Intestinal barrier function is maintained with aging – a comprehensive study in healthy subjects and irritable bowel syndrome patients

Regulation of intestinal epithelial permeability by tight junctions

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Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

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Increased Intestinal Permeability and Decreased Barrier Function: Does It Really Influence the Risk of Inflammation?

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Age-Associated Remodeling of the Intestinal Epithelial Barrier

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MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome

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Age-dependent changes in GI physiology and microbiota: time to reconsider?

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Age-associated modifications of intestinal permeability and innate immunity in human small intestine.

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Novel multi-sugar assay for site-specific gastrointestinal permeability analysis: A randomized controlled crossover trial

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Ageing and the gut

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Small intestinal permeability is increased in diarrhoea predominant IBS , while alterations in gastroduodenal permeability in all IBS subtypes are largely attributable to confounders

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Changes in Small‐Intestine Permeability with Aging

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Ethanol Impairs Intestinal Barrier Function in Humans through Mitogen Activated Protein Kinase Signaling: A Combined In Vivo and In Vitro Approach

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Aging and the mucosal immune system in the intestine

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Nutrition, diet and immunosenescence

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Reinforcement of intestinal epithelial barrier by arabinoxylans in overweight and obese subjects: A randomized controlled trial

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Effect of aging and caloric restriction on intestinal permeability

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Novel analytical approach to a multi-sugar whole gut permeability assay

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Small intestinal permeability in older adults

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THE DOUBLE SUGAR TEST OF INTESTINAL PERMEABILITY IN THE ELDERLY

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Aging-associated increase in intestinal permeability to polyethylene glycol 900

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Effects of Supplementation of the Synbiotic Ecologic® 825/FOS P6 on Intestinal Barrier Function in Healthy Humans: A Randomized Controlled Trial

Wilms, E., Gerritsen, J., Smidt, H., der Vaart, I. B.-V., Rijkers, G. T., Garcia-Fuentes, A., Masclee, A., & Troost, F. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167775 · Cited by 46 · see citing works

Does acute tryptophan depletion affect peripheral serotonin metabolism in the intestine?

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A breakdown in communication? Understanding the effects of aging on the human small intestine epithelium

Mabbott, N. A. (2015) · Clinical Science · doi:10.1042/cs20150364 · Cited by 39 · see citing works

Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms

Mall, J. G., Löfvendahl, L., Lindqvist, C. M., Brummer, R. J., Keita, Å. V., & Schoultz, I. (2018) · Scientific Reports · doi:10.1038/s41598-018-31492-5 · Cited by 33 · see citing works

Exploration of the Esophageal Mucosal Barrier in Non-Erosive Reflux Disease

Rinsma, N. F., Farré, R., Troost, F. J., Elizalde, M., Keszthelyi, D., Helyes, Z., Masclee, A., & Conchillo, J. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18051091 · Cited by 17 · see citing works

Is intestinal oxidative stress involved in patients with compensated liver cirrhosis?

Pijls, K. E., Jonkers, D. M. A. E., Elizalde, M., Drittij-Reijnders, M.-J., Haenen, G. R. M. M., Bast, A., Masclee, A., & Koek, G. H. (2016) · Annals of Hepatology · doi:10.5604/16652681.1198816 · Cited by 6 · see citing works

Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms

Mall, J. G., Löfvendahl, L., Brummer, R. J., Keita, Å. V., & Schoultz, I. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.06.1098 · Cited by 6 · see citing works

Inflammation and aging: signaling pathways and intervention therapies

Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works

The Gut Microbiota and Unhealthy Aging: Disentangling Cause from Consequence

DeJong, E. N., Surette, M. G., & Bowdish, D. M. E. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.07.013 · Cited by 370 · see citing works

Intestinal Barrier Dysfunction in Irritable Bowel Syndrome: A Systematic Review

Hanning, N., Edwinson, A. L., Ceuleers, H., Peters, S. A., De Man, J. G., Hassett, L. C., De Winter, B. Y., & Grover, M. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284821993586 · Cited by 197 · see citing works

Hallmarks of aging and immunosenescence: Connecting the dots

Rodrigues, L. P., Teixeira, V. R., Alencar‐Silva, T., Simonassi-Paiva, B., Pereira, R. W., Pogue, R. E., & Carvalho, J. L. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.01.006 · Cited by 187 · see citing works

