Age-Associated Remodeling of the Intestinal Epithelial Barrier

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Comparative Epidemiological Investigation of Alzheimer’s Disease and Colorectal Cancer: The Possible Role of Gastrointestinal Conditions in the Pathogenesis of AD

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Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels

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HIV enteropathy and aging

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Modulation of gut microbiome in the treatment of neurodegenerative diseases: A systematic review

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Age‐related loss of intestinal barrier integrity plays an integral role in thymic involution and T cell ageing

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Among older adults, age-related changes in the stool microbiome differ by HIV-1 serostatus

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The Aged Intestine: Performance and Rejuvenation

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Physiologically based pharmacokinetic (PBPK) modelling of oral drug absorption in older adults – an AGePOP review

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Age-related alterations in gut homeostasis are microbiota dependent

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Comparisons of the Postprandial Inflammatory and Endotoxaemic Responses to Mixed Meals in Young and Older Individuals: A Randomised Trial

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Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer’s Type Dementia

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The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer

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The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease

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Does calprotectin level identify a subgroup among patients suffering from irritable bowel syndrome? Results of a prospective study

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Regulatory effects of saponins from Panax japonicus on colonic epithelial tight junctions in aging rats

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The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice

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Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework

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Blueberry–Mulberry Extract Alleviates Cognitive Impairment, Regulates Gut Metabolites, and Inhibits Inflammation in Aged Mice

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Improving intestinal inflammaging to delay aging? A new perspective

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Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age

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Aging and immunotherapies: New horizons for the golden ages

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Green tea EGCG effectively alleviates experimental colitis in middle-aged male mice by attenuating multiple aspects of oxi-inflammatory stress and cell cycle deregulation

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Digestion and Postprandial Metabolism in the Elderly

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Alzheimer’s Disease: Models and Molecular Mechanisms Informing Disease and Treatments

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Neurogenic mechanisms in bladder and bowel ageing

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Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon

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Age-Related Deterioration of Mitochondrial Function in the Intestine

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Life-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice

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Aging in Male Wistar Rats Associates With Changes in Intestinal Microbiota, Gut Structure, and Cholecystokinin-Mediated Gut–Brain Axis Function

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Functional Flexibility of Exosomes and MicroRNAs of Intestinal Epithelial Cells in Affecting Inflammation

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A framework for intestinal barrier dysfunction in aging

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The emerging role of the microbiome in Alzheimer's disease

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Alginate oligosaccharide alleviates aging-related intestinal mucosal barrier dysfunction by blocking FGF1-mediated TLR4/NF-κB p65 pathway

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Probiotics, prebiotics, synbiotics and other microbiome-based innovative therapeutics to mitigate obesity and enhance longevity via the gut-brain axis

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Gut-bacteria derived membrane vesicles and host metabolic health: a narrative review

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Different oral and gut microbial profiles in those with Alzheimer's disease consuming anti-inflammatory diets

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Gut microbiota in multiple sclerosis and animal models

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Filtered Kombucha tea ameliorates the leaky gut syndrome in young and old mice model of colitis.

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Intestinal Barrier Dysfunction Participates in the Pathophysiology of Ischemic Stroke

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Microbial–Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory

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Prolonged Exposure of Primary Human Muscle Cells to Plasma Fatty Acids Associated with Obese Phenotype Induces Persistent Suppression of Muscle Mitochondrial ATP Synthase β Subunit

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S100A12 concentrations and myeloperoxidase activities are increased in the intestinal mucosa of dogs with chronic enteropathies

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Role of the gut microbiome in Alzheimer’s disease

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Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signaling

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Diet Associated with Inflammation and Alzheimer’s Disease

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Lactiplantibacillus plantarum Strain FLPL05 Promotes Longevity in Mice by Improving Intestinal Barrier

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The Smurf transition: new insights on ageing from end-of-life studies in animal models

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Relief Effects of Icariin on Inflammation-Induced Decrease of Tight Junctions in Intestinal Epithelial Cells

