Measurement of cumulative physiological dysregulation in an older population
Abstract
The allostatic load framework postulates that an important pathway connecting the social environment with health involves biological responses to stressful stimuli and the subsequent dysregulation of interrelated physiological systems. We formulate a new measure for cumulative physiological dysregulation using a grade of membership model estimated with biodemographic data from a national sample of older Taiwanese persons. We investigate associations between the measure and physical, psychological, and cognitive function. The results provide insights into the relationships between a set of biological profiles and various health outcomes, identify limitations of earlier approaches, and underscore next steps in the development of improved formulations of physiological dysregulation.
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Associations between allostatic load and outcomes are replicated when alternative scoring methods, including canonical correlation analyses, grade-of-membership, and recursive partitioning, are used to create allostatic load indices.
“Subsequent work has shown that these associations are repli-cated when a variety of alternative scoring methods that incorporate more complex and detailed scoring algorithms are used to create indices of AL, including canonical correlation analyses, 169 grade-ofmembership 166,167,182 and recursive partitioning.168”
From Socio‐economic differentials in peripheral biology: Cumulative allostatic load (2010) · cites this paper as [167]
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Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,769 · see citing works
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Self-citationExpert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154 · see citing works
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733 · cited 3× · see citing works
“The deleterious effects of allostatic load, which include poor physical, psychological, and cognitive functioning, are believed to result from chronic exposure to physiological parameters outside “normal” operating ranges (McEwen 1998a).”
Pfeiffer, E. A. (1975) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1975.tb00927.x · Cited by 5,320 · see citing works
The Mini‐Mental State Examination: A Comprehensive Review
Tombaugh, T. N., & McIntyre, N. J. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb01992.x · Cited by 5,152 · see citing works
Stress, adaptation, and disease. Allostasis and allostatic load
McEWEN, B. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09546.x · Cited by 5,092 · see citing works
McEwen, B. S. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.18.2093 · Cited by 4,365 · see citing works
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953 · see citing works
Benton, A. (1994) · Annual Review of Psychology · doi:10.1146/annurev.psych.45.1.1 · Cited by 2,298 · see citing works
Two Shorter Forms of the CES-D Depression Symptoms Index
Kohout, F. J., Berkman, L. F., Evans, D. A., & Cornoni‐Huntley, J. C. (1993) · Journal of Aging and Health · doi:10.1177/089826439300500202 · Cited by 2,292 · see citing works
McEWEN, B. S., & SEEMAN, T. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08103.x · Cited by 1,824 · see citing works
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592 · see citing works
Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging
Seeman, T. E., McEwen, B. S., Rowe, J. W., & Singer, B. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081072698 · Cited by 1,385 · cited 3× · see citing works
“…dysregulation are associated with diverse health outcomes (e.g., mortality, cognitive and physical function, and cardiovascular disease; Karlamangla et al. 2002; Seeman et al. 2001; Seeman et al. 1997) and various dimensions of the social environment (Schnorpfeil et al. 2003; Seeman et al. 2002).”
Seeman, T. E. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440400111013 · Cited by 1,368 · see citing works
Chronic stress and age-related increases in the proinflammatory cytokine IL-6.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,220 · cited 1× · see citing works
“IL-6, a marker of immune system activity, is positively associated with chronic stress ( Kiecolt-Glaser et al. 2003 ) and mortality (Reuben et al. 2002) and may be an indicator of the risk of cardiovascular disease (Jenny et al. 2002; Libby and Ridker 1999; Pai et al. 2004).”