Gut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases

Rinninella, E., Cintoni, M., Raoul, P. C., Ianiro, G., Laterza, L., Lopetuso, L. R., Ponziani, F. R., Gasbarrini, A., & Mele, M. C. (2020) · Microorganisms · doi:10.3390/microorganisms8081140 · Cited by 151 · see citing works

Intestinal barrier dysfunction: an evolutionarily conserved hallmark of aging

Salazar, A. M., Aparício, R., Clark, R. I., Rera, M., & Walker, D. W. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.049969 · Cited by 96 · see citing works

Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota

Vogl, T. J., Klompus, S., Leviatan, S., Kalka, I. N., Weinberger, A., Wijmenga, C., Fu, J., Zhernakova, A., Weersma, R. K., & Segal, E. (2021) · Nature Medicine · doi:10.1038/s41591-021-01409-3 · Cited by 85 · see citing works

The intestinal immune system and gut barrier function in obesity and ageing

Shemtov, S. J., Emani, R., Bielska, O., Covarrubias, A. J., Verdin, E. M., Andersen, J. K., & Winer, D. A. (2022) · FEBS Journal · doi:10.1111/febs.16558 · Cited by 83 · see citing works

A gut‐centric view of aging: Do intestinal epithelial cells contribute to age‐associated microbiota changes, inflammaging, and immunosenescence?

Hohman, L. S., & Osborne, L. C. (2022) · Aging Cell · doi:10.1111/acel.13700 · Cited by 83 · see citing works

Chronic kidney disease and gut microbiota

Khiabani, S. A., Asgharzadeh, M., & Kafil, H. S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18991 · Cited by 76 · see citing works

Gut inflammation associated with age and Alzheimer’s disease pathology: a human cohort study

Heston, M. B., Hanslik, K. L., Zarbock, K. R., Harding, S. J., Davenport‐Sis, N. J., Kerby, R. L., Chin, N. A., Sun, Y., Hoeft, A., Deming, Y. K., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-45929-z · Cited by 64 · see citing works

Anemia and Its Connections to Inflammation in Older Adults: A Review

Wacka, E., Nicikowski, J., Jarmużek, P., & Zembroń-Łacny, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13072049 · Cited by 60 · see citing works

Leaky gut in systemic inflammation: exploring the link between gastrointestinal disorders and age-related diseases

Escalante, J., Artaiz, O., Diwakarla, S., & McQuade, R. M. (2024) · GeroScience · doi:10.1007/s11357-024-01451-2 · Cited by 56 · see citing works

Impairments of intestinal arginine and NO metabolisms trigger aging-associated intestinal barrier dysfunction and ‘inflammaging'

Brandt, A., Baumann, A., Hernández-Arriaga, A. M., Jung, F., Nier, A., Staltner, R., Rajcic, D., Schmeer, C. W., Witte, O. W., Wessner, B., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102528 · Cited by 51 · see citing works

Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster

Golubev, D., Zemskaya, N. V., Шевченко, О. Г., Shaposhnikov, M. V., Kukuman, D. V., Patov, S. A., Punegov, V. V., & Moskalev, A. (2022) · Biogerontology · doi:10.1007/s10522-022-09954-1 · Cited by 52 · see citing works

The role of the gut microbiota in the onset and progression of heart failure: insights into epigenetic mechanisms and aging

Matacchione, G., Piacenza, F., Pimpini, L., Rosati, Y., & Marcozzi, S. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01786-9 · Cited by 41 · see citing works

Trifostigmanoside I, an Active Compound from Sweet Potato, Restores the Activity of MUC2 and Protects the Tight Junctions through PKCα/β to Maintain Intestinal Barrier Function

Parveen, A., Choi, S., Kang, J., Oh, S. H., & Kim, S. Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010291 · Cited by 35 · see citing works

The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review

Stillhart, C., Asteriadis, A., Bocharova, E., Eksteen, G., Harder, F., Kusch, J., Tzakri, T., Augustijns, P., Matthys, C., Vertzoni, M., et al. (2023) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106452 · Cited by 33 · see citing works

Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework

Clerbaux, L., Albertini, M. C., Amigó, N., Beronius, A., Bezemer, G. F. G., Coecke, S., Daskalopoulos, E. P., del Giudice, G., Greco, D., Grenga, L., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11154464 · Cited by 28 · see citing works

Restoration of the gut barrier integrity and restructuring of the gut microbiome in aging by angiotensin-(1–7)

Chittimalli, K., Jahan, J., Sakamuri, A., McAdams, Z. L., Ericsson, A. C., & Jarajapu, Y. P. R. (2023) · Clinical Science · doi:10.1042/cs20220904 · Cited by 25 · see citing works

Microbiota profiling in aging-associated inflammation and liver degeneration

Baumann, A., Hernández-Arriaga, A. M., Brandt, A., Sánchez, V., Nier, A., Jung, F., Kehm, R., Höhn, A., Grune, T., Frahm, C., et al. (2021) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2021.151500 · Cited by 26 · see citing works

A framework for intestinal barrier dysfunction in aging

Tatge, L., Fonseca, R. S., & Douglas, P. M. (2023) · Nature Aging · doi:10.1038/s43587-023-00492-0 · Cited by 23 · see citing works

Intestinal barrier, immunity and gut microbiota-based protective effects of Lactococcus lactis HF08 and its postbiotic derivative on aging and aging colitis mice

Liu, X., Ma, Y., Guan, K., Liu, R., Mao, K., Xu, X., Li, Q., & Wang, R. (2024) · Food Research International · doi:10.1016/j.foodres.2024.115164 · Cited by 23 · see citing works

Role of Stress on Driving the Intestinal Paracellular Permeability

Molotla‐Torres, D. E., Guzmán‐Mejía, F., Godínez‐Victoria, M., & Drago-Serrano, M. E. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45110581 · Cited by 26 · see citing works

Age-dependent effects of gut microbiota metabolites on brain resident macrophages

Hasavci, D., & Blank, T. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.944526 · Cited by 23 · see citing works

Association between gut permeability, brain volume, and cognition in healthy participants and patients with schizophrenia spectrum disorder

Scheurink, T. A. W., Borkent, J., Gangadin, S. S., Aidy, S. E., Mandl, R. C. W., & Sommer, I. E. (2023) · Brain and Behavior · doi:10.1002/brb3.3011 · Cited by 20 · see citing works

Key Molecular Mechanisms of Aging, Biomarkers, and Potential Interventions

Proshkina, E., Solovev, I. A., Shaposhnikov, M. V., & Moskalev, A. (2020) · Molecular Biology · doi:10.1134/s0026893320060096 · Cited by 21 · see citing works

Dark Chocolate Intake Positively Modulates Gut Permeability in Elite Football Athletes: A Randomized Controlled Study

Nocella, C., Cavarretta, E., FOSSATI, C., Pigozzi, F., Quaranta, F., Peruzzi, M., Grandis, F. D., Costa, V., Sharp, C., Manara, M., et al. (2023) · Nutrients · doi:10.3390/nu15194203 · Cited by 18 · see citing works

Ключевые молекулярные механизмы старения, биомаркеры и потенциальные интервенции

Proshkina, E., Соловьёв, И. А., Shaposhnikov, M. V., & Moskalev, A. A. (2020) · Molecular Biology · doi:10.31857/s0026898420060099 · Cited by 18 · see citing works

Young at Gut—Turning Back the Clock with the Gut Microbiome

Narasimhan, H., Ren, C. C., Deshpande, S., & Sylvia, K. E. (2021) · Microorganisms · doi:10.3390/microorganisms9030555 · Cited by 17 · see citing works

Trends in intestinal aging: From underlying mechanisms to therapeutic strategies

Wang, Y., Zhang, X., Qing, M., Dang, W., Bai, X., Wang, Y., Zhou, D., Zhu, L., Qing, D., Zhang, J., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.05.011 · Cited by 19 · see citing works

Exogenous Sequences in Tumors and Immune Cells (Exotic): A Tool for Estimating the Microbe Abundances in Tumor RNA-seq Data

Hoyd, R., Wheeler, C. E., Liu, Y., Singh, M. S. J., Muniak, M., Jin, N. Y., Denko, N. C., Carbone, D. P., Mo, X. M., & Spakowicz, D. J. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-22-0435 · Cited by 15 · see citing works

Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex

Golubev, D., Platonova, E. Y., Zemskaya, N. V., Шевченко, О. Г., Shaposhnikov, M. V., Nekrasova, P., Patov, S. A., Ibragimova, U. M., Valuisky, N., Borisov, A. V., et al. (2023) · Biogerontology · doi:10.1007/s10522-023-10083-6 · Cited by 16 · see citing works

Serum Amyloid A3 Fuels a Feed-Forward Inflammatory Response to the Bacterial Amyloid Curli in the Enteric Nervous System

Verstraelen, P., Remoortel, S. V., Loose, N. D., Verboven, R., Barriga, G. G.-D., Christmann, A., Gries, M., Bessho, S., Li, J., Guerra, C. E., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.03.013 · Cited by 16 · see citing works

Aging and physiological barriers: mechanisms of barrier integrity changes and implications for age-related diseases

Solovev, I. A., Sergeeva, A. D., Geraskina, A., Shaposhnikov, M. V., Vedunova, M. V., Borysova, O., & Moskalev, A. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09833-7 · Cited by 16 · see citing works

Can probiotics mitigate age-related neuroinflammation leading to improved cognitive outcomes?

Anderson, R. C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1012076 · Cited by 14 · see citing works

Fecal luminal factors from patients with irritable bowel syndrome induce distinct gene expression of colonoids

Iribarren, C., Nordlander, S., Sundin, J., Isaksson, S., Savolainen, O. I., Törnblom, H., Magnusson, M. K., Simrén, M., & Öhman, L. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14390 · Cited by 13 · see citing works

Machine learning-based predictive model for enteral nutrition-associated diarrhea in ICU patients and its nursing applications

Liao, X., Li, C., Liu, Q., Wang, X., Liu, Z., Zhu, J., Hu, W., & Hong, Q. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1584717 · Cited by 12 · see citing works

Intestinal aging-related immune dysfunction: mechanisms and interventions

Shen, X., Gao, X., & Wang, L. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025157 · Cited by 12 · see citing works

Gut microb-aging and its relevance to frailty aging

Cosquer, G. L., Vergnolle, N., & Motta, J. (2024) · Microbes and Infection · doi:10.1016/j.micinf.2024.105309 · Cited by 15 · see citing works

Changes in M6A methylation: A key factor in the vicious cycle of flora -gut aging

Ding, M., Yan, J., Chen, Y., Liu, J., Chao, G., & Zhang, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102351 · Cited by 12 · see citing works

Faecal intestinal permeability and intestinal inflammatory markers in older adults with age-related disorders: A systematic review and meta-analysis

Fadzuli, N. I. A., Lim, S. M., Neoh, C. F., Majeed, A. B. A., Tan, M. P., Khor, H. M., Tan, A. H., & Ramasamy, K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102506 · Cited by 12 · see citing works

The role of the three major intestinal barriers in ulcerative colitis in the elderly

Fu, M., Wang, Q.-W., Liu, Y., & Chen, S. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102752 · Cited by 14 · see citing works

Carvacrol attenuated lipopolysaccharide-induced intestinal injury by down-regulating TLRs gene expression and regulating the gut microbiota in rabbit

Wu, D., Xia, M., Yan, A., Jiang, H., Fan, J., Zhou, S., Wei, X., Liu, S., & Chen, B. (2023) · Scientific Reports · doi:10.1038/s41598-023-38577-w · Cited by 12 · see citing works

Age-related sarcopenia and the gut microbiome: mechanistic insights into the gut-muscle axis and potential microbiome based therapeutic interventions

Allen, S., Breen, L., Lord, J. M., & Duggal, N. A. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103065 · Cited by 12 · see citing works

Eugenol Possesses Colitis Protective Effects: Impacts on the TLR4/MyD88/NF-κB Pathway, Intestinal Epithelial Barrier, and Macrophage Polarization

Huang, J.-J., Feng, Y.-M., Zheng, S.-M., Yu, C.-L., Zhou, R.-G., Liu, M., Bo, R., Yu, J., & Li, J. (2024) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x24500216 · Cited by 11 · see citing works

