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Cited by 104Health disparities and outcomesHealth, psychology, and well-beingAging, Health, and Disability

How Are Biomarkers Related to Physical and Mental Well-Being?

Seplaki, C. L., Goldman, N., Weinstein, M., Lin, Y.-H.·2004·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
DOI 10.1093/gerona/59.3.b201
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Abstract

We investigate how biological markers of individual responses to stressful experiences are associated with profiles of physical and mental functioning in a national sample of middle-aged and elderly Taiwanese. Data come from a population-based sample of middle-aged and elderly Taiwanese in 2000. The data combine rich biological measures with self-reported information on physical and mental health. Grade of membership methods are used to summarize functional status, and multinomial logit models provide information on the association between biological measures and function. The analysis identifies significant associations between biomarkers of stressful experience and profiles of physical and mental functioning. The estimates reveal the potential importance for health of both low and high values of biological parameters. The findings point to directions for future research regarding development of aggregate measures of cumulative dysregulation across multiple physiological systems.

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  • Associations between allostatic load and outcomes are replicated when alternative scoring methods, including canonical correlation analyses, grade-of-membership, and recursive partitioning, are used to create allostatic load indices.

    “Subsequent work has shown that these associations are repli-cated when a variety of alternative scoring methods that incorporate more complex and detailed scoring algorithms are used to create indices of AL, including canonical correlation analyses, 169 grade-ofmembership 166,167,182 and recursive partitioning.168”

    From Socio‐economic differentials in peripheral biology: Cumulative allostatic load (2010) · cites this paper as [182]

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Research works printed but not linked: 7

  1. McEwen BS, Goodman HM, eds. Handbook of Physiology Section 7: The Endocrine System, Volume IV: Coping with the Environment: Neural and Endocrine Mechanisms . New York: Oxford University Press; 2001:469-495.
  2. Boey, K.W. Cross-validation of a short form of the CES-D in Chinese elderly. Int J Geriatr Psychiatry. Aug 1999;14(8):608-617.
  3. Goldstein DS, Eisenhofer G. Sympathetic Nervous System Physiology and Pathophysiology. In: McEwen BS, Goodman HM, eds. Handbook of Physiology Section 7: The Endocrine System, Volume IV: Coping with the Environment: Neural and Endocrine Mechanisms . New York: Oxford University Press; 2001:21-43.
  4. McEwen BS. The neurobiology of stress: from serendipity to clinical relevance. Brain Res. Dec 15 2000;886(1-2):172-189.
  5. McEwen BS, ed. Volume IV: Coping with the Environment: Neural and Endocrine Mechanisms . New York: Oxford University Press; 2001. Goodman HM, ed. Handbook of Physiology, Section 7: The Endocrine System.
  6. Portrait F, Lindeboom M, Deeg D. Health and Mortality of the Elderly: The Grade of Membership Method, Classification and Determination. Health Econ. 1999;8(5):441-457.
  7. Singer BH, Ryff CD. Person-Centered Methods for Understanding Aging: The Integration of Numbers and Narratives. In: Binstock RH, George LK, eds. Handbook of Aging and the Social Sciences . 5 ed. San Diego, CA: Academic Press; 2001:44-65.

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Authors
Seplaki, C. L., Goldman, N., Weinstein, M., & Lin, Y.-H.
Affiliations
Princeton University (US)
Corresponding author
Seplaki, C. L.
ORCID
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher
Oxford University Press (OUP)
Published
2004-03-01
Volume
59
Issue
3
Pages
B201-B217
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
DOI
10.1093/gerona/59.3.b201
OpenAlex
W2140866955
Cited by
104
References
64
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 6
FWCI
6.63
Type
journal article
Language
en
Open access
closed
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
  • Georgetown University
  • National Institute on Aging (R01 AG16790, R01-AG16661, R01AG016790, R01AG016661)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (5P30-HD32030, P30HD032030)
Topics
  • Social Sciences › Health › Health disparities and outcomes
  • Health Sciences › Health Professions › General Health Professions › Health, psychology, and well-being
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords
biomarkers, stress response, physical function, mental health, middle-aged and older adults, membership degree, physiological dysregulation, Taiwanese population
MeSH terms
Aged, Female, Health Status, Humans, Male, Mental Health, Middle Aged, Taiwan, Biomarkers, Logistic Models

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