BackgroundInflammatory Markers and the Risk of Coronary Heart Disease in Men and Women
Pai, J. K., Pischon, T., Ma, J., Manson, J. E., Hankinson, S. E., JOSHIPURA, K. J., Curhan, G. C., Rifai, N., Cannuscio, C. C., Stampfer, M. J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040967 · Cited by 1,174 · see citing works
Sex, stress and the hippocampus: allostasis, allostatic load and the aging process
MCEWEN, B. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00027-1 · Cited by 753 · see citing works
Social Relationships, Gender, and Allostatic Load Across Two Age Cohorts
Seeman, T. E., Singer, B. H., Ryff, C. D., Dienberg Love, G., & Levy-Storms, L. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200205000-00004 · Cited by 496 · cited 2× · see citing works
“…dysregulation are associated with diverse health outcomes (e.g., mortality, cognitive and physical function, and cardiovascular disease; Karlamangla et al. 2002; Seeman et al. 2001; Seeman et al. 1997) and various dimensions of the social environment (Schnorpfeil et al. 2003; Seeman et al. 2002).”
Catecholamine regulation of the prefrontal cortex
Arnsten, A. F. T. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100208 · Cited by 489 · see citing works
Allostatic load as a predictor of functional decline
Karlamangla, A. S., Singer, B. H., McEwen, B. S., Rowe, J. W., & Seeman, T. E. (2002) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00399-2 · Cited by 483 · see citing works
Socioeconomic determinants of health: Stress and the biology of inequality
Brunner, E. J. (1997) · BMJ · doi:10.1136/bmj.314.7092.1472 · Cited by 446 · see citing works
Evaluating the quality of self-reports of hypertension and diabetes
Goldman, N. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00580-2 · Cited by 394 · see citing works
Self-citationNovel Inflammatory Markers of Coronary Risk
Libby, P., & Ridker, P. M. (1999) · Circulation · doi:10.1161/01.cir.100.11.1148 · Cited by 375 · see citing works
Social Environment Effects on Health and Aging
Seeman, T., & Crimmins, E. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb02749.x · Cited by 337 · see citing works
Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA).
Kalimi, M., Shafagoj, Y., Loria, R., Padgett, D., & Regelson, W. (1994) · Molecular and Cellular Biochemistry · doi:10.1007/bf00925945 · Cited by 328 · see citing works
Body weight and weight change and their health implications for the elderly
Seidell, J., & Visscher, T. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601023 · Cited by 324 · cited 1× · see citing works
“BMI and waist-to-hip ratio measure body composition and fat distribution, respectively, and refl ect cardiovascular disease risk (Davidson et al. 1999; Seidell and Visscher 2000; Terry, Page, and Haskell 1992).”
Clark, R. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.2.0296 · Cited by 314 · see citing works
Age differences in allostatic load: an index of physiological dysregulation
Crimmins, E. M., Johnston, M., Hayward, M., & Seeman, T. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00099-8 · Cited by 303 · see citing works
Reuben, D. B., Cheh, A. I., Harris, T. B., Ferrucci, L., Rowe, J. W., Tracy, R. P., & Seeman, T. E. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50157.x · Cited by 296 · see citing works
Berr, C., Lafont, S., Debuire, B., Dartigues, J., & Baulieu, É.-É. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13410 · Cited by 292 · see citing works
Cappola, A. R., Xue, Q.-L., Ferrucci, L., Guralnik, J. M., Volpato, S., & Fried, L. P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021694 · Cited by 286 · see citing works
Leng, S. X., Cappola, A. R., Andersen, R. E., Blackman, M. R., Koenig, K., Blair, M., & Walston, J. D. (2004) · Aging Clinical and Experimental Research · doi:10.1007/bf03324545 · Cited by 270 · see citing works
Allostasis, Homeostasis, and the Costs of Physiological Adaptation
(2004) · Cambridge University Press eBooks · doi:10.1017/cbo9781316257081 · Cited by 261 · see citing works
Reliability and validity of screening scales: Effect of reducing scale length
Shrout, P. E., & Yager, T. J. (1989) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(89)90027-9 · Cited by 255 · see citing works
Jenny, N. S., Tracy, R. P., Ogg, M. S., Luong, L. A., Kuller, L. H., Arnold, A. M., Sharrett, A. R., & Humphries, S. E. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000040224.49362.60 · Cited by 243 · see citing works
Statistical Applications Using Fuzzy Sets.