Lymphocyte‐to‐C‐Reactive Protein Ratio as a Novel Marker for Predicting Oncological Outcomes in Patients with Esophageal Cancer

Takeuchi, M., Kawakubo, H., Hoshino, S., Matsuda, S., Mayanagi, S., Irino, T., Fukuda, K., Nakamura, R., Wada, N., & Kitagawa, Y. (2021) · World Journal of Surgery · doi:10.1007/s00268-021-06269-z · Cited by 11 · see citing works

Curcumin-mediated alleviation of dextran-induced leaky gut in Drosophila melanogaster

Khaerani, M., Chaeratunnisa, R., Salsabila, A. C., Asbah, A., Asri, R. M., Shiratsuchi, A., & Nainu, F. (2024) · Narra J · doi:10.52225/narra.v4i1.743 · Cited by 10 · see citing works

Gut Microbiota and Nutrition in Nursing Homes: Challenges and Translational Approaches for Healthy Aging

Jiménez-Arroyo, C., Molinero, N., & Moreno-Arribas, M. V. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100520 · Cited by 10 · see citing works

Microbiota induces aging-related leaky gut and inflammation by dampening mucin barriers and butyrate-FFAR2/3 signalingPreprint

Mishra, S. P., Wang, B., Wang, S., Nagpal, R., Miller, B. C., Jain, S., Lee, J.-Y., Borlongan, C. V., Taraphdar, S., Rane, S. G., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.18.456856 · Cited by 10 · see citing works

Translocation of black carbon particles to human intestinal tissue

Pee, T. V., Vanbrabant, K., Rasking, L., Eyken, P. V., Hogervorst, J. G. F., Caenepeel, P., Ameloot, M. M., Plusquin, M., & Nawrot, T. S. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105464 · Cited by 9 · see citing works

Clinical evidence linking osteoporosis and the gut microbiome in postmenopausal females: A systematic review

Lee, K. J., Kim, H., & Wang, J. (2025) · Bone · doi:10.1016/j.bone.2025.117644 · Cited by 9 · see citing works

Resiliency of the Digestive System During Aging and the Impact of Diet

Sanders, L., Goltz, S. R., & Maki, K. C. (2023) · Nutrition Today · doi:10.1097/nt.0000000000000616 · Cited by 9 · see citing works

The gut microbiome as a modulator of arterial function and age-related arterial dysfunction

Longtine, A. G., Greenberg, N., de Quirós, Y. B., & Brunt, V. E. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00764.2023 · Cited by 9 · see citing works

Mitigating natural aging in Drosophila melanogaster with Tremella fuciformis polysaccharides

Qiang, Y., Min, Y., Li, W., Chen, D., Zhang, S., Chen, H., Guo, Z., ShaoXiao, Z., & Zheng, B. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107145 · Cited by 7 · see citing works

Digestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients

Courelli, V., Ahmad, A. S., Ghassemian, M., Pruitt, C., Mills, P. J., & Schmid‐Schönbein, G. W. (2021) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-021-00693-w · Cited by 7 · see citing works

Grape Seed Proanthocyanidins: A Potential Microbiome‐Targeted Intervention for Healthy Aging in Rats

Sierra‐Cruz, M., Vilalta, A., Miguéns‐Gómez, A., Park, H., Rodríguez‐Gallego, E., Blay, M., Ardèvol, A., Pinent, M., Behmoaras, J. V., Beltrán‐Debón, R., et al. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70150 · Cited by 5 · see citing works

Non-invasive fluorescence sensing reveals changes in intestinal barrier function and gastric emptying rate in a first-in-human study of Crohn’s disease

Gan, J., Chen, Q., Sánchez, E. M., Mandal, N., Xu, J., Wang, Z., Agarwal, A., Oluwatunmise, E., Ramkumar, P., Salam, A., et al. (2025) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848251361634 · Cited by 5 · see citing works

Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in an elderly population

Carvalho, M. C. D. C., Mota, A., do Nascimento, D. D. S. M., de Sousa, I. N. F., Bona, M. D., Ribeiro, K. D. D. S., Lima, A. Â. M., & Maciel, B. L. L. (2025) · Scientific Reports · doi:10.1038/s41598-025-08045-8 · Cited by 3 · see citing works

