The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Sex Differences in the Effect of Dietary Restriction on Life Span and Mortality Rates in Female and Male Drosophila Melanogaster
Open accessAbstract
Dietary restriction (DR) has been shown to increase life span in taxonomically diverse animal species. In this study we tested for sex differences in the response of life span to graded severity of DR in Drosophila melanogaster. In both sexes, life span peaked at an intermediate food concentration and declined on either side. However, the magnitude of the response and the food concentration that minimized adult mortality differed significantly between the sexes. Female life span peaked at a food concentration 60% of the standard laboratory diet compared to a concentration of 40% for males. Moreover, female flies subject to DR lived up to 60% longer than did starved or fully fed females, whereas males subjected to DR lived only up to 30% longer. Analysis of age-specific mortality rates showed that DR extended life span by decreasing baseline mortality rates in both sexes, and to a greater extent in females. The differences in the response to DR in female and male Drosophila may be due to previously documented sex differences in sensitivity of life span to insulin/insulin-like growth factor-1 signalling or in nutrient/energy demand and allocation/utilization.
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Cites
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775
Metabolic fuels and reproduction in female mammals
Wade, G. N., & Schneider, J. E. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80183-6 · Cited by 686
Cited by
Calories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila
Mair, W., Piper, M. D. W., & Partridge, L. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030223 · Cited by 522
Self-citationHigh-quality male field crickets invest heavily in sexual display but die young
Hunt, J., Brooks, R., Jennions, M. D., Smith, M. J., Bentsen, C. L., & Bussière, L. F. (2004) · Nature · doi:10.1038/nature03084 · Cited by 469
Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster
Skorupa, D. A., Dervisefendic, A., Zwiener, J., & Pletcher, S. D. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00400.x · Cited by 437
Increased Internal and External Bacterial Load during Drosophila Aging without Life-Span Trade-Off
Ren, C., Webster, P., Finkel, S. E., & Tower, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.006 · Cited by 362
Survival costs of reproduction in Drosophila
Flatt, T. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2010.10.008 · Cited by 324
Metadata
- Authors
- Magwere, T., Chapman, T., & Partridge, L.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-01-01
- Volume
- 59
- Issue
- 1
- Pages
- B3-B9
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2101172881
- Cited by
- 267
- References
- 3
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Magwere, T., Chapman, T., & Partridge, L. (2004). Sex Differences in the Effect of Dietary Restriction on Life Span and Mortality Rates in Female and Male Drosophila Melanogaster. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. https://doi.org/10.1093/gerona/59.1.b3
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