Haberman, S. J., Mantón, K. G., Woodbury, M. A., & Tolley, H. D. (1995) · Journal of the American Statistical Association · doi:10.2307/2291362 · Cited by 217 · see citing works
Association of IGF-I levels with muscle strength and mobility in older women
Cappola, A. R., Bandeen-Roche, K., Wand, G. S., Volpato, S., & Fried, L. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7868 · Cited by 205 · see citing works
ANTIGLUCOCORTICOID ACTIONS OF DEHYDROEPIANDROSTERONE AND LOW CONCENTRATIONS IN ALZHEIMER'S DISEASE
Svec, F., & Lopez‐S, A. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91940-5 · Cited by 192 · see citing works
Adler, N. E., Marmot, M. G., McEwen, B. S., & Judith, S. (2001) · UCL Discovery (University College London) · Cited by 191 · see citing works
Relationship Between Fasting Plasma Glucose and Glycosylated Hemoglobin
Davidson, M. B., Schriger, D. L., Peters, A. L., & Lorber, B. (1999) · JAMA · doi:10.1001/jama.281.13.1203 · Cited by 189 · see citing works
Allostatic load and work conditions
Schnorpfeil, P., Noll, A., Schulze, R., Ehlert, U., Frey, K., & Fischer, J. E. (2003) · Social Science & Medicine · doi:10.1016/s0277-9536(02)00407-0 · Cited by 175 · see citing works
Mazat, L., Lafont, S., Berr, C., Debuire, B., Tessier, J.-F., Dartigues, J., & Baulieu, É.-É. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121177998 · Cited by 172 · see citing works
Chronic social stress: effects on limbic brain structures
Fuchs, E., & Flügge, G. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00161-6 · Cited by 171 · see citing works
The Anthropology of Taiwanese Society
Cooper, E., Ahern, E. M., & Gates, H. (1997) · Medical Entomology and Zoology · Cited by 165 · see citing works
SEPLAKI, C., GOLDMAN, N., GLEI, D., & WEINSTEIN, M. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.03.002 · Cited by 151 · see citing works
Self-citationStatistical Applications Using Fuzzy Sets
Kandel, A., Mantón, K. G., Woodbury, M. A., & Tolley, H. D. (1995) · Technometrics · doi:10.2307/1269638 · Cited by 148 · see citing works
An Introduction to Neuroendocrinology
Brown, R. E. (1994) · Cambridge University Press eBooks · doi:10.1017/cbo9780511623264 · Cited by 121 · see citing works
Neuropsychiatric Function and Dehydroepiandrosterone Sulfate in Elderly Women: A Prospective Study
Yaffe, K. S., Ettinger, B. B., Pressman, A. R., Seeley, D. G., Whooley, M. A., Schaefer, C. A., & Cummings, S. R. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00303-x · Cited by 120 · see citing works
Social Ties and Perceived Support
Cornman, J. C., Goldman, N., Glei, D. A., Weinstein, M., & Chang, M. (2003) · Journal of Aging and Health · doi:10.1177/0898264303256215 · Cited by 117 · see citing works
Self-citationEffect of DHEAS on skeletal muscle over the life span: the InCHIANTI study.
Valenti, G., Denti, L., Maggio, M., Ceda, G., Volpato, S., Bandinelli, S., Ceresini, G., Cappola, A., Guralnik, J., & Ferrucci, L. (2004) · The journals of gerontology. Series A, Biological sciences and medical sciences · doi:10.1093/gerona/59.5.m466 · Cited by 116 · see citing works
Black/White Differences in Health Status and Mortality Among the Elderly
Berkman, L. F., Singer, B. H., & Mantón, K. G. (1989) · Demography · doi:10.2307/2061264 · Cited by 112 · see citing works
How Are Biomarkers Related to Physical and Mental Well-Being?
