The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Age-Associated Remodeling of the Intestinal Epithelial Barrier
Open accessAbstract
Disorders of the gastrointestinal tract are common in the elderly people; however, the precise trait(s) of aging that contribute to the vulnerability of the gastrointestinal tract are poorly understood. Recent evidence suggests that patients with gastrointestinal disorders have increased intestinal permeability. Here, we address the hypothesis that disruption of the intestinal barrier is associated with aging. Our results demonstrated that permeability was significantly higher in colonic biopsies collected from old baboons compared with young baboons. Additionally, colonic tissue from the older animals had decreased zonula occluden-1, occludin, and junctional adhesion molecule-A tight junction protein expression and increased claudin-2 expression. Upregulation of miR-29a and inflammatory cytokines IFN-γ, IL-6, and IL-1β was also found in colonic biopsies from old baboons relative to young baboons. These results show for the first time that a pivotal contributing factor to geriatric vulnerability to gastrointestinal dysfunction may be increased colonic permeability via age-associated remodeling of intestinal epithelial tight junction proteins.
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“In the aged GI tract, compromised epithelial and mucosal cell turnover, integrity, and function [32, 36, 76, 83] can lead to increased epithelial barrier permeability [19, 75, 118, 120]”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [120]
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Metadata
- Authors
- Tran, L., & Greenwood-Van Meerveld, B.
- Affiliations
- University of Oklahoma Health Sciences Center (US)
- ORCID
- Tran, L.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-07-20
- Volume
- 68
- Issue
- 9
- Pages
- 1045-1056
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC3738030
- OpenAlex
- W2161754779
- Cited by
- 320
- References
- 60
- Citations by year
- 2026: 25 · 2025: 28 · 2024: 25 · 2023: 27 · 2022: 37 · 2021: 31 · 2020: 25 · 2019: 29 · 2018: 22 · 2017: 32 · 2016: 18 · 2015: 9 · 2014: 10 · 2013: 2
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (P40OD010988)
- National Center for Research Resources (P40RR012317)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- intestinal permeability, intestinal barrier, aging, colonic epithelium, tight junction proteins, zonula occludens-1, occludin, claudin-2, JAM-A, miR-29a, inflammatory cytokines, interferon-gamma, interleukin-6, IL-1β, baboons
- MeSH terms
- Aging, Animals, Colon, Gastrointestinal Diseases, Glutamate-Ammonia Ligase, Humans, Intestinal Mucosa, Peroxidase, Permeability, Risk Factors, Cytokines, MicroRNAs, Papio anubis, Tight Junction Proteins
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