Cited by 104Health disparities and outcomesHealth, psychology, and well-beingAging, Health, and Disability

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How Are Biomarkers Related to Physical and Mental Well-Being?

Seplaki, C. L., Goldman, N., Weinstein, M., Lin, Y.-H.·2004·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

DOI 10.1093/gerona/59.3.b201

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Abstract

We investigate how biological markers of individual responses to stressful experiences are associated with profiles of physical and mental functioning in a national sample of middle-aged and elderly Taiwanese. Data come from a population-based sample of middle-aged and elderly Taiwanese in 2000. The data combine rich biological measures with self-reported information on physical and mental health. Grade of membership methods are used to summarize functional status, and multinomial logit models provide information on the association between biological measures and function. The analysis identifies significant associations between biomarkers of stressful experience and profiles of physical and mental functioning. The estimates reveal the potential importance for health of both low and high values of biological parameters. The findings point to directions for future research regarding development of aggregate measures of cumulative dysregulation across multiple physiological systems.

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Authors: Seplaki, C. L., Goldman, N., Weinstein, M., & Lin, Y.-H.
Affiliations: Princeton University (US)
Corresponding author: Seplaki, C. L.
ORCID: Seplaki, C. L.
Goldman, N.
Weinstein, M.
Lin, Y.-H.
Venue: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher: Oxford University Press (OUP)
Published: 2004-03-01
Volume: 59
Issue: 3
Pages: B201-B217
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/59.3.b201
OpenAlex: W2140866955
Cited by: 104
References: 64
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 6
FWCI: 6.63
Type: journal article
Language: en
Open access: closed
Locations: The Journals of Gerontology Series A (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Georgetown University
National Institute on Aging (R01 AG16790, R01-AG16661, R01AG016790, R01AG016661)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (5P30-HD32030, P30HD032030)
Topics: Social Sciences › Health › Health disparities and outcomes
Health Sciences › Health Professions › General Health Professions › Health, psychology, and well-being
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords: biomarkers, stress response, physical function, mental health, middle-aged and older adults, membership degree, physiological dysregulation, Taiwanese population
MeSH terms: Aged, Female, Health Status, Humans, Male, Mental Health, Middle Aged, Taiwan, Biomarkers, Logistic Models

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How Are Biomarkers Related to Physical and Mental Well-Being?

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