Seplaki, C. L., Goldman, N., Weinstein, M., & Lin, Y.-H. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.b201 · Cited by 104 · see citing works
Self-citationTerry, R. B., Page, W. F., & Haskell, W. L. (1992) · PubMed · Cited by 96 · see citing works
Boey (1999) · Pure Amsterdam UMC · doi:10.1002/(sici)1099-1166(199908)14:8 · Cited by 95 · see citing works
Epidemiology of the insulin resistance syndrome
Meigs, J. B. (2003) · Current Diabetes Reports · doi:10.1007/s11892-003-0057-2 · Cited by 86 · see citing works
McEwen, B. S. (2004) · Cambridge University Press eBooks · doi:10.1017/cbo9781316257081.005 · Cited by 83 · see citing works
Wang, T., Chen, W., Chien, K., Su, S., Hsu, H., Chen, M.-F., Liau, C., & Lee, Y. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01843-4 · Cited by 72 · see citing works
Operationalizing Allostatic Load
Singer, B. H., Ryff, C. D., & Seeman, T. E. (2004) · Cambridge University Press eBooks · doi:10.1017/cbo9781316257081.007 · Cited by 69 · see citing works
Goldman, N., Weinstein, M., Cornman, J. C., Singer, B. H., Seeman, T. E., Goldman, N., & Chang, M. (2004) · Journal of Women s Health · doi:10.1089/154099904323087088 · Cited by 55 · see citing works
Self-citationPortrait, F. R. M., Lindeboom, M., & Deeg, D. J. H. (2001) · Demography · doi:10.1353/dem.2001.0038 · Cited by 51 · see citing works
Dehydroepiandrosterone sulfate (DHEAS) and health: does the relationship differ by sex?
Glei, D. A., Goldman, N., Weinstein, M., & Liu, I.-W. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.11.003 · Cited by 46 · see citing works
Self-citationRole of IGF-I in muscular atrophy of aging
Borst, S. E., & Lowenthal, D. T. (1997) · Endocrine · doi:10.1007/bf02778065 · Cited by 33 · see citing works
Flagged first, then by citations
4 of the 69 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Adler, N.E., M. Marmot, B.S. McEwen, and J. Stewart. 1999. "Socioeconomic Status and Health in Industrialized Nations: Social, Psycological, and Biological Pathways." in Annals of the New York Academy of Sciences . New York: The New York Academy of Sciences.
- Boey, K.W. 1999. "Cross-validation of a short form of the CES-D in Chinese elderly." Int J Geriatr Psychiatry 14(8):608-617.
- Goldman, N., I.-F. Lin, M. Weinstein, and Y.-H. Lin. 2003. "Evaluating the Quality of SelfReports of Hypertension and Diabetes." Journal of Clinical Epidemiology 56(2):148-154.
Cited by
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Allostatic load biomarkers of chronic stress and impact on health and cognition
Juster, R.-P., McEwen, B. S., & Lupien, S. J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.10.002 · Cited by 2,565 · see citing works
Socio‐economic differentials in peripheral biology: Cumulative allostatic load
Seeman, T., Epel, E., Gruenewald, T., Karlamangla, A., & McEwen, B. S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05341.x · Cited by 579 · see citing works
A Systematic Review of Allostatic Load, Health, and Health Disparities
Beckie, T. M. (2012) · Biological Research For Nursing · doi:10.1177/1099800412455688 · Cited by 529 · see citing works
Juster, R.-P., Bizik, G., Picard, M., Arsenault-Lapierre, G., Sindi, S., Trepanier, L., Marin, M.-F., Wan, N., Sekerovic, Z., Lord, C., et al. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000289 · Cited by 268 · see citing works
Cohen, A. A., Milot, E., Yong, J., Seplaki, C. L., Fülöp, T., Bandeen‐Roche, K., & Fried, L. P. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.01.004 · Cited by 224 · see citing works
Self-citationPeek, M. K., Cutchin, M. P., Salinas, J. J., Sheffield, K. M., Eschbach, K., Stowe, R. P., & Goodwin, J. S. (2009) · American Journal of Public Health · doi:10.2105/ajph.2007.129312 · Cited by 188 · see citing works
Allostatic Load: Importance, Markers, and Score Determination in Minority and Disparity Populations
Rodriquez, E. J., Kim, E. N., Sumner, A. E., Nápoles, A. M., & Pérez‐Stable, E. J. (2019) · Journal of Urban Health · doi:10.1007/s11524-019-00345-5 · Cited by 167 · see citing works
SEPLAKI, C., GOLDMAN, N., GLEI, D., & WEINSTEIN, M. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.03.002 · Cited by 151 · see citing works
Self-citationChyu, L., & Upchurch, D. M. (2011) · Journal of Women s Health · doi:10.1089/jwh.2010.2170 · Cited by 147 · see citing works
Perceived stress and physiological dysregulation in older adults
Goldman, N., Glei, D., Seplaki, C., Liu, I.-W., & Weinstein, M. (2005) · Stress · doi:10.1080/10253890500141905 · Cited by 113 · see citing works
Self-citationMediators of the relationship between race and allostatic load in African and White Americans.
