complementation analysis of the restriction and modification of DNA in Escherichia coli
Boyer, H. W., & Roulland-dussoix, D. (1969) · Journal of Molecular Biology · doi:10.1016/0022-2836(69)90288-5 · Cited by 3,823
Stoschitzky, K. (2000) · Handbooks in Pharmacology and Toxicology · doi:10.1201/9781420036961.ch18 · Cited by 2,956
LANGLEY, J. N. (1903) · Brain · doi:10.1093/brain/26.1.1 · Cited by 1,656
The structure of the ventral nerve cord of Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1976) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1976.0086 · Cited by 616
Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans
Hall, D. H., & Hedgecock, E. M. (1991) · Cell · doi:10.1016/0092-8674(91)90391-b · Cited by 564
Ferguson, E. L., & Horvitz, H. R. (1985) · Genetics · doi:10.1093/genetics/110.1.17 · Cited by 540
The Caenorhabditis elegans unc-17 Gene: a Putative Vesicular Acetylcholine Transporter
Alfonso, A., Grundahl, K., Duerr, J. S., Han, H.-P., & Rand, J. B. (1993) · Science · doi:10.1126/science.8342028 · Cited by 376
A uniform genetic nomenclature for the nematode Caenorhabditis elegans
Horvitz, H. R., Brenner, S., Hodgkin, J., & Herman, R. K. (1979) · Molecular and General Genetics MGG · doi:10.1007/bf00425528 · Cited by 372
The structure of ion channels in membranes of excitable cells
Unwin, N. (1989) · Neuron · doi:10.1016/0896-6273(89)90235-3 · Cited by 370
Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans
Avery, L., & Horvitz, H. R. (1990) · Journal of Experimental Zoology · doi:10.1002/jez.1402530305 · Cited by 361
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Cited by
The genetics of caloric restriction in Caenorhabditis elegans
Lakowski, B., & Hekimi, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13091 · Cited by 961
Neurobiology of the Caenorhabditis elegans Genome
Bargmann, C. I. (1998) · Science · doi:10.1126/science.282.5396.2028 · Cited by 929
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Matta, S. G., Balfour, D. J., Benowitz, N. L., Boyd, R. T., Buccafusco, J. J., Caggiula, A. R., Craig, C. R., Collins, A. C., Damaj, M. I., Donny, E. C., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0441-0 · Cited by 824
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
Hansen, M., Taubert, S., Crawford, D., Libina, N., Lee, S., & Kenyon, C. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2006.00267.x · Cited by 803
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
Hansen, M., Chandra, A., Mitic, L. L., Onken, B., Driscoll, M., & Kenyon, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040024 · Cited by 766
Metadata
- Authors
- Raizen, D. M., Lee, R. Y., & Avery, L.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-12-01
- Volume
- 141
- Issue
- 4
- Pages
- 1365-1382
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2142017285
- Cited by
- 286
- References
- 26
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Raizen, D. M., Lee, R. Y., & Avery, L. (1995). Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans. Genetics. https://doi.org/10.1093/genetics/141.4.1365
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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