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Plasma exosomal miRNA expression and gut microbiota dysbiosis are associated with cognitive impairment in Alzheimer’s disease

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Aging Increases Enterocyte Damage during a 3-Hour Exposure to Very Hot and Dry Heat: A Preliminary Study

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Changes in the gut microbiota of patients with sarcopenia based on 16S rRNA gene sequencing: a systematic review and meta-analysis

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The Kidney–Gut–Muscle Axis in End-Stage Renal Disease is Similarly Represented in Older Adults

Lustgarten, M. S. (2019) · Nutrients · doi:10.3390/nu12010106 · Cited by 17

The contrasting human gut microbiota in early and late life and implications for host health and disease

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Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17

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Microbial translocation and skeletal muscle in young and old vervet monkeys

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Glucagon-Like Peptide-2 Improve Intestinal Mucosal Barrier Function in Aged Rats

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Clinical features of Epstein–Barr virus in the intestinal mucosa and blood of patients with inflammatory bowel disease

Wang, Y., Zhou, J., Zeng, L., Zhang, Q., Wu, X., Zhang, M.-L., Jing, X.-T., & Gan, H. (2020) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_30_20 · Cited by 15

Ginsenoside Rb1 improves intestinal aging via regulating the expression of sirtuins in the intestinal epithelium and modulating the gut microbiota of mice

Lei, Z., Chen, L., Hu, Q., Yang, Y., Tong, F., Li, K., Lin, T., Nie, Y., Rong, H., Yu, S., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.991597 · Cited by 15

Microbiome Alterations and Alzheimer’s Disease: Modeling Strategies with Transgenic Mice

López-Villodres, J. A., Escamilla, A., Mercado-Sáenz, S., Alba-Tercedor, C., Rodríguez‐Pérez, L., Arranz‐Salas, I., Sanchez-Varo, R. M., & Bermúdez, D. (2023) · Biomedicines · doi:10.3390/biomedicines11071846 · Cited by 16

Stroke and the Microbiome

Banerjee, A., Mohapatra, S., & McCullough, L. D. (2024) · Stroke · doi:10.1161/strokeaha.123.044249 · Cited by 17

Bifidobacterium pseudocatenulatum NCU-08 ameliorated senescence via modulation of the AMPK/Sirt1 signaling pathway and gut microbiota in mice

Zeng, Q., Qi, Z., He, X., Luo, C., Wen, J., Wei, J., Yue, F., Zhao, X., Wei, H., & Chen, T. (2024) · Food & Function · doi:10.1039/d3fo04575g · Cited by 16

Morphological alterations in the jejunal mucosa of aged rats and the possible protective role of green tea

Hassan, Z. A., Zauszkiewicz–Pawlak, A., Abdelrahman, S. A., Algaidi, S. A., Desouky, M. K., & Shalaby, S. M. (2017) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.a2017.0012 · Cited by 15

Classifying Aging As a Disease: The Role of Microbes

Lustgarten, M. S. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00212 · Cited by 15

Clostridium paraputrificum Bacteremia in an Older Patient with No Predisposing Medical Condition

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An inclusive study of recent advancements in Alzheimer's disease: A comprehensive review

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Cognitive Alterations in Old Mice Are Associated with Intestinal Barrier Dysfunction and Induced Toll-like Receptor 2 and 4 Signaling in Different Brain Regions

Brandt, A., Kromm, F., Hernández-Arriaga, A. M., Sánchez, I. M., Bozkır, H. Ö., Staltner, R., Baumann, A., Camarinha‐Silva, A., Heijtz, R. D., & Bergheim, I. (2023) · Cells · doi:10.3390/cells12172153 · Cited by 15

Handbook of Immunosenescence

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Colonic hypersensitivity and low‐grade inflammation in a spontaneous animal model for functional gastrointestinal disorders

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Gut Microorganisms and Neurological Disease Perspectives