Tomfohr‐Madsen, L. M., Pung, M. A., & Dimsdale, J. E. (2016) · Health Psychology · doi:10.1037/hea0000251 · Cited by 103 · see citing works
D’Amico, D., Amestoy, M. E., & Fiocco, A. J. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104849 · Cited by 99 · see citing works
Neighborhood Context and Social Disparities in Cumulative Biological Risk Factors
King, K. E., Morenoff, J. D., & House, J. S. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318227b062 · Cited by 97 · see citing works
Juster, R., Marin, M., Sindi, S., Nair, N. P. V., Ng, Y. K., Pruessner, J. C., & LUPIEN, S. J. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.027 · Cited by 94 · see citing works
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Booth, T., Royle, N. A., Corley, J., Gow, A. J., Valdés Hernández, M. D. C., Muñoz Maniega, S., Ritchie, S. J., Bastin, M. E., Starr, J. M., Wardlaw, J. M., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.12.020 · Cited by 88 · see citing works
Castro‐Diehl, C., Roux, A. V. D., Seeman, T. E., Shea, S., Shrager, S., & Tadros, S. S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.12.013 · Cited by 88 · see citing works
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Self-citationAllostatic Load and Frailty in the Women's Health and Aging Studies
Szanton, S. L., Allen, J. K., Seplaki, C. L., Bandeen‐Roche, K., & Fried, L. P. (2008) · Biological Research For Nursing · doi:10.1177/1099800408323452 · Cited by 84 · see citing works
Self-citationMilot, E., Morissette-Thomas, V., Li, Q., Fried, L. P., Ferrucci, L., & Cohen, A. A. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.10.001 · Cited by 76 · see citing works
Hwang, A.-C., Peng, L.-N., Wen, Y.-W., Tsai, Y.-W., Chang, L.-C., Chiou, S.-T., & Chen, L.-K. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.02.001 · Cited by 76 · see citing works
McLoughlin, S., Kenny, R. A., & McCrory, C. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104789 · Cited by 78 · see citing works
Beese, S., Postma, J. M., & Graves, J. M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192417006 · Cited by 80 · see citing works
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Bízik, G., Picard, M., Nijjar, R., Tourjman, V., McEwen, B., Lupien, S., & Juster, R. (2013) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000012 · Cited by 70 · see citing works
Allostatic Load and the Assessment of Cumulative Biological Risk in Biobehavioral Medicine
Gallo, L. C., Fortmann, A. L., & Mattei, J. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000095 · Cited by 68 · see citing works
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Gersten, O. (2007) · Social Science & Medicine · doi:10.1016/j.socscimed.2007.09.004 · Cited by 66 · see citing works
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Thomas, M. D., Michaels, E. K., Reeves, A. N., Okoye, U., Price, M. M., Hasson, R. E., Chae, D. H., & Allen, A. M. (2019) · Annals of Epidemiology · doi:10.1016/j.annepidem.2019.05.002 · Cited by 60 · see citing works
