Cited by 321Gastrointestinal motility and disordersBarrier Structure and Function StudiesGenetics, Aging, and Longevity in Model Organisms

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Age-Associated Remodeling of the Intestinal Epithelial Barrier

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Tran, L., Greenwood-Van Meerveld, B.·2013·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

DOI 10.1093/gerona/glt106PMC PMC3738030

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Abstract

Disorders of the gastrointestinal tract are common in the elderly people; however, the precise trait(s) of aging that contribute to the vulnerability of the gastrointestinal tract are poorly understood. Recent evidence suggests that patients with gastrointestinal disorders have increased intestinal permeability. Here, we address the hypothesis that disruption of the intestinal barrier is associated with aging. Our results demonstrated that permeability was significantly higher in colonic biopsies collected from old baboons compared with young baboons. Additionally, colonic tissue from the older animals had decreased zonula occluden-1, occludin, and junctional adhesion molecule-A tight junction protein expression and increased claudin-2 expression. Upregulation of miR-29a and inflammatory cytokines IFN-γ, IL-6, and IL-1β was also found in colonic biopsies from old baboons relative to young baboons. These results show for the first time that a pivotal contributing factor to geriatric vulnerability to gastrointestinal dysfunction may be increased colonic permeability via age-associated remodeling of intestinal epithelial tight junction proteins.

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Additional file 5 of The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut
Arnold, J. W., Roach, J., Fabela, S., Moorfield, E., Ding, S., Blue, E., Dagher, S. F., Magness, S. T., Tamayo, R., Bruno-Bárcena, J. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13662774
Additional file 7 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19695986
Additional file 5 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19695980
Additional file 3 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19695974
Additional file 6 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19695983

Authors: Tran, L., & Greenwood-Van Meerveld, B.
Affiliations: University of Oklahoma Health Sciences Center (US)
ORCID: Tran, L.
Venue: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher: Oxford University Press (OUP)
Published: 2013-07-20
Volume: 68
Issue: 9
Pages: 1045-1056
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/glt106
PMC: PMC3738030
OpenAlex: W2161754779
Cited by: 320
References: 60
Citations by year: 2026: 25 · 2025: 28 · 2024: 25 · 2023: 27 · 2022: 37 · 2021: 31 · 2020: 25 · 2019: 29 · 2018: 22 · 2017: 32 · 2016: 18 · 2015: 9 · 2014: 10 · 2013: 2
FWCI: 12.28
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Journals of Gerontology Series A (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (P40OD010988)
National Center for Research Resources (P40RR012317)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: intestinal permeability, intestinal barrier, aging, colonic epithelium, tight junction proteins, zonula occludens-1, occludin, claudin-2, JAM-A, miR-29a, inflammatory cytokines, interferon-gamma, interleukin-6, IL-1β, baboons
MeSH terms: Aging, Animals, Colon, Gastrointestinal Diseases, Glutamate-Ammonia Ligase, Humans, Intestinal Mucosa, Peroxidase, Permeability, Risk Factors, Cytokines, MicroRNAs, Papio anubis, Tight Junction Proteins

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Age-Associated Remodeling of the Intestinal Epithelial Barrier

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