The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Phytoalexin-Deficient Mutants of Arabidopsis Reveal That PAD4 Encodes a Regulatory Factor and That Four PAD Genes Contribute to Downy Mildew Resistance
Open accessAbstract
We are working to determine the role of the Arabidopsis phytoalexin, camalexin, in protecting the plant from pathogen attack by isolating phytoalexin-deficient (pad) mutants in the accession Columbia (Col-0) and examining their response to pathogens. Mutations in PAD1, PAD2, and PAD4 caused enhanced susceptibility to the bacterial pathogen Pseudomonas syringae pv. maculicola strain ES4326 (PsmES4326), while mutations in PAD3 or PAD5 did not. Camalexin was not detected in any of the double mutants pad1-1 pad2-1, pad1-1 pad3-1 or pad2-1 pad3-1. Growth of PsmES4326 in pad1-1 pad2-1 was greater than that in pad1-1 or pad2-1 plants, while growth in pad1-1 pad3-1 and pad2-1 pad3-1 plants was similar to that in pad1-1 and pad2-1 plants, respectively. The pad4-1 mutation caused reduced camalexin synthesis in response to PsmES4326 infection, but not in response to Cochliobolus carbonum infection, indicating that PAD4 has a regulatory function. PAD1, PAD2, PAD3 and PAD4 are all required for resistance to the eukaryotic biotroph Peronospora parasitica. The pad4-1 mutation caused the most dramatic change, exhibiting full susceptibility to four of six Col-incompatible parasite isolates. Interestingly, each combination of double mutants between pad1-1, pad2-1 and pad3-1 exhibited additive shifts to moderate or full susceptibility to most of the isolates.
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Cites
Current Status of the Gene-For-Gene Concept
Flor, H. H. (1971) · Annual Review of Phytopathology · doi:10.1146/annurev.py.09.090171.001423 · Cited by 3,185
Transgenic Plants with Enhanced Resistance to the Fungal Pathogen Rhizoctonia solani
Brogue, K., Chet, I., Holliday, M. J., Cressman, R. F., Biddle, P., Knowlton, S., Mauvais, C. J., & Broglie, R. (1991) · Science · doi:10.1126/science.254.5035.1194 · Cited by 982
RPS2 of Arabidopsis thaliana : a Leucine-Rich Repeat Class of Plant Disease Resistance Genes
Bent, A. F., Kunkel, B. N., Dahlbeck, D., Brown, K. L., Schmidt, R., Giraudat, J., Leung, J., & Staskawicz, B. J. (1994) · Science · doi:10.1126/science.8091210 · Cited by 954
Plant chitinases are potent inhibitors of fungal growth
Schlumbaum, A., Mauch, F., Vögeli, U., & Boller, T. (1986) · Nature · doi:10.1038/324365a0 · Cited by 910
Phytoalexins and their Elicitors-A Defense Against Microbial Infection in Plants
Darvill, A. G., & Albersheim, P. (1984) · Annual Review of Plant Physiology · doi:10.1146/annurev.pp.35.060184.001331 · Cited by 850
Signals and transduction mechanisms for activation of plant defenses against microbial attack
Lamb, C. J., Lawton, M. A., Dron, M., & Dixon, R. A. (1989) · Cell · doi:10.1016/0092-8674(89)90894-5 · Cited by 737
Mindrinos, M., Katagiri, F., Yu, G.-L., & Ausubel, F. M. (1994) · Cell · doi:10.1016/0092-8674(94)90282-8 · Cited by 712
Self-citationWhalen, M. C., Innes, R. W., Bent, A. F., & Staskawicz, B. J. (1991) · The Plant Cell · doi:10.1105/tpc.3.1.49 · Cited by 667
Small cysteine-rich antifungal proteins from radish: their role in host defense.
Terras, F. R., Eggermont, K., Kovaleva, V, Raikhel, N. V., Osborn, R. W., Kester, A., Rees, S. B., Torrekens, S., Van Leuven, F., & Vanderleyden, J. (1995) · The Plant Cell · doi:10.1105/tpc.7.5.573 · Cited by 665
Arabidopsis is susceptible to infection by a downy mildew fungus.
Koch, E., & Slusarenko, A. (1990) · The Plant Cell · doi:10.1105/tpc.2.5.437 · Cited by 663
Cited by
Contrasting Mechanisms of Defense Against Biotrophic and Necrotrophic Pathogens
Glazebrook, J. (2005) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.43.040204.135923 · Cited by 4,367
Self-citationAarts, N., Metz, M., Holub, E., Staskawicz, B. J., Daniels, M. J., & Parker, J. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10306 · Cited by 788
Self-citationFungal Resistance to Plant Antibiotics as a Mechanism of Pathogenesis
Morrissey, J. P., & Osbourn, A. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.3.708-724.1999 · Cited by 635
Interplay of signaling pathways in plant disease resistance
Feys, B. J., & Parker, J. E. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02107-7 · Cited by 558
Ferrari, S., Plotnikova, J. M., De Lorenzo, G., & Ausubel, F. M. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01794.x · Cited by 532
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Metadata
- Authors
- Glazebrook, J., Zook, M., Mert, F., Kagan, I., Rogers, E. E., Crute, I. R., Holub, E. B., Hammerschmidt, R., & Ausubel, F. M.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-05-01
- Volume
- 146
- Issue
- 1
- Pages
- 381-392
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W1932988598
- Cited by
- 352
- References
- 32
- FWCI
- 22.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Phytoalexin-Deficient Mutants of Arabidopsis Reveal That PAD4 Encodes a Regulatory Factor and That Four PAD Genes Contribute to Downy Mildew Resistance. https://app.cochat.ai/papers/10.1093/genetics/146.1.381
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- Glazebrook, J., Zook, M., Mert, F., Kagan, I., Rogers, E. E., Crute, I. R., Holub, E. B., Hammerschmidt, R., & Ausubel, F. M. (1997). Phytoalexin-Deficient Mutants of Arabidopsis Reveal That PAD4 Encodes a Regulatory Factor and That Four PAD Genes Contribute to Downy Mildew Resistance. Genetics. https://doi.org/10.1093/genetics/146.1.381
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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