Neuromuscular contributions to age-related weakness
Open accessAbstract
BACKGROUND: Declines in skeletal muscle mass and quality are important factors contributing to age-related weakness. Neural activation of agonist and antagonist muscles may also be important contributing factors. METHODS: We conducted a review of the scientific literature on older adults to determine (a) methodologies used to quantify activation, (b) the potential role of agonist and antagonist activation on weakness, and (c) some possible neurophysiological mechanisms that may underlie impaired activation. RESULTS: The cumulative evidence indicates that agonist activation is impaired in some, but not all, older adults and that this impairment contributes to age-related weakness. It is possible that antagonist coactivation also plays a role in age-related weakness, though a definitive link has not been established. CONCLUSION: Future research should focus on improving quantitative measurement and mechanistic understanding of impaired activation with aging.
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Age-related impairment of neuromuscular activation contributes to weakness in older adults.
“Age-related impairment of neuromuscular activation has been shown to contribute to weakness in older adults.”
From Does quadriceps neuromuscular activation capability explain walking speed in older men and women? (2014) · cites this paper as [4]
Impaired neuromuscular activation is an important factor in the multifactorial etiology of loss of power production.
“Loss of power production has a multi-factorial etiology, and our recent studies indicate that impaired neuromuscular activation is an important factor 4, 5.”
From Does quadriceps neuromuscular activation capability explain walking speed in older men and women? (2014) · cites this paper as [4]
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“Loss of power production has a multi-factorial etiology, and our recent studies indicate that impaired neuromuscular activation is an important factor (Clark & Fielding, 2012; Reid et al., 2012).”
Self-citation
- Authors
- Clark, D. J., & Fielding, R. A.
- Affiliations
- University of Florida (US)
- Tufts University (US)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-03-17
- Volume
- 67A
- Issue
- 1
- Pages
- 41-47
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC3260482
- OpenAlex
- W2112130905
- Cited by
- 115
- References
- 77
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 10 · 2020: 13 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 4 · 2014: 13 · 2013: 15 · 2012: 9
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture (58-1950-7-707, 1P30AG031679, AG-18844)
- U.S. Department of Veterans Affairs
- National Institutes of Health (UL1TR000064, 5p30ag031679-15)
- National Institute on Aging (1 P30 AG031679, R01AG018844, R01-AG18844, P30AG028740)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- neuronal activation, agonist activation, antagonist coactivation, muscle quality, muscle mass, neurophysiological mechanisms
- MeSH terms
- Aging, Electromyography, Female, Humans, Male, Motor Neurons, Muscle Contraction, Neuromuscular Junction, Pyramidal Tracts, Reflex, Muscle, Skeletal, Muscle Weakness, Sarcopenia
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