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Juster, R., Moskowitz, D. S., Lavoie, J., & D’Antono, B. (2013) · Stress · doi:10.3109/10253890.2013.835395 · Cited by 53 · see citing works
Stress, Place, and Allostatic Load Among Mexican Immigrant Farmworkers in Oregon
McClure, H. H., Snodgrass, J. J., Martínez, C. R., Squires, E. C., Jiménez, R. A., Isiordia, L. E., Eddy, J. M., McDade, T. W., & Small, J. (2015) · Journal of Immigrant and Minority Health · doi:10.1007/s10903-014-0066-z · Cited by 52 · see citing works
Williams, S. R., Kanter, G. P., & Leitsch, S. A. (2009) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbn015 · Cited by 51 · see citing works
The Biology of Social Adversity Applied to Oral Health
Gomaa, N. A., Tenenbaum, H. C., Glogauer, M., & Quiñonez, C. (2019) · Journal of Dental Research · doi:10.1177/0022034519876559 · Cited by 44 · see citing works
Prior, L., Manley, D., & Jones, K. (2018) · Health & Place · doi:10.1016/j.healthplace.2018.05.003 · Cited by 36 · see citing works
Exploring the optimal allostatic load scoring method in women of reproductive age
Li, Y., Rosemberg, M.-A. S., Dalton, V. K., Lee, S. J., & Seng, J. S. (2019) · Journal of Advanced Nursing · doi:10.1111/jan.14014 · Cited by 32 · see citing works
The application of allostasis and allostatic load in animal species: A scoping review
Seeley, K. E., Proudfoot, K. L., & Edes, A. N. (2022) · PLoS ONE · doi:10.1371/journal.pone.0273838 · Cited by 31 · see citing works
Job stress related to glyco‐lipid allostatic load, adiponectin and visfatin
Li, W., Zhang, J., Sun, J., Ke, J., Dong, Z., & Wang, S. (2007) · Stress and Health · doi:10.1002/smi.1145 · Cited by 31 · see citing works
Yang, Y.-T., Wang, Y.-H., Chiu, H.-T., Wu, C.-R., Handa, Y., Liao, Y.-L., & Hsu, Y. E. (2015) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2015.07.005 · Cited by 30 · see citing works
Kobrosly, R. W., Seplaki, C. L., Cory‐Slechta, D. A., Moynihan, J. A., & van Wijngaarden, E. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3878 · Cited by 26 · see citing works
Self-citationTesting allostatic load factor structures among adolescents: A structural equation modeling approach
King, A. L., Garnier‐Villarreal, M., Simanek, A. M., & Johnson, N. L. (2019) · American Journal of Human Biology · doi:10.1002/ajhb.23242 · Cited by 27 · see citing works
Buschmann, R. N., Prochaska, J. D., Cutchin, M. P., & Peek, M. K. (2018) · Annals of Epidemiology · doi:10.1016/j.annepidem.2018.03.014 · Cited by 24 · see citing works
The influences of power, politics, and climate risk on US subnational climate action
Gurney, R. M., Hamlet, A. F., & Regan, P. M. (2020) · Environmental Science & Policy · doi:10.1016/j.envsci.2020.06.023 · Cited by 22 · see citing works
Assari, S., Caldwell, C. H., Abelson, J. L., & Zimmerman, M. (2019) · Journal of Urban Health · doi:10.1007/s11524-019-00360-6 · Cited by 21 · see citing works
Do Interviewer and Physician Health Ratings Predict Mortality?