Drug-induced gastrointestinal toxicity and barrier integrity: cytoskeleton-mediated impairment in a clinically relevant human intestinal epithelium model

Yu, W. D., Lee, S., Cho, H., Kwon, O., Lim, J. H., Jung, C., Jang, B., Lee, K. J., Yoo, J., Kim, D., et al. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01635-6 · Cited by 4 · see citing works

Effects of probiotics on cognitive and emotional functions in healthy older adults: Protocol for a double‐blind randomized placebo‐controlled crossover trial

Ruiz‐González, C., Cardona, D., Rodríguez-Arrastia, M. J., Ropero‐Padilla, C., Rueda‐Ruzafa, L., Carvajal, F., Sánchez‐Labraca, N., Mota, A. A., & Román, P. (2022) · Research in Nursing & Health · doi:10.1002/nur.22209 · Cited by 4 · see citing works

The phenomenon of intestinal permeability and its association with cardiovascular disease. Current status

Kashtanova, D. A., & Ткачева, О. Н. (2020) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2020-2474 · Cited by 4 · see citing works

New indicator of small intestinal ageing in senescence-accelerated mice

Kurihara, F., Hempstock, W., Ishizuka, N., & Hayashi, H. (2025) · The Journal of Physiological Sciences · doi:10.1016/j.jphyss.2025.100030 · Cited by 3 · see citing works

Advanced human organoid-on-chip with physiological cellular complexity reveals bidirectional secretion patterns

Hensel, I. V., Éliás, S., Steinhauer, M., Günther, C., & Resnik-Docampo, M. (2025) · iScience · doi:10.1016/j.isci.2025.114418 · Cited by 3 · see citing works

Predicting nanocarrier permeation across the human intestine in vitro : model matters

Jung, N., Schreiner, J., Baur, F., Vogel‐Kindgen, S., & Windbergs, M. (2024) · Biomaterials Science · doi:10.1039/d4bm01092b · Cited by 3 · see citing works

Composition and anti-colitis efficacy analysis of ethanol and aqueous extraction of Moringa oleifera leaves

Feng, Y., Huang, J., Gong, J.-Z., Peng, W., Yu, C.-L., Huai, Y., Chen, C., Bo, R., Liu, M., & Li, J. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.106720 · Cited by 3 · see citing works

Aging by autodigestion

DeLano, F. A., & Schmid‐Schönbein, G. W. (2024) · PLoS ONE · doi:10.1371/journal.pone.0312149 · Cited by 3 · see citing works

Pathogenicity of commensal gut biofilm in prefrail aging

Cosquer, G. L., Pannier, M., Servanne-Meunier, E., Thevenin, J., Pyhourquet, E., Guyonnet, S., Vellas, B. J., Santin, Y., Guiard, B. P., Parini, A., et al. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00716-8 · Cited by 2 · see citing works

Aging of the Colon – A Mechanistic View

Hofmann, C., & Geiger, H. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112143 · Cited by 2 · see citing works

Low-grade mucosal inflammation in aged senescence-accelerated mouse-prone 8 mice blunts epithelial barrier recovery after dextran sodium sulphate-induced chronic colitis

Verboven, R., Verstraelen, P., Loose, N. D., Ott, J., Hanning, N., Winter, B. Y. D., Timmermans, J.-P., & Vos, W. H. D. (2026) · Biogerontology · doi:10.1007/s10522-026-10385-5 · Cited by 1 · see citing works

The Design of Patient-centric Dosage Forms for Older Adults

Page, S., da Costa, S. B., Stillhart, C., Timpe, C., & Wagner, L. (2023) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-031-35811-1_4 · Cited by 1 · see citing works

Development and validation of an LC-MS/MS method for the quantification of oral-sugar probes in plasma to test small intestinal permeability and absorptive capacity in the domestic cat (Felis catus)

Patterson, K., Fraser, K., Bernstein, D. R., Bermingham, E. N., Weidgraaf, K., Shoveller, A. K. K., & Thomas, D. G. (2024) · Journal of Chromatography B · doi:10.1016/j.jchromb.2024.124216 · Cited by 1 · see citing works

Associação entre microbioma intestinal e ocorrência de delirium em idosos agudamente enfermos

