Difference in Muscle Quality over the Adult Life Span and Biological Correlates in the Baltimore Longitudinal Study of Aging
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Objectives: To examine differences in a proxy measure of muscle quality across the adult life span and explore potential mechanisms of muscle quality change through identification of cross‐sectional correlates of muscle quality. Design: Cross‐sectional study. Setting: B altimore L ongitudinal S tudy of A ging. Participants: Seven hundred eighty‐six individuals with a mean age of 66.3 (range 26–96) (N = 786). A sensitivity analysis was conducted in a subset of participants matched according to sex, muscle mass, and body size. Measurements: Muscle quality was operationalized as the ratio of knee‐extension strength (isokinetic dynamometry) to thigh muscle cross‐sectional area (computed tomography). Differences in muscle strength, muscle area, and muscle quality ratio with age were evaluated, and the association between the muscle quality ratio and measures reflecting domains of cognitive function, motor control, peripheral nerve function, adiposity, glucose homeostasis, and inflammation were assessed through multivariate regression analyses. Results: A linear relationship between age and muscle quality ratio was observed, suggesting a gradual decline in muscle quality over the adult life course. Associations were observed between muscle quality ratio and measures of adiposity, as well as peroneal nerve motor conduction velocity, finger tapping speed, and memory performance ( P < .01). The association between muscle quality ratio and nerve conduction velocity was maintained after adjustment for anthropometric measurements ( P < .05). Conclusion: Muscle quality declines progressively with age over the adult life span and is affected by obesity and neurological factors. Studies are needed to clarify the mechanisms of these associations and their implications for functional outcomes.
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The growing mismatch between muscle mass and strength during ageing is probably caused by deterioration in muscle quality.
“The progressive mismatch between mass and strength probably occurs because of a deterioration of muscle quality.20”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [20]
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“The Health, Aging and Body Composition (ABC) Study, a study limited to high-functioning subjects aged 70 and older, subsequently confirmed that change with aging in quadriceps cross-sectional area only explained about 6% to 8% of the between-subject differences in isometric strength.(8) In the present analyses, it was…”
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- Authors
- Moore, A. Z., Caturegli, G., Metter, E. J., Makrogiannis, S., Resnick, S. M., Harris, T. B., & Ferrucci, L.
- Affiliations
- Longitudinal Studies Section Translational Gerontology Branch Baltimore Maryland
- National Institute on Aging (US)
- National Institutes of Health (US)
- Corresponding author
- Moore, Ann Zenobia
- ORCID
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2014-01-17
- Volume
- 62
- Issue
- 2
- Pages
- 230-236
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- PMC
- PMC3945403
- OpenAlex
- W1991562722
- Cited by
- 144
- References
- 42
- Citations by year
- 2025: 8 · 2024: 4 · 2023: 7 · 2022: 11 · 2021: 21 · 2020: 15 · 2019: 14 · 2018: 15 · 2017: 12 · 2016: 18 · 2015: 13 · 2014: 5 · 2012: 1
- FWCI
- 10.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Intramural Research Program of the National Institutes of Health
- National Institute on Aging
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Keywords
- muscle quality, quadriceps strength, thigh muscle cross-sectional area, aging, adiposity, obesity, motor control, finger tapping speed, memory performance, glucose homeostasis, inflammation, muscle mass
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Tomography, X-Ray Computed, Baltimore, Geriatric Assessment, Body Mass Index, Muscle, Skeletal, Quadriceps Muscle, Muscle Strength
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