Todd, M. A., & Goldman, N. (2013) · Epidemiology · doi:10.1097/ede.0b013e3182a713a8 · Cited by 19 · see citing works
Self-citationPhysiologic Dysfunction Scores and Cognitive Function Test Performance in US Adults
Kobrosly, R. W., Seplaki, C. L., Jones, C. M. C., & van Wijngaarden, E. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182385b1e · Cited by 19 · see citing works
Self-citationGalé, C. R., Batty, G. D., Cooper, S., Deary, I. J., Der, G., McEwen, B. S., & Cavanagh, J. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000189 · Cited by 19 · see citing works
McDade, T. W. (2007) · Social Science & Medicine · doi:10.1016/j.socscimed.2007.09.005 · Cited by 19 · see citing works
Late-life depression, allostatic load, and risk of dementia: The AGES-Reykjavik study
Twait, E. L., Basten, M., Gerritsen, L., Gudnason, V. G., Launer, L. J., & Geerlings, M. I. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105975 · Cited by 17 · see citing works
Calcaterra, V., Cena, H., Silvestri, A. D., Albertini, R., AMICI, M. D., Valenza, M., & Pelizzo, G. (2017) · Hormone Research in Paediatrics · doi:10.1159/000477906 · Cited by 16 · see citing works
Nobel, L., Roblin, D. W., Becker, E. R., Druss, B. G., Joski, P. I., & Allison, J. J. (2016) · Biomarkers · doi:10.1080/1354750x.2016.1201535 · Cited by 15 · see citing works
Edison, S., & Haynie, D. L. (2023) · Women & Criminal Justice · doi:10.1080/08974454.2023.2246955 · Cited by 13 · see citing works
Li, Y., Rosemberg, M.-A. S., & Seng, J. S. (2018) · Midwifery · doi:10.1016/j.midw.2018.04.002 · Cited by 12 · see citing works
Physiological Dysregulation, Frailty, and Impacts on Adverse Health and Functional Outcomes
Lu, Y., Gwee, X., Chua, D. Q. L., Tan, C. T. Y., Yap, K. B., Larbi, A., & Ng, T. P. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.751022 · Cited by 11 · see citing works
Phillips, E. L. (2011) · Deep Blue (University of Michigan) · Cited by 12 · see citing works
McKee, K. S., Seplaki, C. L., Fisher, S. G., Groth, S. W., & Fernandez, I. D. (2016) · Maternal and Child Health Journal · doi:10.1007/s10995-016-2103-0 · Cited by 8 · see citing works
Self-citationJinez, A. M., Cabriales, E. C. G., D’Alonzo, K. T., Esquivel, A. U., López-Rincón, F. J., & Salazar-González, B. C. (2018) · Aquichan · doi:10.5294/aqui.2018.18.3.5 · Cited by 7 · see citing works
Taxonomic Diversity, Complexity and the Evolution of Senescence
Cohen, A. A. (2017) · Cambridge University Press eBooks · doi:10.1017/9781139939867.005 · Cited by 8 · see citing works
Azizi, Z. R., Hirst, R. J., O’Dowd, A., McCrory, C., Kenny, R. A., Newell, F. N., & Setti, A. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105155 · Cited by 7 · see citing works
Sex × Gender and Sexual Orientation in Relation to Stress Hormones and Allostatic Load
Juster, R. (2019) · Gender and the Genome · doi:10.1177/2470289719862555 · Cited by 7 · see citing works
Data Sources for Studying Aging
Schafer, M. H., & Ferraro, K. F. (2009) · Springer eBooks · doi:10.1007/978-1-4020-8356-3_2 · Cited by 7 · see citing works
Arbeitsbedingter Stress und der Allostatic Load Index – eine systematische Übersichtsarbeit
Mauss, D., Li, J., Schmidt, B., Angerer, P., & Jarczok, M. N. (2015) · Das Gesundheitswesen · doi:10.1055/s-0035-1555951 · Cited by 9 · see citing works
Analysis of the Natural History of Dementia Using Longitudinal Grade of Membership Models
Stallard, E., & Sloan, F. A. (2016) · The Springer series on demographic methods and population analysis · doi:10.1007/978-94-017-7587-8_17 · Cited by 5 · see citing works
Does allostatic load predict incidental coronary events differently among sexes?
