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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

Hansen, Malene, Taubert, Stefan, Crawford, Douglas, Libina, Nataliya, Lee, Seung‐Jae, Kenyon, Cynthia·2007·Aging Cell
DOI 10.1111/j.1474-9726.2006.00267.x
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Abstract

Summary: Many conditions that shift cells from states of nutrient utilization and growth to states of cell maintenance extend lifespan. We have carried out a systematic lifespan analysis of conditions that inhibit protein synthesis. We find that reducing the levels of ribosomal proteins, ribosomal‐protein S6 kinase or translation‐initiation factors increases the lifespan of Caenorhabditis elegans . These perturbations, as well as inhibition of the nutrient sensor target of rapamycin (TOR), which is known to increase lifespan, all increase thermal‐stress resistance. Thus inhibiting translation may extend lifespan by shifting cells to physiological states that favor maintenance and repair. Interestingly, different types of translation inhibition lead to one of two mutually exclusive outputs, one that increases lifespan and stress resistance through the transcription factor DAF‐16/FOXO, and one that increases lifespan and stress resistance independently of DAF‐16. Our findings link TOR, but not sir‐2.1 , to the longevity response induced by dietary restriction (DR) in C. elegans , and they suggest that neither TOR inhibition nor DR extends lifespan simply by reducing protein synthesis.

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Crossref · 10.1111/j.1474-9726.2006.00267.x

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  • Genetic inhibition of mTORC1 or downstream pathways extends lifespan in yeast, worms, and flies.

    “Studies in yeast, worms and flies found that genetic inhibition of mTORC1 or signaling pathways downstream of mTORC1, including S6K and translation initiation factors, extends lifespan 5–11.”

    From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [9]

Citations

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Research works printed but not linked: 46

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Metadata

Authors
Hansen, M., Taubert, S., Crawford, D., Libina, N., Lee, S., & Kenyon, C.
Venue
Aging Cell
Publisher
Wiley
Published
2006-12-05
Volume
6
Issue
1
Pages
95-110
ISSN
  • 1474-9718
  • 1474-9726
DOI
10.1111/j.1474-9726.2006.00267.x
Cited by
803
References
5
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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