Faruqui, N. A., Prium, D. H., Mowna, S. A., Ullah, M. A., Araf, Y., Sarkar, B., Zohora, U. S., & Rahman, M. S. (2021) · Future Neurology · doi:10.2217/fnl-2020-0026 · Cited by 15

Xenobiotic-induced ribosomal stress compromises dysbiotic gut barrier aging: A one health perspective

Sun, J., Kim, J., Jeong, H., Kwon, D., & Moon, Y. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102565 · Cited by 13

Food anaphylaxis in the elderly: Analysis of allergy vigilance network data from 2002 to 2021

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Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys

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Intestinal aging-related immune dysfunction: mechanisms and interventions

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Age-related sarcopenia and the gut microbiome: mechanistic insights into the gut-muscle axis and potential microbiome based therapeutic interventions

Allen, S., Breen, L., Lord, J. M., & Duggal, N. A. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103065 · Cited by 12

Changes in M6A methylation: A key factor in the vicious cycle of flora -gut aging

Ding, M., Yan, J., Chen, Y., Liu, J., Chao, G., & Zhang, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102351 · Cited by 12

Physical frailty, genetic predisposition, and the risks of severe non‐alcoholic fatty liver disease and cirrhosis: a cohort study

Yang, H., Ou, F., Chang, Q., Jiang, J., Liu, Y., Ji, C., Chen, L., Xia, Y., & Zhao, Y. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13506 · Cited by 12

Faecal intestinal permeability and intestinal inflammatory markers in older adults with age-related disorders: A systematic review and meta-analysis

Fadzuli, N. I. A., Lim, S. M., Neoh, C. F., Majeed, A. B. A., Tan, M. P., Khor, H. M., Tan, A. H., & Ramasamy, K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102506 · Cited by 12

Changes of Colon in Rats with Different Ages in Response to Lipopolysaccharide

Li, Y., Guo, Y., Aoqi, L., Ma, C., Xiong, Z., Yuan, D., Zhang, C., Zhang, J., & Dun, Y. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230113112803 · Cited by 11

Sensor-integrated gut-on-a-chip for monitoring senescence-mediated changes in the intestinal barrier

Brandauer, K., Lorenz, A., Schobesberger, S., Schuller, P., Frauenlob, M., Spitz, S., & Ertl, P. (2025) · Lab on a Chip · doi:10.1039/d4lc00896k · Cited by 11

Modeling aging in HIV infection in nonhuman primates to address an emerging challenge of the post-ART era

He, T., Falwell, E., Brocca‐Cofano, E., & Pandrea, I. (2017) · Current Opinion in Virology · doi:10.1016/j.coviro.2017.07.012 · Cited by 12

Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer’s mouse models

Petrisko, T. J., Gargus, M. D., Chu, S., Selvan, P., Whiteson, K., & Tenner, A. J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02885-9 · Cited by 11

The stress polarity pathway: AMPK 'GIV'-es protection against metabolic insults

Ghosh, P. (2017) · Aging · doi:10.18632/aging.101179 · Cited by 11

Evidence that the loss of colonic anti-microbial peptides may promote dysbiotic Gram-negative inflammaging-associated bacteria in aging mice

Forsyth, C. B., Shaikh, M. W., Engen, P. A., Preuss, F., Naqib, A. D., Palmen, B. A., Green, S. J., Zhang, L., Bogin, Z. R., Lawrence, K. M., et al. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1352299 · Cited by 11

Innate immunity in peripheral tissues is differentially impaired under normal and endotoxic conditions in aging

Noh, J. Y., Han, H. W., Kim, D. M., Giles, E. D., Farnell, Y. Z., Wright, G. A., & Sun, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1357444 · Cited by 11

Colonic Aging and Colorectal Cancer: An Unignorable Interplay and Its Translational Implications

Yin, Q., Qin, F., Gan, F., Zhao, G., Chen, R., Wen, Y., Hua, X., Zeng, F., Zhang, Y., Xiao, Y., et al. (2025) · Biology · doi:10.3390/biology14070805 · Cited by 14