Demirer, I., Schmidt, B., Schramm, S. H., Erbel, R. M., Jöckel, K., & Pförtner, T. (2021) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100089 · Cited by 5 · see citing works
Barbosa, B. J. A. P., Souza‐Talarico, J. N., de Jesus, M. C. F., Mota, G. P. S., de Oliveira, M. O., Cassimiro, L., Avolio, I. B., Trés, E. S., Borges, C. R., Teixeira, T. B. M., et al. (2024) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2024.108365 · Cited by 4 · see citing works
Monitoring Social Determinants of Health Assessing Patients and Communities
Morelli, V., & Heizelman, R. (2023) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2023.04.005 · Cited by 2 · see citing works
Holochwost, S. J., Volpe, V. V., Collins, A. N., Propper, C. B., Mills-Koonce, R., Brown, E. D., & Jaffee, S. R. (2024) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001292 · Cited by 2 · see citing works
Assari, S., Azad, M. A., & Zare, H. (2024) · Global Journal of Epidemiology and Infectious Disease · doi:10.31586/gjeid.2024.1014 · Cited by 1 · see citing works
Comparing allostatic load scoring methods and timing: their links to preterm birth outcomes
Forcheh, N., Tavangar, F., Ronksley, P. E., Khan, N. B., Nausheen, S., Lalani, S. B., & Premji, S. (2026) · AJOG Global Reports · doi:10.1016/j.xagr.2026.100655 · Cited by 1 · see citing works
Kobrosly, R. W. (2013) · UR Research (University of Rochester) · Cited by 1 · see citing works
The Social Environment and Biomarkers of Aging Study (SEBAS)
Cornman, J. C., Glei, D. A., Goldman, N., & Weinstein, M. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_983-1 · Cited by 1 · see citing works
Self-citationBiological, Psychosocial, and Social Capital Implications of the Neighborhood Built Environment.
King, K. E. (2011) · Deep Blue (University of Michigan)
Neves, A. C. A. (2011) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Cultural Awareness, Diversity, and the Stress Response
Everly, G. S., & Lating, J. M. (2019) · Springer eBooks · doi:10.1007/978-1-4939-9098-6_9
Thomas, M. D. (2019) · eScholarship (California Digital Library)
Maternal mental health and child allostatic load in rural Nicaragua
Hoehn, N. C. (2018) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/32962
The Social Environment and Biomarkers of Aging Study (SEBAS)
Cornman, J. C., Glei, D. A., Goldman, N., & Weinstein, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_983
Self-citationTu, R., Pei, J.-J., Wolthon, A., Li, Y., & Wang, H. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12110429
Roosmawati, N., & Goda, K. (2026) · International Journal of Disaster Risk Reduction · doi:10.1016/j.ijdrr.2026.106209
Hernandez, R., Schneider, S., Moore, R. C., Gonzalez, J. S., Hoogendoorn, C. J., Roll, S. C., Jin, H., Fanning, J. T., Ginsberg, J. P., & Pyatak, E. A. (2026) · Ergonomics · doi:10.1080/00140139.2026.2683140
- Authors
- Seplaki, C. L., Goldman, N., Weinstein, M., & Lin, Y.-H.
- Affiliations
- Johns Hopkins University (US)
- Princeton University (US)
- Georgetown University (US)
- Ministry of Health and Welfare (TW)
- Corresponding author
- Seplaki, Christopher L.
- Venue
- Demography
- Publisher
- Duke University Press
- Published
- 2006-02-01
- Volume
- 43
- Issue
- 1
- Pages
- 165-183
- ISSN
- 0070-3370 (ISSN-L)
- 1533-7790
- OpenAlex
- W2168595688
- Cited by
- 84
- References
- 69
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 10 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 2
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Demography (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Project Muse (Johns Hopkins University) (submittedVersion)
- Funders
- National Institute on Aging (R01 AG16790, R01-AG16661, R01AG016790, R01AG016661)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (5P30-HD32030, P30HD032030)
- Topics
- Social Sciences › Health › Health disparities and outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Keywords
- allostatic load, grade of membership model, older adults, physiological stress response, physical function, psychological functioning, cognitive function, social environment and health
- MeSH terms
- Aged, Aging, Cognition, Data Collection, Female, Humans, Male, Middle Aged, Stress, Psychological, Taiwan, Cohort Studies, Biomarkers
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