Carvalho, F. B. G. (2021) · doi:10.11606/t.5.2021.tde-09082021-085157

Gut inflammation associated with age and Alzheimer’s disease pathologyPreprint

Heston, M. B., Hanslik, K. L., Zarbock, K. R., Harding, S. J., Davenport‐Sis, N. J., Kerby, R. L., Chin, N. A., Sun, Y., Hoeft, A., Deming, Y. K., et al. (2022) · medRxiv · doi:10.1101/2022.09.21.22280179

Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activityPreprint

Golubev, D., Platonova, E. Y., Zemskaya, N. V., Шевченко, О. Г., Shaposhnikov, M. V., Nekrasova, P., Patov, S. A., Ibragimova, U. M., Valuisky, N., Borisov, A., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3372894/v1

Differences in Mucosal Permeability Among Patients With Ulcerative Colitis Classified Based on the Colonic Location and Disease Activity

Shiratori, W., Ohta, Y., Matsusaka, K., Ohyama, Y., Mamiya, Y., Nakazawa, H., Takahashi, S., Horio, R., Goto, C., Sonoda, M., et al. (2024) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000692

Predicting nanocarrier permeation across the human intestine in vitro : Model mattersPreprint

Jung, N., Schreiner, J., Baur, F., Vogel‐Kindgen, S., & Windbergs, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.08.584089

Exploring the Interplay Between Gut Microflora and Parkinson’s

Swathi, M., Hazra, A., Dhanu, A. S., & Basalingappa, K. M. (2024) · Springer eBooks · doi:10.1007/978-981-99-8803-7_15

The Relationship Between Dietary Fiber Intake and C-reactive Protein Levels in Elderly Diabetic Patients With Cardiovascular Disease RiskPreprint

Yin, B., Wang, T., Wu, Y., & Lv, J. (2024) · Research Square · doi:10.21203/rs.3.rs-5340040/v1

Gut Barrier Permeability, Microbiota, and Brain Health

Madison, A. A., Duff, A. F., & Bailey, M. T. (2025) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.17

Age‐Dependent Increase in Small Intestinal Permeability and Sex‐Dependent Absorptive Capacity in Cats ( Felis catus )

Patterson, K., Bermingham, E. N., Fraser, K., Bernstein, D. R., Weidgraaf, K., Shoveller, A. K. K., & Thomas, D. G. (2025) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.70015

Impact of chronological ageing on tight junction-related gene expression at the human gastrointestinal epithelium: An exploratory study

Kusch, J., Argyropoulos, T., Goumas, K., Tribonias, G., Reppas, C. I., & Vertzoni, M. (2026) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2026.107513

Unveiling the aging-immune axis in irritable bowel syndrome: a multi-omics and machine learning approach to biomarker discovery and validation

Yao, Y., Li, J. B., Zhang, B., Li, T., Linghu, E., Li, X. Y., & Zhao, M. H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1893702

The Impact of Pectin Supplementation on Intestinal Barrier Function in Healthy Young Adults and Healthy Elderly

Wilms, E., Jonkers, D. M. A. E., Savelkoul, H. F. J., Elizalde, M., Tischmann, L., de Vos, P., Masclee, A., & Troost, F. J. (2019) · Nutrients · doi:10.3390/nu11071554 · Cited by 68 · see citing works

Small intestinal permeability in older adults

Valentini, L., Ramminger, S., Haas, V., Postrach, E., Werich, M., Fischer, A., Koller, M., Swidsinski, A., Bereswill, S., Lochs, H., et al. (2014) · Physiological Reports · doi:10.1002/phy2.281 · Cited by 73 · see citing works

Age-Associated Remodeling of the Intestinal Epithelial Barrier

Tran, L., & Greenwood-Van Meerveld, B. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt106 · Cited by 320 · see citing works

A breakdown in communication? Understanding the effects of aging on the human small intestine epithelium

Mabbott, N. A. (2015) · Clinical Science · doi:10.1042/cs20150364 · Cited by 39 · see citing works

Aging Increases the Severity of Colitis and the Related Changes to the Gut Barrier and Gut Microbiota in Humans and Mice

Liu, A., Lv, H., Wang, H., Yang, H. B., Li, Y., & Qian, J. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz263 · Cited by 147 · see citing works