Natural Product Co-Metabolism and the Microbiota–Gut–Brain Axis in Age-Related Diseases

Obrenovich, M. E., Singh, S. K., Li, Y., Perry, G. L., Siddiqui, B., Haq, W., & Reddy, V. P. (2022) · Life · doi:10.3390/life13010041 · Cited by 11

Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1–Infected Men

Scully, E. P., Lockhart, A. A. K., Huang, L. P., Robles, Y., Becerril, C., Romero‐Tejeda, M., Albrecht, M., Palmer, C. D., Bosch, R. J., Altfeld, M. A., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv501 · Cited by 10

Aging, inflammation, and HSC

DeGregori, J. V. (2020) · Blood · doi:10.1182/blood.2020006070 · Cited by 10

Gut microbiome metabolites as key actors in atherosclerosis co-depression disease

Liao, X.-X., Wu, X., Zhou, Y.-L., Li, J., Wen, Y.-L., & Zhou, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.988643 · Cited by 10

Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response

Chen, H., Sun, H., Wu, B., Sun, T., Han, L.-Z., Wang, G., Shang, Y.-F., Yang, S., & Zhou, D. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111760 · Cited by 9

Rhubarb ameliorates cognitive dysfunction in a rat model of Alzheimer's disease through regulation of the intestinal microbiome

Zhao, H., Gao, X., & Gao, X. (2019) · Journal of Traditional Chinese Medical Sciences · doi:10.1016/j.jtcms.2019.08.004 · Cited by 9

Aluminum in Coffee

Windisch, J., Keppler, B. K., & Jirsa, F. (2020) · ACS Omega · doi:10.1021/acsomega.0c01410 · Cited by 9

The Aging Bowel Dysfunction and Elderly Vulnerability towards COVID-19 Infection

Lerner, A., & McCarty, M. F. (2021) · Life · doi:10.3390/life11020097 · Cited by 10

Assessment of the impact of age and of blood‐derived inflammatory markers in horses with colitis

Sage, S. E., Bedenice, D., McKinney, C. A., Long, A. E., PACHECO, A. P. D. S., Wagner, B., Mazan, M. R., & Paradis, M. R. (2021) · Journal of Veterinary Emergency and Critical Care · doi:10.1111/vec.13099 · Cited by 10

Low-molecular-weight heparin ameliorates intestinal barrier dysfunction in aged male rats via protection of tight junction proteins

Wang, S., & Yang, H. (2024) · Biogerontology · doi:10.1007/s10522-024-10118-6 · Cited by 8

Age-Associated Remodeling of the Intestinal

Gerontol, C. J., Biol, A., Med, S. T., September, S., Barrier, E., Tran, L., & Meerveld, B. G. (2012)

Age-associated modifications of intestinal permeability and innate immunity in human small intestine.

Man, A., Bertelli, E., Rentini, S., Regoli, M., Briars, G., Marini, M., Watson, A., & Nicoletti, C. (2015) · Clinical science · doi:10.1042/cs20150046 · Cited by 189

A breakdown in communication? Understanding the effects of aging on the human small intestine epithelium

Mabbott, N. A. (2015) · Clinical Science · doi:10.1042/cs20150364 · Cited by 39

Age-related changes in small intestinal mucosa epithelium architecture and epithelial tight junction in rat models

Ren, W., Wu, K., Li, X., Luo, M., Liu, H., Zhang, S., & Hu, Y. (2013) · Aging Clinical and Experimental Research · doi:10.1007/s40520-013-0148-0 · Cited by 94

Intestinal barrier function is maintained with aging – a comprehensive study in healthy subjects and irritable bowel syndrome patients

Wilms, E., Troost, F. J., Elizalde, M., Winkens, B., de Vos, P., Mujagic, Z., Jonkers, D. M. A. E., & Masclee, A. A. M. (2020) · Scientific Reports · doi:10.1038/s41598-019-57106-2 · Cited by 83